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| 1 | Extracts of passion fruit peel and seed of Passiflora edulis(Passifloraceae) attenuate oxidative stress in diabetic rats显示文摘This study was aimed at evaluating the anti-diabetic potential of passion fruit Passiflora edulis(EPE) extracts in diabetic rats, following Streptozotocin(STZ) induced oxidative stress. Thirty adult Wistar rats were divided into five groups, with six rats in each group. The control rats were injected intraperitoneally with citrate buffer(pH 4.5). The remaining groups of rats were administered single dose of 45 mg·kg-1 of STZ by intraperitoneal route to induce diabetes. The diabetic animals were treated with 250 and 500 mg·kg-1 of EPE and glibenclamide 0.6 mg·kg-1 for fifteen days by oral route. Blood glucose, end organ oxidative stress marker, and anti-oxidants were assayed. Further, histopathological investigation of pancreas was studied at the end of the experimentation. The results revealed that subacute administration of EPE significantly(P < 0.001) controlled the blood glucose level in the diabetic rats. In addition, EPE extract protected the end organs by restoring the anti-oxidants enzyme, significantly increasing super oxide dismutase level(SOD) and decreasing catalase(CAT) and TBARS level in visceral organs. In conclusion, that EPE extracts showed anti-diabetic and anti-oxidant potential against streptozotocin-induced diabetes. | Salanee Kandandapani Ashok K.Balaraman Haja N.Ahamed | 2015 | Chinese Journal of Natural Medicines2015，13，9： | 18 |
| 2 | The Sandfish's Skin:Morphology,Chemistry and Reconstruction显示文摘The sandfish is a lizard having the remarkable ability to move in desert sand in a swimming-like fashion. The most out-standing adaptations to this mode of life are the low friction behaviour and the extensive abrasion resistance of the sandfish skin against sand, outperforming even steel. We investigated the topography, the composition and the mechanical properties of sandfish scales. These consist of glycosylated keratins with high amount of sulphur but no hard inorganic material, such as silicates or lime. Remarkably, atomic force microscopy shows an almost complete absence of attractive forces between the scale surface and a silicon tip, suggesting that this is responsible for the unusual tribological properties. The unusual glycosylation of the keratins was found to be absolutely necessary for the described phenomenon. The scales were dissolved and reconstituted on a polymer surface resulting in properties similar to the original scale. Thus, we provide a pathway towards exploitation of the reconstituted scale material for future engineering applications. | Werner Baumgartner Friederike Saxe Agnes Weth David Hajas Darwin Sigumonrong Jens Emmerlich Martin Singheiser Wolfgang Bhme Jochen M. Schneider | 2007 | Journal of Bionic Engineering2007，4，1： | 10 |
| 3 | Improving genomic predictions by correction of genotypes from genotyping by sequencing in livestock populations显示文摘Background: Genotyping by sequencing(GBS) is a robust method to genotype markers. Many factors can influence the genotyping quality. One is that heterozygous genotypes could be wrongly genotyped as homozygotes,dependent on the genotyping depths. In this study, a method correcting this type of genotyping error was demonstrated. The efficiency of this correction method and its effect on genomic prediction were assessed using simulated data of livestock populations.Results: Chip array(Chip) and four depths of GBS data was simulated. After quality control(call rate ≥ 0.8 and MAF ≥ 0.01), the remaining number of Chip and GBS SNPs were both approximately 7,000, averaged over 10 replicates. GBS genotypes were corrected with the proposed method. The reliability of genomic prediction was calculated using GBS, corrected GBS(GBSc), true genotypes for the GBS loci(GBSr) and Chip data. The results showed that GBSc had higher rates of correct genotype calls and higher correlations with true genotypes than GBS. For genomic prediction, using Chip data resulted in the highest reliability. As the depth increased to 10, the prediction reliabilities using GBS and GBSc data approached those using true GBS data. The reliabilities of genomic prediction using GBSc data were 0.604, 0.672, 0.684 and 0.704 after genomic correction, with the improved values of 0.013, 0.009, 0.006 and 0.001 at depth = 2, 4, 5 and 10, respectively.Conclusions: The current study showed that a correction method for GBS data increased the genotype accuracies and, consequently, improved genomic predictions. These results suggest that a correction of GBS genotype is necessary, especially for the GBS data with low depths. | Xiao Wang Mogens SandΦ Lund Peipei Ma Luc Janss Haja N.Kadarmideen Guosheng Su | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 4 |
| 4 | Comparisons of improved genomic predictions generated by different imputation methods for genotyping by sequencing data in livestock populations显示文摘Background:Genotyping by sequencing(GBS)still has problems with missing genotypes.Imputation is important for using GBS for genomic predictions,especially for low depths,due to the large number of missing genotypes.Minor allele frequency(MAF)is widely used as a marker data editing criteria for genomic predictions.In this study,three imputation methods(Beagle,IMPUTE2 and FImpute software)based on four MAF editing criteria were investigated with regard to imputation accuracy of missing genotypes and accuracy of genomic predictions,based on simulated data of livestock population.Results:Four MAFs(no MAF limit,MAF≥0.001,MAF≥0.01 and MAF≥0.03)were used for editing marker data before imputation.Beagle,IMPUTE2 and FImpute software were applied to impute the original GBS.Additionally,IMPUTE2 also imputed the expected genotype dosage after genotype correction(GcIM).The reliability of genomic predictions was calculated using GBS and imputed GBS data.The results showed that imputation accuracies were the same for the three imputation methods,except for the data of sequencing read depth(depth)=2,where FImpute had a slightly lower imputation accuracy than Beagle and IMPUTE2.GcIM was observed to be the best for all of the imputations at depth=4,5 and 10,but the worst for depth=2.For genomic prediction,retaining more SNPs with no MAF limit resulted in higher reliability.As the depth increased to 10,the prediction reliabilities approached those using true genotypes in the GBS loci.Beagle and IMPUTE2 had the largest increases in prediction reliability of 5 percentage points,and FImpute gained 3 percentage points at depth=2.The best prediction was observed at depth=4,5 and 10 using GcIM,but the worst prediction was also observed using GcIM at depth=2.Conclusions:The current study showed that imputation accuracies were relatively low for GBS with low depths and high for GBS with high depths.Imputation resulted in larger gains in the reliability of genomic predictions for GBS with lower depths.These results suggest that the application of IMPUTE2,based on a corrected GBS(GcIM)to improve genomic predictions for higher depths,and FImpute software could be a good alternative for routine imputation. | Xiao Wang Guosheng Su Dan Hao Mogens SandøLund Haja N.Kadarmideen | 2020 | Journal of Animal Science and Biotechnology2020，11，2： | 4 |
| 5 | Cytisus scoparius link-a natural antioxidant显示文摘 | Sundamrajan R Haja NA Venkatesan K | 2006 | BMC Complement Altern Med2006，6，3： | 1 |
| 6 | Sensorineural heating loss in patients with mixed connective tissue dis- ease: immunological markers and cytokine levels 显示文摘 | Hajas A Szodoray P Barath S | 2009 | J Rheumatol2009，36，9： | 1 |
| 7 | Modified urea thiekeners - now also for aqueous systems 显示文摘 | HAJAS J WOOCKER A | 2003 | Paintindia2003，，： | 1 |
| 8 | Study of draw solutes using 2-methylimidazole-based compounds in forward os- mosis显示文摘 | Yen S K Haja F M N Su M | 2010 | Journal of Membrane Science2010，364，12： | 1 |
| 9 | Genetic parameters and evaluations from single-and multiple-trait a-nalysis of dairy cow fertility and milk production显示文摘 | Haja N Kadarmideen A Robin Thompsonb | 2003 | Journal of dairy science2003，86，06： | 1 |
| 10 | Fine-needle aspiration biopsy of lymphoproliferative disorders--interprotations based Oil morphologic criteria alone:results from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytopathology显示文摘 | Young NA Moriarty AT Haja JC | | 0，，12： | 1 |
| 11 | Assessment of genetic diversity and population structure of Vietnamese indigenous cattle populations by microsatellites显示文摘 | Lan Doan Pham Duy Ngoc Do Nguyen Trong Binh Le Quang Nam Nguyen Van Ba Tran Thi Thu Thuy Tran Xuan Hoan Vu Chi Cuong Haja N. Kadarmideen | 2013 | Livestock Science2013，，1： | 1 |
| 12 | Study of draw solutes using 2-methylimidazole based compounds in forward osmosis显示文摘 | Yen S K Haja F M N | 2010 | J Membr Sci2010，364，： | 1 |
| 13 | New insights into clinical trial for colostrininTM in Alzheimer's disease显示文摘 | SZANISZLO P GERMAN P HAJAS G | 2009 | The Journal of Nutrition Health Aging2009，13，3： | 1 |
| 14 | Targeting dendritic cells for priming cellular immune responses 显示文摘 | Gogolak P Rethi B Hajas G | 2003 | J Mol Recognit2003，16，5： | 1 |
| 15 | Antilithiatic Effect of Melia azedarach on Ethylene Glycol - Induced Nephrolithiasis in Rats显示文摘 | Christina A J M Haja Najumadeen N A Vimal Kumar S | 2006 | Pharmaceutical Biology2006，44，6： | 1 |
| 16 | Anemia and performance status as prognostic markers in acute hypercapnic respiratory failure due to chronic obstructive pulmonary disease显示文摘 | Helmy Haja Mydin Clague Murphy Taylor Sridharan | 2013 | International Journal of Chronic Obstructive Pulmonary Disease . 2013 (defa)2013，，： | 1 |
| 17 | Cytisus scoparius Link-A natural antioxidant显示文摘 | Sundararajan R Haja N A Venkatesan K | 2006 | BMC complementary and alternative medicine2006，6，1： | 1 |
| 18 | Distinct phenotypes in mixed connective tissue disease: subgroups and survival显示文摘 | Szodoray P Hajas A Kardos L | 2012 | Lupus2012，21，13： | 1 |
| 19 | Targeting dendritic cells for priming cellular immune responses 显示文摘 | Gogolak PB Rethi G Hajas | 2003 | J Mol Recognit2003，16，5： | 1 |
| 20 | Study of draw solutes us- ing 2-methylimidazole-based compounds in forward osmo- sis显示文摘 | Yen S K Haja N F M Su M | 2010 | Journal of Membrane Science2010，364，： | 1 |
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