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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Carburization behavior of HK40 steel in furnaces used for ethylene production 显示文摘 | D J Hall M K Hossain and R F Atkinson | 1982 | High Temperature High Pressure1982，14，： | 1 |
| 3 | Laboranory mutants of OXA-10 beta- lactamase giving ceftazidime resistance in Pseudomonas aeruginosa 显示文摘 | Danel F Hall L M Livermore D M | 1999 | J Antimicrob Chemother1999，43，3： | 1 |
| 4 | Identification and characterization of the Escherichia coli RecT protein, a protein encoded by the recE region that promotes renaturtion of homologous single-stranded DNA显示文摘 | Hall S D Kane M F Kolodner R D | 1993 | J Bacteriol1993，175，： | 1 |
| 5 | Spectral mixture analysis and geometric-optical reflectance modeling of boreal forest biophysical structure 显示文摘 | Peddle D R Hall F G LeDrew E F | 1999 | Remote Sensing of Environment1999，67，3： | 1 |
| 6 | The fractional inhibitory concentration (FIC) index as a measure of syn- ergy显示文摘 | Hall M J Middleton R F Westmacott D | 1983 | J Antimierob Chemother1983，11，5： | 1 |
| 7 | Large- Scale Patterns of Forest Succession as Determined by Re- mote Sensing 显示文摘 | HALL F G BOTKIN D B STREBEL D E | 1991 | Ecology1991，72，2： | 1 |
| 8 | Plasma antioxidant vitamins and carotenoids and age-related cataract显示文摘 | Gale C R Hall N F Phillips D I | 2001 | Ophthalmology2001，108，11： | 1 |
| 9 | Near-source ground motion and its effects on flexible buildings显示文摘 | Hall J F Heaton T H Halling MW Wald D J | 1995 | Earthquake Spectra1995，11，4： | 1 |
| 10 | Relations between surface conductance and spectral vegetation Indices at Intermediate (100 m2 to 15 km2) Length Scales显示文摘 | Sellers P J -/-Ieiser M D Hall F G | 1992 | Journal of Geophysical Research1992，97，17： | 1 |
| 11 | Pesticide tracers for measuring orchard spray drift显示文摘 | Fox R D Hall F R Reichard D L | 1993 | Applied Engineering in Agriculture1993，9，6： | 1 |
| 12 | Binding, distribution, and plant uptake of mercury in a soil from Oak Ridge, Tennessee, USA 显示文摘 | Hall F X Su Y Monts D L | 2006 | Science of the Total Environment2006，368，： | 1 |
| 13 | A Comparison of NDVI and Spectral Mixture Analysis for Estimating Biophysical Properties in Boreal Forest Terrain显示文摘 | Peddle D R Hall F G LeDrew E F | 1996 | IEEE1996，，： | 1 |
| 14 | Physiological and molecular effects of brassinosteroids on Arabidopsis thaliana显示文摘 | Clouse S D Hall A F Langford M | 1993 | Plant Growth Regul1993，12，： | 1 |
| 15 | Spectral Mixture Analysis and Geometric-Optical Reflectance Modeling of Boreal Forest Biophysical Structure显示文摘 | Peddle D R Hall F G LeDrew E F | 1999 | Remote Sensing of Environment1999，67，3： | 1 |
| 16 | Mutagenicity of azo dyesused in foods, drugs and cosmetics before and after reduction byClostridium species from the human intestinal tract显示文摘 | Rafii F Hall J D Cemiglia C E | 1997 | Food ChemToxicol1997，35，9： | 1 |
| 17 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 18 | The effect of shortterm fasting and a single meal on protein synthesis and oxygen consumption in cod Gadus morhua 显示文摘 | Lyndon A R Houlihan D F Hall S J | 1992 | J Comp Physiol1992，71，： | 1 |
| 19 | Managing the impact of increasing microprocessor power consumption 显示文摘 | GUNTHER S BINNS F CARNIEAN D M HALL J C | 2001 | Intel Technology Journal2001，5，1： | 1 |
| 20 | Safety and immunogenicity of a prototype enterotoxigenic Esche- richia coil vaccine administered transeutaneously 显示文摘 | GURENA-BURGLENO F HALL E H TAYLOR D N | 2002 | Infect Im- mun2002，70，4： | 1 |
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