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| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | Rotgenologische studie zur h(a)ufigkeit der asymptomatischen processus coronoideus vergroesserung 显示文摘 | Honig JF Merten HA Halling F et al | 1993 | Schweiz Monatschr Zahnheikund1993，103，： | 1 |
| 3 | Continuously proliferative stem germ cells partially repopulate the aged,atrophic rat testis after gonadotropin-releasing hormone agonist therapy显示文摘 | Schoenfeld HA Hall SJ Boekelheide K | 2001 | Bioi Reprod2001，64，4： | 1 |
| 4 | Continuously proliferative stem germ cells partially repopulate the aged, atrophic rat testis after gonadotropin-releasing hormone agonist therapy 显示文摘 | Schoenfeld HA Hall SJ Boekelheide K | 2001 | Biol Reprod2001，64，4： | 1 |
| 5 | Preoperative localization of nonpalpable breast lesions demonstrated by mammography显示文摘 | Frank HA Hall FM Steer ML | 1976 | N Engl J Med1976，295，5： | 1 |
| 6 | Continuously proliferative stem germ cells partially repopulate the aged,atrophic rat testis after gonadotropin-releasing hormone agonist therapy显示文摘 | Schoenfeld HA Hall SJ Boekelheide K | 2001 | Biol Reprod2001，64，6： | 1 |
| 7 | Tumors of the heart and pericardium显示文摘 | McAllister HA Jr Hall R J Cooley DA | 1999 | Curr Probl in Cardiol1999，24，2： | 1 |
| 8 | Baicalein inhibits IL - 113 - and TNF - et - induced inflammatory cytokine production from human mast ceils via regulation of the NF - KB pathway 显示文摘 | Chia Jung Hsieh Kenton Hall Tuanzhu Ha | 2007 | Clinical and Molecular Allergy2007，23，5： | 1 |
| 9 | Baicalein inhibits IL-113 and TNF-α induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway显示文摘 | Hsieh C J Hall K Ha T | 2007 | Clin Mol Allergy2007，5，1： | 1 |
| 10 | Continuously proliferative stem germ cells partially repopulate the aged,atrophic rat testis after gonadotropin2releasing hormone agonist therapy显示文摘 | HALL SJ BOEKELHEIDE K | 2001 | Biol Reprod2001，64，4： | 1 |
| 11 | Characterization of amino acid side chain losses in ECD显示文摘 | COOPER H J HA°KANSSON K MARSHALL A G | 2002 | J Am Soc Mass Spectrom2002，13，： | 1 |
| 12 | Effectiveness of Glucosamine and Chondroitin for Osteoarthdtis显示文摘 | Hall HA | 2012 | American Family Physician2012，86，11： | 1 |
| 13 | Baicalein inhibits IL-1β and TNF-α-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway显示文摘 | Chia-Jung Hsieh Kenton Hall Tuanzhu Ha etal | 2007 | Clinical and Molecular Allergy2007，5，： | 1 |
| 14 | Autophagy in- duction is a Tor- and Tp53-independent cell survival re- sponse in a zebrafish model of disrupted ribosome biogenesis 显示文摘 | Boglev Y Badrock AP Trotter AJ Du Q Richardson FA Parslow AC Markmiller SJ Hall NE de Jong-Curtain TA Ng AY Verkade H Ober EA Field HA Shin D Shin CH Hannan KM Hannan RD Pearson RB Kim SH Ess KC Lieschke GJ Stainier DY Heath JK | 2013 | PLoS Genet2013，9，10： | 1 |
| 15 | The spleen contributes to stroke induced neurodegeneration through interferon gamma sig- naling 显示文摘 | Seifert HA Leonardo CC Hall AA | 2012 | Metab Brain Dis2012，27，2： | 1 |
| 16 | Baicalin inhibits IL-1 betaand TNF-alpha-induced inflammatory cytokine production from human mast cells via regulation of the NF-kappaB pathway显示文摘 | Hsieh CJ Hall K Ha T | 2007 | Clin Mol Allergy2007，26，5： | 1 |
| 17 | A Transient Decrease in Spleen Size Following Stroke Corresponds to Splenocyte Release into Systemic Circulation 显示文摘 | Seifert HA Hall AA Chapman CB | 2012 | J Neumimmune Pharmaeol2012，7，4： | 1 |
| 18 | Preoperative direction of nonpalpable breast lesions demonstrated by mammography显示文摘 | Frank HA Hall FM Steer ML | 1976 | N Engl J Med1976，295，： | 1 |
| 19 | Tumors of the heart and pericardium显示文摘 | McAllister HA Jr Hall R J Cooley DA | 1999 | Curr Prob Cardiol1999，24，： | 1 |
| 20 | Baicalein inhibits IL-1β- and TNF-α-induced inflammatory cytokine production from human mast cells via regulation of the NF-KB pathway显示文摘 | Hsieh CJ Hall K Ha T | 2007 | Clinical and Moleculor Allergy2007，5，： | 1 |
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