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| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | Interleukin-2 production and effect of thymosin fractio n 5 on interleukin-2 production in rheumatoid arthritis显示文摘 | WOLF RE HALL VC | 1987 | J Rheumatol1987，14，5： | 1 |
| 3 | Apolipoprotein D: a novel cellular marker for HGPIN and prostate cancer显示文摘 | Hall RE Horsfall DJ Stahl J | 2004 | Prostate2004，58，2： | 1 |
| 4 | Glenoid inclination is associated with full-thickness rotator cuff tears显示文摘 | Hughes RE Bryant CR Hall JM | 2003 | Clin Orthop Relat Res2003，407，2： | 1 |
| 5 | Estimation and inference in non-linear structural model 显示文摘 | Berndt EK Hall HB Hall RE | 1974 | Annals of Economic and Social Measurement1974，3，： | 1 |
| 6 | Variation in hospital rates of intra-aortic balloon pump use in coronary artery bypass operations显示文摘 | Ghail WA Ash AS Hall RE | 1999 | Ann Thorac Sury1999，67，2： | 1 |
| 7 | Apolipoprotein-D:a novelcellular marker for HGPIN and prostate cancer显示文摘 | Hall RE Horsfall DJ Stahl J | 2004 | Prostate2004，58，2： | 1 |
| 8 | Photodynanic inactivation of normal and antifungal resistant Candida species显示文摘 | Mang TS Mikulski L Hall RE | 2010 | Photodiagn Photodyn Ther2010，7，： | 1 |
| 9 | Expression of the andro gen receptor and an androgen-responsive protein, apolipoprotein D,in human breast Cancer显示文摘 | Hall RE Aspinall JO Horsfall DJ | 1996 | Br J Cancer1996，74，8： | 1 |
| 10 | Full denture construction显示文摘 | Hall RE | 1929 | JADA1929，16，6： | 1 |
| 11 | Paroxysmal nocturnal hemoglobinuria with onset in childhood and adolescence显示文摘 | Ware RE Hall SE Rossc WF | | 0，，14： | 1 |
| 12 | Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery显示文摘 | Brenner DJ Curtis RE Hall E J | 2000 | Cancer2000，88，2： | 1 |
| 13 | Human patient simulation is effective for teaching paramedic students endotracheal intu- bation显示文摘 | Hall RE Plant JR Bands CJ | 2005 | Acad Emerg Med2005，12，9： | 1 |
| 14 | Delayed type Hyper- sensitivity anergy in human immunodeficiency virus - infected persons screened for infection with mycobacterium tuberculosis 显示文摘 | Huebner RE Schein MF Hall CA | 1994 | Clin Infect Dis1994，19，1： | 1 |
| 15 | Productivity and the Density of Economic Activity显示文摘 | A Ciccone RE Hall | 1993 | American Economic Review1993，，86： | 1 |
| 16 | Why Do Some Countries Pro,duce So Much More Output Per Worker Than Others? 显示文摘 | Hall RE Jones CI | 1999 | Quarterly Journal of Economics1999，114，1： | 1 |
| 17 | Predictors of patient uptake of colorectal cancer gene environment risk assessment 显示文摘 | Hall MJ Manne SL Myers RE | 2012 | Genome Med2012，4，11： | 1 |
| 18 | Maintenance treatment with interferon for advanced ovarian cancer:results of Northern and Yorkshire gynaecology group randomized phase Ⅲ study显示文摘 | Hall GD Brown JM Coleman RE | 2004 | Br J Cancer2004，91，4： | 1 |
| 19 | MDA-MB-453,an androgenresponsive human breast carcinoma cell line with high level androgen receptor expression显示文摘 | Hall RE Birrell SN Tilley WD | 1994 | Eur J Cancer1994，30，4： | 1 |
| 20 | Diet, break- fast, and academic performance in children 显示文摘 | Kleinman RE Hall S Green H | 2002 | Ann Nutr Metab2002，46，： | 1 |
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