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| 1 | 亚甲基四氢叶酸还原酶基因多态性与结直肠癌易感性的关系显示文摘目的:研究亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase,MTHFR)基因C677T、A1298C多态性与结直肠癌易感性的关系.方法:在江苏省进行了一个病例-对照研究(结直肠癌患者315例,人群对照371例),调查研究对象的生活习惯,抽取静脉血,提取白细胞DNA,采用PCR-RFLP检测研究对象的MTHFR C677T、A1298C基因型.结果:1)男女合计的结直肠癌组、结肠癌组和直肠癌组与对照组之间的MTHFR C677T、A1298C基因型分布频度和等位基因频度差异无统计学意义,MTHFR C677T、A1298C基因多态与结直肠癌、结肠癌和直肠癌的易感性无显著相关.2)在男性中,结肠癌组MTHFR C677T T/T基因型的频度为24.6%,明显高于对照组的14.8%,但差异无统计学意义,X2=3.42,P=0.064.与C677T C等位基因携带者相比,T/T基因型者发生结肠癌的危险性显著升高,其性别、年龄、居住地区及吸烟、饮酒和饮茶习惯调整后的OR为2.15(95%CI:1.07~4.33).与同时携带MTHFR C677T C等位基因和A1298C A/A基因型者相比,男性的MTHFR C677T T/T和A1298C A/A基因型携带者发生结肠癌的危险性显著升高,其调整OR为2.64(95%CI:1.20~5.81),而他们发生直肠癌的危险性则明显降低,(调整OR=0.47,95%CI:0.22~1.03).结论:MTHFR C677T基因多态可以影响男性结、直肠癌的易感性,MTHFR A1298C多态与C677T多态在对男性结、直肠癌易感性的影响中有协同作用. | 高长明 Takezaki Toshiro 吴建中 丁建华 周建农 刘燕婷 李苏平 苏平 曹佳 Hamajima Nobuyuki Tajima Kazuo | 2005 | 肿瘤防治杂志2005，12，16： | 12 |
| 2 | CYP2E1 RsaⅠpolymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking显示文摘AIM: To investigate associations between the RsaⅠ polymorphism of CYP2E1 and risk of colorectal cancer. METHODS: A case-control study was conducted with 315 colorectal cancer cases (105 colon, 210 rectal) and 439 population-based controls in Jiangsu Province of China. Genomic DNA samples were assayed for restriction fragment length polymorphisms in CYP2E1 by PCR amplification followed by digestion with Rsa Ⅰ. Information on smoking and alcohol drinking was collected using a questionnaire. Odds ratios (ORs) were estimated with an unconditional logistic model. RESULTS: The proportional distribution of the CYP2E1 RsaⅠc1/c1, c1/c2 and c2/c2 genotypes were 61.4%, 35.6% and 3.0% in controls, 60.6%, 33.7% and 5.8% in colon cancer cases, and 58.4%, 34.0% and 7.7% in rectal cancer cases, respectively. A significant difference was noted between controls and rectal cancer cases (P = 0.029), the c2/c2 genotype being associated with elevated OR (adjusted age, sex and status of the smoking and alcohol drinking) for rectal cancer (1.64, 95% CI, 1.12-2.41, vs c1 allele carriers), but not for colon cancer. In interaction analysis between the CYP2E1 RsaⅠgenotype and smoking and drinking habits, we found a significant cooperative action between the c2/c2 genotype and alcohol drinking in the sex-, age-adjusted ORs for both colon (4.74, 95% CI, 1.10-20.40) and rectal (5.75, 95% CI, 1.65-20.05) cancers. Among nonsmokers, the CYP2E1 RsaⅠc2/c2 genotype was also associated with elevated ORs in the two sites (1.95, 95% CI, 0.99-3.86 and 2.30, 95% CI, 1.32-3.99). CONCLUSION: The results of the present study suggest that the CYP2E1 c2/c2 genotype increases susceptibility to rectal cancer and the gene-environmental interactions between the CYP2E1 polymorphism and smoking or alcohol drinking exist for colorectal neoplasia in general. | Chang-Ming Gao Toshiro Takezaki Jian-Zhong Wu Min-Bin Chen Yan-Ting Liu Jian-Hua Ding Haruhiko Sugimura Jia Cao Nobuyuki Hamajima Kazuo Tajima | 2007 | World Journal of Gastroenterology2007，13，43： | 9 |
| 3 | Id2 regulates the proliferation of squamous cell carcinoma in vitro via the NF-κB/Cyclin D1 pathway显示文摘Squamous cell carcinoma (SCC) is a significant cause of cancer morbidity and mortality worldwide, with an incidence of up to 166 cases per 100 000 population. It arises in the skin, upper aerodigestive tract, lung, and cervix and affects more than 200 000 Americans each year. We report here that a microarray experiment comparing 41 SCC and 13 normal tissue specimens showed that Id2, a gene that controls the cell cycle, was significantly up-regulated in SCC. Enforced expression of Id2 in vitro stimulated the proliferation of SCC cells and up-regulated the transcription of nuclear factor kappa B (NF-κB) and cyclin D1. Enhancement of the NF-κB activity with p65 significantly increased the cell proliferation and the transcription of cyclin D1, whereas inhibition of the NF-κB activity with I kappa B alpha mutant (IκBα M) and pyrroline dithiocarbamate (PDTC) abrogated cell proliferation and transcription of cyclin D1. Furthermore, a mutated NF-κB binding site in the cyclin D1 promoter fully abrogated the Id2-induced transcription of cyclin D1. Taken together, these data indicate that Id2 induces SCC tumor growth and proliferation through the NF-κB/cyclin D1 pathway. | Chuan Wang Qiang Chen Yuki Hamajima Wei Sun Yi-Qing Zheng Xiao-Hua Hu Frank G. Ondrey Ji-Zhen Lin | 2012 | Chinese Journal of Cancer2012，31，9： | 8 |
| 4 | Inducible nitric oxide synthase polymorphism is associated with the increased risk of differentiated gastric cancer in a Japanese population显示文摘AIM: To examine the association of inducible nitric oxide synthase (iNOS) C150T polymorphism with gastric cancer, as well as with gastric atrophy and H pylori seropositivity. METHODS: A single nucleotide polymorphism of iNOS C150T was examined for 454 Japanese health checkup examinees (126 males and 328 females) aged 35 to 85 years without a history of cancer and 202 gastric cancer patients (134 males and 68 females) aged 33 to 94 years with pathologically confirmed diagnosis of gastric adenocarcinoma. RESULTS: The iNOS C150T polymorphism was not associated with gastric atrophy or with H pylori seropositivity. The odds ratio (OR) of the C/T + T/T for gastric cancer was increased without statistical significance (OR=1.19, 95% confidence interval (CI): 0.68-2.08). In the differentiated subgroup (n = 113), however, the OR of the C/T genotype for gastric cancer was significant (OR = 2.02, 95% CI: 1.04-3.92) relative to the C/C genotype. In addition, considering the location of gastric cancer (n = 105), there were significant differences between the controls and non-cardia group with the OR of 2.13 (95% CI: 1.08-4.18) for C/T and 1.94 (95% CI: 1.00-3.78) for C/T + T/T. CONCLUSION: The iNOS C150T polymorphism is associated with the risk of H pylori-related gastric cancerin a Japanese population. This polymorphism may play an important role in increasing the risk of gastric cancer in Asian countires with the highest rates of gastric cancer. | Yasuyuki Goto Takafumi Ando Mariko Naito Hidemi Goto Nobuyuki Hamajima | 2006 | World Journal of Gastroenterology2006，12，39： | 6 |
| 5 | 细胞色素P450 2E1基因多态性、烟酒习惯与直肠癌易感性的关系显示文摘目的:研究细胞色素P4502E1(CYP2E1)基因RsaⅠ多态性、烟酒习惯与直肠癌遗产易感性的关系。方法:在江苏省进行病例-对照研究(直肠癌患者210例,人群对照439例),调查研究对象的生活习惯,抽取静脉血,提取白细胞DNA,采用PCR-RFLP检测研究对象的CYP2E1RsaⅠ位点基因型。结果:CYP2E1RsaⅠc1/c1、c1/c2和c2/c2基因型分布频度在直肠癌组分别为58.4%、34.0%和7.7%,对照组分别为61.4%、35.6%和3.0%,两组之间差异有显著性(χ2MH=7.07,P=0.029)。在调整性别、年龄、吸烟和饮酒习惯后,CYP2E1c2/c2基因型携带者与c1/c1基因型者相比,发生直肠癌的危险性显著升高(OR=1.64,95%CI:1.12~2.41)。多因素分析结果显示,有饮酒习惯者发生直肠癌的危险性显著升高,其调整后OR为2.08(95%CI:1.36~3.19),而吸烟与增加或降低直肠癌的危险性无显著相关。CYP2E1基因多态与吸烟、饮酒相互作用的分层分析发现,在不吸烟者中,c2/c2基因型者与c1等位基因型者相比,发生直肠癌的危险性显著上升(性别和年龄调整OR=2.30,95%CI:1.32~3.99);在饮酒者中,携带c2/c2基因型者发生直肠癌的调整OR为5.75(95%CI:1.65~20.05),提示CYP2E1RsaⅠ多态与饮酒习惯有显著的协同作用。结论:CYP2E1RsaⅠ基因多态和饮酒习惯影响直肠癌的易感性,二者在直肠癌发生中有显著的协同作用。 | 龚建平 高长明 Takezaki Toshiro 吴建中 陈敏斌 曹海霞 曹佳 Hamajima Nobuyuki Tajima Kazuo 周建农 | 2006 | 南京医科大学学报(自然科学版)2006，26，12： | 6 |
| 6 | Dietary Factors and the Risk of Gastric Cancer Among Japanese Women显示文摘 | Lucy Sayuri Ito Manami Inoue Kazuo Tajima Yoshitaka Yamamura Yasuhiro Kodera Kaoru Hirose Toshiro Takezaki Nobuyuki Hamajima Tetsuo Kuroishi Suketami Tominaga | 2002 | Annals of Epidemiology2002，，1： | 4 |
| 7 | Associations between circulating microRNAs (miR-21, miR-34a, miR-122 and miR-451) and non-alcoholic fatty liver显示文摘 | Hiroya Yamada Koji Suzuki Naohiro Ichino Yoshitaka Ando Akira Sawada Keisuke Osakabe Keiko Sugimoto Koji Ohashi Ryouji Teradaira Takashi Inoue Nobuyuki Hamajima Shuji Hashimoto | 2013 | Clinica Chimica Acta2013，，： | 3 |
| 8 | Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males显示文摘AIM: To evaluate the relationship between drinking and polymorphisms of alcohol dehydrogenase 2 (ADH2) and/or aldehyde dehydrogenase 2 (ALDH2) for risk of colorectal cancer (CRC) in Chinese males. METHODS: A case-control study was conducted in 190 cases and 223 population-based controls. ADH2 Arg47His (G-A) and ALDH2 Glu487Lys (G-A)genotypes were identified by PCR and denaturing high-performance liquid chromatography (DHPLC). Information on smoking and drinking was collected and odds ratio (OR) was estimated. RESULTS: The ADH2 A/A and ALDH2 G/G genotypes showed moderately increased CRC risk. The age- and smoking-adjusted OR for ADH2 A/A relative to G/A and G/G was 1.60 (95% CI=1.08-2.36), and the adjusted OR for ALDH2 G/G relative to G/A and A/A was 1.79 (95% CI=1.19-2.69). Signif icant interactions between ADH2, ALDH2 and drinking were observed. As compared to the subjects with ADH2 G and ALDH2 A alleles, those with ADH2 A/A and ALDH2 G/G genotypes had a signif icantly increased OR (3.05, 95% CI= 1.67-5.57). The OR for CRC among drinkers with the ADH2 A/A genotype was increased to 3.44 (95% CI= 1.84-6.42) compared with non-drinkers with the ADH2 G allele. The OR for CRC among drinkers with the ALDH2 G/G genotype was also increased to 2.70 (95% CI= 1.57-4.66) compared with non-drinkers with the ALDH2 A allele. CONCLUSION: Polymorphisms of the ADH2 and ALDH2 genes are significantly associated with CRC risk. There are also signifi cant gene-gene and gene- environment interactions between drinking and ADH2 and ALDH2 polymorphisms regarding CRC risk in Chinese males. | Chang-Ming Gao Toshiro Takezaki Jian-Zhong Wu Xiao-Mei Zhang Hai-Xia Cao Jian-Hua Ding Yan-Ting Liu Su-Ping Li Jia Cao Keitaro Matsuo Nobuyuki Hamajima Kazuo Tajima | 2008 | World Journal of Gastroenterology2008，14，32： | 3 |
| 9 | Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions显示文摘Gastric cancer is the most common malignancy of the gastrointestinal tract in East Asian populations and the second most frequent cause of cancer-related mortality in the world. While previous studies have investigated the genetic factors involved in gastric carcinogenesis, there still exist relatively few studies that have investigated the genetic traits associated with the risk of gastric precancerous conditions. In this paper we will review the biology and genetic polymorphisms involved in the genesis of gastric precancerous conditions reported to date and discuss the future prospects of this field of study. The associations of gastric precancerous conditions with polymorphisms in the cytotoxin-associated gene A-related genes (e.g. PTPN11 G/A at intron 3, rs2301756), those in the genes involved in host immunity against Helico-bacter pylori (H. pylori) infection (e.g.TLR4 +3725G/C, rs11536889) or polymorphisms of the genes essential for the development/ differentiation of the gastric epithelial cells (e.g. RUNX3 T/A polymorphism at intron 3, rs760805) have been reported to date. Genetic epide-miological studies of the associations between H. pylori-induced gastric precancerous conditions and other gene polymorphisms in these pathways as well as polymor-phisms of the genes involved in other pathways like oxidative DNA damage repair pathways would provide useful evidence for the individualized prevention of these H. pylori-induced gastric precancerous conditions. | Asahi Hishida Keitaro Matsuo Yasuyuki Goto Nobuyuki Hamajima | 2010 | World Journal of Gastrointestinal Oncology2010，2，10： | 3 |
| 10 | Significant Association between Serum Interleukin-6 and Helicobacter pylori Antibody Levels among H. pylori -Positive Japanese Adults显示文摘 | Hiroko Nakagawa Takashi Tamura Yoko Mitsuda Yasuyuki Goto Yoshikazu Kamiya Takaaki Kondo Kenji Wakai Nobuyuki Hamajima Leif P. Andersen | 2013 | Mediators of Inflammation2013，，： | 2 |
| 11 | Subsite (cervix/endometrium) -specific risk and protective factors in uterus cancer 显示文摘 | Hirose K Tajima K Hamajima N | 1996 | Jpn J Cancer Res1996，87，9： | 1 |
| 12 | Immunization of RANTES expression plasmid with a DNA vaccine enhances HIV-1-specific immunity显示文摘 | Lu Y Hamajima K | 1999 | Clin Immunol1999，92，1： | 1 |
| 13 | Immunomodulatory effects of a plasmid expressing B7-2 on human immunodeficiency virus-1-specific cell-mediated immunity induced by a plasmid encoding the viral antigen显示文摘 | Hamajima K Ishii N | 1997 | Eur J Immunol1997，27，3： | 1 |
| 14 | Dietary factors protective against breast cancer in Japanese premenopausal and postmenopausal women显示文摘 | Hirose K Takezaki T Hamajima N | 2003 | Int J Cancer2003，107，2： | 1 |
| 15 | Prognostic significance of P53 alternations in patients with non small cell lung cancer显示文摘 | Mitsudomi T Hamajima N Ogawa M | 2000 | A Meta-analysis Clin Cancer Res2000，6，10： | 1 |
| 16 | Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1,ACC-1,in patients receiving HLA genotypically matched unrelated bone marrow transplant显示文摘 | Akatsuka Y Morishima Y Hamajima N Tsujimura K Kuzushima K Kodera Y Takahashi T | 2004 | Br J Haematol2004，124，5： | 1 |
| 17 | A limited association of OGG1 Ser326Cys polymorphism for adenocarcinoma of the lung显示文摘 | Ito H Hamajima N Takezaki T | 2002 | J Epidemiol2002，12，3： | 1 |
| 18 | Possible association of beta2-and beta3-adrenergic receptor gene polymorphisms with susceptibility to breast cancer显示文摘 | HUANG X E HAMAJIMA N SAITO T | 2001 | Breast Cancer Res2001，3，4： | 1 |
| 19 | Internal stress influence on high current density superconducting magnet performance显示文摘 | MASANORI A HAMAJIMA T OHSAKI O | 1995 | IEEE Transactions on Applied Superconductivity1995，5，2： | 1 |
| 20 | Subjects with TNF- A-857TT and -10313TT genotypes showed the highest Helicobacter pyloti seropositive rate compared with those with other genotypes显示文摘 | HAMAJIMA N SHIBATA A KATSUDA N | 2003 | Gastric Cancer2003，6，4： | 1 |
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