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| 1 | Biochemical characteristics of neonatal cholestasis induced by citrin deficiency显示文摘AIM:To explore differences in biochemical indices between neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) and that with other etiologies. METHODS:Patients under 6 mo of age who were referred for investigation of conjugated hyperbiliru-binaemia from June 2003 to December 2010 were eligible for this study. After excluding diseases affecting the extrahepatic biliary system, all patients were screened for the two most common SLC25A13 mutations; the coding exons of the entire SLC25A13 gene was sequenced and Western blotting of citrin protein performed in selected cases. Patients in whom homo-zygous or compound heterozygous SLC25A13 mutation and/or absence of normal citrin protein was detected were defined as having NICCD. Cases in which no specific etiological factor could be ascertained after a com-prehensive conjugated hyperbilirubinaemia work-up were defined as idiopathic neonatal cholestasis (INC). Thirty-two NICCD patients, 250 INC patients, and 39 infants with cholangiography-confirmed biliary atresia (BA) were enrolled. Laboratory values at their first visit were abstracted from medical files and compared. RESULTS:Compared with BA and INC patients, the NICCD patients had significantly higher levels of total bile acid (TBA) [all measures are expressed as median (inter-quartile range):178.0 (111.2-236.4) μmol/L in NICCD vs 112.0 (84.9-153.9) μmol/L in BA and 103.0 (70.9-135.3) μmol/L in INC, P = 0.0001]. The NICCD patients had significantly lower direct bilirubin [D-Bil 59.6 (43.1-90.9) μmol/L in NICCD vs 134.0 (115.9-151.2) μmol/L in BA and 87.3 (63.0-123.6) μmol/L in INC, P = 0.0001]; alanine aminotransferase [ALT 34.0 (23.0-55.0) U/L in NICCD vs 108.0 (62.0-199.0) U/L in BA and 84.5 (46.0-166.0) U/L in INC, P = 0.0001]; aspartate aminotransferase [AST 74.0 (53.5-150.0) U/L in NICCD vs 153.0 (115.0-239.0) U/L in BA and 130.5 (81.0-223.0) U/L in INC, P = 0.0006]; albumin [34.9 (30.7-38.2) g/L in NICCD vs 38.4 (36.3-42.2) g/L in BA and 39.9 (37.0-42.3) g/L in INC, P = 0.0001]; glucose [3.2 (2.0-4.4) mmol/L in NICCD vs 4.1 (3.4-5.1) mmol/L in BA and 4.0 (3.4-4.6) mmol/L in INC, P = 0.0014] and total cholesterol [TCH 3.33 (2.97-4.00) mmol/L in N ICCD vs 4.57 (3.81-5.26) mmol/L in BA and 4.00 (3.24-4.74) mmol/L in INC, P = 0.0155] levels. The D-Bil to total bilirubin (T-Bil) ratio was significantly lower in NICCD patients [all measures are expressed as median (inter-quartile range):0.54 (0.40-0.74)] than that in BA patients [0.77 (0.72-0.81), P = 0.001] and that in INC patients [0.74 (0.59-0.80), P = 0.0045]. A much higher AST/ALT ratio was found in NICCD patients [2.46 (1.95-3.63)] compared to BA patients [1.38 (0.94-1.97), P = 0.0001] and INC patients [1.48 (1.10-2.26), P = 0.0001]. NICCD patients had significantly higher TBA/D-Bil ratio [3.36 (1.98-4.43) vs 0.85 (0.72-1.09) in BA patients and 1.04 (0.92-1.14) in INC patients, P = 0.0001], and TBA/TCH ratio [60.7 (32.4-70.9) vs 24.7 (19.8-30.2) in BA patients and 24.2 (21.4-26.9) in INC patients, P = 0.0001] compared to the BA and INC groups. CONCLUSION:NICCD has significantly different bio- chemical indices from BA or INC. TBA excretion in NICCD appeared to be more severely disturbed than that of bilirubin and cholesterol. | Jian-She Wang Xiao-Hong Wang Ying-Jie Zheng Hai-Yan Fu Rui Chen Yi Lu Ling-Juan Fang Takeyori Saheki Keiko Kobayashi | 2012 | World Journal of Gastroenterology2012，18，39： | 35 |
| 2 | Regulation of Arabidopsis Early Anther Development by the Mitogen-Activated Protein Kinases, MPK3 and MPK6, and the ERECTA and Related Receptor-Like Kinases显示文摘激活 Mitogen 的蛋白质 kinase (MAPK ) 和表明小径的像受体的 kinase (LRR-RLK ) 被显示出调整植物生长和开发的多样的方面的充满白氨酸的重复。在 Arabidopsis,合适的花药开发依靠细胞间的通讯协调房间增长和区别。二密切相关的基因编码 MAPK, MPK3 和 MPK6,在调整有气孔的 patterning 冗余地工作。尽管 mpk6 异种减少了富饶,在花药开发的 MPK3 和 MPK6 的函数没被描绘。同样, ERECTA (嗯) , ERECTA-LIKE1 (ERL1 ) 和 ERL2 基因编码 LRR-RLKs 一起工作指导有气孔的房间命运说明和 er-105 erl1-2 erl2-1 三元组异种是无菌的。因为 mpk3 mpk6 两倍空异种是胚胎致命,花药开发在可行 mpk3/+mpk6/ 和 er-105 erl1-2 erl2-1 异种被描绘。我们发现两个变异的花药通常没能形成四片花药脑叶中的至少一个,与展出 mpk3/+mpk6/ 异种的比那些的更严重的显型的 er-105 erl1-2 erl2-1 三元组异种。区分的变异的脑叶的体的房间层显得更大,更多比的瓦解了野类型。另外, er-105 erl1-2 erl2-1 三元组异种有雄蕊,其多数拥有完全无差别或下面区分的花药的一个减少的数字。有时,而且, mpk3/+mpk6/ 异种花药不张口,并且 er-105 erl1-2 erl2-1 花药没被观察张口。因此,我们的结果显示 ER/ERL1/ERL2 和 MPK3/MPK6 在正常花药脑叶形成和花药房间区别起重要作用。在在另外的发展过程的这些基因和异种的二种类型的发展显型报导了的花药的类似之间的近功能的关系进一步这里建议这些基因可能也在一样的小径工作调整花药房间分割和区别的可能性。 | Carey L.H. Hord Yu-Jin Sun Lynn J. Pillitteri Keiko U. Torii Huachun Wang Shuqun Zhang Hong Ma | 2008 | Molecular Plant2008，1，4： | 29 |
| 3 | Overview of Citrin Deficiency:SLC25A13 Mutations and the Frequency显示文摘Citrin deficiency,autosomal recessive disorder,caused by mutation of SLC25A13 gene on chromosome 7q21.3 has two major phenotypes:neonatal intrahepatic cholestatic hepatitis(NICCD)and adult-onset type Ⅱ citrullinemia(CTLN2).So far,we have identified 52 SLC25A13 mutations and diagnosed the patients not only in Japan(166 CTLN2 and 238 NICCD) but also in other countries.We have detected 76 Chinese,13 Korean and 15 Vietnamese patients with the same mutations as Japanese,and 13 patients(from Israel,UK,USA or Czech)with mutations different from those found in Japanese,indicating a wide distribution of citrin deficiency.DNA diagnoses of 13 known SLC25A13 mutations revealed that the carrier frequency was high in East Asian populations:Chinese(73/4 600=1/63),Japanese(21/1 372=1/65) and Korean(25/2 690=1/108),suggesting that near by 100 000 East Asians are homozygotes.It is important to find out patients with citrin deficiency,to treat them,and to prevent onset of severe CTLN2. | Keiko Kobayashi Miharu Ushtkai Yuan - Zong Song Hong - Zhi Gao Jian - Sheng Sheng Ayako Tabata Furnihiko Okumura Sayaka lkeda Takeyori Saheki | 2008 | 实用儿科临床杂志2008，23，20： | 26 |
| 4 | Short term results of endoscopic submucosal dissection in superficial esophageal squamous cell neoplasms显示文摘AIM: To evaluate the efficacy of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms. METHODS: Between July 2007 and March 2009, 27 consecutive superficial esophageal squamous cell neoplasms in 25 enrolled patients were treated by endoscopic submucosal dissection. The therapeutic efficacy, complications, and follow-up results were assessed. RESULTS: The mean size of the lesions was 21 ± 13 mm (range 2-55 mm); the mean size of the resection specimens was 32 ± 12 mm (range 10-70 mm). The enblock resection rate was 100% (27/27), and en block resection with tumor-free lateral/basal margins was 88.9% (24/27). Perforation occurred in 1 patient who was managed by conservative medical treatments. None of the patients developed local recurrence or distant metastasis in the follow-up period. CONCLUSION: Endoscopic submucosal dissection is applicable to superficial esophageal squamous cell neoplasms with promising results. | Kouichi Nonaka Shin Arai Keiko Ishikawa Masamitsu Nakao Yousuke Nakai Osamu Togawa Koji Nagata Michio Shimizu Yutaka Sasaki Hiroto Kita | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，2： | 19 |
| 5 | Bleeding after endoscopic submucosal dissection: Risk factors and preventive methods显示文摘Endoscopic submucosal dissection(ESD) has become widely accepted as a standard method of treatment for superficial gastrointestinal neoplasms because it enables en block resection even for large lesions or fibrotic lesions with minimal invasiveness, and decreases the local recurrence rate. Moreover, specimens resected in an en block fashion enable accurate histological assessment. Taking these factors into consideration, ESD seems to be more advantageous than conventional endoscopic mucosal resection(EMR), but the associated risks of perioperative adverse events are higher than in EMR. Bleeding after ESD is the most frequent among these adverse events. Although post-ESD bleeding can be controlled by endoscopic hemostasis in most cases, it may lead to serious conditions including hemorrhagic shock. Even with preventive methods including administration of acid secretion inhibitors and preventive hemostasis, post-ESD bleeding cannot be completely prevented. In addition high-risk cases for post-ESD bleeding, which include cases with the use of antithrombotic agents or which require large resection, are increasing. Although there have been many reports about associated risk factors and methods of preventing post-ESD bleeding, many issues remain unsolved. Therefore, in this review, we have overviewed risk factors and methods of preventing post-ESD bleeding from previous studies. Endoscopists should have sufficient knowledge of these risk factors and preventive methods when performing ESD. | Yosuke Kataoka Yosuke Tsuji Yoshiki Sakaguchi Chihiro Minatsuki Itsuko Asada-Hirayama Keiko Niimi Satoshi Ono Shinya Kodashima Nobutake Yamamichi Mitsuhiro Fujishiro Kazuhiko Koike | 2016 | World Journal of Gastroenterology2016，22，26： | 16 |
| 6 | Metabolomic Screening Applied to Rice FOX Arabidopsis Lines Leads to the Identification of a Gene-Changing Nitrogen Metabolism显示文摘植物 metabolomics 作为一个强大的工具发展了检验基因功能并且获得更深的卓见进植物房间的生理学。在这研究,我们屏蔽了 Arabidopsis 线 overexpressing 米饭全身(FL ) 用煤气的 chromatographytime-of-flight 团 spectrometry (GCTOF/MS ) 的 cDNAs (米饭狐狸 Arabidopsis 线) 基于技术识别引起了新陈代谢的变化的米饭基因。这个屏蔽系统允许显示出改变的代谢物侧面的候选人线的快、可靠的鉴定。我们执行了怀有 Arabidopsis 的侧面的机关边界(高球) 领域(LBD )/Asymmetric 象 Leaves2 一样(ASL ) 基因的米饭 ortholog 的 FL cDNA 的一根米饭狐狸 Arabidopsis 线的 metabolomic 和 transcriptomic 分析, At-LBD37/ASL39。调查米饭狐狸 Arabidopsis 线在与氮新陈代谢有关的代谢物的层次显示出突出的变化。象从 Arabidopsis At-LBD37/ASL39-overexpressor 植物的代谢物分析的结果一样的 transcriptomic 数据与这些调查结果一致。而且, Os-LBD37/ASL39-overexpressing 米饭植物的 metabolomic 和 transcriptomic 分析显示 Os-LBD37/ASL39 在米饭与与氮新陈代谢有关的过程被联系。因此,一个基于 metabolomics 的屏蔽方法的联合和一条 gain-of-function 途径为在 Arabidopsis 和米饭的新奇基因的快速的描述是有用的。 | Doris Albinsky Miyako Kusano Mieko Higuchi Naomi Hayashi Makoto Kobayashi Atsushi Fukushima Masaki Mori Takanari Ichikawa Keiko Matsui Hirofumi Kuroda Yoko Horii Yuko Tsumoto Hitoshi Sakakibara Hirohiko Hirochika Minami Matsui Kazuki Saito | 2010 | Molecular Plant2010，3，1： | 15 |
| 7 | The Role of Cyclic Nucleotide-Gated Ion Channels in Plant Immunity显示文摘因为第一种周期的核苷酸门离子隧道(CNGC ) , HvCBT1,作为 calmodulin 绑定蛋白质被识别,超过一十年过去了,工作的大量的数量被做了理解这些隧道蛋白质的分子的性质和函数。基于 electrophysiological 和 heterologous 表达式分析,工厂 CNGC 功能作为非选择的阳离子隧道并且,到目前为止,他们的生物角色在防卫回答,开发,和离子动态平衡被报导了。向前基因的途径识别了四 AtCNGCs (AtCNGC2, 4, 11,和 12 ) 作为为 AtCNGC2 的空异种, 4, 11,和 12 象 gain-of- 一样工作涉及工厂免疫为在防卫回答的 AtCNGC11 和 12 展出改变变异。因为离子流动变化是被报导了,在病原体识别之上并且也的早事件之一是为防卫回答的激活的一个必要部件,在这些离子流动变化的 CNGC 的参与被建议了。然而,空异种的最近的详细描述建议了这个隧道家庭的更复杂的参与。在这评论,我们集中于这些 CNGC 异种的发现和描述并且在工厂免疫作为部件讨论 CNGC 的可能的角色。 | Wolfgang Moeder William Urquhart Huoi Ung Keiko Yoshioka | 2011 | Molecular Plant2011，4，3： | 14 |
| 8 | CT-maximum intensity projection is a clinically useful modality for the detection of gastric varices显示文摘AIM: To evaluate the efficacy of CT-maximum intensity projection (CT-MIP) in the detection of gastric varicesand their inflowing and outflowing vessels in patientswith gastric varices scheduled to undergo balloonoccluded retrograde transvenous obliteration (B-RTO). METHODS: Sixteen patients with endoscopicallyconfirmed gastric varices were included in this study. All patients were evaluated with CT-MIP using threedimensional reconstructions, before and after B-RTO. RESULTS: CT-MIP clearly depicted gastric varices in 16 patients (100%), the left gastric vein in 6 (32.5%),the posterior gastric vein in 12 (75.0%), the short gastric veins in 13 (81.3%), gastrorenal shunts in 16 (100%), the hemiazygos vein (HAZV) in 4 (25.0%), the pericardiophrenic vein (PCPV) in 9 (56.3%), and the left inferior phrenic vein in 9 patients (56.3%). Although flow direction itself cannot be determined from CT-MIP,this modality provided clear images of the inflowing and the outflowing vessels. Moreover, in one patient, short gastric veins were not seen on conventional angiographic portography images of the spleen, but were clearly revealed on CT-MIP,CONCLUSION: We suggest that CT-MIP should be considered as a routine method for detecting and diagnosing collateral veins in patients with gastric varices scheduled for B-RTO. Furthermore, CT-MIP is more useful than endoscopy in verifying the early therapeutic effects of B-RTO. | Toru Ishikawa Takashi Ushiki Ken-ichi Mizuno Tadayuki Togashi Kouji Watanabe Kei-ichi Seki Hironobu Ohta Toshiaki Yoshida Keiko Takeda Tomoteru Kamimura | 2005 | World Journal of Gastroenterology2005，11，47： | 13 |
| 9 | Utility of linked color imaging for endoscopic diagnosis of early gastric cancer显示文摘BACKGROUND Linked color imaging(LCI) is a method of endoscopic imaging that emphasizes slight differences in red mucosal color.AIM To evaluate LCI in diagnostic endoscopy of early gastric cancer and to compare LCI and pathological findings.METHODS Endoscopic images were obtained for 39 patients(43 lesions) with early gastric cancer. Three endoscopists evaluated lesion recognition with white light imaging(WLI) and LCI. Color values in Commission Internationale de l'Eclairage(CIE)1976 L*a*b* color space were used to calculate the color difference(ΔE) between cancer lesions and non-cancer areas. After endoscopic submucosal dissection,blood vessel density in the surface layer of the gastric epithelium was evaluated pathologically. The identical region of interest was selected for analyses of endoscopic images(WLI and LCI) and pathological analyses.RESULTS LCI was superior for lesion recognition(P < 0.0001), and ΔE between cancer and non-cancer areas was significantly greater with LCI than WLI(29.4 vs 18.6, P <0.0001). Blood vessel density was significantly higher in cancer lesions(5.96% vs4.15%, P = 0.0004). An a* cut-off of ≥ 24 in CIE 1976 L*a*b* color space identified a cancer lesion using LCI with sensitivity of 76.7%, specificity of 93.0%, and accuracy of 84.9%.CONCLUSION LCI is more effective for recognition of early gastric cancer compared to WLI as a result of improved visualization of changes in redness. Surface blood vessel density was significantly higher in cancer lesions, and this result is consistent with LCI image analysis. | Toshihisa Fujiyoshi Ryoji Miyahara Kohei Funasaka Kazuhiro Furukawa Tsunaki Sawada Keiko Maeda Takeshi Yamamura Takuya Ishikawa Eizaburo Ohno Masanao Nakamura Hiroki Kawashima Masato Nakaguro Masahiro Nakatochi Yoshiki Hirooka | 2019 | World Journal of Gastroenterology2019，25，10： | 12 |
| 10 | Endoscopic ultrasonography guided-fine needle aspirationfor the diagnosis of solid pancreaticobiliary lesions:Clinicalaspects to improve the diagnosis显示文摘Endoscopic ultrasonography-guided fine-needle aspiration(EUS-FNA) has been applied to pancreaticobiliary lesions since the 1990 s and is in widespread use throughout the world today. We used this method to confirm the pathological evidence of the pancreaticobiliary lesions and to perform suitable therapies. Complications of EUS-FNA are quite rare, but some of them are severe. Operators should master conventional EUS observation and experience a minimum of 20-30 cases of supervised EUS-FNA on non-pancreatic and pancreatic lesions before attempting solo EUSFNA. Studies conducted on pancreaticobiliary EUSFNA have focused on selection of suitable instruments(e.g., needle selection) and sampling techniques(e.g., fanning method, suction level, with or without a stylet, optimum number of passes). Today, the diagnostic ability of EUS-FNA is still improving; the detection of pancreatic cancer(PC) currently has a sensitivity of 90%-95% and specificity of 95%-100%. In addition to PC, a variety of rare pancreatic tumors can be discriminated by conducting immunohistochemistry on the FNA materials. A flexible, large caliber needle has been used to obtain a large piece of tissue, which can provide sufficient histological information to be helpful in classifying benign pancreatic lesions. EUSFNA can supply high diagnostic yields even for biliary lesions or peri-pancreaticobiliary lymph nodes. This review focuses on the clinical aspects of EUS-FNA in the pancreaticobiliary field, with the aim of providing information that can enable more accurate and efficient diagnosis. | Hiroyuki Matsubayashi Toru Matsui Yohei Yabuuchi Kenichiro Imai Masaki Tanaka Naomi Kakushima Keiko Sasaki Hiroyuki Ono | 2016 | World Journal of Gastroenterology2016，22，2： | 12 |
| 11 | Usefulness of anti-ulcer drugs for the prevention and treatment of peptic ulcers induced by low doses of aspirin显示文摘AIM:To investigate the usefulness of anti-ulcer drugs for the prevention and treatment of low-dose aspirin- induced peptic ulcer. METHODS:Upper gastrointestinal endoscopy was performed in 68 patients receiving daily low-dose aspirin(81 or 100 mg/day).The endoscopic findings were classified according to the Lanza score,and the scores were compared between groups categorized according to the concomitant use of anti-ulcer drugs and the types of drugs used.In another study,31 hemorrhagic peptic ulcer patients who had been receiving low-dose aspirin were enrolled.The patients were randomly classified into the proton pump inhibitor (PPI)-treated group and the H2 receptor antagonist (H2RA)-treated group.The administration of low-dose aspirin was continued concomitantly,and endoscopic examinations were performed 8 wk later. RESULTS:The Lanza scores(mean±SD)of the gastro-mucosal lesions were 1.0±1.9 and 1.9±2.3 in 8 and 16 patients receiving prevention therapy with a PPI and an H2RA,respectively.Both scores were significantly smaller than the scores in 34 patients who were not receiving prevention therapy(4.7±1.0)and in 10 patients receiving cytoprotective anti-ulcer drugs (4.3±1.6).In the prospective study,18 and 13 patients received a PPI and an H2RA,respectively.Endoscopic examinations revealed that the tissue in the region of the gastro-mucosal lesions had reverted to normal in all patients in the PPI-treated group and in 12 patients (92%)in the H2RA-treated group;no significant differences were observed between the groups. CONCLUSION:H2RA therapy was effective for both the prevention and treatment of low-dose aspirin- induced peptic ulcer,similar to the effects of PPIs, while cytoprotective anti-ulcer drugs were ineffective in preventing ulceration. | Sayaka Nakashima Shinichi Ota Shin Arai Kiyoko Yoshino Mie Inao Keiko Ishikawa Nobuaki Nakayama Yukinori Imai Sumiko Nagoshi Satoshi Mochida | 2009 | World Journal of Gastroenterology2009，15，6： | 11 |
| 12 | IRF family proteins and type I interferon induction in dendritic cells显示文摘树枝状的房间(DC ) 在造血的房间的一张次要的人口,生产类型我干扰素(IFN ) 和另外的 cytokines 并且为天生的免疫是必要的。他们也是有势力抗原演讲者并且调整适应免疫。在 DC 子类型血浆之中似细胞的 DC (pDC ) 生产类型的最高的数量我 IFN。另外,象 IL-12 和 IL-10 那样的支持 inflammatory 和反煽动性的 cytokines 响应象发信号的受体(TLR ) 一样并且在病毒的感染之上的代价在 DC 被导致。在 IRF 家庭的蛋白质控制 DC 活动的许多方面。IRF-8 和 IRF-4 为 DC 开发是必要的。他们差别控制四个 DC 子集的开发。IRF-8-/- 老鼠大部分缺乏 pDC 和 CD8alpha+ DC,当 IRF-4-/- 老鼠缺乏 CD4+DC 时。IRF-8-/- , IRF4-/- ,两倍猛烈老鼠有仅仅很少 CD8a-CD4-DC 那缺乏 MHC II。IRF 蛋白质也控制类型我在 DC 的 IFN 正式就职。IRF-7,在 TLR 发信号之上激活不仅在 pDC,而且在常规 DC (cDC ) 为 IFN 正式就职被要求, non-DC 房间打字。IRF-3 贡献在成纤维细胞感应的 IFN,在在 DC 感应的 IFN 是非必需的。我们的最近的证据揭示那种类型我在 DC 感应的 IFN 非常依赖于 IRF-8,它在 DC 在 IFN 基因正式就职的反馈阶段行动。类型我在 pDC 感应的 IFN 被 MyD88 调停依赖发信号小径,并且不同于在另外的房间采用的小径,它主要依靠 TLR3 和 RIG-I 家庭蛋白质。另外的支持 inflammatory cytokines 以一种 IRF-5 依赖方式被生产。然而, IRF-5 没为 IFN 正式就职被要求,建议为类型的正式就职的分开的机制的存在我 IFN 和其它支持 inflammatory cytokines。激活的 DC 接着生产的 IFN 和另外的 cytokines 预付 DC 成熟并且改变 DC 的显型和功能。这些过程也是可能的被 IRF 家庭蛋白质管理。 | Prafullakumar Tailor Tomohiko Tamura Keiko Ozato | 2006 | Cell Research2006，16，2： | 9 |
| 13 | Behavior of Siderophile and Chalcophile Elements in the Subcontinental Lithospheric Mantle beneath the Changbaishan Volcano,NE China显示文摘The mantle xenoliths in the Quaternary ChangbaishanVolcano in southern Jilin Province contain spinel-facies lherzolites.The equilibration temperatures for these samples range from 902oC to 1064oC based on the two-pyroxene thermometer of Brey and K?hler(1990),and using the oxybarometry of Nell and Wood(1991),the oxidation state was estimated from FMQ-1.32 to-0.38 with an average value of FMQ-0.81(n=8),which is comparable to that of abyssal peridotites and the asthenospheric mantle.The fO2 values of peridotites,together with their bulk rock compositions(e.g.,Mg#,Al2O3,CaO,Ni,Co,Cr) and mineral compositions(e.g.,Mg# of olivine and pyroxene,Cr# [=Cr/[Cr+Al]] and Mg# [=Mg/[Mg+Fe2+] of spinel),suggest that the present-day subcontinental lithospheric mantle(SCLM) beneath the Changbaishan Volcano most likely formed from an upwelling asthenosphere at some time after the late Mesozoic and has undergone a low degree of partial melting.The studied lherzolite xenoliths show low concentrations of S,Cu,and platinum group elements(PGE),which plot a flat pattern on primitive-mantle normalized diagram.Very low concentrations in our samples suggest that PGEs occur as alloys or hosted by silicate and oxide minerals.The compositions of the studied samples are similar to those of peridotite xenoliths in the Longgang volcanic field(LVF) in their mineralogy and bulk rock compositions including the abundance of chalcophile and siderophile elements.However,they are distinctly different from those of peridotite xenoliths in other areas of the North China Craton(NCC) in terms of Cu,S and PGE.Our data suggest that the SCLM underlying the northeastern part of the NCC may represent a distinct unit of the newly formed lithospheric mantle. | WANG Jian LIU Jinlin HATTORI Keiko XU Wenliang XIE Zhipeng SONG Yue | 2012 | Acta Geologica Sinica(English Edition)2012，86，2： | 8 |
| 14 | 在哪个与狭窄的乐队成像放大了内视镜检查法的胃的联系 mucosa 的淋巴的组织淋巴瘤的一个盒子在诊断是有用的显示文摘 Recently, we reported a case of gastric mucosaassociated lymphoid tissue (MALT) lymphoma presenting with unique vascular features. In the report, we defined the tree-like appearance (TLA) on the images of abnormal blood vessels which resembled branches from the trunk of a tree in the shiny mucosa, in which the glandular structure was lost. The 67-year-old female was diagnosed with gastric MALT lymphoma. The patient received eradication therapy for H. pylori. Conventional endoscopy revealed multiple ill-delineated brownish depressions in the stomach and cobblestonelike mucosa was observed at the greater curvature to the posterior wall of the upper gastric body 7 mo after successful eradication. Unsuccessful treatment of gastric MALT lymphoma was suspected on conventional endoscopy. Conventional endoscopic observations found focal depressions and cobblestone-like appearance, and these lesions were subsequently observed using magnified endoscopy combined with narrow band imaging to identify abnormal vessels presenting with a TLA within the lesions. Ten biopsies were taken from the area where abnormal vessels were present within these lesions. Ten biopsies were also taken from the lesions without abnormal vessels as a control. A total of 20 biopsy samples were evaluated to determine whether the diagnosis of MALT lymphoma could be obtained histologically from each sample. A positive diagnosis was obtained in 8/10 TLA (+) sites and in 2/10 TLA(-) sites. Target biopsies of the site with abnormal blood vessels can potentially improve diagnostic accuracy of gastric MALT lymphoma. | Kouichi Nonaka Keiko Ishikawa Shin Arai Masamitsu Nakao Michio Shimizu Takaki Sakurai Koji Nagata Makoto Nishimura Osamu Togawa Yasutoshi Ochiai Yutaka Sasaki Hiroto Kita | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，4： | 8 |
| 15 | Arterial-phase contrast-enhanced ultrasonography for evaluating anti-angiogenesis treatment: A pilot study显示文摘AIM:To verify whether arterial-phase contrast-enhanced ultrasonography(CEUS) of tumor parenchymal tissue is useful for evaluation of anti-angiogenesis agents.METHODS:Rabbits with liver tumor were subjected to CEUS,and images of the nodular maximal diameter in vascular phase were recorded.Image analysis was performed to plot the time intensity curve(TIC) at the tumor parenchyma,which set the diameter of the region of interest of intensity measurement.The TIC was calculated to obtain the time to peak intensity(TPI) and the magnitude of PI.Rabbits were randomly assigned to a treatment group with sorafenib and a control group.Two weeks later,the same ultrasound examination was repeated followed by pathological testing to assess the effect of sorafenib on the liver tumor.RESULTS:In four rabbits in the treatment group,the rate of change of tumor size was decreased comparedwith that of the control(the rate 2.3 vs 7.9,P = 0.02).The TPI of the treatment group elongated significantly(the rate 3.1 vs 1.1,P = 0.07 for SonoVue,2.0 vs 0.88,P = 0.09 for Sonazoid).The magnitude of PI showed no significant changes.In pathological examination,capillary diameters in the treatment group were significantly smaller than those in the control group(26.4 vs 42.8 μm,P = 0.013).CONCLUSION:Analysis of the TIC in the arterial phase of tumor tissue could evaluate the efficacy of antiangiogenesis drug treatment in liver tumor. | Keiko Yoshida Tomihiko Hirokawa Fuminori Moriyasu Masahiko Yamada Yasuharu Imai | 2011 | World Journal of Gastroenterology2011，17，8： | 7 |
| 16 | Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases显示文摘 | Bryan T. MacDonald Keiko Tamai Xi He | 2009 | Developmental Cell2009，，1： | 6 |
| 17 | Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers显示文摘AIM:To investigate the optimum period of treatment for post endoscopic submucosal dissection(ESD)ulcers.METHODS:Patients who underwent ESD for gastric cancer were randomized to two groups and treated with esomeprazole 20 mg per day for 4 wk(4W group)or 2 wk(2W group).At 4 wk after ESD,we measured the size of the artificial ulcers by endoscopy and determined the ulcer healing rate,compared with the size of the ESD specimens.This randomized controlled trial study was approved by our ethics committee and registered in the UMIN Clinical Trial Registry.RESULTS:A total of 60 consecutive patients were included in the study.All patients received rebamipide 300 mg per day for 4 wk.One patient in 2W group who showed bleeding within two weeks and received endoscopic treatment was excluded from further analysis.The numbers of patients with ulcers in the healing/scar stage in the 2W and 4W groups at 4 wk after ESD were 20/6 and 28/5,respectively,with no significant difference.The ulcer healing rate in the 2W and 4W groups were 96.1%[95%confidence interval(CI):94.6%-97.55]vs 94.8%(95%CI:92.6%-97.1%),respectively,with no statistical difference(UMIN000006951).CONCLUSION:Two-wk treatment with a proton pump inhibitor is as effective as four-week treatment for healing post ESD ulcers. | Makoto Arai Tomoaki Matsumura Kenichiro Okimoto Arata Oyamada Keiko Saito Shoko Minemura Daisuke Maruoka Takeshi Tanaka Tomoo Nakagawa Tatsuro Katsuno Osamu Yokosuka | 2014 | World Journal of Gastroenterology2014，20，43： | 6 |
| 18 | 有为决定早阶段的区分的胃的癌的扩展区域的 NBI 的在我的 DL 的实用性显示文摘 AIM: To investigate whether magnifying endoscopy with narrow band imaging (ME-NBI) is useful for evaluating the area of superficial, depressed- or flat-type differentiated adenocarcinoma of the stomach. METHODS: This procedure was performed in Saitama Medical University International Medical Center, Japanese Red Cross Kumamoto Hospital and Kitakyushu Municipal Medical Center. The subjects were 31 patients in whom biopsy findings, from superficial, depressed- or flat-type gastric lesion, suggested differentiated adenocarcinoma in the above 3 hospitals between January and December 2009. Biopsy was performed on the lesion and non-lesion sides of a boundary (imaginary boundary) visualized on ME-NBI. The results were pathologically investigated. We evaluated the accuracy of estimating a demarcation line (DL) on ME-NBI in comparison with biopsy findings as a gold standard. RESULTS: The DL that could be recognized at 2 points on the orifice and anal sides of each lesion during ME-NBI was consistent with the pathological findings in 22 patients with 0-Ⅱc lesions, 7 with 0-Ⅱb lesions, and 2 with 0-Ⅱb + Ⅱc lesions, showing an accuracy of 100%. CONCLUSION: The results suggest the usefulness of ME-NBI for evaluating the area of superficial, depressed- and flat-type differentiated adenocarcinoma of the stomach. | Kouichi Nonaka Masaaki Namoto Hideki Kitada Michio Shimizu Yasutoshi Ochiai Osamu Togawa Masamitsu Nakao Makoto Nishimura Keiko Ishikawa Shin Arai Hiroto Kita | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，8： | 6 |
| 19 | Non-exposed endoscopic wall-inversion surgery as a novel partial gastrectomy technique显示文摘 | Takashi Mitsui Keiko Niimi Hiroharu Yamashita Osamu Goto Susumu Aikou Fumihiko Hatao Ikuo Wada Nobuyuki Shimizu Mitsuhiro Fujishiro Kazuhiko Koike Yasuyuki Seto | 2014 | Gastric Cancer2014，，3： | 5 |
| 20 | Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids显示文摘We are reporting a rare case of acute liver injury that developed after an internal hemorrhoid treatment with the aluminum potassium sulfate and tannic acid(ALTA) regimen. A 41-year-old man developed a fever and liver injury after undergoing internal hemorrhoid treatment with a submucosal injection of ALTA with lidocaine. The acute liver injury was classified clinically as hepatocellular and pathologically as cholestastic. We could not classify the mechanism of injury. High eosinophil and immunoglobulin E levels characterized the injury,and a drug lymphocyte stimulation test was negative on postoperative day 25. Fluid replacement for two weeks after hospitalization improved the liver injury. ALTA therapy involves injecting chemicals into the submucosa,from the rectum to the anus,and this is the first description of a case that developed a severe liver disorder after this treatment; hence,an analysis of future cases as they accumulate is desirable. | Kenichi Yoshikawa Reimi Kawashima Yuki Hirose Keiko Shibata Takafumi Akasu Noriko Hagiwara Takeharu Yokota Nami Imai Akira Iwaku Go Kobayashi Hirohiko Kobayashi Akiyoshi Kinoshita Nao Fushiya Hiroyuki Kijima Kazuhiko Koike Masayuki Saruta | 2017 | World Journal of Gastroenterology2017，23，27： | 5 |
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