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| 1 | Programmed cell death-1 inhibitor-related sclerosing cholangitis:A systematic review显示文摘BACKGROUND Programmed cell death-1(PD-1)inhibitor has been indicated for many types of malignancies.However,these inhibitors also cause immune-related adverse events.Hepatobiliary disorder is a phenotype of immune-related adverse event affecting 0%–4.5%of patients treated with PD-1 inhibitors.Recent studies have reported PD-1 inhibitor-related sclerosing cholangitis(SC);however,the associated clinical and pathological features are unclear.AIM To evaluate the clinical and pathological features of PD-1 inhibitor-related SC through a systematic review of the literature.METHODS The review,conducted using electronic databases in PubMed,was restricted to the period from January 2014 to September 2019 and focused on case reports/series on PD-1 inhibitor-related SC published in English.We scanned the references of the selected literature to identify any further relevant studies.Six cases previously studied by us,including three that have not yet been published,were included in this review.RESULTS Thirty-one PD-1 inhibitor-related SC cases were evaluated.Median age of patients was 67 years(range,43–89),with a male to female ratio of 21:10.The main disease requiring PD-1 inhibitor treatment was non-small cell lung cancer.Agents that caused PD-1 inhibitor-related SC were nivolumab(19 cases),pembrolizumab(10 cases),avelumab(1 case),and durvalumab(1 case).The median number of cycles until PD-1 inhibitor-related SC onset was 5.5(range,1–27).Abdominal pain or discomfort(35.5%,11/31)was the most frequent symptom.Blood serum tests identified liver dysfunction with a notable increase in biliary tract enzymes relative to hepatic enzymes,and a normal level of serum immunoglobulin G4.Biliary dilation without obstruction(76.9%,20/26),diffuse hypertrophy of the extrahepatic biliary tract(90.5%,19/21),and multiple strictures of the intrahepatic biliary tract(30.4%,7/23)were noted.In 11/23(47.8%)cases,pathological examination indicated that CD8+T cells were the dominant inflammatory cells in the bile duct or peribiliary tract.Although corticosteroids were mainly used for PD inhibitor-related SC treatment,the response rate was 11.5%(3/26).CONCLUSION Some clinical and pathological features of PD-1 inhibitor-related SC were revealed.To establish diagnostic criteria for PD-1 inhibitor-related SC,more cases need to be evaluated. | Takumi Onoyama Yohei Takeda Taro Yamashita Wataru Hamamoto Yuri Sakamoto Hiroki Koda Soichiro Kawata Kazuya Matsumoto Hajime Isomoto | 2020 | World Journal of Gastroenterology2020，26，3： | 7 |
| 2 | Environmental regulation and the productivity of Japanese manufacturing industries显示文摘 | Mitsutsugu Hamamoto | 2006 | Resource and Energy Economics2006，，4： | 6 |
| 3 | Narrow-Band Imaging in the Diagnosis of Colorectal Mucosal Lesions: A Pilot Study显示文摘 | H. Machida Y. Sano Y. Hamamoto M. Muto T. Kozu H. Tajiri S. Yoshida | 2004 | Endoscopy2004，，12： | 4 |
| 4 | Prediction of acute left main coronary artery obstruction by 12-lead electrocardiography显示文摘 | Hirosuke Yamaji Kohichiro Iwasaki Shozo Kusachi Takashi Murakami Ryouichi Hirami Hiromi Hamamoto Kazuyoshi Hina Toshimasa Kita Noburu Sakakibara Takao Tsuji | 2001 | Journal of the American College of Cardiology2001，，5： | 3 |
| 5 | A new technique for endoscopic mucosal resection with an insulated-tip electrosurgical knife improves the completeness of resection of intramucosal gastric neoplasms显示文摘 | Shin’ichi Miyamoto Manabu Muto Yasuo Hamamoto Narikazu Boku Atsushi Ohtsu Satoshi Baba Motoki Yoshida Masana Ohkuwa Kouichi Hosokawa Hisao Tajiri Shigeaki Yoshida | 2002 | Gastrointestinal Endoscopy2002，，4： | 3 |
| 6 | Incidence of deep fascial space infection after surgical removal of the mandibular third molars显示文摘 | Yoshii T Hamamoto Y Muraoka S | 2001 | J Infect Chemother2001，7，： | 2 |
| 7 | Electronic structure of the 4 × 4 silicene monolayer on semi-infinite Ag(111)显示文摘 | H Ishida Y Hamamoto Y Morikawa E Minamitani R Arafune N Takagi | 2015 | New Journal of Physics2015，，： | 2 |
| 8 | The mechanism of renal stone formation and renal failure induced by administration of melamine and cyanuric acid显示文摘 | Takahiro Kobayashi Atsushi Okada Yasuhiro Fujii Kazuhiro Niimi Shuzo Hamamoto Takahiro Yasui Keiichi Tozawa Kenjiro Kohri | 2010 | Urological Research2010，，2： | 2 |
| 9 | Hypotrontality and microvascular dysregulation in remitted late -onset depression assessed by functional near-infrared spectroscopy显示文摘 | Matsuo K Onodera Y Hamamoto T | 2005 | Neuroimage2005，26，1： | 1 |
| 10 | Capability of nondegenerated and degenerated discs in producing inflamma- tory agents with or without macrophage interaction 显示文摘 | Hamamoto H Miyamoto H Doita M | 2012 | Spine2012，37，3： | 1 |
| 11 | Efficacy of retroperitoneal laparo- scopic uretemlithotomy for the treatment of large proximal ureteric stones and itsimpact on renal function显示文摘 | Yasui T Okada A Hamamoto S | 2013 | Springerplus2013，2，： | 1 |
| 12 | Prognosis of primary central nervous system lymphoma treated with radiotherapy alone显示文摘 | Taguchi S Hamamoto Y Fujii T | 2012 | Jap J Radiol2012，30，10： | 1 |
| 13 | PCR-based detection of sterol demethylation inhitor-resistant strains of Penicillium digitatum显示文摘 | Hamamoto H Hasegawa K Nakaune R | 2001 | Pest Manag Sci2001，57，： | 1 |
| 14 | Environmental Regulation and the Productivity of Japanese Manufacturing Industries显示文摘 | Hamamoto M | | 0，，04： | 1 |
| 15 | Model experiments of ship capsize in astern seas显示文摘 | UMED N HAMAMOTO M SERA W | 1996 | Journal of the Society of Naval Architects of Japan1996，7787，： | 1 |
| 16 | Possible synergic effect of angiotensin-I converting enzyme gene Insertion/Deletion polymorphism and angiotensin-II type-1 receptor 1166A/C gene polymorphism on ischemic heart disease in patients with Kawasaki disease显示文摘 | Fukazawa R Sonobe T Hamamoto K | 2004 | Pediatr Res2004，56，4： | 1 |
| 17 | Tandem repeat of a transcriptional enhancer upstream of the sterol 14 alpha-demethylase gene ( CYP51 ) in Penicillium digitatum 显示文摘 | HAMAMOTO H HASEGAWA K NAKAUNE R | 2000 | Appl Environ Microbiol2000，66，： | 1 |
| 18 | An iterative learning control algorithm within prescribed input-output subspace显示文摘 | Hamamoto K Sugie T | 2001 | Automatica2001，37，11： | 1 |
| 19 | Development of virus concentration methods for detection of koi herpesvirus in water显示文摘 | Hamamoto E Kitajima M Katayama M | 2009 | Journal of Fish Diseases2009，32，3： | 1 |
| 20 | Localization of cytosolic NADP-dependent isocitrate dehydrogenase in the peroxisomes of rat liver cells显示文摘 | YOSHIHARA T HAMAMOTO T MUNAKATA R | 2001 | J Histochem Cytochem2001，49，9： | 1 |
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