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| 1 | Immune response after photodynamic therapy increases anti-cancer and anti-bacterial effects显示文摘Photodynamic therapy(PDT) is a clinically approved procedure for treatment of cancer and infections. PDT involves systemic or topical administration of a photosensitizer(PS), followed by irradiation of the diseased area with light of a wavelength corresponding to an absorbance band of the PS. In the presence of oxygen, a photochemical reaction is initiated, leading to the generation of reactive oxygen species and cell death. Besides causing direct cytotoxic effects on illuminated tumor cells, PDT is known to cause damage to the tumor vasculature and induce the release of pro-inflammatory molecules. Pre-clinical and clinical studies have demonstrated that PDT is capable of affecting both the innate and adaptive arms of the immune system. Immune stimulatory properties of PDT may increase its beneficial effects giving the therapy wider potential to become more extensively used in clinical practice. Be-sides stimulating tumor-specific cytotoxic T-cells capable to destroy distant untreated tumor cells, PDT leads to development of anti-tumor memory immunity that can potentially prevent the recurrence of cancer. The immunological effects of PDT make the therapy more effective also when used for treatment of bacterial infections, due to an augmented infiltration of neutrophils into the infected regions that seems to potentiate the outcome of the treatment. | Eleonora Reginato Peter Wolf Michael R Hamblin | 2014 | World Journal of Immunology2014，4，1： | 14 |
| 2 | Importance of intellectual property generated by biomedical research at universities and academic hospitals显示文摘Biomedical research has many different facets.Researchers and clinicians study disease biology and biochemistry to discover novel therapeutic targets,unravel biochemical pathways and identify biomarkers to improve diagnosis,or devise new approaches to clinically manage diseases more effectively.In all instances,the overall goal of biomedical research is to ensure that results thereof(such as a therapy,a device,or a method which may be broadly referred to as“inventions”)are clinically implemented.Most of the researchers’efforts are centered on the advance of technical and scientific aspects of an invention.The development and implementation of an invention can be arduous and very costly.Historically,it has proven to be crucial to protect intellectual property rights(IPR)to an invention(i.e.,a patent)to ensure that companies can obtain a fair return on their investment that is needed to develop an academic invention into a product for the benefit of patients.However,the importance of IPR is not generally acknowledged among researchers at academic institutions active in biomedical research.Therefore this paper aims to(1)raise IP awareness amongst clinical and translational researchers;(2)provide a concise overview of what the patenting trajectory entails;and(3)highlight the importance of patenting for research and the researcher.Importance for patients:Adequate patent protection of inventions generated through biomedical research at academic institutions increases the probability that patients will benefit from these inventions,and indirectly enables the financing of clinical studies,mainly by opening up funding opportunities(e.g.specific grants aimed at start-ups,pre-seed and seed capital)that otherwise would not be accessible.As a consequence,patented inventions are more likely to become clinically tested and reach the market,providing patients with more treatment options. | Joris J.Heus Elmar S.de Pauw Mirjam Leloux Margherita Morpurgo Michael R Hamblin Michal Heger | 2017 | Journal of Clinical & Translational Research2017，3，2： | 3 |
| 3 | Antigen presentation of type Ⅱ collagen in rats 显示文摘 | Catchpole B Staines NA Hamblin AS | 2001 | Clin Exp Immunol2001，125，3： | 1 |
| 4 | The convergent evolution of annual seed crop in agriculture显示文摘 | Donald C M Hamblin J | 1968 | Adv Agron1968，36，： | 1 |
| 5 | Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imaging显示文摘 | Hamblin MR O'Donnell DA Murthy N | 2002 | Pbotochem Photobiol2002，75，1： | 1 |
| 6 | Photodynamic therapyand anti-tumour immunity显示文摘 | Castano AP Mroz P Hamblin MR | 2006 | Nat Rev Cancer2006，6，7： | 1 |
| 7 | Epidermal growth factor receptor-targeted immunophotodiagnosis and photoimmunotherapy of oral precancer in vivo显示文摘 | Soukos NS Hamblin MR Keel S | 2001 | Cancer Res2001，61，： | 1 |
| 8 | Photodynamic therapy for lo- calized infections-state of the art 显示文摘 | Dai T Huang YY Hamblin MR | 2009 | Photodiagrwsis Photodyn Ther2009，6，34： | 1 |
| 9 | Photodynamic therapy targeted to pathogens显示文摘 | Demidova T N Hamblin M R | 2004 | Int J Immunopathol Pharmacol2004，17，3： | 1 |
| 10 | Immunologic abnormalities in myelodysplastic syndromes显示文摘 | | 1996 | Semin Hematol1996，3，2： | 1 |
| 11 | CD40/CD154 interactions are required for the optimal maturation of skin-derived APCs and the induction of hehninth-specific IFN-gamma but not IL-4 显示文摘 | Hewitson JP Jenkins GR Hamblin PA | 2006 | J Immunol2006，177，5： | 1 |
| 12 | Immunologic abnormalities in myelodysplastic syndrome显示文摘 | Hamblin T | 1992 | Hematol Oncol North Am1992，6，： | 1 |
| 13 | Sequence varia-tion at candidate loci in the starch metabolism pathway in sorghum:prospects for linkage disequilibrium mapping 显示文摘 | Hamblin M T Femandez M G S Tuinstra M R | 2007 | Crop Science2007，，： | 1 |
| 14 | Unmutated IgV (H) genes are associated with a more aggressive form of chronic lymphocytic leukemia 显示文摘 | Hamblin TJ Davis Z Gardiner A | 1999 | Blood1999，94，6： | 1 |
| 15 | Mechanisms in photodynamic ther- apy: part three-photosensitizer pharmacok- inetics,biodistribution, tumor localization and modes of tumor destruction Photodiag 显示文摘 | Castano AP Demidova TN Hamblin MR | 2005 | Photodyn Ther2005，2，： | 1 |
| 16 | Peroxisome proliferator-activated receptor delta regulation of miR-15a in ischemia-induced cerebral vascular endothelial injury显示文摘 | Yin K J Deng Z Hamblin M | 2010 | J Neurosci2010，30，18： | 1 |
| 17 | Antimicrobialphotodynamic therapy to kill Gram-negative bacteria 显示文摘 | Sperandio F F Huang Y Y Hamblin M R | 2013 | Recent Pat Antiinfect Drug Discov2013，8，2： | 1 |
| 18 | Rheumatoid arthritis-associated intersti- tial lung disease:diagnostic dilemma 显示文摘 | Hamblin MJ Horton MR | 2011 | Pulm Med2011，2011，87： | 1 |
| 19 | High-resolution mapping of resistance to cassava mosaic geminiviruses in cassava using genotyping-by-sequencing and its implications for breeding显示文摘 | Ismail Y. Rabbi Martha T. Hamblin P. Lava Kumar Melaku A. Gedil Andrew S. Ikpan Jean-Luc Jannink Peter A. Kulakow | 2013 | Virus Research2013，，： | 1 |
| 20 | Vertical mixing and weak stratification over zebra mussel coloneis in western lake erie 显示文摘 | Boegman L Loewen M R Hamblin P F | 2008 | Limnology and Oceanography2008，5，33： | 1 |
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