|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | 甜菜碱对肥育猪生长激素脉冲释放和血清代谢的影响显示文摘用添加含量为0和0.125%甜菜碱的日粮饲喂肥育猪,试验对杂交肥育猪日粮中甜菜碱对猪的生长性能、生长激素(GH)脉冲释放及血清代谢的影响进行研究。每试验组3个重复,每个重复8头猪(4头去势公猪,4头母猪),试验在饲喂后3h内每15min采集一次血液样本,测定生长激素脉冲释放。结果表明:添加甜菜碱组平均日增重增加5.45%(P〈0.05),而平均日采食量和饲料转化率则不受影响。 | Huang Q C Xu Z R Han X Y Li W F | 2007 | 饲料博览(技术版)2007，，7： | 2 |
| 3 | Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue显示文摘 | Deng W Han Q Liao L Li C Ge W Zhao Z You S Deng H Murad F Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 4 | Investigation of PEG adsorption on the surface of zinc oxide nanoparticles 显示文摘 | Liu F Sheng C Han N X | 2004 | Power Technology2004，145，1： | 1 |
| 5 | Effect of supplemental synthetic anaino acids to the low diels on the perfnrmanee of growing pigs显示文摘 | Jin C F Kim I H Han I K | 1998 | Asian Australas J Anita Sci1998，11，1： | 1 |
| 6 | Optimization of an impact drive mechanism based on real-coded genetic algorithm 显示文摘 | Ha J L Fung R F Han C F | 2005 | Sensors and Actuators2005，121，2： | 1 |
| 7 | Effects of supplemental synthetic amino acids to the low diets on the performance of growing pigs显示文摘 | JIN C F KIM I H HAN K | 1999 | Asian-Aus J Anim Sci1999，11，： | 1 |
| 8 | Remote measurement of algal chlorophyll in surface waters:the case for the first derivative of reflectance near 690nm显示文摘 | Rundquitst D C Han L Schalles J F | 1996 | Photogramm Eng Remote Sens1996，62，： | 1 |
| 9 | Least Squares Tracking on the Euclidean Group显示文摘 | Han Y Park F C | 2001 | IEEE Transaction on Automatic Control2001，46，7： | 1 |
| 10 | Microwave-assisted one pot synthesis of water-soluble rare earth doped fluoride luminescent nanoparti cles with tunahle colors显示文摘 | Mi C C Tian Z H Han B F | 2012 | J Alloy Compd2012，525，15： | 1 |
| 11 | Thrombospondin, a negative modulator of megakaryocytopoiesis显示文摘 | Chen Y Z Incardona F Legrand C Momeux L Caen J Han Z C | 1997 | J Lab Clin Med1997，129，： | 1 |
| 12 | Optimization of an impact drive mechanism based on real-coded genetic algorithm显示文摘 | Ha J L Fung R F Han C F | | 0，，02： | 1 |
| 13 | Long-term outcomes and prog- nostic factors of re-irradiation for locally recurrent nasopharyngeal carcinoma using intensity-modulated radiotherapy 显示文摘 | Han F Zhao C Huang SM | 2012 | Clin Oncol (R Coil Radiol)2012，24，8： | 1 |
| 14 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 15 | Influenced of yttrium on microstructure,mechanical properties and deformability of Ti-43Al-9V alloy显示文摘 | Chen Y Y Kong F T Han J C Chen Z Y Tian J | 2005 | Intermetallics2005，13，34： | 1 |
| 16 | Membrane aromatic recovery system (MARS) - a new membrane process :for the recovery of phenols from wastewaters显示文摘 | Han S Ferreira F C Linvingston A G | 2001 | J Membr Sci2001，188，： | 1 |
| 17 | An Uncertain Structural Optimization Method Based on Nonlinear Interval Number Program ming and Interval Analysis Method 显示文摘 | Jiang C Han X Guan F J | 2007 | Engineering Structures2007，29，11： | 1 |
| 18 | High-efficiency-sensitized solar cell with a novel co-adsorbent显示文摘 | Han L Y Islam A Chen H Malapaka C Chiranjeevi B Zhang S F Yang X D Yanagida M | | 0，，03： | 1 |
| 19 | Identification of lung cancer patients by serum protein profiling using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry 显示文摘 | Han K Q Huang G Gao C F | 2008 | Am J Clin Oncol2008，31，2： | 1 |
| 20 | Cooperation Evolution and Dynamics in Metal Population: Stage Quilitrium Hypothesis 显示文摘 | Hui C Zhang F Han X | 2005 | Ecol Model2005，184，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员