|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 3 | Proinflammatory cytokines cause NO dependent and independent changes in expression and localization of tight junction proteins in intestinal epithelial cells显示文摘 | Han X Fink M P Delude R L | 2003 | Shock2003，19，3： | 1 |
| 4 | Optimization of an impact drive mechanism based on real-coded genetic algorithm 显示文摘 | Ha J L Fung R F Han C F | 2005 | Sensors and Actuators2005，121，2： | 1 |
| 5 | Assessment of erosion haz- ard with the USLE and GIS A ease study of the Upper Ewaso Nglro North basin of Kenya显示文摘 | Bancy M Mati Royston P C Morgan Francis N Gichuki John N Quinton Tim R Brewer Hans P l iniger | 2000 | lnternation Journal of Applied Earth Ob- servation and Geoinformation2000，2，2： | 1 |
| 6 | Optimization of an impact drive mechanism based on real-coded genetic algorithm显示文摘 | Ha J L Fung R F Han C F | | 0，，02： | 1 |
| 7 | Neuroprotective effects of ginsen-oside Rd against oxygen - glucose deprivation in cultured hippocampalneurons显示文摘 | Ye R D Li N L Han J L | 2009 | Neuroscience Research2009，64，： | 1 |
| 8 | B io a v a ila b ility andpopulation pharm acokinetics o f voriconazole in lungtransplant recipien ts 显示文摘 | Han K C apitano B B ies R et a l | 2010 | Antimicrob Agents Chemother2010，54，10： | 1 |
| 9 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 10 | Hydrophilicity and photocatalysis of Ti1-xVxO2 films prepared by sol-gel method显示文摘 | Li H Zhao G L Han G R | 2007 | Surf Coat Technol2007，201，18： | 1 |
| 11 | Quantifying signed directed graphs with the fuzzy set for fault diagnosis resolution improvement显示文摘 | Han C C Shih R Lee L | 1994 | Industrial & Engineering Chemistry Research1994，33，8： | 1 |
| 12 | Microwave complex permea- bility of planar anisotropy carbonyl-iron particles显示文摘 | Han R Qiao L Wang T | 2010 | Journal of Alloys and Compounds2010，509，6： | 1 |
| 13 | Constraint-based,multidimensional data mining显示文摘 | Han J Lakshmanan L V S Ng R T | 1999 | Computer1999，32，8： | 1 |
| 14 | Combustion and pyrolysis reactions in a naphtha cracking furnace 显示文摘 | Han Y L Xiao R Zhang M Y | 2007 | Chemical Engineering & Tech- nology2007，30，1： | 1 |
| 15 | Prediction of flow-induced structure vibration and sound radiation using energy flow analysis显示文摘 | BERNHARD R J MONGEAU L G | 1999 | Journal of Sound and Vibration1999，227，4： | 1 |
| 16 | Effects of race-earth elements Gd and Y on the solid solution strengthening of Mg alloys显示文摘 | GAO L CHEN R S HAN E H | 2009 | Journal of Alloys and Compounds2009，481，12： | 1 |
| 17 | Caspase family proteases and apoptosis显示文摘 | Fan T J Han L H Cong R S | 2005 | Acta Biochim Biophys Sin2005，37，11： | 1 |
| 18 | Expandable metal stents for the palliation of malignant gastroduodenal obstruction显示文摘 | Rudeean R Hans -Ulrich L Ruth E | 2001 | Cardiovasc Intervent Radiol2001，24，5： | 1 |
| 19 | Identification and characterization of Bphl4, a gene conferring resistance to brown planthopper in rice 显示文摘 | Du B Zhang W Liu B Hu J Wet Z Shi Z He R Zhu L Chen R Han B He G | 2009 | Proceedings of the National Academy of Sciences2009，106，22： | 1 |
| 20 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员