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| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | Novel reaction route for dimethyl carbonate synthesis from CO2 and methanol 显示文摘 | Zhao T S Han Y Z Sun Y H | 2000 | Fuel process Technol2000，62，2： | 1 |
| 3 | Adsorption of cadmium by biochar derived from municipal sewage sludge:Impact factors and adsorption mechanism显示文摘 | Chen T Zhou Z Y Han R | 2015 | Chemosphere2015，134，9： | 1 |
| 4 | Association of interleukin-17F gene polymorphism with enterovirus 71 encephalitis in patients with hand,foot,and mouth disease 显示文摘 | Lv T Li J Han Z | 2013 | Inflammation2013，36，4： | 1 |
| 5 | Influenced of yttrium on microstructure,mechanical properties and deformability of Ti-43Al-9V alloy显示文摘 | Chen Y Y Kong F T Han J C Chen Z Y Tian J | 2005 | Intermetallics2005，13，34： | 1 |
| 6 | Four prodator- prey models with infectious diseases 显示文摘 | HAN L T MA Z E HETHCOTE H W | 2001 | Mathl Comput Modelling2001，34，： | 1 |
| 7 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 8 | On the oscilla- tion of second-order Emden-Fowler neutral differential e- quations 显示文摘 | LI T X HAN Z L ZHANG C H | 2011 | J Appl Math Comput2011，37，： | 1 |
| 9 | Characteristics, development and mapping of Gossypium hirsutum derived EST-SSRs in allotetraploid cotton显示文摘 | HAN Z G WANG C B SONG X L GUO W Z GOU J Y LI C H CHEN X Y ZHANG T Z | 2006 | Theor Appl Genet2006，112，： | 1 |
| 10 | What is the Astronomical Unit of Length显示文摘 | Huang T Y Han C H Yi Z H | 1995 | Astron and Astrop1995，298，： | 1 |
| 11 | Field Experimental 'Star Type' Metropolitan Quantum Key Distribution Network显示文摘 | CHEN W HAN Z F ZHANG T | 2009 | IEEE Photonics Technology Letters2009，21，9： | 1 |
| 12 | Functional homologs of cyanovirin-N amenable to mass production in prokaryotic and eukaryotic hosts显示文摘 | Mori T Barrientos LG Han Z | 2002 | Protein Expr Purif2002，26，1： | 1 |
| 13 | Analysis of the electric field and ion current density under ultra high voltage direct current transmission lines based on finite element method显示文摘 | Lu T B Han F Zhao Z B etal | 2007 | IEEE Transactions on Magnetics2007，43，4： | 1 |
| 14 | Mesopoorus aluminosilicates with ordered hexagonal structure,strong acidity,and extraordinary hydrothermal stability at high temperatures显示文摘 | Zhang Z T Han Y Xiao F S | | 0，，2： | 1 |
| 15 | Controlled synthesis of Ag/TiO2 core-shell nanowires with smooth and bristled surfaces via a one-step solution route显示文摘 | Du J M Zhang J L Liu Z M Han B X Jiang T Huang Y | 2006 | Langmuir2006，22，3： | 1 |
| 16 | Strongly acidic and high - temperature hydrothermally stable mesoporous aluminosilicates with ordered hexagonal structure显示文摘 | Zhang Z T Han Y Zhu L | 2001 | Angew chem int ed2001，40，7： | 1 |
| 17 | Effect of intravenous of 12-Otetradecanoylphorbal-13-acetate(TPA) in patients with myelocytic leukemia:preliminary studies on therapeutic efficacy 显示文摘 | Han Z T Zhu X X Yang R Y | 1998 | Proc Natl Acad Sci USA1998，95，9： | 1 |
| 18 | Oscillation criteria for third order nonlinear delay dynamic equations on time scales 显示文摘 | HAN Z LI T SUN S | 2010 | Ann Polon Math2010，99，： | 1 |
| 19 | Metal-free efficient photocatalyst for stable visible water splitting via a two-electron pathway显示文摘 | Liu J Liu Y Liu N Han Y Zhang X Huang H Lifshitz Y Lee S T Zhong J Kang Z | 2014 | Science2014，347，6225： | 1 |
| 20 | Controlled synthesis of Ag/TiO2 core-shell nanowires with smooth and bristled surfaces via a one-step solution route显示文摘 | Du J M Zhang J L Liu Z M Han B X Jiang T Huang Y | 2006 | Langmuir2006，22，3： | 1 |
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