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| 1 | Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells显示文摘Breast cancer is the most common invasive cancer in women worldwide.Sirtuin 1(SIRT1)has recently been shown to have implications in regulating cancer cell growth and apoptosis.SIRT1 regulates Forkhead box O3a(FOXO3a)by both inhibiting FOXO3-induced apoptosis and potentiating the ability of FOXO3a to resist oxidative stress.Matrix metalloproteinase 2(MMP2)participates in tumor invasion and metastasis by degrading extracellular matrix.SIRT1 up regulates MMP2 expression by its deacetylation activity.This study aimed to investigate the expression of SIRT1,FOXO3a and MMP2 in breast tissues of women with breast cancer.In addition,the effect of SIRT1 inhibition on both FOXO3a and MMP2 expression in breast cancer(MCF-7)cells was assessed.The expression levels of SIRT1,FOXO3a and MMP2 in the breast tissues were determined by real-time PCR in 60 patients with malignant tumor and in 24 patients with benign tumors.After SIRT1 inhibition,protein levels of SIRT1 and FOXO3a were assessed by Western Blot and levels of MMP2 by ELISA in MCF-7 cells.The expression levels of SIRT1,FOXO3a and MMP2 were significantly higher in breast cancer tissues compared to in benign breast tumor and adjacent normal tissues.SIRT1,MMP2 and FOXO3a expression were associated directly with each other.SIRT1 inhibition suppresses MMP2 and FOXO3a expression compared to control MCF7.Sirtinol(SIRT1 inhibitor)effectively induced inhibition of MMP2 and FOXO3a expression in MCF-7 cells,indicating the promising therapeutic strategy of targeting SIRT1 for breast cancer. | Hanan Abdelmawgoud Rehab Refaat El Awady | 2017 | Genes & Diseases2017，4，4： | 3 |
| 2 | Neutron-gamma discrimination method based on blind source separation and machine learning显示文摘The discrimination of neutrons from gamma rays in a mixed radiation field is crucial in neutron detection tasks.Several approaches have been proposed to enhance the performance and accuracy of neutron-gamma discrimination.However,their performances are often associated with certain factors,such as experimental requirements and resulting mixed signals.The main purpose of this study is to achieve fast and accurate neutron-gamma discrimination without a priori information on the signal to be analyzed,as well as the experimental setup.Here,a novel method is proposed based on two concepts.The first method exploits the power of nonnegative tensor factorization(NTF)as a blind source separation method to extract the original components from the mixture signals recorded at the output of the stilbene scintillator detector.The second one is based on the principles of support vector machine(SVM)to identify and discriminate these components.In addition to these two main methods,we adopted the Mexican-hat function as a continuous wavelet transform to characterize the components extracted using the NTF model.The resulting scalograms are processed as colored images,which are segmented into two distinct classes using the Otsu thresholding method to extract the features of interest of the neutrons and gamma-ray components from the background noise.We subsequently used principal component analysis to select the most significant of these features wich are used in the training and testing datasets for SVM.Bias-variance analysis is used to optimize the SVM model by finding the optimal level of model complexity with the highest possible generalization performance.In this framework,the obtained results have verified a suitable bias–variance trade-off value.We achieved an operational SVM prediction model for neutron-gamma classification with a high true-positive rate.The accuracy and performance of the SVM based on the NTF was evaluated and validated by comparing it to the charge comparison method via figure of merit.The results indicate that the proposed approach has a superior discrimination quality(figure of merit of 2.20). | Hanan Arahmane El-Mehdi Hamzaoui Yann Ben Maissa Rajaa Cherkaoui El Moursli | 2021 | Nuclear Science and Techniques2021，32，2： | 2 |
| 3 | Long-term outcomes of coronary-artery bypass grafting versus stent implantation显示文摘 | Racz MJ Walford G | 2005 | N Engl J Med2005，352，21： | 1 |
| 4 | Adherence to medication: A nation-wide study from the Children's Cancer Hospital, Egypt显示文摘AIM: To investigate adherence to medical regimen and predictors for non-adherence among children with cancer in Egypt. METHODS: We administered two study specific questionnaires to 304 parents of children diagnosed with cancer at the Children's Cancer Hospital in Cairo, Egypt, one before the first chemotherapy treatment and the other before the third. The questionnaires were translated to colloquial Egyptian Arabic, and due, to the high illiteracy level in Egypt an interviewer read thequestions in Arabic to each parent and registered the answers. Both questionnaires consisted of almost 90 questions each. In addition, a Case Report Form was filled in from the child's medical journal. The study period consisted of 7 mo(February until September 2008) and we had a participation rate of 97%. Descriptive statistics are presented and Fisher's exact test was used to check for possible differences between the adherent and non-adherent groups. A P-value below 0.05 was considered significant. Software used was SAS version 9.3 for Windows(SAS Institute Inc., Cary, NC, United States).RESULTS: Two hundred and eighty-one(90%) parents answered the second questionnaire, regarding their child's adherence behaviour. Approximately two thirds of the children admitted to their third chemotherapy treatment had received medical recommendations upon discharge from the first or second chemotherapy treatment(181/281, 64%). Sixty-eight percent(123/181) of the parents who were given medical recommendations reported that their child did not follow the recommendations. Two main predictors were found for non-adherence: child resistance(111/123, 90%) and inadequate information(100/123, 81%). In the adherent group, 20% of the parents(n = 12/58) reported trust in their child's doctor while 14 percent 8/58 reported trust in the other health-care professionals. Corresponding numbers for the non-adherent group are 8/123(7%) for both their child's doctor and other health-care professionals. Almost all of the parents expressed a lack of optimism towards the treatment(116/121, 96%), yet they reported an intention to continue with the treatment for two main reasons, for the sake of their child's life(70%)(P = 0.005) and worry that their child would die if they discontinued the treatment(81%)(P < 0.0001).CONCLUSION: Non-adherence to medical regimen is common among children diagnosed with cancer inEgypt, the main reasons being child resistance and inadequate information. | Hanan El Malla Nathalie Ylitalo Helm Ulrica Wilder?ng Yasser El Sayed Elborai Gunnar Steineck Ulrika Kreicbergs | 2013 | World Journal of Psychiatry2013，3，2： | 1 |
| 5 | Transfusion-related acute lung injury 显示文摘 | Hanane El Kenz P Vander L | 2014 | Euro J Anaesth2014，31，2： | 1 |
| 6 | Establishment of human clones producing neutralizing humanmonoclonal antibodies to the envelope E1/E2 protein of hepatitis C virus by EBVimmortalization of immune CD22+ B cells显示文摘 | Ashraf Tabll Yasmine El Abd Noha G. Bader El Din Reem El Shenawy Tawfeek H. Abdelhafez Mostafa El Awady Hanan El-Mohamady Sergei Viazov | | 2014 (3,4)0，，： | 1 |
| 7 | Gastric carcinoma at Tanta Cancer Center: A comparative retrospective clinico-pathological study of the elderly versus the non-elderly显示文摘 | Ahmed A. Zeeneldin Hanan Ramadan Mosaad M. El Gammal Magdy M. Saber Dina Elgamal Mohamed A. Sherisher | 2014 | Journal of the Egyptian National Cancer Institute2014，，： | 1 |
| 8 | Secure End-to-End Architecture for E-commerce Security-Oriented Transaction显示文摘 | Houssam El Ismaili Hanane Houmani Hicham Madroumi | 2013 | 通讯和计算机(中英文版)2013，10，7： | 1 |
| 9 | Severe ische- mic retinopathy in a patient with systemic lupus erythema- tosus without antiphospholipid syndrome: a case report 显示文摘 | Fouad el A Hanane M Mounir B | 2015 | Saudi J Ophthalmol2015，29，2： | 1 |
| 10 | Thyroid and Pregnancy显示文摘Thyroid diseases are common in women of childbearing age.Different factors of maternal thyroid function occur during pregnancy;therefore,guidelines recommend trimester-specific pregnancy reference range for thyroid-stimulating hormone.Manifestly,thyroid dysfunctions have deleterious obstetrical and neonatal outcomes.Therefore,an adequate treatment is important to prevent adverse pregnancy complications.Furthermore,iodine deficiency during pregnancy could originate maternal and fetal problems.Consequently,scientific organizations recommend prenatal iodine supplementation for all pregnant women.However,treatment of thyroid autoimmunity is intriguing,but adequately powered randomized controlled trials are needed.The aim of this article was to summarize the reported results of the literature related to the management of thyroid disease during pregnancy in order to help endocrinologists in decision-making processes. | Nadia Belmahi Said Boujraf Hanan El Ouahabi | 2018 | Reproductive and Developmental Medicine2018，2，3： | 1 |
| 11 | Effect of Laparoscopic versus Open Gastric Bypass Surgery on Postoperative Pain and Bowel Function显示文摘 | Hanan El Shobary MD Nicolas Christou MD PhD Steven B Backman MD PhD Branka Gvocdic MD Thomas Schricker MD PhD | 2006 | Obesity Surgery2006，，4： | 1 |
| 12 | Mortality and locomotion 6 months after hospitalization for hip fracture: risk factors and risk-adjusted hospital outcomes显示文摘 | Hanan EL Magaziner J Wang JJ | 2001 | JAMA2001，285，21： | 1 |
| 13 | Echoguided pair technique in diagnosis and treat-ment of abdominal hydatid cystic disease in Egyptian patients: clnical and ultrasonographic follow up显示文摘 | El Kady N Ramzy I Hanan HA | 2011 | J Egypt Soc Parasitol2011，41，3： | 1 |
| 14 | Hepatitis B genotypes/subgenotypes and MHR variants among Moroccan chronic carriers显示文摘 | Bouchra Kitab Abdellah Essaid El Feydi Rajaa Afifi Omar Derdabi Younes Cherradi Mustapha Benazzouz Khadija Rebbani Ikram Brahim Hanane Salih Alj Fabien Zoulim Christian Trepo Isabelle Chemin Sayeh Ezzikouri Soumaya Benjelloun | 2011 | Journal of Infection2011，，1： | 1 |
| 15 | Evaluation of coronary flow reserve in hypertensive patients by dipyridamole transesophageal Doppler echocardiography显示文摘 | Mohamed S Hamouda Hanan K Kassem Mai Salama Magdy El Masry Naseem Shaaban Ekram Sadek Bijoy K Khandheria James B Seward Abdou Elhendy | 2000 | The American Journal of Cardiology2000，，3： | 1 |
| 16 | The Marrara syndrome: a hypersensitivity reaction of the upper respiratory tract and buccopharyngeal mucosa to nymphs of Linguatula serrata显示文摘 | Hashim Yagi Sabir El Bahari Hanan A. Mohamed El Rasheed Sid Ahmed Babiker Mustafa Magdi Mahmoud Mohamed B.A. Saad Suad M. Sulaiman Ahmed M. El Hassan | 1996 | Acta Tropica1996，，3： | 1 |
| 17 | Preparation and physicochemical characteri- zation of dioctyl sodium sulfosuccinate ( Aerosol OT) microemulsion for oral drug delivery 显示文摘 | HANAN M EL - LAITHY | 2003 | Phann Sci Tech2003，4，1： | 1 |
| 18 | Investigation of the antioxidant defensive role of both AD-MSCs and BM-MSCs in modulating the alteration in the oxidative stress status in various STZ-diabetic rats’tissues显示文摘Diabetes mellitus(DM)could negatively affect patients’health via inducing a lot of serious functional hazards in many tissues’cells at molecular levels.Recently,many scientists had proposed stem cell therapy being an appropriate alternative treatment protocol for numerous health threatening issues including diabetes.Therefore,the current study was designed to investigate the antioxidant potentiality of two MSCs types in alleviating tissues’oxidative stress dramatic elevation resulting as a consequence of Type 1 DM induction.In our 4 weeks study,animals were divided into four groups:control group,STZ-diabetic group(D),D+AD-MSCs group and D+BM-MSCs group.Data reported that diabetic rats treated with either AD-MSCs or BM-MSCs exhibited a marvelous body tissues(Pancreas,Liver and Kidney)enhancing capabilities in attenuating the oxidative stress status;as evidenced by XO,ROS,and MDA levels down-regulation;with a general concomitant elevation in the antioxidants’content;evidenced by many enzymatic and non-enzymatic antioxidants up-regulation;relative to the diabetic untreated group.Interestingly,comparing both treatments with each other and to control group,most of the measured parameters were reverted back to near normal levels after AD-MSCs injection;which clearly point out their stunning health benefits and superiority as anti-diabetic agent in overcoming different tissues’complications;owing to their marked cytoprotective and regenerative potentialities. | SHADY G.EL-SAWAH FAYEZ ALTHOBAITI ADIL ALDHAHRANI EMAN FAYAD MARWA A.ABDEL-DAYEM REHAB M.AMEN EL SHAIMAA SHABANA EHAB I.EL-HALLOUS HANAN M.RASHWAN | 2021 | BIOCELL2021，45，6： | 0 |
| 19 | Anti-inflammatory and antioxidant potential capacities of AD-MSCs and BM-MSCs in suppressing pancreaticβ-cells auto-immunity and apoptosis in rats with T1DM induced model显示文摘Since Type 1 diabetes(T1DM)occurs whenβ-cells mass is reduced to less than 20%of the normal level due to autoimmune destruction of cells resulting in the inability to secrete insulin,preservation or replenishment of the functionalβ-cells mass has become a major therapeutic focus for this diabetic type treatment.Thus,this 4-week work plan was designed to determine which mesenchymal stem cells(MSCs)type is more appropriate to alleviate pancreatic hazards resulting from diabetes induction;via tracking a comparative study between MSCs derived from adipose tissue(AD-MSCs)and from bone marrow(BM-MSCs)in management of T1DM considering their immunomodulatory,anti-apoptotic and antioxidative roles.Rats were divided randomly into 4 groups;control,STZdiabetic(D),D+AD-MSCs,and D+BM-MSCs groups.Both stem cells types in this study were allogenic.Herein,both oxidative stress and antioxidant markers were evaluated using colorimetric analysis,while inflammatory,immune and apoptotic markers were assessed through flow cytometric analysis.Results showed that diabetic rats treated with either AD-MSCs or BM-MSCs exhibited marked pancreatic antioxidant and anti-inflammatory activities that were able to initiate pancreatic immunomodulation and reducingβ-cells apoptotic death,thus,help to restore their normal insulin secretion and hypoglycemic abilities.However,AD-MSCs injection was shown to be superior as a pancreatic regenerative tool in overcoming diabetes;owing to their marked antioxidant,anti-inflammatory,immunomodulatory,and anti-apoptotic characteristics over BM-MSCs treatment. | SHADY G.EL-SAWAH FAYEZ ALTHOBAITI HANAN M.RASHWAN ADIL ALDHAHRANI MARWA A.ABDEL-DAYEM EMAN FAYAD REHAB M.AMEN EL SHAIMAA SHABANA EHAB I.EL-HALLOUS | 2022 | BIOCELL2022，46，3： | 0 |
| 20 | Dendritic cell co-stimulatory and co-inhibitory markers in chronic HCV: An Egyptian study显示文摘AIM:To assess co-stimulatory and co-inhibitory markers of dendritic cells(DCs)in hepatitis C virus(HCV)infected subjects with and without uremia.METHODS:Three subject groups were included in the study:group 1 involved 50 control subjects,group2 involved 50 patients with chronic HCV infection and group 3 involved 50 HCV uremic subjects undergoing hemodialysis.CD83,CD86 and CD40 as co-stimulatory markers and PD-L1 as a co-inhibitory marker were assessed in peripheral blood mononuclear cells by realtime polymerase chain reaction.Interleukin-10(IL-10)and hyaluronic acid(HA)levels were also assessed.All findings were correlated with disease activity,viral load and fibrogenesis.RESULTS:There was a significant decrease in costimulatory markers;CD83,CD86 and CD40 in groups2 and 3 vs the control group.Co-stimulatory markers were significantly higher in group 3 vs group 2.There was a significant elevation in PD-L1 in both HCV groups vs the control group.PD-L1 was significantly lower in group 3 vs group 2.There was a significant elevation in IL-10 and HA levels in groups 2 and 3,where IL-10was higher in group 3 and HA was lower in group 3 vs group 2.HA level was significantly correlated with disease activity and fibrosis grade in group 2.IL-10 was significantly correlated with fibrosis grade in group 2.There were significant negative correlations between co-stimulatory markers and viral load in groups 2 and3,except CD83 in dialysis patients.There was a significant positive correlation between PD-L1 and viral load in both HCV groups.CONCLUSION:A significant decrease in DC co-stimulatory markers and a significant increase in a DC coinhibitory marker were observed in HCV subjects and to a lesser extent in dialysis patients. | Hanan Fouad Maissa Saeed El Raziky Rasha Ahmed Abdel Aziz Dina Sabry Ghada Mahmoud Abdel Aziz Manal Ewais Ahmed Reda Sayed | 2013 | World Journal of Gastroenterology2013，19，43： | 0 |
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