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| 1 | Exosomes: roles and therapeutic potential in osteoarthritis显示文摘Exosomes participate in many physiological and pathological processes by regulating cell–cell communication, which are involved in numerous diseases, including osteoarthritis(OA). Exosomes are detectable in the human articular cavity and were observed to change with OA progression. Several joint cells, including chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and secrete exosomes that influence the biological effects of targeted cells. In addition, exosomes from stem cells can protect the OA joint from damage by promoting cartilage repair, inhibiting synovitis, and mediating subchondral bone remodeling.This review summarizes the roles and therapeutic potential of exosomes in OA and discusses the perspectives and challenges related to exosome-based treatment for OA patients in the future. | Zhenhong Ni Siru Zhou Song Li Liang Kuang Hangang Chen Xiaoqing Luo Junjie Ouyang Mei He Xiaolan Du Lin Chen | 2020 | Bone Research2020，8，2： | 10 |
| 2 | FGF/FGFR signaling in health and disease显示文摘Growing evidences suggest that the fibroblast growth factor/FGF receptor(FGF/FGFR)signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment,differentiation,proliferation,and apoptosis of various types of cells.In this review,we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development,injury repair,and the pathophysiology of spectrum of diseases,which is a consequence of FGF signaling dysregulation,including cancers and chronic kidney disease(CKD).In this context,the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems. | Yangli Xie Nan Su Jing Yang Qiaoyan Tan Shuo Huang Min Jin Zhenhong Ni Bin Zhang Dali Zhang Fengtao Luo Hangang Chen Xianding Sun Jian Q.Feng Huabing Qi Lin Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 3 | Pacemaker current exists in ventricular myocytes显示文摘 | Hangang Y Ira S | 1993 | Circ Res1993，72，： | 1 |
| 4 | Kadsulignan A and B,Two Novel Lignans fromIL coeeinea显示文摘 | Liu Jiasen Li Lianiang Yu Hangang | 1989 | Can J Chem1989，67，4： | 1 |
| 5 | Inhibition of aberrant Hif1αactivation delays intervertebral disc degeneration in adult mice显示文摘The intervertebral disc(IVD) is the largest avascular tissue. Hypoxia-inducible factors(HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease(DDD) is one of the leading causes of disability, and current therapies are ineffective. This study sought to explore the role of HIFs in DDD pathogenesis in mice. The findings of this study showed that among HIF family members, Hif1α was significantly upregulated in cartilaginous endplate(EP) and annulus fibrosus(AF) tissues from human DDD patients and two mouse models of DDD compared with controls. Conditional deletion of the E3 ubiquitin ligase Vhl in EP and AF tissues of adult mice resulted in upregulated Hif1α expression and age-dependent IVD degeneration. Aberrant Hif1α activation enhanced glycolytic metabolism and suppressed mitochondrial function. On the other hand, genetic ablation of the Hif1α gene delayed DDD pathogenesis in Vhl-deficient mice. Administration of 2-methoxyestradiol(2ME2), a selective Hif1α inhibitor, attenuated experimental IVD degeneration in mice. The findings of this study show that aberrant Hif1α activation in EP and AF tissues induces pathological changes in DDD, implying that inhibition of aberrant Hif1α activity is a potential therapeutic strategy for DDD. | Zuqiang Wang Hangang Chen Qiaoyan Tan Junlan Huang Siru Zhou Fengtao Luo Dali Zhang Jing Yang Can Li Bo Chen Xianding Sun Liang Kuang Wanling Jiang Zhenhong Ni Quan Wang Shuai Chen Xiaolan Du Di Chen Chuxia Deng Liangjun Yin Lin Chen Yangli Xie | 2022 | Bone Research2022，10，1： | 1 |
| 6 | Thin-walled multicell straight box-girder finite element显示文摘 | GHANI Razaqpur A HANGANG U | 1991 | Journal of Structural Engineering1991，117，10： | 1 |
| 7 | Thin-walled multicell box-girder finite element显示文摘 | Ghani R A Hangang U | 1991 | Structure Engineering ASCE1991，117，10： | 1 |
| 8 | Thin-walled multicell box-girder finite element显示文摘 | Ghani Razaqpur A Hangang U | 1991 | Struct Engrg ASCE1991，117，10： | 1 |
| 9 | Effects of the renin-angiotensin system on the current Itoin epicardial and endocardial ventricylar myocytes from the caine heart显示文摘 | Yu Hangang Gao Junyuan Wang Hongsheng | 2000 | Circulation research2000，86，10： | 1 |
| 10 | Study of delayed neutron emission in slightly super-prompt-critical systemwith analog Monte Carlo method显示文摘 | Xie Qilin Fan Xiangqiang Liu Hangang | 2011 | Nucl Sci Eng2011，169，11： | 1 |
| 11 | Developmental change in the voltage-dependence of the pacemaker current, if, in rat ventricle cells显示文摘 | R. B. Robinson Hangang Yu Fang Chang Ira S. Cohen | 1997 | Pflügers Archiv European Journal of Physiology1997，，4： | 1 |
| 12 | Phosphatase inhibition by calyculin A increases if in canine Purkinje fibers and myocytes显示文摘 | Hangang Yu Fang Chang Ira S. Cohen | 1993 | Pflügers Archiv European Journal of Physiology1993，，6： | 1 |
| 13 | 大型水库消落带中西来稗种子耐淹性沿高程梯度的种内分化显示文摘在水文节律稳定、每年蓄水时间很长且水位涨落落差很大的水库中,生长在水库库岸消落带不同高程区域中的植物每年要面对长时间的不同强度的水淹,这种每年发生持续的水淹胁迫可能会导致水库库岸消落带中生长的植物的种子耐淹能力发生种内分化。西来稗(Echinochloa crusgalli var.zelayensis)是在三峡水库消落带中自然生长的优势一年生植物,在三峡水库消落带植被及消落带生态环境保护中发挥着重要作用。本研究的目的在于探究三峡水库消落带中生长的西来稗种子的耐淹能力是否已发生种内分化,以及此分化的发生是否与较弱的种子扩散能力有关。在本研究中,采集来自三峡水库消落带不同高程区域中生长的西来稗种子,在三峡水库即将蓄水时将所有采集的种子放置于三峡水库消落带中4个不同高程位置接受不同深度不同时长的水库蓄水水淹,同时把所有采集的种子也放置于不会被水库蓄水淹没的非消落带河岸上作为对照处理;测定种子在水中的漂浮持续时间和蓄水期间水库水位上涨速度以量化在水库蓄水水位上涨时种子的扩散能力,水库蓄水结束水退后检测放置于水库消落带和非消落带河岸上的种子的种子完好率、种子萌发能力和成苗率。研究结果发现,在经历三峡水库蓄水水淹后,西来稗种子的完好率和最终成苗率随种子母株在消落带中所处的高程的增加而显著降低,表明在三峡水库成库运行七年后,在三峡水库消落带中生长的西来稗的种子耐淹能力已发生了种内分化。三峡水库蓄水水位上涨时西来稗种子在水中较短的漂浮持续时间和水库蓄水时较慢的水位上升速度限制了西来稗种子的水媒传播和扩散距离,从而有利于西来稗种子的耐淹能力发生种内分化。 | Songping Liu Feng Lin Xiaolei Su Qiaoli Ayi Hangang Niu Shaohua Shi Binna Wan Bo Zeng Xiaoping Zhang | 2021 | Journal of Plant Ecology2021，14，1： | 0 |
| 14 | ROBUST MODULATION CLASSIFIER BASED ON CUMULANTS FOR MDPSK WITH FREQUENCY OFFSET显示文摘This paper presents an improved algorithm for classification of M-Differential Phase-Shift Keying(MDPSK) signals based on cumulant. The feature proposed in the algorithm is invariant with respect to constellation scale, rotation, the shift and the carrier frequency offset between transmitter and receiver. The invariant property is proved theoretically. Through computer simulation the performance is evaluated and the results show that the improved classification algorithm is better and valuable in practice. | HanGang LiJiandong ChenChen | 2004 | Journal of Electronics(China)2004，21，3： | 0 |
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