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| 1 | Timing of Uranium Mineralization and Geological Implications of Shazijiang Granite-Hosted Uranium Deposit in Guangxi, South China: New Constraint from Chemical U-Pb Age显示文摘Miaoershan (MES ) 铀矿石地是在中国的最重要的铀来源,之一和许多另外的招待花岗石的铀存款在华南招待最大的 Chanziping carbonaceous-siliceous-pelitic 岩石类型铀存款。Shazijiang (SZJ ) 铀存款是 MES 铀矿石地里的代表性的招待花岗石的铀存款之一,位于 Ziyuan, Guangxi 省,华南。在 SZJ 存款的铀矿化作用主要与空间地在这个区域与 mafic 女同性恋被联系的石英和方解石静脉作为沥青铀矿发生。热水的改变包括 silicification,碳酸饱和和 hematitization。新沥青铀矿化学药品 U-Pb 地球年代学和 petrographic 证据提供预定限制和新卓见进 SZJ 铀存款的形成。第一铀矿化作用上演的结果表演在 97.5 湯漠 ? 桴 ? 敚慤杮愠摮 ? 潵畢慳瀠牥摩瑯瑩獥椠 ? 潣獮獩整瑮眠瑩 ? 潢桴愠祢獳污愠摮猠'T 畤瑣潩 ? | Jincheng Luo Ruizhong Hu Shaohua Shi | 2015 | Journal of Earth Science2015，26，6： | 21 |
| 2 | Characteristics and Source Identification of Polycyclic Aromatic Hydrocarbons (PAHs) in Urban Soils: A Review显示文摘Polycyclic aromatic hydrocarbons(PAHs) are mainly produced by combustion processes and consist of a number of toxic compounds.They are always emitted as a mixture and have become a major type of pollutants in urban areas.The degree of soil contamination by PAHs is of special concern in areas immediately in proximity to cities with heavy traffic,factories,older buildings,and infrastructure.The accumulation of soil PAHs is also affected by non-anthropogenic factors,such as climate,vegetation,and soil property.This paper reviews three typical source identification techniques,including diagnostic ratios,positive matrix factorization,and principle components analysis.The advantages or disadvantages of these techniques are analyzed.It is recommended that multiple identification techniques be used to determine the sources in order to minimize the weaknesses inherent in each method and thereby to strengthen the conclusions for PAH source identification. | WANG Chunhui WU Shaohua ZHOU Shenglu SHI Yaxing SONG Jing | 2017 | Pedosphere2017，27，1： | 18 |
| 3 | Phosphorus recovery from wastewater by struvite crystallization:Property of aggregates显示文摘Struvite crystallization is a promising method to remove and recover phosphorus from wastewater to ease both the scarcity of phosphorus rock resources and water eutrophication worldwide. To date, although various kinds of reactor systems have been developed, supporting methods are required to control the struvite fines flushing out of the reactors. As an intrinsic property, aggregation is normally disregarded in the struvite crystallization process, although it is the key factor in final particle size and therefore guarantees phosphorus recovery efficiency. The present study developed a method to analyze the characteristics of struvite aggregates using fractal geometry, and the influence of operational parameters on struvite aggregation was evaluated. Due to its typical orthorhombic molecular structure, struvite particles are prone to crystallize into needle or rod shapes, and aggregate at the corners or edges of crystals. The determined fractal dimension(Dpf) of struvite aggregates was 1.52–1.31, with the corresponding range of equivalent diameter(d0.5) at 295.9–85.4 μm. Aggregates formed in relatively low phosphorus concentrations(3.0–5.0 mmol/L) and mildly alkaline conditions(pH 9.0–9.5) displayed relatively compact structures, large aggregate sizes and high aggregation strength. Increasing pH values led to continuous decrease of aggregate sizes, while the variation of Dpfwas insignificant. As to the aggregate evolution, fast growth in a short time followed by a long steady stage was observed. | Zhilong Ye Yin Shen Xin Ye Zhaoji Zhang Shaohua Chen Jianwen Shi | 2014 | Journal of Environmental Sciences2014，26，5： | 16 |
| 4 | Modeling and optimal energy management of a power split hybrid electric vehicle显示文摘With the combination modes of engine and two electric machines,the power split device allows higher efficiency of the engine.The operation and of a power split HEV are analyzed,and the system dynamic model HEV is established event-driven for HEV forward system simulation dynamics controller design.Considering the mode,the fact the mode that the operation modes of is the are and the the is continuous theory.time-driven this for each structure selection of the controller built and the described finite with hybrid automaton control In control structure,process is depicted by the state mode machine(FSM).The multi-mode switch controller is designed to realize power distribution.Furthermore,vehicle operations programming are optimized,and finite the prediction nonlinear model horizon.predictive control(NMPC)strategy is applied by that implementing the dynamic(DP)and in the Comparative simulation The results optimal demonstrate strategy hybrid in control structure is effective feasible for HEV energy management design.NMPC is superior improving fuel economy. | SHI DeHua WANG ShaoHua Pierluigi Pisu CHEN Long WANG RuoChen WANG RenGuang | 2017 | Science China(Technological Sciences)2017，60，5： | 14 |
| 5 | Finite element investigation of the poroelastic effect on the Xinfengjiang Reservoir-triggered earthquake显示文摘Coulomb failure stress changes (ΔCFS) are used in the study of reservoir-induced seismicity (RIS) generation.The threshold value of ΔCFS that can trigger earthquakes is an important issue that deserves thorough research.The M s 6.1 earthquake in the Xinfengjiang Reservoir in 1962 is well acknowledged as the largest reservoir-induced earthquake in China.Therefore, it is a logical site for quantitative calculation of ΔCFS induced by the filling of the reservoir and for investigating the magnitude of CFS that can trigger reservoir seismic activities.To better understand the RIS mechanism, a three-dimensional poroelastic finite element model of the Xinfengjiang Reservoir is proposed here, taking into consideration of the precise topography and dynamic water level.We calculate the instant changes of stress and pore pressure induced by water load, and the time variation of effective stresses due to pore water diffusion.The CFS on the seismogenesis faults and the accumulation of strain energy in the reservoir region are also calculated.Primary results suggest that the reservoir impoundment increases both pore pressure and CFS on the fault at the focal depth.The diffusion of pore pressure was likely the main factor that triggered the main earthquake, whereas the elastic stress owing to water load was relatively small.The magnitude of CFS on seismogenesis fault can reach approximately 10 kPa, and the ΔCFS values at the hypocenter can be about 0.7-3.0 kPa, depending on the fault diffusion coefficient.The calculated maximum vertical subsidence caused by the water load in the Xinfengjiang Reservoir is 17.5 mm, which is in good agreement with the observed value of 15 mm.The accumulated strain energy owing to water load was only about 7.3×10 11 J, even less than 1% of the seismic wave energy released by the earthquake.The reservoir impoundment was the only factor that triggered the earthquake. | CHENG HuiHong ZHANG Huai ZHU BoJing SUN YuJun ZHENG Liang YANG ShaoHua SHI YaoLin | 2012 | Science China Earth Sciences2012，55，12： | 11 |
| 6 | Overview of China's Antarctic research progress 1984–2016显示文摘It is more than 30 years since the first Chinese National Antarctic Research Expedition(CHINARE) landed in Antarctica in 1984, representing China's initiation in polar research. This review briefly summarizes the Chinese Antarctic scientific research and output accomplished over the past 30 years. The developments and progress in Antarctic research and the enhancement of international scientific cooperation achieved through the implementation of the CHINARE program have been remarkable. Since the 1980 s, four permanent Chinese Antarctic research stations have been established successively and 33 CHINAREs have been completed. The research results have been derived from a series of spatiotemporal observations in association with various projects and multidisciplinary studies in the fields of oceanography, glaciology, geology, geophysics, geochemistry, atmospheric science, upper atmospheric physics, Antarctic astronomy, biology and ecology, human medicine, polar environment observation, and polar engineering. | CHEN Liqi LIU Xiaohan BIAN Lingen CHEN Bo HUANG Hongliang HU Hongqiao LUO Wei SHI Guitao SHI Jiuxin XU Chengli YANG Guang ZHAO Yue ZHANG Shaohua | 2017 | Advances in Polar Science2017，28，3： | 9 |
| 7 | The origin, diversification and adaptation of a major mangrove clade (Rhizophoreae) revealed by whole-genome sequencing显示文摘Mangroves invade some very marginal habitats for woody plants—at the interface between land and sea.Since mangroves anchor tropical coastal communities globally, their origin, diversification and adaptation are of scientific significance, particularly at a time of global climate change. In this study, a combination of single-molecule long reads and the more conventional short reads are generated from Rhizophora apiculata for the de novo assembly of its genome to a near chromosome level. The longest scaffold, N50 and N90 for the R. apiculata genome, are 13.3 Mb, 5.4 Mb and 1.0 Mb, respectively. Short reads for the genomes and transcriptomes of eight related species are also generated. We find that the ancestor of Rhizophoreae experienced a whole-genome duplication ~70 Myrs ago, which is followed rather quickly by colonization and species diversification. Mangroves exhibit pan-exome modifications of amino acid(AA) usage as well as unusual AA substitutions among closely related species. The usage and substitution of AAs, unique among plants surveyed, is correlated with the rapid evolution of proteins in mangroves. A small subset of these substitutions is associated with mangroves' highly specialized traits(vivipary and red bark) thought to be adaptive in the intertidal habitats. Despite the many adaptive features, mangroves are among the least genetically diverse plants, likely the result of continual habitat turnovers caused by repeated rises and falls of sea level in the geologically recent past. Mangrove genomes thus inform about their past evolutionary success as well as portend a possibly difficult future. | Shaohua Xu Ziwen He Zhang Zhang Zixiao Guo Wuxia Guo Haomin Lyu Jianfang Li Ming Yang Zhenglin Du Yelin Huang Renchao Zhou Cairong Zhong David E. Boufford Manuel Lerdau Chung-I Wu Norman C. Duke Suhua Shi | 2017 | National Science Review2017，4，5： | 7 |
| 8 | 3D printing of multilayered scaffolds for rotator cuff tendon regeneration显示文摘Repairing massive rotator cuff tendon defects remains a challenge due to the high retear rate after surgical intervention.3D printing has emerged as a promising technique that enables the fabrication of engineered tissues with heterogeneous structures and mechanical properties,as well as controllable microenvironments for tendon regeneration.In this study,we developed a new strategy for rotator cuff tendon repair by combining a 3D printed scaffold of polylactic-co-glycolic acid(PLGA)with cell-laden collagen-fibrin hydrogels.We designed and fabricated two types of scaffolds:one featuring a separate layer-by-layer structure and another with a tri-layered structure as a whole.Uniaxial tensile tests showed that both types of scaffolds had improved mechanical properties compared to single-layered PLGA scaffolds.The printed scaffold with collagen-fibrin hydrogels effectively supported the growth,proliferation,and tenogenic differentiation of human adipose-derived mesenchymal stem cells.Subcutaneous implantation of the multilayered scaffolds demonstrated their excellent in vivo biocompatibility.This study demonstrates the feasibility of 3D printing multilayered scaffolds for application in rotator cuff tendon regeneration. | Xiping Jiang Shaohua Wu Mitchell Kuss Yunfan Kong Wen Shi Philipp N.Streubel Tieshi Li Bin Duan | 2020 | Bioactive Materials2020，5，3： | 7 |
| 9 | Spatiotemporal variations of deep-sea sediment components and their fluxes since the last glaciation in the northern South China Sea显示文摘Sediment components and their fluxes of Cores MD12-3428(water depth: 903 m), MD12-3433(water depth: 2125 m),and MD12-3434(water depth: 2995 m), obtained along a transect on the continental slope of the northern South China Sea, have been conducted to reveal the spatiotemporal variations and the controlling factors of the sediment components and of their fluxes.Results show that deep-sea sediments in the northern South China Sea are composed mainly of terrigenous(59–89%) and carbonate(6–38%) particles, with minor components of opal(1.6–9.4%) and organic matter(0.7–1.9%). Fluxes of terrigenous and carbonate particles reach up to 2.4–21.8 and 0.4–6.5 g cm–2 kyr–1, respectively, values that are one to two orders of magnitude higher than the fluxes of opal and organic matter. Temporal variations of the percentages and fluxes of deep-sea sediment components have displayed clear glacial-interglacial cyclicity since the last glaciation. Terrigenous, opal, and organic matter percentages and their fluxes increas clearly during marine isotope stage 2, while carbonate percentages and fluxes show an opposite variation pattern or are characterized by an unremarkable increase. This implies that deep-sea carbonate in the South China Sea is affected by the dilution of terrigenous inputs during the sea-level lowstand. With increasing water depth along the transect, the terrigenous percentage increases but with largely decreased fluxes. Both the percentage and flux of carbonate decrease, while the percentages and fluxes of opal and organic matter display much more complicated variational features. The spatiotemporal variations of deep-sea sediment components and of their fluxes since the last glaciation in the northern South China Sea are strongly controlled by sea-level fluctuations. Simultaneously, terrigenous supply associated with monsoonal rainfall, marine primary productivity,and the dilution effect between terrigenous and biogenic particles, also play interconnected roles in the sediment accumulation processes. | ZHAO ShaoHua LIU ZhiFei CHEN Quan WANG XingXing SHI JiangNan JIN HaiYan LIU JingJing JIAN ZhiMin | 2017 | Science China Earth Sciences2017，60，7： | 5 |
| 10 | Si-substrate vertical-structure InGaN/GaN micro-LED-based photodetector for beyond 10 Gbps visible light communication显示文摘Visible light communication(VLC)has emerged as a promising communication method in 6G.However,the development of receiving devices is much slower than that of transmitting devices,limited by materials,structures,and fabrication.In this paper,we propose and fabricate an InGaN/GaN multiple-quantum-well-based vertical-structure micro-LED-based photodetector(μPD)on a Si substrate.A comprehensive comparison of the photoelectrical performance and communication performance of three sizes ofμPDs,10,50,and 100μm,is presented.The peak responsivity of all threeμPDs is achieved at 400 nm,while the passband full-widths at half maxima are 87,72,and 78 nm for 10,50,and 100μmμPDs,respectively.The−20 dB cutoff bandwidth is up to 822 MHz for 50μmμPD.A data rate of 10.14 Gbps is experimentally demonstrated by bit and power loading discrete multitone modulation and the proposed digital pre-equalizer algorithm over 1 m free space utilizing the self-designed 4×450μmμPD array as a receiver and a 450 nm laser diode as a transmitter.This is the first time a more than 10 Gbps VLC system has been achieved utilizing a GaN-based micro-PD,to the best of our knowledge.The investigation fully demonstrates the superiority of Si substrates and vertical structures in InGaN/GaNμPDs and shows its great potential for high-speed VLC links beyond 10 Gbps. | JIANYANG SHI ZENGYI XU WENQING NIU DONG LI XIAOMING WU ZIWEI LI JUNWEN ZHANG CHAO SHEN GUANGXU WANG XIAOLAN WANG JIANLI ZHANG FENGYI JIANG SHAOHUA YU NAN CHI | 2022 | Photonics Research2022，10，10： | 5 |
| 11 | Vehicle tracking by detection in UAV aerial video显示文摘With the maturity and popularity of UAV(un-manned aerial vehicle)technology [1-3],UAV video is becoming an effective supplement to the fixed monitoring video [4,5].In the aspect of traffic information acquisition,the advantages of UAV are obvious.UAV can fly not only between the buildings,but also on the freeway,and even into the tunnel,showing the unique flexibility and maneuverability. | Shaohua LIU Suqin WANG Wenhao SHI Haibo LIU Zhaoxin LI Tianlu MAO | 2019 | Science China(Information Sciences)2019，62，2： | 4 |
| 12 | Implementation of One-Way Quantum Computing with a Hybrid Solid-State Quantum System显示文摘We proposed an efficient scheme for implementing the large-scale one-way Quantum computing(QC)with a novel hybrid solid-state quantum system. This system consists of N Nitrogen-vacancy(N-V) centers coupled to N separate Transmission line resonators(TLRs), which are interconnected by a Current-biased Josephson junction(CBJJ) superconducting phase qubit. We showed the way of preparation of N-qubit linear cluster state with N N-V centers, then we demonstrated the way of extending cluster state by connecting two pieces of linear cluster states into two-dimensional cluster state, last, with our designed new structures, we demonstrated the QC basic operations.It means that our scheme may open up promising possibilities for implementing the practical and scalable one-way quantum computers with the hybrid solid-state quantum system. We discussed the experimental feasibility of our system. | ZHAO Yujing CHEN Xiongwen SHI Zhengang ZHOU Fang XIANG Shaohua SONG Kehui | 2017 | Chinese Journal of Electronics2017，26，1： | 3 |
| 13 | Convergent adaptation of the genomes of woody plants at the land-sea interface显示文摘Sequencing multiple species that share the same ecological niche may be a new frontier for genomic studies.While such studies should shed light on molecular convergence,genomic-level analyses have been unsuccessful,due mainly to the absence of empirical controls.Woody plant species that colonized the global tropical coasts,collectively referred to as mangroves,are ideal for convergence studies.Here,we sequenced the genomes/transcriptomes of 16 species belonging in three major mangrove clades.To detect convergence in a large phylogeny,a CCS+model is implemented,extending the more limited CCS method(convergence at conservative sites).Using the empirical control for reference,the CCS+model reduces the noises drastically,thus permitting the identification of 73 convergent genes with Ptrue(probability of true convergence)>0.9.Products of the convergent genes tend to be on the plasma membrane associated with salinity tolerance.Importantly,convergence is more often manifested at a higher level than at amino-acid(AA)sites.Relative to>50 plant species,mangroves strongly prefer 4 AAs and avoid 5 others across the genome.AA substitutions between mangrove species strongly reflect these tendencies.In conclusion,the selection of taxa,the number of species and,in particular,the empirical control are all crucial for detecting genome-wide convergence.We believe this large study of mangroves is the first successful attempt at detecting genome-wide site convergence. | Ziwen He Shaohua Xu Zhang Zhang Wuxia Guo Haomin Lyu Cairong Zhong David EBoufford Norman CDuke The International Mangrove Consortium Suhua Shi | 2020 | National Science Review2020，7，6： | 3 |
| 14 | In situ X-ray diffraction and thermal analysis of LiNi0.8Co0.15Al0.05O2 synthesized via co-precipitation method显示文摘LiNi_(0.8)Co_(0.15)Al_(0.05)O_2(NCA) material is successfully synthesized with a modified co-precipitation method,in which NH_3·H_2O and EDTA are used as two chelating agents. The obtained LiNi_(0.8)Co_(0.15)Al_(0.05)O_2 material has well-defined layered structure and uniform element distribution, which reveals an enhanced electrochemical performance with a capacity retention of 97.9% after 100 cycles at 0.2 C, and reduced thermal runaway from the isothermal calorimetry test. In situ X-ray diffraction(XRD) was employed to capture the structural changes during the charge–discharge process. The reversible evolutions of lattice parameters(a, b, c, and V) further verify the structural stability. | Na Zhang Xiaoyu Zhang Erbo Shi Shiyong Zhao Kezhu Jiang Di Wang Pengfei Wang Shaohua Guo Ping He Haoshen Zhou | 2018 | Journal of Energy Chemistry2018，27，6： | 2 |
| 15 | Glucagon-like peptide 1 reverses myocardial hypertrophy through cAMP/PKA/RhoA/ROCK2 signaling显示文摘Myocardial hypertrophy is a major pathological and physiological process during heart failure.Glucagon-like peptide 1(GLP-1)is a glucagon incretin hormone released from the gut endocrine L-cells that has protective effects on various cardiovascular diseases,in eluding hyperte nsion,atherosclerosis,and myocardial hypertrophy.However,the protective mechanisms of GLP-1 in myocardial hypertrophy remain unclear.Here,we showed that the GLP-1 agonist liraglutide and dipeptidyl peptidase 4 inhibitor alogliptin decreased heart weight and cardiac muscle cell volume in spontaneously hypertensive rats(SHR).In H9C2 cell hypertensive models induced by angiotensin II,GLP-1 treatment reduced myocardial cell volume,inhibited the expressions of atrial natriuretie peptide,brain/B-type natriuretic peptide,p-myosin heavy chain,RhoA,and ROCK2,and decreased MLC and MYPT1 phosphorylation.When H9C2 cells were treated with H89,a PKA inhibitor,the inhibitory effect of GLP-1 disappeared,while the inhibitory role was enhaneed under the treatment of Y-27632,a ROCK2 inhibitor.These results suggested that GLP-1 might reverse myocardial hypertrophy through the PKA/RhoA/ROCK2 signaling pathway. | Shaohua Fan Qianfeng Xiong Xin Zhang Lihui Zhang Yawei Shi | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 2 |
| 16 | Three-dimensional numerical simulation of glacial trough forming process显示文摘The glacial trough is a common glacier erosion landscape, which plays an important role in the study of glacier erosion processes. In a sharp contrast with the developing river, which is generally meandering, the developing glacial trough is usually wide and straight. Is the straightness of the glacial trough just the special phenomenon of some areas or a universal feature? What controls the straightness of the glacial trough? Until now, these issues have not been studied yet. In this paper, we conduct systematic numerical models of the glacier erosion and simulate the erosion evolution process of the glacial trough. Numerical simulations show that:(1) while the meandering glacier is eroding deeper to form the U-shaped cross section, the glacier is eroding laterally. The erosion rate of the ice-facing slope is bigger than that of the back-slope.(2) The smaller(bigger) the slope is, the smaller(bigger) the glacier erosion intensity is.(3) The smaller(bigger) the ice discharge is, the smaller(bigger) the glacier erosion intensity is. In the glacier erosion process, the erosion rate of the ice-facing slope is always greater than that of the back-slope. Therefore, the glacial trough always develops into more straight form. This paper comes to the conclusion that the shape evolution of the glacial trough is controlled mainly by the erosion mechanism of the glacier. Thereby, the glacial trough prefers straight geometry. | YANG ShaoHua SHI YaoLin | 2015 | Science China Earth Sciences2015，58，9： | 2 |
| 17 | Transarterial infusion chemotherapy with FOLFOX for advanced hepatocellular carcinoma:a multi-center propensity score matched analysis of real-world practice显示文摘Background:To compare the treatment effectiveness and safety among transarterial infusion chemotherapy(TAI)with FOLFOX regimen,transarterial chemoembolization(TACE),and sorafenib in patients with BCLC stage C hepatocellular carcinoma(HCC).Methods:The data of consecutive patients with BCLC stage C HCC treated with TAI,TACE,or sorafenib from January 2015 to December 2018 at three centers were retrospectively analyzed.Propensity-score matched(PSM)analysis was pairwise performed to reduce selection bias.Treatment effectiveness and safety were evaluated and compared using the Kaplan-Meier method,log-rank test,Cox regression models,andχ2 test.Results:The median overall survival(OS)in the matched TAI cohort was significantly longer than the sorafenib cohort(19.6 vs.7.5 months,P=0.009),and the TACE cohort(estimated 27.8 vs.6.6 months,P<0.001).The difference in median progression-free survival(PFS)between the matched TAI and sorafenib cohorts was not significant(5.8 vs.2.3 months,P=0.219).The median PFS in the matched TAI cohort was significantly longer than the TACE cohort(6.5 vs.2.8 months,P<0.001).The objective response rate(ORR)in the matched TAI cohort was significantly higher than the sorafenib cohort(36.4%vs.0.0%,P<0.001)and the TACE cohort(48.7%vs.4.7%,P<0.001).The incidences of adverse events(AEs)were similar among these three cohorts.Conclusions:TAI with FOLFOX regimen was an effective and safe therapy that improved survival of patients with BCLC stage C HCC. | Shaohua Li Jie Mei Qiaoxuan Wang Feng Shi Hongyan Liu Ming Zhao Lianghe Lu Yihong Ling Zhixing Guo Yabing Guo Xiaoming Chen Ming Shi Wan Yee Lau Wei Wei Rongping Guo | 2021 | Hepatobiliary Surgery and Nutrition2021，10，5： | 2 |
| 18 | Measurement of a Three-dimensional Gas Temperature Field with Holographic Interferometry显示文摘MeasurementofaThree-dimensionalGasTemperatureFieldwithHolographicInterferometry￥CHENShaohua(YibinTeacher'sCollege,Yibin644007... | CHEN Shaohua(Yibin Teacher’s College, Yibin 644007, CHN)ZHAO Xuxin HUANG Suyi SHI Dufang(Huazhong University of Science and Technology, Wuhan 430074, CHN) | 1996 | Semiconductor Photonics and Technology1996，2，1： | 2 |
| 19 | Adjunctive sepsis therapy with aminophylline(STAP):a randomized controlled trial显示文摘Background:Sepsis is a serious disease caused by infection.Aminophylline has anti-asthma and anti-inflammatory effects.We aimed to explore the safety and effect of aminophylline in sepsis.Methods:We conducted a clinical randomized controlled trial involving 100 patients diagnosed with sepsis within 48 h after intensive care unit(ICU)admission in two sites.All patients were randomized in a 1:1 ratio to receive standard therapy with or without aminophylline.The primary clinical outcome was all-cause mortality at 28 days.Results:From September 27,2018 to February 12,2020,we screened 277 septic patients and eventually enrolled 100 patients,with 50 assigned to the aminophylline group and 50 to the usual-care group.At 28 days,7 of 50 patients(14.0%)in the aminophylline group had died,compared with 16 of 50(32.0%)in the usual-care group(P=0.032).Cox regression showed that the aminophylline group had a lower hazard of death(hazard ratio=0.312,95%confidence interval:0.129–0.753).Compared with the usual-care group,patients in the aminophylline group had a longer survival time(P=0.039 by the log-rank test).The effects of aminophylline on vasopressor dose,oxygenation index,and sequential organ failure assessment score were timedependent with treatment.There were no significant differences in total hospitalization days,ICU hospitalization days,and rates of serious adverse events(all P>0.05).No adverse events were observed in the trial.Conclusions:Aminophylline as an adjunct therapy could significantly reduce the risk of death and prolong the survival time of patients with sepsis.Trial registration:ChiCTR.org.cn,ChiCTR1800019173. | Ruifang Zhang Huan Liu Dongmei Dai Xianfei Ding Dong Wang Yan Wang Xuexiu Shi Shuguang Zhang Xiaoguang Duan Haixu Wang Yonggang Luo Shaohua Liu Bing Han Xiaojuan Zhang Yu Fang Jing Yang Wangbin Xu Tongwen Sun | 2022 | Chinese Medical Journal2022，135，23： | 2 |
| 20 | Adaptive convergence at the genomic level—prevalent,uncommon or very rare?显示文摘Convergent evolution is one of the central topics in evolutionary genetics[1].While there has been ample evidence of phenotypic convergence,the issue is whether each and any of the phenotypic convergences have an underlying cause in genic convergence[2,3].Fortunately,the torrent of genomic data has made it possible to address the issue[4-8].Convergence can happen at multiple levels of the genetic architecture.For example,many studies have reached the conclusion of genic convergence when the same gene has experienced many more amino acid(AA)changes than expected[3,9-11].Another prominent example is the TCGA(The Cancer Genome Atlas)data on the evolution of tumors,whereby convergence is defined as the sharing of mutations in the same genes,rather than the same change at the same site[12,13].Many others have further relaxed the stringency in defining convergent evolution.For example,convergence could also mean copy number or evolutionary rate changes in the same genes[14,15]. | Ziwen He Shaohua Xu Suhua Shi | 2020 | National Science Review2020，7，6： | 2 |
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