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| 1 | 高产奶量的母猪有更高的采食量和体动员显示文摘选择能哺育更大窝产仔数的超高产母猪以提高产仔数,但是综合考虑这些现代母猪产奶量、采食量和体动员相互之间联系的研究还很有限。试验旨在研究什么样的母猪产奶量高、窝产仔数多,不同胎次有何影响,以及哺乳期生产性能对下一胎繁殖性能有何影响。选择565头1~4胎母猪,试验期从产前7 d至断奶。产后第2天每窝仔猪统一调整为14头。产前7 d、产后第2天和断奶时测定母猪体重和背膘厚度。产后第2天和断奶时称取仔猪窝重。计算变量之间的皮尔森相关系数,建立回归模型。母猪的平均日采食量(6.1±1.1)kg,仔猪每天窝增重(2.92±0.53)kg,每头母猪的平均断奶仔猪数(13.0±1.1)头。总的来讲,与2~4胎母猪相比,1胎母猪平均日采食量和产奶量更低,下一胎总产仔数也下降,这可能是因为初产母猪相比经产母猪会动用更多体储。仔猪每窝平均日增重与母猪的采食量、窝产仔数和体重损失呈正相关。1~4胎母猪整个哺乳期日采食量每提高1 kg,仔猪窝日增重提高220~440 g,母猪哺乳期体重下降6.6~13.9 kg。但是每天平均产奶量提高1 kg,第4胎母猪哺乳期体重损失减少4.3~21.0 kg。下一胎总产仔数与上一胎产仔数呈正相关。总之,高采食量和高体动员是高产奶量的先决条件。母猪可能已经非常接近他们身体饲料摄取的生理极限,因此,未来的研究应着眼于优化哺乳期超高产母猪的饲粮能量和营养浓度以及初产母猪和经产母猪之间的区别。 | Strathe A V Bruun T S Hansen C F 李元凤 | 2017 | 养猪2017，，4： | 8 |
| 2 | INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis(NASH).METHODS The effects of INT-767 on histological features of NASH were assessed in two studies using Lep^(ob/ob)(ob/ob) NASH mice fed the AMLN diet(high fat with transfat, cholesterol and fructose). In a proof-of-conceptstudy, Lep^(ob/ob)(ob/ob) NASH mice were first dosed with INT-767(3 or 10 mg/kg for 8 wk). A second ob/ob NASH study compared INT-767(3 and 10 mg/kg) to obeticholic acid(OCA)(10 or 30 mg/kg; 16 wk). Primary histological endpoints included qualitative and quantitative assessments of NASH. Other metabolic and plasma endpoints were also assessed. A comparative assessment of INT-767 and OCA effects on drug distribution and hepatic gene expression was performed in C57 Bl/6 mice on standard chow. C57 Bl/6 mice were orally dosed with INT-767 or OCA(1-30 mg/kg) for 2 wk, and expression levels of candidate genes were assessed by RNA sequencing and tissue drug levels were measured by liquid chromatography tandem-mass spectrometry.RESULTS INT-767 dose-dependently(3 and 10 mg/kg, PO, QD, 8 wk) improved qualitative morphometric scores on steatohepatitis severity, inflammatory infiltrates and fibrosis stage. Quantitative morphometric analyses revealed that INT-767 reduced parenchymal collagen area, collagen fiber density, inflammation(assessed by Galectin-3 immunohistochemistry) and hepatocyte lipid droplet area following INT-767 treatment. In a comparative study(16 wk), the FXR agonists OCA(10 and 30 mg/kg) and INT-767(3 and 10 mg/kg) both improved NASH histopathology, with INT-767 exerting greater therapeutic potency and efficacy than OCA. Mechanistic studies suggest that both drugs accumulate similarly within the liver and ileum, however, the effects of INT-767 may be driven by enhanced hepatic, but not ileal, FXR function. CONCLUSION These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH. | Jonathan D Roth Michael Feigh Sanne S Veidal Louise KD Fensholdt Kristoffer T Rigbolt Henrik H Hansen Li C Chen Mathieu Petitjean Weslyn Friley Niels Vrang Jacob Jelsing Mark Young | 2018 | World Journal of Gastroenterology2018，24，2： | 7 |
| 3 | Thalassiolins A-C: new marine-derived inhibitors of HIV eDNA integrase显示文摘 | Rowley D C Hansen M S T Rhodes D | 2002 | Bioorg Med Chen2002，10，： | 1 |
| 4 | Cyclic AMP induced neuronal differentiation via activation of p38 mitogen-activated protein kinase显示文摘 | Hansen T O Rehfeld J F Nielsen F C | 2000 | J Neurochem2000，75，5： | 1 |
| 5 | Time-dependent behavior of different ice slurries during storage显示文摘 | Pronk P Hansen T M Ferreira C A I | 2005 | International Journal of Refrigeration2005，28，1： | 1 |
| 6 | Ecophysiological responses of Empetrum nigrum to heavy metal pollution 显示文摘 | Matos A T Uhlig C Hansen E | 2001 | Environmental Pollution2001，112，： | 1 |
| 7 | Caudal ropivacaine in infant : population pharmacokinetics and plasma concentrations 显示文摘 | HANSEN T G ILETI' K F EID C | 2001 | Anesthesiology2001，94，4： | 1 |
| 8 | Insulinr esistance:interactions between obesity and a common variant of insulin receptor substrate-1显示文摘 | Clausen JO Hansen T Bjorbaek C | | 0，，： | 1 |
| 9 | Ti O2photocatalysis in cementitious systems:Insights into self-cleaning and depollution chemistry显示文摘 | Folli A Pade C Hansen T B | 2012 | Cement and Concrete Research2012，42，3： | 1 |
| 10 | Rapid quantification of viable Campylobacter bacteria on chicken carcasses,using real-time PCR and propidium monoazide treatment,as a tool for quantitative risk assessment显示文摘 | JOSEF SEN M H LOFSTROM C HANSEN T B | 2010 | Appl Environ Microbiol2010，76，15： | 1 |
| 11 | Strength of recycled concrete made fromcrushed concrete coarse aggregate显示文摘 | HANSEN T C NARU D H | 1983 | Concrete International1983，1，1： | 1 |
| 12 | Expression of trophoblastic interferon genes in sheep and cattle 显示文摘 | Farin C E Imakawa K Hansen T R et ol | 1990 | Biol Reprod1990，43，： | 1 |
| 13 | Environmental labelling and consumers choice:An empirical analysis of the effect of the Nordic Swan显示文摘 | Bjφrner T B Hansen L L G Russell C S | 2004 | Journal of Environmental Economics and Management2004，47，3： | 1 |
| 14 | Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals显示文摘 | Andersson E A Pilgaard K Pisinger C Harder M N Grarup N Faerch K Sandholt C Poulsen P Witte D R Jorgensen T Vaag A Pedersen O and Hansen T | | 0，，12： | 1 |
| 15 | Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population 显示文摘 | Willum Hansen T Staessen JA Torp-Pedersen C | 2006 | Circulation2006，113，： | 1 |
| 16 | A three-constituent multi-continuum theory for woven fabric composite materials显示文摘 | Six R W Hansen A C | 2003 | Composites Science and Technology2003，63，： | 1 |
| 17 | Synthesis and pharmacological evaluatin of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethyl-Sulfonyl penyl) acylamide derivatives as potential activators of ATP sensitive potassium channels显示文摘 | SCHOU S C HANSEN H C TAGMOSE T M | 2005 | Bioorg Med Chem2005，13，： | 1 |
| 18 | Regulation of neuronal cholecy stokinin gene transcription 显示文摘 | Hansen T V Nielsen F C | 2001 | Scand J Clin Lab Invest Suppl2001，234，： | 1 |
| 19 | Recycled aggregate and recycled aggregate concrete 显示文摘 | Hansen T C | 1986 | Material and Structures1986，，5： | 1 |
| 20 | Assessment of measles immunity among infants in Maputo City, Mozambique 显示文摘 | Jani JV Holm - Hansen C Mussa T | 2008 | BMC Public Health2008，8，1： | 1 |
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