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| 1 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 2 | Paleozoic oil–source rock correlations in the Tarim basin, NW China显示文摘 | S.C Zhang A.D Hanson J.M Moldowan S.A Graham D.G Liang E Chang F Fago | 2000 | Organic Geochemistry2000，，： | 3 |
| 3 | Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects显示文摘 | Owen, KR Groves, CJ Hanson, RL Knowler, WC Shuldiner, AR Elbein, SC Mitchell, BD Froguel,P Ng, MCY Chan, JC Jia, WP Deloukas, P Hitman, GA Walker, M Frayling, TM Hattersley, AT Zeggini, E McCarthy, MI | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 4 | Improvement in oxygenation by phenylephrine and nitric oxide in patients with adult respiratory distress syndrome 显示文摘 | Doering E B Hanson C W Reily D J | 1997 | Anesthesiology1997，87，： | 2 |
| 5 | Myeloid-derived suppressor cells down-regulate L-selectin expression on CD4+ and CD8+ T cells显示文摘 | Hanson E M Clements V K Sinha P | 2009 | J Immunol2009，183，2： | 1 |
| 6 | Generalized parallel- perspective stereo mosaics from airborne video 显示文摘 | Zhu Z G Hanson A R Riseman E M | 2004 | IEEE Transactions on Pattern Analysis and Machine Intelligence2004，26，2： | 1 |
| 7 | Sour cherry trees response to foliar boron applications显示文摘 | HANSON E J | | Hort Sci0，26，： | 1 |
| 8 | Zinc treatment effects on corrosion behavior of alloy 600 in high temperature, hydrogenated water 显示文摘 | Ziemniak S E Hanson M | 2006 | Corrosion Science2006，48，： | 1 |
| 9 | Some results from continuummechanics analyses of (he hydraulic fracturing process 显示文摘 | Hanson M E Shaffer R J | 1980 | Society of Petroleum Engineers Journal1980，20，2： | 1 |
| 10 | A contextual postprocess- ing system for error correction using binary n-grams显示文摘 | Rieseman E M Hanson A R | 1974 | IEEE Transactions on Computers1974，23，： | 1 |
| 11 | Plasmid-mediated, carbapenem-hydrolysing beta-lactamase, KPC-2, in Klebsiella pneumoniae isolates 显示文摘 | SMITH M E HANSON N D HERREEA V L | 2007 | Antimicrob Agents Chemother2007，51，2： | 1 |
| 12 | Relative humidity around apple fruit influences its accumulation of calcium显示文摘 | Cline J A Hanson E J | 1992 | J Amer Soc Hort Sci1992，117，： | 1 |
| 13 | Quantification of basal and stimulated ROS levels as predictors of islet potency and function显示文摘 | AMANN B HANSON M S HATCH E | 2007 | Am J Transplant2007，7，1： | 1 |
| 14 | Current trcnds in Rwanda's HIV/AIDS epidemic显示文摘 | Kayirangwa E Hanson J Mlmyakazi L Kabeja A | 2006 | Sex Transm Infect2006，82，1： | 1 |
| 15 | Measuring stem water content in four deciduous hardwoods with a time-domain reflectometer 显示文摘 | Wullschleger S D Hanson P J Todd D E | 1996 | Tree Physiology1996，16，10： | 1 |
| 16 | Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1 q显示文摘 | Prokopenko I Zeggini E Hanson RL | | 0，，7： | 1 |
| 17 | Multimedia Projects for EFL/ESL Students显示文摘 | Hanson Smith E | 1997 | CAELL Journal1997，，7： | 1 |
| 18 | Power and perform-ance management of virtualized computing environments via looka-head control 显示文摘 | KUSIC D KEPHART J O HANSON J E | 2009 | Cluster Computing2009，12，1： | 1 |
| 19 | Plasmid-mediated, carbapenem-hydrolysing beta-lactamase, KPC-2, in Klebsiella pneumoniae isolates显示文摘 | Smith-Moland E Hanson ND Herrera VL | 2003 | J Antimicrob Chemother2003，51，3： | 1 |
| 20 | Common polymorphisms in the adiponectin gene ACDC are not associated with diabetes in PimaIndians显示文摘 | Vozavova D E Courten B Hanson R L | 2005 | Diabetes2005，54，1： | 1 |
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