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| 1 | Multiple responses optimization in the development of a headspace gas chromatography method for the determination of residual solvents in pharmaceuticals显示文摘An efficient generic static headspace gas chromatography(HSGC) method was developed,optimized and validated for the routine determination of several residual solvents(RS) in drug substance,using a strategy with two sets of calibration.Dimethylsulfoxide(DMSO) was selected as the sample diluent and internal standards were used to minimize signal variations due to the preparative step.A gas chromatograph from Agilent Model 6890 equipped with flame ionization detector(FID) and a DB-624(30 m × 0.53 mm i.d.,3.00 μm film thickness) column was used.The inlet split ratio was 5:1.The influencing factors in the chromatographic separation of the analytes were determined through a fractional factorial experimental design.Significant variables:the initial temperature(IT),the final temperature(FT) of the oven and the carrier gas flow rate(F) were optimized using a central composite design.Response transformation and desirability function were applied to find out the optimal combination of the chromatographic variables to achieve an adequate resolution of the analytes and short analysis time.These conditions were 30 ℃ for IT,158 ℃ for FT and 1.90 mL/min for F.The method was proven to be accurate,linear in a wide range and very sensitive for the analyzed solvents through a comprehensive validation according to the ICH guidelines. | Carla M.Teglia Milagros Montemurro María M.De Zan María S.Cmara | 2015 | Journal of Pharmaceutical Analysis2015，5，5： | 8 |
| 2 | 2,8-二氨基-10-甲氧基-5,10-二氢磷杂吖嗪-10-氧化物的合成、诱变性及应用性能研究显示文摘10 羟基 5 ,10 二氢磷杂吖嗪 10 氧化物 ( 1)经酰氯化、甲基化得到 10 甲氧基 5 ,10 二氢磷杂吖嗪 10 氧化物 ( 2 ) ,2经硝化得到 10 甲氧基 2 ,8 二硝基 5 ,10 二氢磷杂吖嗪 10 氧化物 ( 3 ,62 %) .3在Pd/C (w =0 .0 5 )存在下 ,用氢气还原为 2 ,8 二氨基 10 甲氧基 5 ,10 二氢磷杂吖嗪 10 氧化物 ( 4 ,71%) ,考察了Pd/C (w =0 0 5 )用量对氢化还原反应的影响 .经过Salmonella/mammalianmicrosomeassay测试 ,4表现为非诱变性 ,用 4与乙酰J 酸作用得到新型双偶氮酸性染料 ( 5 ) .5对羊毛和丝绸分别在 2 %与 3 %色度下浸染都得到黑色染样 ,考察了 5的上染曲线 ,并对染样进行了测色研究 ,发现该染料属于酸性蓝黑染料 ,其黑度优于目前市场上流行的酸性黑 10B . | 尹志刚 熊卫东 赵德丰 FREEMAN Harold S.c | 2004 | 化学学报2004，62，10： | 7 |
| 3 | 热致液晶共聚酯/PA6/RSMA原位复合材料 2.力学性质与破坏行为显示文摘选用 Vectra A950热致液晶共聚酯(LCP)制备热致液晶共聚酯(LCP)/聚酰胺 6(PA6)/苯乙烯-马来酸酐无规共聚物(RSMA)三元共混物,并注射成型制得复合板材,研究三元 LCP/PA 6/RSMA原位复合材料的形态结构、力学性质和破坏行为结果表明,RSMA是LC/ PA6 复合材料的有效增容剂,RSMA的加入有利于LCP在PA 6基体中原位成纤,增强了两相之间的界面粘 接 加入RSMA后,LCP/PA 6原位复合材料的杨氏模量、抗拉强度和抗冲击强度明显提高. RSMA 能延长 LCP/PA6复合材料的裂纹引发时间,增加裂纹引发能和总冲击能,对 LCP/PA6原位复合材料 有增韧作用 RSMA的加入量存在一临界值. | 解孝林 LI R.K.Y TJONG S.C | 2001 | 材料研究学报2001，15，5： | 4 |
| 4 | Heavy metals in agricultural soils of the Pearl River Delta, South China显示文摘 | S.C Wong X.D Li G Zhang S.H Qi Y.S Min | 2002 | Environmental Pollution2002，，1： | 4 |
| 5 | Advances in solid oxide fuel cell technology显示文摘 | S.C Singhal | 2000 | Solid State Ionics2000，，1： | 3 |
| 6 | Low carbon steel with nanostructured surface layer induced by high-energy shot peening显示文摘 | G Liu S.C Wang X.F Lou J Lu K Lu | 2001 | Scripta Materialia2001，，8： | 3 |
| 7 | Paleozoic oil–source rock correlations in the Tarim basin, NW China显示文摘 | S.C Zhang A.D Hanson J.M Moldowan S.A Graham D.G Liang E Chang F Fago | 2000 | Organic Geochemistry2000，，： | 3 |
| 8 | A network model of urban taxi services显示文摘 | Hai Yang S.C Wong | 1998 | Transportation Research Part B1998，，4： | 2 |
| 9 | Microstructural and mechanical characteristics of in situ metal matrix composites显示文摘 | S.C Tjong Z.Y Ma | 2000 | Materials Science & Engineering R2000，，3： | 2 |
| 10 | A microplate fluorimetric assay for the study of enzyme diversity in soils显示文摘 | M.-C Marx M Wood S.C Jarvis | 2001 | Soil Biology and Biochemistry2001，，12： | 2 |
| 11 | Microstructural and mechanical characteristics of in situ metal matrix composites显示文摘 | S.C Tjong Z.Y Ma | 2000 | Materials Science & Engineering R2000，，3： | 2 |
| 12 | Solid oxide fuel cells for stationary, mobile, and military applications显示文摘 | S.C Singhal | 2002 | Solid State Ionics2002，，： | 2 |
| 13 | A microplate fluorimetric assay for the study of enzyme diversity in soils显示文摘 | M.-C Marx M Wood S.C Jarvis | 2001 | Soil Biology and Biochemistry2001，，12： | 2 |
| 14 | Risk of colonoscopic polypectomy bleeding with anticoagulants and antiplatelet agents: analysis of 1657 cases显示文摘 | Aric J Hui Ronald M.Y Wong Jessica Y.L Ching Lawrence C.T Hung S.C Sydney Chung Joseph J.Y Sung | 2004 | Gastrointestinal Endoscopy2004，，1： | 2 |
| 15 | Low carbon steel with nanostructured surface layer induced by high-energy shot peening显示文摘 | G Liu S.C Wang X.F Lou J Lu K Lu | 2001 | Scripta Materialia2001，，8： | 2 |
| 16 | Limits on rough-particle sizing with low-defocus interferometric imaging显示文摘We present a rigorous theoretical model for the influence of the aperture in interferometric out-of-focus imaging.We investigate the role of this effect on the properties of speckle-like patterns generated by irregular,rough particles.Finally,we determine the conditions under which these patterns are no longer representative of particle size but of the aperture itself and the defocus parameter. | M.Brunel L.Ouldarbi H.Shen G.Grehan S.Cetmellec | 2015 | Particuology2015，13，5： | 2 |
| 17 | The next generation of collective action research显示文摘 | Wright S.C | | 0，，04： | 1 |
| 18 | A leucine-rich repeat containing receptor-like kinase marks somatic plant cells competent to form embryos显示文摘 | Schmidt E.D Guzzo F Toonen M.A de Vries S.C | | 0，，10： | 1 |
| 19 | 查看详情显示文摘 | Li X Geng W Zhou J Luo W. Wang F. Wang L. Tsang S.C | | 0，，： | 1 |
| 20 | Pragmatics and the grammar of anaphora:a partial pragmatic reduction of binding and control phenomena显示文摘 | Levinson S.C | | 0，，23： | 1 |
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