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| 1 | Targeting p53 pathways:mechanisms,structures,and advances in therapy显示文摘The TP53 tumor suppressor is the most frequently altered gene in human cancers,and has been a major focus of oncology research.The p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles in regulating cell cycle,apoptosis,and genomic stability,and is widely regarded as the“guardian of the genome”.Accumulating evidence has shown that p53 also regulates cell metabolism,ferroptosis,tumor microenvironment,autophagy and so on,all of which contribute to tumor suppression.Mutations in TP53 not only impair its tumor suppressor function,but also confer oncogenic properties to p53 mutants.Since p53 is mutated and inactivated in most malignant tumors,it has been a very attractive target for developing new anti-cancer drugs.However,until recently,p53 was considered an“undruggable”target and little progress has been made with p53-targeted therapies.Here,we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression.We also discuss key structural features of the p53 protein and its inactivation by oncogenic mutations.In addition,we review the efforts that have been made in p53-targeted therapies,and discuss the challenges that have been encountered in clinical development. | Haolan Wang Ming Guo Hudie Wei Yongheng Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 4 |
| 2 | Template synthesis of multi- shelled CuzO hollow spheres with a single-crystalline shell wall显示文摘 | Xu Haolan Wang Wenzhong | 2007 | Angew Chem Int Ed2007，46，9： | 1 |
| 3 | Rapid seeded growth of monodisperse, quasi-spherical, citrate-stabilized gold nanoparticles via H202 reduction 显示文摘 | Liu Xiaokong Xu Haolan Wang Dayang | 2012 | Langmuir2012，28，13： | 1 |
| 4 | Bi2O3hierarchical nanostructures:controllable synthesis,growth mechanism,and their application in photocatalysis显示文摘 | ZHOU Lin WANG Wenzhong XU Haolan | 2009 | Chemistry-A European Journal2009，15，7： | 1 |
| 5 | A facile strat- egy to porous materials: Coordination-assisted heteroge neous dissolution route to the spherical Cu2O single crystallites with hierarchical pores 显示文摘 | Xu Haolan Wang Wenzhong Zhu Wei | 2006 | Micropor Meso- por Mater2006，95，： | 1 |
| 6 | Recent strategies for constructing efficient interfacial solar evaporation systems显示文摘Interfacial solar evaporation(ISE)is a promising technology to relieve worldwide freshwater shortages owing to its high energy conversion efficiency and environmentally sustainable potential.So far,many innovative materials and evaporators have been proposed and applied in ISE to enable highly controllable and efficient solar-to-thermal energy conversion.With rational design,solar evaporators can achieve excellent energy management for lowering energy loss,harvesting extra energy,and efficiently utilizing energy in the system to improve freshwater production.Beyond that,a strategy of reducing water vaporization enthalpy by introducing molecular engineering for water-state regulation has also been demonstrated as an effective approach to boost ISE.Based on these,this article discusses the energy nexus in two-dimensional(2D)and three-dimensional(3D)evaporators separately and reviews the strategies for design and fabrication of highly efficient ISE systems.The summarized work offers significant perspectives for guiding the future design of ISE systems with efficient energy management,which pave pathways for practical applications. | Yida Wang Junqing Hu Li Yu Xuan Wu Yingying Zhang Haolan Xu | 2023 | Nano Research Energy2023，2，2： | 1 |
| 7 | Sonochemical synthesis of crystalline CuS nanoplates via an in situ template route显示文摘 | Xu Haolan Wang Wenzhong Zhu Wei | 2006 | Materials Letters2006，60，1718： | 1 |
| 8 | Shape evolution and size-controllable synthesis of Cu2O octahedra and their morphology-dependent photocatalytic properties显示文摘 | Xu Haolan Wang Wenzhong Zhu Wei | 2006 | J Phys Chem B2006，110，13： | 1 |
| 9 | Controllable syn- thesis of three-dimensional well-defined BiVQ mesoerys-tals via a facile additive-free aqueous strategy显示文摘 | Zhou Lin Wang Wenzhong Xu Haolan | 2008 | Crystal Growth & Design2008，8，2： | 1 |
| 10 | Fabrication of inorganic molybdenum disulfide fullerenes by arc in water 显示文摘 | Nofiaki Sano Haolan Wang Manish Chhowalla | 2003 | Chemical Physics Letters2003，368，： | 1 |
| 11 | A facile strat- egy to porous materials: Coordination-assisted hetero- geneous dissolution route to the spherical Cu20 single crystallites with hierarchical pores 显示文摘 | Xu Haolan Wang Wenzhong Zhu Wei | 2006 | Microporous MesoporousMater2006，95，： | 1 |
| 12 | Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion显示文摘Multilayers incorporated with stimuli-responsive substances by means of layer-by-layer(LbL) self-assembly are much attractive due to their advantages of stimuli-responsiveness and potential applications in different fields. In this study, pyrenemethyl acrylate(PA) was synthesized, and was copolymerized with acrylic acid(AA) to obtain the amphiphilic and photodegradable P(PA-co-AA)polymers with a PA:AA molar ratio of 1.3:3, and an average molecular weight of 6.9 kDa and polydispersity index of 1.04. They formed micelles spontaneously when dispersed in aqueous solution with a size of 27.5 nm in a dry state and 136.6 nm in a wet state. The micelles were readily decomposed to form aggregates as a result of the cleavage of the pyrenemethyl ester bonds under UV-irradiation. UV-responsive micelles-containing multilayers were prepared by LbL self-assembly of the UV-responsive micelles and polyallylamine hydrochloride(PAH). UV-irradiation of the multilayers resulted in the decomposition of micelles, leading to larger surface roughness, and enhanced swelling ratio and wettability of the multilayers. In vitro culture of A549, HepG2 and endothelial cells showed significantly better adhesion at 4 h on the UV-illuminated multilayers, whereas the cell proliferation was not affected significantly until 5 d. | Haolan Zhang Danyu Wang Xue Lin Nikolaos Politakos Jimena S. Tuninetti Sergio Enrique Moya Changyou Gao | 2018 | Science China Chemistry2018，61，1： | 0 |
| 13 | Implementing Routine HIV Screening in Hospitals:An Effective Practice to Expand HIV Testing—Xishuangbanna Prefecture,Yunnan Province,China,2019–2020显示文摘Summary What is already known about this topic?Research evidence is insufficient to suggest whether routine human immunodeficiency virus(HIV)screening in healthcare settings is effective in promoting greater awareness of HIV-positive status.What is added by this report?This study found that,following the implementation of routine HIV screening in hospitals in Xishuangbanna Prefecture,Yunnan Province,there was a significant increase in the number of HIV screenings,positive results,and the positive rate of HIV screening in primary-level hospitals.What are the implications for public health practice?Routine hospital-based HIV screening is effective in identifying HIV infections in areas with concentrated epidemics. | Yidan Wang Yanling Ma Qiyu Zhu Wenyue Xu Haolan Sun Dongmin Li Cong Jin | 2023 | China CDC weekly2023，5，13： | 0 |
| 14 | Boosting extraction of Pb in contaminated soil via interfacial solar evaporation of multifunctional sponge显示文摘Interfacial solar water evaporation is a reliable way to accelerate water evaporation and contaminant remediation.Embracing the recent advance in photothermal technology,a functional sponge was prepared by coating a sodium alginate(SA)impregnated sponge with a surface layer of reduced graphene oxide(rGO)to act as a photothermal conversion medium and then subsequently evaluated for its ability to enhance Pb extraction from contaminated soil driven by interfacial solar evaporation.The SA loaded sponge had a Pb adsorption capacity of 107.4 mg g^(-1).Coating the top surface of the SA sponge with rGO increased water evaporation performance to 1.81 kg m^(-2)h^(-1)in soil media under one sun illumination and with a wind velocity of 2 m s^(-1).Over 12 continuous days of indoor evaporation testing,the Pb extraction efficiency was increased by 22.0%under 1 sun illumination relative to that observed without illumination.Subsequently,Pb extraction was further improved by 48.9%under outdoor evaporation conditions compared to indoor conditions.Overall,this initial work shows the significant potential of interfacial solar evaporation technologies for Pb contaminated soil remediation,which should also be applicable to a variety of other environmental contaminants. | Pan Wu Xuan Wu Yida Wang Jingyuan Zhao Haolan Xu Gary Owens | 2023 | Green Energy & Environment2023，8，5： | 0 |
| 15 | Reactive oxygen species-scavenging nanoparticles coated with chondroitin sulfate protect cartilage against osteoarthritis in vivo显示文摘Osteoarthritis(OA)is a prevalent chronic inflammatory disease in joints.Current interventions confront systemic toxicity and insufficient bioavailability.The unbalanced microenvironment of OA joints mainly fosters over-expressed reactive oxygen species(ROS),extracellular matrix disintegration,and apoptosis of chondrocytes.In this study,a kind of ROS-scavenging,biodegradable and drug-free nanoparticles(PP NPs)were constructed by the crosslinking of poly(propylene fumarate)(PPF)and ROS-scavenging poly(thioketal)(PTK).The high content of PTK and high crosslinking density of PPF and PTK innovatively endowed the NPs with slow degradation and prolonged ROS-elimination ability.The NPs were further surface-modified with chondroitin sulfate(CS),one of the dietary supplements for osteoarthritis.The intrinsic properties of resultant PP-CS NPs were excavated in vitro and in vivo.The PP-CS NPs could desirably consume 1,10-diphenyl-2-picrylhydrazyl(DPPH)radicals without toxicity to RAW264.7 cells in vitro.With an average diameter of~300 nm,the PP-CS NPs could be intra-articular administrated in OA rats and showed prolonged joint retention time,allowing only one injection per month.Moreover,the PP-CS NPs possessed a prolonged ROS depletion and M2 macrophage induction effect,down-regulated inflammatory cytokines,and reduced glycosaminoglycans loss.Consequently,the PP-CS NPs protected articular surface erosion,inhibited uneven cartilage matrix,and attenuated OA progression. | Zhaoyi Wang Hao Xiong Zihe Zhai Yuejun Yao Tong Zhou Haolan Zhang Cunyi Fan Changyou Gao | 2023 | Nano Research2023，16，2： | 0 |
| 16 | Can Eurasia Experience a Cold Winter under a Third-Year La Nina in 2022/23?显示文摘The Northern Hemisphere(NH)often experiences frequent cold air outbreaks and heavy snowfalls during La Nina winters.In 2022,a third-year La Nina event has exceeded both the oceanic and atmospheric thresholds since spring and is predicted to reach its mature phase in December 2022.Under such a significant global climate signal,whether the Eurasian Continent will experience a tough cold winter should not be assumed,despite the direct influence of mid-to high-latitude,large-scale atmospheric circulations upon frequent Eurasian cold extremes,whose teleconnection physically operates by favoring Arctic air invasions into Eurasia as a consequence of the reduction of the meridional background temperature gradient in the NH.In the 2022/23 winter,as indicated by the seasonal predictions from various climate models and statistical approaches developed at the Institute of Atmospheric Physics,abnormal warming will very likely cover most parts of Europe under the control of the North Atlantic Oscillation and the anomalous anticyclone near the Ural Mountains,despite the cooling effects of La Nina.At the same time,the possibility of frequent cold conditions in mid-latitude Asia is also recognized for this upcoming winter,in accordance with the tendency for cold air invasions to be triggered by the synergistic effect of a warm Arctic and a cold tropical Pacific on the hemispheric scale.However,how the future climate will evolve in the 2022/23 winter is still subject to some uncertainty,mostly in terms of unpredictable internal atmospheric variability.Consequently,the status of the mid-to high-latitude atmospheric circulation should be timely updated by medium-term numerical weather forecasts and sub-seasonal-to-seasonal prediction for the necessary date information and early warnings. | Fei ZHENG Bo WU Lin WANG Jingbei PENG Yao YAO Haifeng ZONG Qing BAO Jiehua MA Shuai HU Haolan REN Tingwei CAO Renping LIN Xianghui FANG Lingjiang TAO Tianjun ZHOU Jiang ZHU | 2023 | Advances in Atmospheric Sciences2023，40，4： | 0 |
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