|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Therapeutic strategies of glioblastoma (GBM):The current advances in the molecular targets and bioactive small molecule compounds显示文摘Glioblastoma(GBM)is the most common aggressive malignant tumor in brain neuroepithelial tumors and remains incurable.A variety of treatment options are currently being explored to improve patient survival,including small molecule inhibitors,viral therapies,cancer vaccines,and monoclonal antibodies.Among them,the unique advantages of small molecule inhibitors have made them a focus of attention in the drug discovery of glioblastoma.Currently,the most used chemotherapeutic agents are small molecule inhibitors that target key dysregulated signaling pathways in glioblastoma,including receptor tyrosine kinase,PI3K/AKT/mTOR pathway,DNA damage response,TP53 and cell cycle inhibitors.This review analyzes the therapeutic benefit and clinical development of novel small molecule inhibitors discovered as promising anti-glioblastoma agents by the related targets of these major pathways.Meanwhile,the recent advances in temozolomide resistance and drug combination are also reviewed.In the last part,due to the constant clinical failure of targeted therapies,this paper reviewed the research progress of other therapeutic methods for glioblastoma,to provide patients and readers with a more comprehensive understanding of the treatment landscape of glioblastoma. | Hui Liu Weimin Qiu Tianyu Sun Lei Wang Chenxi Du Yanyu Hu Wenyuan Liu Feng Feng Yao Chen Haopeng Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 2 | RS and GIS-based Analysis of Landscape Pattern Changes in Urban-rural Ecotone:A Case Study of Daiyue District,Tai' an City,China显示文摘Based on RS data of Daiyue District,Tai'an City in 2000,2005 and 2010,changes of land use types in urban-rural ecotone of Tai'an City from 2000 to 2010 were analyzed.Ecological theories,ArcGIS techniques and landscape structure analysis software Fragstats were applied to select relevant landscape pattern indexes and analyze changes of landscape structure,and compare changes in two durations(2000-2005,2005-2010).The results showed that area of natural landscapes in the study area declined from 2000 to 2010,construction land expanded,land use types were mainly transferred from natural landscapes to man-made landscapes.In terms of landscape level,number of patches(NP),patch density(PD),patch shape index(SHAPE),Shannon's diversity index(SHDI) and Shannon's evenness index(SHEI) increased,the largest patch index(LPI) declined.In terms of type level,arable land were influenced by the most human interventions,large-scale patches turned fragmented,and landscape dominance degraded;woodland landscapes were concentrated in mountainous areas,waterscape indexes showed slight changes.Dominance of regional dominant landscape types degraded,landscape fragmentation and landscape heterogeneity increased,and landscape stability declined. | SHI Haopeng YU Kaiqin FENG Yongjun DONG Xiaochang ZHAO Haiyan DENG Xiaomei | 2012 | Journal of Landscape Research2012，4，9： | 2 |
| 3 | Bacteria inactivation by sulfate radical:progress and non-negligible disinfection by-products显示文摘Sulfate radicals have been increasingly used for the pathogen inactivation due to their strong redox ability and high selectivity for electron-rich species in the last decade.The application of sulfate radicals in water disinfection has become a very promising technology.However,there is currently a lack of reviews of sulfate radicals inactivated pathogenic microorganisms.At the same time,less attention has been paid to disinfection by-products produced by the use of sulfate radicals to inactivate microorganisms.This paper begins with a brief overview of sulfate radicals’properties.Then,the progress in water disinfection by sulfate radicals is summarized.The mechanism and inactivation kinetics of inactivating microorganisms are briefly described.After that,the disinfection by-products produced by reactions of sulfate radicals with chlorine,bromine,iodide ions and organic halogens in water are also discussed.In response to these possible challenges,this article concludes with some specific solutions and future research directions. | Xin Zhou Xiaoya Ren Yu Chen Haopeng Feng Jiangfang Yu Kang Peng Yuying Zhang Wenhao Chen Jing Tang Jiajia Wang Lin Tang | 2023 | Frontiers of Environmental Science & Engineering2023，17，3： | 0 |
| 4 | Population genomic analysis reveals distinct demographics and recent adaptation in the black flying fox(Pteropus alecto)显示文摘As the only mammalian group capable of powered flight,bats have many unique biological traits.Previous comparative genomic studies in bats have focused on long-term evolution.However,the microevolutionary processes driving recent evolution are largely under-explored.Using resequencing data from 50 black flying foxes(Pteropus alecto),one of the model species for bats,we find that black flying fox has much higher genetic diversity and lower levels of linkage disequilibrium than most of the mammalian species.Demographic inference reveals strong population fluctuations(>100 fold)coinciding with multiple historical events including the last glacial change and Toba super eruption,suggesting that the black flying fox is a very resilient species with strong recovery abilities.While long-term adaptation in the black flying fox is enriched in metabolic genes,recent adaptation in the black flying fox has a unique landscape where recently selected genes are not strongly enriched in any functional category.The demographic history and mode of adaptation suggest that black flying fox might be a well-adapted species with strong evolutionary resilience.Taken together,this study unravels a vibrant landscape of recent evolution for the black flying fox and sheds light on several unique evolutionary processes for bats comparing to other mammalian groups. | Haopeng He Hechuan Yang Randy Foo Wharton Chan Feng Zhu Yunsong Liu Xuming Zhou Liang Ma Lin-Fa Wang Weiwei Zhai | 2023 | Journal of Genetics and Genomics2023，50，8： | 0 |
| 5 | Adenovirus-mediated short hairpin RNA interference against p75 neurotrophin receptor in pheochromocytoma cells显示文摘Previous studies have confirmed that motor neuron apoptosis in the anterior horn of the lumbosacral spinal cord is positively correlated with p75 neurotrophin receptor (p75NTR) expression in rat models of cauda equina syndrome. This study used adenovirus to carry a short hairpin RNA (shRNA) for p75NTR gene silencing, to reduce p75NTR expression in the damaged phase and to decrease motor neuron apoptosis. Three p75 siRNA template oligonucleotide segments (shRNA) were designed, and cloned into the 1.0 CMV shuttle vector. HEK293 cells were cotransfected with shuttle vector (carrying shRNA) and an adenovirus vector framework expressing enhanced green fluorescent protein. Thus, this study successfully obtained adenovirus carrying p75shRNA. The obtained viruses were named Ad.shRNA1, Ad.shRNA2, and Ad.shRNA3. The recombinant adenoviruses were separately used to infect cultured pheochromocytoma cells (PC12). Forty-eight hours later, p75NTR mRNA and total protein were analyzed from the PC12 cells. Compared with the negative controls, RNA interference rates were separately 98.49 ± 0.68%, 95.08 ± 1.79% and 96.60 ± 1.14% at the mRNA level, and 72.89 ± 2.17%, 58.83 ± 1.15% and 59.88 ± 0.44% at the protein level in the Ad.shRNA1, Ad.shRNA2, and Ad.shRNA3 groups, respectively. Thus, recombinant adenovirus shRNA-mediated gene silencing successfully suppressed p75NTR expression. | Dongxu Feng Haopeng Li Siyue Xu YU Liu Xiaofei Hou | 2011 | Neural Regeneration Research2011，6，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员