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| 1 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 2 | Pharmacological- and non-pharmacological therapeutic approaches in inflammatory bowel disease in adults显示文摘Inflammatory bowel diseases(IBDs) are a group of chronic inflammatory conditions mainly of the colon and small intestine. Crohn's disease(CD) and ulcerative colitis(UC) are the most frequent types of IBD. IBD is a complex disease which arises as a result of the interaction of environmental, genetic and immunological factors. It is increasingly thought that alterations of immunological reactions of the patients to their own enterable bacteria(microfilm) may contribute to inflammation. It is characterized by mucosal and sub mucosal inflammation, perpetuated by infiltration of activated leukocytes. CD may affect the whole gastrointestinal tract while UC only attacks the large intestine. The therapeutic goal is to achieve a steroidfree long lasting remission in both entities. UC has the possibility to be cured by a total colectomy, while CD never can be cured by any operation. A lifelong intake of drugs is mostly necessary and essential. Medical treatment of IBD has to be individualized to each patient and usually starts with anti-inflammatory drugs. The choice what kind of drugs and what route administered(oral, rectal, intravenous) depends on factors including the type, the localization, and severity of the patient's disease. IBD may require immune-suppression to control symptoms such as prednisolone, thiopurines, calcineurin or sometimes folic acid inhibitors or biologics like TNF-α inhibitors or anti-integrin antibodies. For both types of disease(CD, UC) the same drugs are available but they differ in their preference in efficacy between CD and UC as 5-aminosalicylic acid for UC or budesonide for ileocecal CD. As therapeutic alternative the main mediators of the disease, namely the activated pro-inflammatory cytokine producing leukocytes can be selectively removed via two apheresis systems(Adacolumn and Cellsorba) in steroid-refractory or dependent cases. Extracorporeal photopheresis results in an increase of regulatory B cells, regulatory CD8^+ T cells and T-regs Type 1. Both types of apheresis were able to induce clinical remission and mucosal healing accompanied by tapering of steroids. | Gerda C Leitner Harald Vogelsang | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 3 |
| 3 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | 2010 (9746)2010，，9746： | 2 |
| 4 | The future of Mzheimer' s disease:The next 10 years显示文摘 | Harald Hampel David Prvulovi C Stefan Teipel | 2011 | Progress in Neurobiolo- -2011，95，4： | 1 |
| 5 | Performance anal-ysis of CCSDS File Delivery Protocoland Erasure CodingTechniques in Deep Space Environments显示文摘 | TOMASO C HARALD E MARIO M | 2007 | ComputerNetworks2007，51，14： | 1 |
| 6 | Amber force-field parameters for phosphorylated amino acids in different protonation states:phosphoserine,phosphothreonine,phosphotyrosine,and phosphohistidine显示文摘 | NADINE H ANSELM C H HARALD L | 2006 | Journal of Molecular Modeling2006，12，3： | 1 |
| 7 | Influence of growth condition on biofilm development and mass transfer at the bulk/biofilm interface显示文摘 | STEFAN HARALD DIETMAR C | 2002 | Water Research2002，36，： | 1 |
| 8 | Polyphenols and glutathione synthesis regulation显示文摘 | Jan MΦ Harald C Mari CWM | 2005 | Am J Clin Nutr2005，81，1： | 1 |
| 9 | High tempera- ture smart-cut SO1 pressure sensor显示文摘 | GUO S W HARALD E KIMIKO C | 2009 | Sensors and Actua-tors: A2009，154，2： | 1 |
| 10 | Characterization of mtDNA SNP typing and mixture ratio assessment with simultaneous real-time PCR quantification of both allelic states 显示文摘 | Harald N Michael D C Petra G | 2006 | Int J Leg Med2006，120，： | 1 |
| 11 | Platelets and neurovascular inflammation显示文摘 | Harald FL Triantafyllos C | 2013 | Thromb Haemost2013，110，2： | 1 |
| 12 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | The Lancet2010，，9746： | 1 |
| 13 | PPAR activators as antiinflammatory mediators in human T lymphocytes : implications for atherosclerosis and transplantation-associated arteriosclerosis 显示文摘 | Marx N Debard C Harald S | 2002 | Circ Res2002，90，： | 1 |
| 14 | Technical calcium nitrate as set accelerator for cement at low temperatures显示文摘 | HARALD J NYGAARD ERIK C | 1995 | Cement and Concrete Research1995，25，8： | 1 |
| 15 | Computerized Control of the VOD Process With the Application of a Mass Spectrometer 显示文摘 | Alok C Cerhard B Harald S | 1988 | Metallurgical Plant and Technology1988，，5： | 1 |
| 16 | Mild cognitive impairment显示文摘 | Serge Gauthier Barry Reisberg Michael Zaudig Ronald C Petersen Karen Ritchie Karl Broich Sylvie Belleville Henry Brodaty David Bennett Howard Chertkow Jeffrey L Cummings Mony de Leon Howard Feldman Mary Ganguli Harald Hampel Philip Scheltens Mary C Tierne | 2006 | The Lancet . 2006 (9518)2006，，： | 1 |
| 17 | Strong in vivo activation of NF-κB in mouse lenses by classic stressors显示文摘 | George A Harald C Rune B | 2003 | Investigative Oph- Thalmology and Visual Science2003，44，6： | 1 |
| 18 | Mild cognitive impairment显示文摘 | Serge Gauthier Barry Reisberg Michael Zaudig Ronald C Petersen Karen Ritchie Karl Broich Sylvie Belleville Henry Brodaty David Bennett Howard Chertkow Jeffrey L Cummings Mony de Leon Howard Feldman Mary Ganguli Harald Hampel Philip Scheltens Mary C Tierne | 2006 | The Lancet2006，，9518： | 1 |
| 19 | The Safety and Effectiveness of Remifentanil as an Adjunct Sedative for Regional Anesthesia显示文摘 | MARYLIN L FREDERIC C HARALD B R | 1999 | Anesth Analg1999，88，1： | 1 |
| 20 | Hepatocellular fat accumulation and low serum cholesterol in patients infected with HCV-3a显示文摘 | Harald Hofer Hans C Bankl Friedrich Wrba Petra Steindl-Munda Markus Peck-Radosavljevic Christoph ?sterreicher Christian Mueller Alfred Gangl Peter Ferenci | 2002 | The American Journal of Gastroenterology2002，，11： | 1 |
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