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| 1 | Metastatic pattern in esophageal and gastric cancer:Influenced by site and histology显示文摘BACKGROUND Detailed information on metastatic patterns in of patients with esophageal and gastric cancer is limited.Early recognition of metastases is important to avoid futile locoregional treatments.Furthermore,knowledge on metastatic patterns is necessary for further development of personalized treatment modalities.AIM To gain insight into the metastatic pattern of gastroesophageal cancer.METHODS A nationwide retrospective autopsy study of 3876 patients with adenocarcinoma(AC)or squamous cell carcinoma(SCC)of the esophagus or stomach between 1990 and 2017 was performed.Only patient with metastases were included for analysis.The metastatic pattern was analyzed according to the primary tumor location and histological subtype.RESULTS Metastatic disease was found in 268 esophageal and 331 gastric cancer patients.In esophageal cancer,the most common metastatic locations were liver(56%),distant lymph nodes(53%)and lung(50%).Esophageal AC showed more frequently metastases to the peritoneum and bone compared with esophageal SCC.In gastric cancer,the most common metastatic locations were distant lymph nodes(56%),liver(53%)and peritoneum(51%).Intestinal-type AC of the stomach showed metastases to the liver more frequently,whereas metastases to the bone,female reproductive organs and colorectum were observed more frequently in diffuse-type gastric AC.CONCLUSION This study showed differences in metastatic patterns of patients with esophageal and gastric cancer according to the primary tumor location and histological subtype. | Moniek HP Verstegen Mitchell Harker Carlijn van de Water Jolanda van Dieren Niek Hugen Iris D Nagtegaal Camiel Rosman Rachel S van der Post | 2020 | World Journal of Gastroenterology2020，26，39： | 9 |
| 2 | A narrative review of the success of intramuscular gluteal injections and its impact in psychiatry显示文摘 | Erfan Soliman Sarujan Ranjan Tianyou Xu Carol Gee Aidan Harker Alvaro Barrera John Geddes | 2018 | Bio-Design and Manufacturing2018，1，3： | 3 |
| 3 | Finite-dimensional variational inequalities and non-linear complementarity problems: a survey of theory, algorithms and applications显示文摘 | Harker P T Pang J S | 1990 | Mathematical Programming1990，48，2： | 2 |
| 4 | Finite-dimensional variational inequality and nonlinear complementarity problems: A survey of theory, algorithms and applications显示文摘 | Patrick T. Harker Jong-Shi Pang | 1990 | Mathematical Programming (-)1990，，1： | 2 |
| 5 | Water-aided colonoscopy: a systematic review显示文摘 | Felix W. Leung Arnaldo Amato Christian Ell Shai Friedland Judith O. Harker Yu-Hsi Hsieh Joseph W. Leung Surinder K. Mann Silvia Paggi Jürgen Pohl Franco Radaelli Francisco C. Ramirez Rodelei Siao-Salera Vittorio Terruzzi | 2012 | Gastrointestinal Endoscopy2012，，3： | 2 |
| 6 | The Capabilities and Performance Advantages of Market-Driven Firms: An Empirical Investigation显示文摘 | DOUGLAS VORHIES W MICHAEL HARKER | 2000 | Australian Journal of Management2000，25，2： | 2 |
| 7 | Finite dimensional variational inequality and nonlinear complementarity problems:a survey of theory,algorithms and applications显示文摘 | Harker P T Pang J S | 1990 | Math Program1990，48，： | 2 |
| 8 | Sevoflu- rane sedation in infants undergoingMRI: a preliminary report 显示文摘 | Sury MR Harker H Thomas ML | 2005 | Paediatr Anaesth2005，15，1： | 1 |
| 9 | A non-interior-point continuation method for linear complementarity problems显示文摘 | Chen B Harker P | 1993 | SIAM J Matrix Anal Appl1993，14，4： | 1 |
| 10 | Screening for undernutrition in geriatric practice:developing the short-form Mini-Nutritional Assessment (MNA-SF)显示文摘 | Rubenstein L Z Harker J O SalvaA | | 0，，6： | 1 |
| 11 | Generalized Nash games and quasi-variationalinequalities 显示文摘 | Harker P | 1991 | Eur J Oper Res1991，54，1： | 1 |
| 12 | The CD8alpha gene locus is regulated by the Ikaros family of proteins显示文摘 | Harker N Naito T Cortes M | 2002 | Mol Cell2002，10，1： | 1 |
| 13 | Finite-dimensional variational inequality and nonlinear complementarity problems, a survey review of theory, algorithms and applications显示文摘 | HARKER P T PANG J S | 1990 | Math Program1990，48，： | 1 |
| 14 | Physical and mechanical changes in strawberry fruit after high carbondioxide treatments显示文摘 | Harker F R Elgar H J Watkins C B | 2000 | Postharvest Biology and Technology2000，19，2： | 1 |
| 15 | Measurement of human endothelial cells in whole blood显示文摘 | Takahashi H Harker LA | 1983 | Thromb Res1983，31，： | 1 |
| 16 | Role of platelets and thrombosis in mechanisms of acute occlusion and restenosis after angioplasty显示文摘 | Harker LA | 1989 | Am J Cardiol1989，60，： | 1 |
| 17 | Regulation of platelet-derived growth factor ligand and receptor gene expression by alpha-thrombin in vascular smooth muscle cells 显示文摘 | Okazaki H Majesky M W Harker L A | 1992 | Cire Res1992，71，6： | 1 |
| 18 | Metabolic engineering of astaxanthin production in tobacco flowers 显示文摘 | Mann V Harker M Pecker I | 2000 | Nat Biotechnol2000，18，： | 1 |
| 19 | Physical and mechanical changes in strawberry fruit after high carbondioxide treatments显示文摘 | HARKER F R ELGAR H J WATKINS C B | 2000 | Postharvest Biology and Technology2000，19，2： | 1 |
| 20 | Generalized Nash Games and Quasi-variational ineuqualities显示文摘 | Harker P T | 1991 | European Journal of Operational Research1991，54，： | 1 |
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