|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neuroticism, extraver sion,life events and depression: the cardiff depression study 显示文摘 | Farmer A Redman K Harlis T | 2002 | Br J Psychiatry2002，181，： | 1 |
| 2 | Telomeres shorten during aging of human fibroblasts显示文摘 | Harly CB Futcher AB Greider CW | | 0，，： | 1 |
| 3 | Control of IPM synchronous generator for maximum wind power generation considering magnetic saturation显示文摘 | QIAO W QU L HARLY R G | 2009 | IEEETrans on Industry Applications2009，45，3： | 1 |
| 4 | Sex, drug and HIV : Does methadone maintenance reduce drug use and risky sexual ,ehavior显示文摘 | harlie ML Harry SS Dale DC | 2000 | J Behav Med2000，23，6： | 1 |
| 5 | Telomere loss:mitotic clock or genetic time bomb显示文摘 | | 1991 | Mutat Res1991，256，： | 1 |
| 6 | Telomeres shorten during aging of human fibroblasts显示文摘 | Harly CB Greider CW Futcher AB | | 0，，： | 1 |
| 7 | The NS3 protein of bluetongue virus exhibits vi- roporin-like properties显示文摘 | Han Z Harly RN | 2004 | J Biol Chem2004，279，43： | 1 |
| 8 | Up-regulation of cytolytic functions of human V82-~/T lymphocytes through engagement of ILT2 expressed by tumor target cells 显示文摘 | Harly C Peyrat MA Netzer S | 2011 | Blood2011，117，： | 1 |
| 9 | Chronic intermittent hypoxia activates nuclear factor-κB in cardiovascular tissues in vivo显示文摘 | Harly Greenberg Xiaobing Ye David Wilson Aung K. Htoo Todd Hendersen Shu Fang Liu | 2006 | Biochemical and Biophysical Research Communications2006，，2： | 1 |
| 10 | Transmitter deficits in Alzheimer's disease显示文摘 | Harly J Adolfsson K Alafuzoff I | 1985 | Neurochem Intl1985，7，： | 1 |
| 11 | Up-regulation of cyto- lyric functions of human Vδ2-γ tlymphoeytes through engage- ment of ILT2 expressed by tumor target cells 显示文摘 | Harly C Peyrat MA Netzer S | 2011 | Blood2011，117，10： | 1 |
| 12 | Chronic intermittent hypoxia activates nuclear factor-κB in cardiovascular tissues in vivo显示文摘 | Harly Greenberg Xiaobing Ye David Wilson Aung K. Htoo Todd Hendersen Shu Fang Liu | 2006 | Biochemical and Biophysical Research Communications2006，，2： | 1 |
| 13 | Up-regulation of cytolytic functions of human Vδ2-γ T lymphocytes through engagement of ILT2 expressed by tumor target cells显示文摘 | Harly C Peyrat MA Netzer S | | 0，，10： | 1 |
| 14 | The telomere hypothesis of cellular aging显示文摘 | C B Harly H Viziri C Counter | 1992 | Exp Gerontol1992，27，： | 1 |
| 15 | Up-regulation of cytolytic functions of human Vδ2-γT lymphocytes through engagement of ILT2expressed by tumor target cells显示文摘 | Harly C Peyrat M A Netzer S | 2011 | Blood2011，117，10： | 1 |
| 16 | Enterocutaneous fistula aretreatments improving显示文摘 | Draus JM Huss SA Harly NJ | 2006 | surgery2006，140，4： | 1 |
| 17 | Neurotieism, extra- version, life events and depression: the cardiff depression study 显示文摘 | Farmer A Redman K Harlis T | 2002 | Br J Psychiatry2002，181，： | 1 |
| 18 | A comparison between com-mercial kits and conventional methods for enumeration of salivary mutans streptococci and lactobacilli显示文摘 | Davenport ES Day S Harlie JM | 1992 | Community Dent Health1992，9，3： | 1 |
| 19 | Telomerase shorten during aging of fibroblasts 显示文摘 | Harly CB Futcher AB Greider CW | 1990 | Nature1990，345，6724： | 1 |
| 20 | Latent, sex-specific metabolic health effects in CD-1 mouse offspring exposed to PFOA or HFPO-DA (GenX) during gestation显示文摘Background:Perfluorooctanoic acid(PFOA)is an environmental contaminant associated with adverse metabolic outcomes in developmentally exposed human populations and mouse models.Hexafluoropropylene oxide-dimer acid(HFPO-DA,commonly called GenX)has replaced PFOA in many industrial applications in the U.S.and Europe and has been measured in global water systems from<1 to 9350 ng/L HFPO-DA.Health effects data for GenX are lacking.Objective:Determine the effects of gestational exposure to GenX on offspring weight gain trajectory,adult metabolic health,liver pathology and key adipose gene pathways in male and female CD-1 mice.Methods:Daily oral doses of GenX(0.2,1.0,2.0 mg/kg),PFOA(0.1,1.0 mg/kg),or vehicle control were administered to pregnant mice(gestation days 1.5-17.5).Offspring were fed a high-or low-fat diet(HFD or LFD)at weaning until necropsy at 6 or 18 weeks,and metabolic endpoints were measured over time.PFOA and GenX serum and urine concentrations,weight gain,serum lipid parameters,body mass composition,glucose tolerance,white adipose tissue gene expression,and liver histopathology were evaluated.Results:Prenatal exposure to GenX led to its accumulation in the serum and urine of 5-day old pups(P=0.007,P<0.001),which was undetectable by weaning.By 18 weeks of age,male mice fed LFD in the 2.0 mg/kg GenX group displayed increased weight gain(P<0.05),fat mass(P=0.016),hepatocellular microvesicular fatty change(P=0.015),and insulin sensitivity(P=0.014)in comparison to control males fed LFD.Female mice fed HFD had a significant increase in hepatocyte single cell necrosis in 1.0 mg/kg GenX group(P=0.022)and 1.0 mg/kg PFOA group(P=0.003)compared to control HFD females.Both sexes were affected by gestational GenX exposure;however,the observed phenotype varied between sex with males displaying more characteristics of metabolic disease and females exhibiting liver damage in response to the gestational exposure.Conclusions:Prenatal exposure to 1 mg/kg GenX and 1 mg/kg PFOA induces adverse metabolic outcomes in adult mice that are diet-and sex-dependent.GenX also accumulated in pup serum,suggesting that placental and potentially lactational transfer are important exposure routes for GenX. | Harlie A.Cope Bevin E.Blake Charlotte Love James McCord Susan A.Elmore Janice B.Harvey Vesna A.Chappell Suzanne E.Fenton | 2021 | Emerging Contaminants2021，7，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员