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| 1 | Dextran sulfate sodium-induced colitis-associated neoplasia:a promising model for the development of chemopreventive interventions显示文摘与 ulcerative 大肠炎诊断的个人面对开发颜色的显著地增加的风险表面的发育异常和癌症在他们的一生期间。迄今为止,注意为葡聚糖硫酸盐钠(决策支持系统)的这个 high-riskpopulation.The 鼠标模型被给了 chemopreventive 干预的开发的很少导致了大肠炎代表两个都描绘面对发炎为肿瘤形成要求的分子的事件并且估计精选代理人的能力到的一个优秀现出症状之前的潜的系统在在长期的大肠炎的建立和颜色的开发喝水结果禁止决策支持系统的 thisprocess.Cyclic 管理有人的联系大肠炎的瘤形成类似于那些的病理学的特征的表面的发育异常和癌症。观察的损害的发生和复合变化取决于使用的鼠标紧张(即,瑞士韦伯斯特, C57BL/6J , CBA , ICR )并且剂量(0.7%-5.0%)和瘤形成的 DSS.Theincidence 的时间表( 1-15 周期与或没有一个随后的恢复时期)能被增加,它到侵略癌症的前进由与已知的冒号致癌物在联合管理决策支持系统显著地加速了( azoxymethane ( AOM ), 2-ammo-3-methylimidazo [ 4,5-f ]喹啉( IQ ), 2-amino-l-methyl-6-phenylimidazo [ 4,5-b ] pyridine ( PhTP ))在遗传上定义的老鼠的联系大肠炎的瘤形成的最近的正式就职拉紧的 oriron.More 提供了新卓见进特定的基因的角色(即, adenomatous polyposiscoli ( Apc ), p53 ,可诱导的氮的氧化物 synthase ( i NOS ), Msh2 )在从 chemopreventive 干预的 colitis-associatedneoplasias.Emerging 数据的开发,研究在禁止导致决策支持系统的瘤形成记录几个代理人的功效并且提供 colitis-associatedcolorectal 瘤形成是可防止的疾病的大诺言。 | Margie Lee CLAPPER Harry Stanley COOPER Wen-Chi Lee CHANG | 2007 | Acta Pharmacologica Sinica2007，28，9： | 17 |
| 2 | Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC mice显示文摘AIM To evaluate the effect of orally administered plecanatide on colorectal dysplasia in Apc^(+/Min-FCCC) mice with dextran sodium sulfate(DSS)-induced inflammation. METHODS Inflammation driven colorectal carcinogenesis was induced in Apc^(+/Min-FCCC) mice by administering DSS in their drinking water. Mice were fed a diet supplemented with plecanatide(0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid,flat and indeterminate dysplasia was evaluated. Plecanatide-mediated activation of guanylate cyclase-C(GC-C) signaling was assessed in colon tissues by measuring cyclic guanosine monophosphate(cG MP) by ELISA, protein kinase G-II and vasodilator stimulated phosphoprotein by immunoblotting. Ki-67, c-myc and cyclin D1 were used as markers of proliferation. Cellular levels and localization of b-catenin in colon tissues were assessed by immunoblotting and immunohistochemistry, respectively. Uroguanylin(UG) and GC-C transcript levels were measured by quantitative reverse transcription polymerase chain reaction(RT-PCR). A mouse cytokine array panel was used to detect cytokines in the supernatant of colon explant cultures. RESULTS Oral treatment of Apc^(+/Min-FCCC) mice with plecanatide produced a statistically significant reduction in the formation of inflammation-driven polypoid, flat and indeterminate dysplasias. This anti-carcinogenic activity of plecanatide was accompanied by activation of cG MP/GC-C signaling mediated inhibition of Wnt/b-catenin signaling and reduced proliferation. Plecanatide also decreased secretion of pro-inflammatory cytokines(IL-6, IL-1 TNF), chemokines(MIP-1, IP-10) and growth factors(GCSF and GMCSF) from colon explants derived from mice with acute DSS-induced inflammation. The effect of plecanatidemediated inhibition of inflammation/dysplasia on endogenous expression of UG and GC-C transcripts was measured in intestinal tissues. Although GC-C expression was not altered appreciably, a statistically significant increase in the level of UG transcripts was detected in the proximal small intestine and colon, potentially due to a reduction in intestinal inflammation and/or neoplasia. Taken together, these results suggest that reductions in endogenous UG, accompanied by dysregulation in GC-C signaling, may be an early event in inflammation-promoted colorectal neoplasia; an event that can potentially be ameliorated by prophylactic intervention with plecanatide.CONCLUSION This study provides the first evidence that orally administered plecanatide reduces the multiplicity of inflammation-driven colonic dysplasia in mice, demonstrating the utility for developing GC-C agonists as chemopreventive agents. | Wen-Chi L Chang Shet Masih Anusha Thadi Viren Patwa Apoorva Joshi Harry S Cooper Vaseem A Palejwala Margie L Clapper Kunwar Shailubhai | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 5 |
| 3 | A- nalysis of railgun barrel material显示文摘 | Khershed P Cooper Harry N Jones Robert A Meger | 2007 | IEEE Trans Magn2007，43，1： | 1 |
| 4 | Synthesis of Research on Homework显示文摘 | Harris Cooper | 1989 | Education Leadership1989，，： | 1 |
| 5 | Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase显示文摘 | Aino Soro-Paavonen Wei-Zeng Zhang Kylie Venardos Melinda T Coughlan Emma Harris David CK Tong Daniella Brasacchio Karri Paavonen Jaye Chin-Dusting Mark E Cooper David Kaye Merlin C Thomas Josephine M Forbes | 2010 | Journal of Hypertension2010，，4： | 1 |
| 6 | Heavy metals in organic phases of river and estuarine sediment 显示文摘 | COOPER B S HARRIS R C | 1974 | Mar Pollut Bull1974，5，2： | 1 |
| 7 | Endoscopic imaging and size estimation of colorectal adenomas in the multiple intestinal neoplasia mouse显示文摘 | Harvey H. Hensley Carrie E. Merkel Wen-Chi L. Chang Karthik Devarajan Harry S. Cooper Margie L. Clapper | 2009 | Gastrointestinal Endoscopy2009，，3： | 1 |
| 8 | Comparison of bone graft matrices for human mesenchymal stem cell-directed osteogenesis显示文摘 | Harris CT Cooper LF | 2004 | J Biomed Mater Res A2004，68，4： | 1 |
| 9 | Toll-Like Receptor-4 Promotes the Development of Colitis-Associated Colorectal Tumors显示文摘 | Masayuki Fukata Anli Chen Arunan S. Vamadevan Jason Cohen Keith Breglio Suneeta Krishnareddy David Hsu Ruliang Xu Noam Harpaz Andrew J. Dannenberg Kotha Subbaramaiah Harry S. Cooper Steven H. Itzkowitz Maria T. Abreu | 2007 | Gastroenterology2007，，6： | 1 |
| 10 | Prevalence of oral mucesal lesions in alcohol misnsers in south London显示文摘 | Harris CK Warnakulasuriya KA Cooper DJ | 2004 | J Oral Pathol Med2004，33，5： | 1 |
| 11 | Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin 显示文摘 | S N S Murfliy Harry S Cooper Helen Shim | 1993 | Dig Dis Sci1993，38，9： | 1 |
| 12 | Make room for a mak- erspace 显示文摘 | JENNIFER HARRIS CHRIS COOPER | 2015 | Computers in Libraries2015，，3： | 1 |
| 13 | 显示文摘 | Harris PJ Cooper ME Hiranyachattada S | 1997 | Am J Physiol1997，272，： | 1 |
| 14 | Amino Acid Analysis,using postcolumn ninhydrin detection,in a biotechnology laboratory显示文摘 | Macchi F D Shen F J Keck R G Harris R J Cooper C Packer N Williams K | 2001 | Methods Mol Biol2001，，159： | 1 |
| 15 | Appendicovesicostomy: the Mitrofanoff procedure-a 15 year perspective显示文摘 | Harris C F Cooper C S Hutcheson J C | 2000 | J Urol2000，163，： | 1 |
| 16 | Simulating nitrate leaching under winter wheat grown on a structured clay soil considering bypass flow 显示文摘 | Ragab R Cooper DM Harris GL | 1996 | Journal of Hydrology1996，182，： | 1 |
| 17 | Type-Selective Benefits of Medications in Treatment of Acute Aortic Dissection (from the International Registry of Acute Aortic Dissection [IRAD])显示文摘 | Toru Suzuki Eric M. Isselbacher Christoph A. Nienaber Reed E. Pyeritz Kim A. Eagle Thomas T. Tsai Jeanna V. Cooper James L. Januzzi Alan C. Braverman Daniel G. Montgomery Rossella Fattori Linda Pape Kevin M. Harris Anna Booher Jae K. Oh Mark Peterson Vija | 2012 | The American Journal of Cardiology2012，，1： | 1 |
| 18 | Conscientious objection and its impact on abortion service provision in South Africa: a qualitative study显示文摘 | Harries J Cooper D Strebel A | 2014 | Reprod Health2014，11，1： | 1 |
| 19 | Make Room for a Makerspace显示文摘 | Harris J Cooper C | 2015 | Computers in Libraries2015，35，2： | 1 |
| 20 | Interim Report and Recommendations of the World Health Organization Task-Force for Osteoporosis显示文摘 | Harry K. Genant Cyrus Cooper Gyula Poor Ian Reid George Ehrlich J. Kanis B. E. Christopher Nordin Elizabeth Barrett-Connor Dennis Black J.-P. Bonjour Bess Dawson-Hughes Pierre D. Delmas J. Dequeker Sergio Ragi Eis Carlo Gennari Olaf Johnell C. Conrad John | 1999 | Osteoporosis International1999，，4： | 1 |
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