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| 1 | Lipids in liver transplant recipients显示文摘Hyperlipidemia is very common after liver transplantation and can be observed in up to 71% of patients. The etiology of lipid disorders in these patients is multifactorial, with different lipid profiles observed depending on the immunosuppressive agents administered and the presence of additional risk factors, such as obesity, diabetes mellitus and nutrition. Due to recent improvements in survival of liver transplant recipients, the prevention of cardiovascular events has become more important, especially as approximately 64% of liver transplant recipients present with an increased risk of cardiovascular events. Management of dyslipidemia and of other modifiable cardiovascular risk factors, such as hypertension, diabetes and smoking, has therefore become essential in these patients. Treatment of hyperlipidemia after liver transplantation consists of life style modification, modifying the dose or type of immunosuppressive agents and use of lipid lowering agents. At the start of administration of lipid lowering medications, it is important to monitor drugdrug interactions, especially between lipid lowering agents and immunosuppressive drugs. Furthermore, as combinations of various lipid lowering drugs can lead to severe side effects, such as myopathies and rhabdomyolysis, these combinations should therefore be avoided. To our knowledge, there are no current guidelines targeting the management of lipid metabolism disorders in liver transplant recipients. This paper therefore recommends an approach of managing lipid abnormalities occurring after liver transplantation. | anna hüsing iyad kabar hartmut h schmidt | 2016 | World Journal of Gastroenterology2016，22，12： | 6 |
| 2 | Single-operator cholangioscopy for biliary complications in liver transplant recipients显示文摘AIM To evaluate cholangioscopy in addition to endoscopic retrograde cholangiopancreatography(ERCP) for management of biliary complications after liver transplantation(LT).METHODS Twenty-six LT recipients with duct-to-duct biliary reconstruction who underwent ERCP for suspected biliary complications between April and December2016 at the university hospital of Muenster were consecutively enrolled in this observational study. After evaluating bile ducts using fluoroscopy, cholangioscopy using a modern digital single-operator cholangioscopy s y s t e m(S py G la s s D S ?) wa s pe r fo r me d dur ing the same procedure with patients under conscious sedation. All patients received peri-interventional antibiotic prophylaxis and bile was collected during the intervention for microbial analysis and for antibiotic susceptibility testing.RESULTS Thirty-three biliary complications were found in a total of 22 patients, whereas four patients showed normal bile ducts. Anastomotic strictures were evident in 14(53.8%) patients, non-anastomotic strictures in seven(26.9%), biliary cast in three(11.5%), and stones in six(23.1%). A benefit of cholangioscopy was seen in 12(46.2%) patients. In four of them, cholangioscopy was crucial for selective guidewire placement prior to planned intervention. In six patients, biliary cast and/or stones failed to be diagnosed by ERCP and were only detectable through cholangioscopy. In one case, a bile duct ulcer due to fungal infection was diagnosed by cholangioscopy. In another case, signs of bile duct inflammation caused by acute cholangitis were evident. One patient developed post-interventional cholangitis. No further procedure-related complications occurred. Thirty-seven isolates were found in bile. Sixteen of these were gram-positive(43.2%), 12(32.4%) were gram-negative bacteria, and Candida species accounted for 24.3% of all isolated microorganisms. Interestingly, only 48.6% of specimens were sensitive to prophylactic antibiotics.CONCLUSION Single-operator cholangioscopy can provide important diagnostic information, helping endoscopists to plan and perform interventional procedures in LT-related biliary complications. | Anna Hüsing-Kabar Hauke Sebastian Heinzow Hartmut Hans-Jürgen Schmidt Carina Stenger Hans Ulrich Gerth Michele Pohlen Gerold Tholking Christian Wilms Iyad Kabar | 2017 | World Journal of Gastroenterology2017，23，22： | 4 |
| 3 | Paclitaxel-eluting balloon dilation of biliary anastomotic stricture after liver transplantation显示文摘AIM:To investigate the safety and effectiveness of endoscopic therapy with a paclitaxel-eluting balloon(PEB) for biliary anastomotic stricture(AS) after liver transplantation(LT).METHODS:This prospective pilot study enrolled 13 consecutive eligible patients treated for symptomatic AS after LT at the University Hospital of Münster between January 2011 and March 2014.The patients were treated by endoscopic therapy with a PEB and followed up every 8 wk by endoscopic retrograde cholangiopancreatography(ERCP).In cases of re-stenosis,further balloon dilation with a PEB was performed.Follow-up was continued until 24 mo after the last intervention.RESULTS:Initial technical feasibility,defined as successful balloon dilation with a PEB during the initial ERCP procedure,was achieved in 100% of cases.Long-term clinical success(LTCS),defined as no need for further endoscopic intervention for at least 24 mo,was achieved in 12 of the 13 patients(92.3%).The mean number of endoscopic interventions required to achieve LTCS was only 1.7 ± 1.1.Treatment failure,defined as the need for definitive alternative treatment,occurred in only one patient,who developed recurrent stenosis with increasing bile duct dilatation that required stent placement.CONCLUSION:Endoscopic therapy with a PEB is very effective for the treatment of AS after LT,and seems to significantly shorten the overall duration of endoscopic treatment by reducing the number of interventions needed to achieve LTCS. | Anna Hüsing Holger Reinecke Vito R Cicinnati Susanne Beckebaum Christian Wilms Hartmut H Schmidt Iyad Kabar | 2015 | World Journal of Gastroenterology2015，21，3： | 4 |
| 4 | 海洋真菌Aspergillus sp.中的抗肿瘤成分显示文摘目的:研究一株分离自条斑紫菜丝状体上的真菌代谢产物的活性成分。方法:利用电镜观察真菌形态特征,利用MEA培养基进行大规模发酵,经硅胶层析、葡聚糖凝胶层析等各种层析手段分离化合物,通过波谱技术鉴定化合物结构,并利用MTT法测定化合物抗肿瘤活性。结果:该菌属于曲霉属,分离得到了两个化合物1和2,分别为cyclo(L-Trp-L-Phe)(1)和WIN64821(2)。MTT法测试结果表明,cyclo(L-Trp-L-Phe)和WIN64821对37株人体肿瘤细胞株具有中等细胞毒活性,其平均IC50分别为3.3和5.8μg·mL-1。结论:第一次报道这两种化合物的抗肿瘤活性。 | 丁玲 李富超 秦梅 秦松 KELTER Gerhard FIEBIG Heinz H LAATSCH Hartmut | 2008 | 中国天然药物2008，6，6： | 3 |
| 5 | Non-convulsive status epilepticus in adults:clinical forms and treatment显示文摘 | Hartmut M Martin H | 2007 | Lancet Neurol2007，6，4： | 1 |
| 6 | Endoscopic therapy for esophageal perforation or anastomotic leak with a self-expandable metallic stent显示文摘 | Jessica M. Leers Carlo Vivaldi Hartmut Sch?fer Marc Bludau Jan Brabender Georg Lurje Till Herbold Arnulf H. H?lscher Ralf Metzger | 2009 | Surgical Endoscopy2009，，10： | 1 |
| 7 | Discrimination of sepsis and systemicinflammatory response Syndrome by determination of circulating plasma co ncentrations of procalcitonin,protein complement 3a,and interlenkin-6 显示文摘 | Oliver S Hartmut H Michael M | 2000 | Crit Care Med2000，28，8： | 1 |
| 8 | Botox, dilation, or myotomy? Clinical outcome of interventional and surgical therapies for achalasia显示文摘 | Christian Alexander Gutschow Ulrich T?x Jessica Leers Hartmut Sch?fer Klaus Ludwig Prenzel Arnulf H. H?lscher | 2010 | Langenbeck’s Archives of Surgery2010，，8： | 1 |
| 9 | Impact of allogeneic haematopoietic stem cell transplantation in patients with abnl(17p) acute myeloid leukaemia显示文摘 | Brigitte Mohr Johannes Schetelig Kerstin Sch?fer‐Eckart Norbert Schmitz Mathias H?nel Wolf R?sler Norbert Frickhofen Hartmut Link Andreas Neubauer Ulrich Schuler Uwe Platzbecker Jan M. Middeke Gerhard Ehninger Martin Bornh?user Markus Schaich Friedrich St | 2013 | Br J Haematol2013，，： | 1 |
| 10 | Nonconvulsive status epilepticus: a diagnostic and therapeutic challenge in the intensive care setting 显示文摘 | Martin H Hartmut M | 2011 | Neurological Disorders2011，4，3： | 1 |
| 11 | Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy显示文摘 | Kevin J Martin Klaus Olgaard Jack W Coburn Giorgio M Coen Masafumi Fukagawa Craig Langman Hartmut H Malluche James T McCarthy Shaul G Massry Otto Mehls Isidro B Salusky Justin M Silver Miroslaw T Smogorzewski Eduardo M Slatopolsky Linda McCann | 2004 | American Journal of Kidney Diseases2004，，3： | 1 |
| 12 | Parent bisphenol A accumula-tion in the human maternal-fetal-placental unit显示文摘 | Gilbert S Werner W Hartmut H | 2002 | Environ HealthPerspect2002，110，： | 1 |
| 13 | Trifluoroacetate in ocean waters显示文摘 | Hartmut Frank Eugen H Christoph | | 0，，： | 1 |
| 14 | On moving continua with contacts and sliding friction:Modeling,general properties and examples显示文摘 | Hartmut H | 2009 | International Journal of Solids and Structures2009，46，13： | 1 |
| 15 | Natural regeneration and succession-results from a 13 years study with reference to mesofauna and vegetation, and implications for management显示文摘 | KOEHLER HARTMUT H | 2000 | landscape and urban planning2000，51，： | 1 |
| 16 | Reduction of Spri- ngback using simultaneous stretch -bending processes 显示文摘 | Hansjrg S Joungsik S Hartmut H | 2012 | International Journal of Mechanical Sciences2012，，： | 1 |
| 17 | Mid-term course after pediatric right ventricular outflow tract reconstruction:a comparison of homografts,porcine xenografts and contegras显示文摘 | Dietmar B Wolf-Rudiger T Hartmut H | 2005 | European Cardiothorac Surg2005，27，1： | 1 |
| 18 | A muscle-reflex model that en- codes principles of legged mechanics produces human walking dynamics and muscle activities 显示文摘 | Hartmut G Hugh H | 2010 | IEEE Trans- actions on Neural Systems and Rehabilitation Engineer- ing2010，18，3： | 1 |
| 19 | Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel,on behalf of the European Leukemia Net显示文摘 | Hartmut Dhner Elihu H Estey Sergio Amadori | 2010 | The American Society of Hematology2010，115，3： | 1 |
| 20 | Role of genotyping in Wilson's disease显示文摘 | Hartmut H | 2009 | J Hepatol2009，50，3： | 1 |
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