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| 1 | Comparison of pre-treatment and post-treatment use of selenium in retinal ischemia reperfusion injury显示文摘AIM: To investigate the effects of selenium in rat retinal ischemia reperfusion(IR) model and compare pretreatment and post-treatment use.METHODS: Selenium pre-treatment group(n =8) was treated with intraperitoneal(i.p.) selenium 0.5 mg/kg for7 d and terminated 24 h after the IR injury. Selenium posttreatment group( n = 8) was treated with i. p. selenium0.5 mg/kg for 7d after the IR injury with termination at the end of the 7d period. Sham group(n =8) received i.p.saline injections identical to the selenium volume for 7d with termination 24 h after the IR injury. Control group(n =8) received no intervention. Main outcome measures were retina superoxide dismutase(SOD), glutathione(GSH),total antioxidant status(TAS), malondialdehyde(MDA),DNA fragmentation levels, and immunohistological apoptosis evaluation.RESULTS: Compared to the Sham group, selenium pre-treatment had a statistical difference in all parameters except SOD. Post-treatment selenium also resulted in statistical differences in all parameters except the MDA levels. When comparing selenium groups, the pre-treatment selenium group had a statistically higher success in reduction of markers of cell damage such as MDA and DNA fragmentation. In contrast, the post-selenium treatment group had resulted in statisticallyhigher levels of GSH. Histologically both selenium groups succeeded to limit retinal thickening and apoptosis. Pre-treatment use was statistically more successful in decreasing apoptosis in ganglion cell layer compared to post-treatment use.CONCLUSION: Selenium was successful in retinal protection in IR injuries. Pre-treatment efficacy was superior in terms of prevention of tissue damage and apoptosis. | Alper Yazici Hasan Aksit Esin Sogutlu Sari Arzu Yay Haydar Ali Erken Dilek Aksit Harun Cakmak Kamil Seyrek Sitki Samet Ermis | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 3 |
| 2 | Corneal white-to-white distance and mesopic pupil diameter显示文摘·AIM:To study the relationship between corneal white-to- white (WTW) distance and mesopic pupil diameter. ·METHODS:This study is composed of 30 cases that underwent photorefractive keratotomy (PRK). Pupil size measurements were performed with Schwind ORK wavefront analyzer in mesopic conditions. WTW distance was measured with a measuring caliper. Also, A-scan ultrasound examination was performed in all patients. The relationship among the mesopic pupil diameter and age, sex, axial length, lens thickness, anterior chamber depth(ACD), horizontal WTW distance, vertical WTW distance, spherical equivalent, and average keratometry were analyzed with univariate and multivariate regression analysis. ·RESULTS:Mean pupil diameter was (6.39±0.80)mm (range:3.70mm to 7.73mm. Horizontal WTW distance measurements were between 11.00mm and 12.50mm and mean horizontal WTW distance was (11.79±0.43)mm. On the other hand, vertical WTW distances ranged between 10.00mm and 13.00mm, and their mean was(11.42±0.72)mm. Bivariate correlation between pupil diameter and other variables showed that the axial length, ACD, spherical equivalent, and horizontal WTW distance had a moderate correlation with mesopic pupil diameter. Multiple regression analysis revealed that spherical equivalent and horizontal WTW distances were significantly associated with mesopic pupil diameter (R =0.598, R 2=0.358 P =0.02). ·CONCLUSION:This study shows that mesopic pupil diameter is closely related to horizontal WTW distance. These two factors must be taken in consideration together in preoperative ablation zone planning. | Hasan Basri Cakmak Nurullah Cagil Huseyin Simavli Sabri Raza | 2012 | International Journal of Ophthalmology(English edition)2012，5，4： | 1 |
| 3 | A statistical approach to classification of keratoconus显示文摘INTRODUCTION The front portion of the eye consists of a transparent layer called the cornea.The cornea is an important optical component for vision and plays a role in the specific refraction of the eye.The cornea normally has convexity but the amount of protrusion progressively increases in patients with keratoconus.In other words,the cornea prolapses forward.Keratoconus is a bilateral,typically asymmetric and non-inflammatory degeneration of the cornea caused by corneal protrusion as a result of progressive thinning of the corneal stroma.Corneal thinning generally occurs in the inferior,inferotemporal or central regions of the cornea^([1]).However,corneal thinning in the upper quadrants of | Murat Ucar Hasan Basri Cakmak Baha Sen | 2016 | International Journal of Ophthalmology(English edition)2016，9，9： | 1 |
| 4 | Synthesis and characteriza tion of a new silaborazine derivative 显示文摘 | Hasan Cakmak Martin Jansen | 2011 | Z Anorg Allg Chem2011，637，： | 1 |
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