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| 1 | Should antibiotics be administered before arthroscopic knee surgery? A systematic review of the literature显示文摘AIM To explore the current evidence surrounding the administration of prophylactic antibiotics for arthroscopic knee surgery. METHODS Databases were searched from inception through May of 2018 for studies examining prophylactic antibiotic use and efficacy in knee arthroscopy. Studies with patient data were further assessed for types of arthroscopic procedures performed,number of patients in the study,use of antibiotics,and outcomes with the intention of performing a pooled analysis. Data pertaining to 'deep tissue infection' or 'septic arthritis' were included in our analysis. Reported data on superficial infection were not included in our data analysis. For the pooled analysis,a relative risk ratio was calculated and χ~2 tests were used to assess for statistical significance between rates of infection amongst the various patient groups. Post hoc power analyses were performed to compute the statistical power obtained from our sample sizes. Number needed to treat analyses were performed for statistically significant differences by dividing 1 by the difference between the infection rates of the antibiotic and no antibiotic groups. An alpha value of 0.05 was used for our analysis. Study heterogeneity was assessed by Cochrane's Q test as well as calculation of the I^2 value.RESULTS A total of 49682 patients who underwent knee ar-throscopy for a diverse set of procedures across 19 studies met inclusion critera for pooled analysis. For those not undergoing graft procedures,there were 27 cases of post-operative septic arthritis in 34487 patients(0.08%) who received prophylactic antibiotics and 16 cases in 10911(0.15%) who received none [risk ratio(RR) = 0.53,95% confidence interval(CI): 0.29-0.99,P = 0.05]. A sub-group analysis in which bony procedures were excluded was performed which found no significant difference in infection rates between patients that received prophylactic antibiotics and patients that did not(P > 0.05). All anterior cruciate ligament reconstruction studies used prophylactic antibiotics,but two studies investigating the effect of soaking the graft in vancomycin in addition to standard intravenous(IV) prophylaxis were combined for analysis. There were 19 cases in 1095 patients(1.74%) who received IV antibioitics alone and no infections in 2034 patients who received IV antibiotics and had a vancomycin soaked graft(RR = 0.01,95%CI: 0.001-0.229,P < 0.01).CONCLUSION Prophylactic antibiotics are effective in preventing septic arthritis following simple knee arthroscopy. In procedures involving graft implantation,graft soaking reduces the rate of infection. | John Carney Nathanael Heckmann Erik N Mayer Ram K Alluri Carleton Thomas Vangsness George F Hatch Ⅲ Alexander E Weber | 2018 | World Journal of Orthopedics2018，9，11： | 2 |
| 2 | Using supplier networks to learn faster 显示文摘 | Dyer J H Hatch N | 2004 | Sloan Management Review2004，45，3： | 1 |
| 3 | Relation - specific capabilities and barriers to knowledge transfers: Creating advantage through network relationships显示文摘 | Dyer J H Hatch N W | 2006 | Strategic Management Journal2006，27，8： | 1 |
| 4 | Relation-specific Capabilities and Barriers to Knowledge Transfers: Creating Advantage Through Network Relationships显示文摘 | Dyer J H Hatch N W | 2006 | Strategic Management Journal2006，27，： | 1 |
| 5 | The serum sensitivity,colonial morphology,serogroup specificity,and outer membrane protein of Pseudomonas aeruginosa strains isolated from several clinical sites显示文摘 | Schiller N L Hatch R A | 1983 | Diagn Microbiol Infect Di1983，1，： | 1 |
| 6 | Carbonic anhydrase activity in leaves and its role in the first step of C4 photosynthesis 显示文摘 | Hatch M D Burnell J N | 1990 | Plant Physiol1990，93，： | 1 |
| 7 | Effect of exercise garment fabric and environment on cutaneous conditions of human subjects显示文摘 | MARKEE N L HATCH K L FRENCH S N | 1991 | Clothing and Textile Research Journal1991，9，4： | 1 |
| 8 | FGF signaling in craniofacial biologicalcontrol and pathological craniofacial development 显示文摘 | Hatch N E | 2010 | Crit Rev Eukaryot Gene Expr2010，20，4： | 1 |
| 9 | Damage control resuscitation is associated with a reduction in resuscitation volumes and improvement in survival in 390 damage control laparotomy patients显示文摘 | Cotton BA Reddy N Hatch QM | 2011 | Ann Surg2011，254，4： | 1 |
| 10 | Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection - California, April-May, 2009显示文摘 | Louie J Winter K Harriman K Vugia D Glaser C Matyas B Schnurr D Guevara H Pan C Y Saguar E Berumen R Hunley E Messenger S Preas C Hatch D Chavez G Kriner P Lopez K Sunega D Rexin D Roach S Kempf J Gonzalez R Morgan L Barnes N Berm | 2009 | MMWR Morbidity and Mortality Weekly Report2009，，19： | 1 |
| 11 | Carbonic anhydrase activity in leaves and its role in the first step of C3 photosynthesis显示文摘 | Bumell J N | 1990 | Plant Physiol1990，93，： | 1 |
| 12 | Low bundle sheath carbonic anhydrase is apparently essential for effective C4 pathway operation显示文摘 | Burnell J N Hatch M D | 1988 | Plant Physiol1988，86，： | 1 |
| 13 | Impact of nostalgia and past experience on recreational demand for wilderness显示文摘 | ACHARYA N PAUDEL K P HATCH L U | | 0，，05： | 1 |
| 14 | Relation-specific capabilitiesand barriers to knowledge transfers: Creating advan-tage through network relationships显示文摘 | Dyer J H Hatch N W | 2006 | Strategic Mana-gement Journal2006，27，8： | 1 |
| 15 | Impact of Nostalgia and Past Experience Eonre Creational Demand for Wilderness显示文摘 | Acharya Ram N Paudel KrishnaP Hatch L Upto | | 0，，16： | 1 |
| 16 | Using Supplier Networks to Learn Faster显示文摘 | Dyer JH Hatch N W | 2004 | Sloan Management Review2004，，3： | 1 |
| 17 | Relation-specific capabilities and barriers to knowledge transfers: Creating advantage through network relationships 显示文摘 | Dyer J H Hatch N W | 2006 | Strategic Management Journal2006，27，： | 1 |
| 18 | Relation - specific capabilities and barriers to knowledge transfers: creating advantage through network relationships 显示文摘 | Dyer J H Hatch N W | 2006 | Strategic Management Journal2006，27，8： | 1 |
| 19 | Human capital and learning as a source of sustainable competitive advantage显示文摘 | Hatch N W Dyer J H | 2004 | Strategic Management Journal2004，25，12： | 1 |
| 20 | Low bundle sheath carbonic anhydrase is apparently essential for effective C4 pathway operation显示文摘 | Burnell J N Hatch M D | 1990 | Plant Physiolog1990，86，： | 1 |
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