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| 1 | Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection显示文摘Plasmonic nanoantennas offer new applications in mid-infrared(mid-IR)absorption spectroscopy with ultrasensitive detection of structural signatures of biomolecules,such as proteins,due to their strong resonant near-fields.The amide I fingerprint of a protein contains conformational information that is greatly important for understanding its function in health and disease.Here,we introduce a non-invasive,label-free mid-IR nanoantenna-array sensor for secondary structure identification of nanometer-thin protein layers in aqueous solution by resolving the content of plasmonically enhanced amide I signatures.We successfully detect random coil to crossβ-sheet conformational changes associated withα-synuclein protein aggregation,a detrimental process in many neurodegenerative disorders.Notably,our experimental results demonstrate high conformational sensitivity by differentiating subtle secondary-structural variations in a nativeβ-sheet protein monolayer from those of crossβ-sheets,which are characteristic of pathological aggregates.Our nanoplasmonic biosensor is a highly promising and versatile tool for in vitro structural analysis of thin protein layers. | Dordaneh Etezadi John B Warner IV Francesco S Ruggeri Giovanni Dietler Hilal A Lashuel Hatice Altug | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 2 | Use of surfactants to remove water-based inks from plastic film:effect of calcium ion concentration and length of surfactant hydrophobe显示文摘 | Hatice G John F S Sherril D C | 2004 | Colloid Polymer Science2004，283，： | 1 |
| 3 | Decreased plasma concentrations of adiponectin in patients with slow coronary flow显示文摘 | Hatice S Mehmet Ts Ahmet T | 2009 | Heart Vessels2009，24，1： | 1 |
| 4 | The effects of regular aerobic exercise on renal functions in streptozotocin induced diabetic rats显示文摘 | Hatice K Sunay S Nilay E | 2010 | Journal of Sports Science and Medicine2010，9，： | 1 |
| 5 | Use ol surlactants to removewater-based inks from plastic film: effect of calcium ionconcentration and length of surfactant hydrophobe 显示文摘 | Hatice G John F S Sherril D C | 2004 | ColloidPolymer Science2004，283，： | 1 |
| 6 | 3-T MRI of the biliary tract variations显示文摘 | Hakan ?nder Muhammed S?dd?k ?zdemir Güven Tekba? Faysal Ekici Hatice Gümü? Aslan Bilici | 2013 | Surgical and Radiologic Anatomy2013，，2： | 1 |
| 7 | Particulated juvenile articular cartilage graft(DeNovo NT Graft) for treatment of osteochondral lesions of the talus显示文摘 | Hatic S O 2nd Berlet G C | 2010 | Foot Ankle Spe2010，3，6： | 1 |
| 8 | Ginkgo biloba( EGB761 ) affects apoptosis and nitric- oxide synthases in testicular torsion: An experimental study显示文摘 | Turgay A Ersagun K Hatice S | 2009 | Int Urol Nephrol2009，41，： | 1 |
| 9 | The influence of humic acids on the phytoexaction of cadmium from soil 显示文摘 | Michael W H E Hatice D Andreas S | 2004 | Chemosphere2004，57，： | 1 |
| 10 | Decreased plasma concentrations of adiponectin in patients with slow coronary flow显示文摘 | Hatice S Mehmet Ts Ahmet T | | Heart and Vessels0，，： | 1 |
| 11 | Dynamic flux balanceanalysis for pharmaceutical protein production by Pichia pastoris :Human growth hormone 显示文摘 | Pinar C Merve S Hatice T | 2011 | Journal of Biotechnology2011，48，3： | 1 |
| 12 | The effeets of regular aerobic exer- cise on renal fimctions in streptozotocin induced diabetic rats显示文摘 | HATICE K SUNAY S N1LAY E | 2010 | Journal of Sports Science and Medicine2010，，9： | 1 |
| 13 | Deinking of water-based ink printing form plastic film using nonionic surfactants显示文摘 | HATICE G JOHN F S SHERRIL D C | 2002 | Surfactants and Detergents2002，5，4： | 1 |
| 14 | Use of Surfactants to Remove Water-Based Inks From Plastic Film: Effect of Calcium Ion Concentration and Length of Surfactant Hydrophobe 显示文摘 | Hatice G John F S Sherril D Christian | 2004 | Colloid Polymer Science2004，283，： | 1 |
| 15 | The role of VEGF and its receptors in the etiology of early pregnancy loss显示文摘 | Ilknur ? ? l-Madendag Yusuf Madendag Sü ndü z ? zlem Altinkaya Hatice Bayramoglu Nuri Danisman | 2013 | Gynecological Endocrinology2013，，2： | 1 |
| 16 | Serum malondialdehyde level in patients infected with Ascaris lumbricoides显示文摘AIM:The aim of the study was to investigate the changes of serum malondialdehyde level, I.e; the oxidative stress hypothesis in patients infected with Ascaris lumbricoides.METHODS: Serum malondialdehyde activity was measured in 43 patients who were positive for intestinal parasite of Ascaris lumbricoides. Scores were obtained for the positives and their age-and sex-matched 60 Ascaris lumbricoides negative healthy controls.RESULTS: The difference between malondialdehyde levels of patients infected with Ascaris lumbricoides and control group was statistically significant both for females (P<0.05)and for males (P<0.05). In the patient and control groups,no correlation was found between age and malondialdehyde levels (P>0.05) both in females and in males. In addition,no significant correlation could be found between malondialdehyde levels of both females and males for patients and control groups (P>0.05).CONCLUSION: Malondialdehyde levels clearly increase in patients infected with Ascaris lumbricoides. | Eser Kilic Süleyman Yazar Recep Saraymen Hatice Ozbilge | 2003 | World Journal of Gastroenterology2003，9，10： | 0 |
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