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		题名	作者	年代	出处	被引量
	1	Genome sequence of the Thermotoga thermarum type strain (LA3T) from an African solfataric spring 显示文摘	G?ker M Spring?S Scheuner C Anderson I Zeytun A Nolan M Lucas S Tice H Del Rio TG Cheng JF Han C Tapia R Goodwin LA Pitluck S Liolios K Mavromatis K Pagani I Ivanova N Mikhailova N Pati A Chen A Palaniappan K Land M Hauser L Chang YJ Jeffries CD Rohde M Detter JC Woyke T Bristow J Eisen JA Markowitz V Hugenholtz P Kyrpides NC Klenk HP Lapidus A	2014	Stand Genomic Sci2014，9，3：	1
	2	Nephrin and endothelial injury显示文摘	Hauser P V Collino F Bussolati B	2009	Curr Opin Nephrol Hypertens2009，18，1：	1
	3	The Chlamydomonas genome reveals the evolution of key animal and plant functions 显示文摘	Merchant S S Prochnik S E Vallon O Harris E H Karpowicz S J Witman G B Terry A Salamov A Fritz-Laylin L K Marechal- Drouard L Marshall W F Qu L H Nelson D R Sanderfoot A A Spalding M H Kapitonov V V Ren Q Ferris P Lindquist E Shapiro H Lucas S M Grimwood J Schmutz J Cardol P Cerutti H Chanfreau G Chen C L Cognat V Croft M T Dent R Dutcher S Fernandez E Fukuzawa H Gonzalez-Ballester D Gonzalez-Halphen D Hallmann A Hanikenne M Hippler M Inwood W Jabbari K Kalanon M Kuras R Lefebvre P A Lemaire S D Lobanov A V Lohr M Manuell A Meier I Mets L Mittag M Mittelmeier T Moroney J V Moseley J Napoli C Nedelcu A M Niyogi K Novoselov S V Paulsen I T Pazour G Purton S Ral J P Riano-Pachon D M Riekhof W Rymarquis L Schroda M Stern D Umen J Willows R Wilson N Zimmer S LAllmer J Balk J Bisova K Chen C J Elias M Gendler K Hauser C Lamb M R Ledford H Long J C Minagawa J Page M D Pan J Pootakham W Roje S Rose A Stahlberg E Terauchi A M Yang P Ball S Bowler C Dieckmann C L GIadyshev V N Green P Jorgensen R Mayfield S Mueller-Roeber B Rajamani S Sayre R T Brokstein P Dubchak I Goodstein D Hornick L Huang Y W Jhaveri J Luo Y Martinez D Ngau W C Otillar B Poliakov A Porter A Szajkowski L Werner G Zhou K Grigoriev I V Rokhsar D S Grossman A R	2007	Science2007，318，5848：	1
	4	Stem cells derived from human amniotic fluid contribute to acute kidney injury recovery显示文摘	Hauser P V De Fazio R Bruno S	2010	Am J Pathol2010，177，4：	1
	5	Apolipoprotein E: from lipid transport to neurobiology显示文摘	Hauser P S Narayanaswami V Ryan R O	2011	Prog Lipid Res2011，50，1：	1
	6	Late sequelae of whiplash injury with dissection of cervical arteries显示文摘	Hauser V Zangger P Winter Y	2010	Eur Neurol2010，64，4：	1
	7	Apolipopro- tein E: From lipid transport to neurobiology显示文摘	Hauser P S Narayanaswami V Ryan R O 2011	2011	Progress in Lipid Research2011，50，1：	1
	8	Stem cells derived from human amniotic fluid contribute to acute kidney injury recovery显示文摘	Hauser P V De Fazio R Bruno S	2010	Am J Pathol2010，177，4：	1
	9	Apoli- poprotein E: from lipid transport to neurobiology 显示文摘	HAUSER P S NARAYANASWAMI V RYAN R O	2011	Pros Lip- id Res2011，50，1：	1
	10	Stem cells derived from human amr~otic fluid contribute to acute kidney injury recovery显示文摘	Hauser P V De Fazio R Bruno S	2010	Am J Patho12010，177，4：	1
	11	Effect of Pigment Particle Size on Application Properties显示文摘	Gilnthert P Hauser P Radtke V	1989	Review of Progress in Coloration and Related Topics1989，19，1：	1
	12	Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors显示文摘Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support methods.Digital drug assignment(DDA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted agents.DDA has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical trial.The aim of this study was to evaluate the utility of DDA in pediatric oncology.Methods Between 2017 and 2020,103 high-risk pediatric cancer patients(<21 years)were involved in our precision oncology program,and samples from 100 patients were eligible for further analysis.Tissue or blood samples were analyzed by whole-exome(WES)or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the DDA algorithm for therapeutic decision support.Finally,a molecular tumor board(MTB)evaluated the results to provide therapy recommendations.Results Of the 100 cases with comprehensive molecular diagnostic data,88 yielded WES and 12 panel sequencing results.DDA identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug resistance.Actionability reached 88%(29/33)by 2020 due to the continuous updates of the evidence database.MTB approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed therapies.Filtering of WES results for targeted panels missed important mutations affecting therapy selection.Conclusions DDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine care of high-risk pediatric cancers.Knowledgebase updates enable automatic interpretation of a continuously expanding gene set,a“virtual”panel,filtered out from genome-wide analysis to always maximize the performance of precision treatment planning.	Barbara Vodicska Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKispéter Róbert Dóczi Dóra Lakatos Anna Dirner Mátyás Vidermann Péter Filotás Réka Szalkai-Dénes István Szegedi Katalin Bartyik Krisztina Míta Gábor Réka Simon Péter Hauser György Péter Csongor Kiss Miklós Garami István Peták	2023	World Journal of Pediatrics2023，19，10：	0

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