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| 1 | Recent advances in mammalian reproductive biology显示文摘Reproductive biology is a uniquely important topic since it is about germ cells, which are central for transmitting genetic information from generation to generation. In this review, we discuss recent advances in mammalian germ cell development,including preimplantation development, fetal germ cell development and postnatal development of oocytes and sperm. We also discuss the etiologies of female and male infertility and describe the emerging technologies for studying reproductive biology such as gene editing and single-cell technologies. | Lu Wen Qiang Liu Jingjing Xu Xixi Liu Chaoyi Shi Zuwei Yang Yili Zhang Hong Xu Jiang Liu Hui Yang Hefeng Huang Jie Qiao Fuchou Tang Zi-Jiang Chen | 2020 | Science China(Life Sciences)2020，63，1： | 6 |
| 2 | Recruited CD68^(+)CD206^(+)macrophages orchestrate graft immune tolerance to prompt xenogeneic-dentin matrix-based tooth root regeneration显示文摘Successful regenerative medicine strategies of xenogeneic extracellular matrix need a synergistic balance among inflammation,fibrosis,and remodeling process.Adaptive macrophage subsets have been identified to modulate inflammation and orchestrate the repair of neighboring parenchymal tissues.This study fabricated PPARγ-primed CD68+CD206+M2 phenotype(M2γ),and firstly verified their anti-inflammatory and tissue-regenerating roles in xenogeneic bioengineered organ regeneration.Our results showed that Th1-type CD3^(+)CD8^(+)T cell response to xenogeneic-dentin matrix-based bioengineered root complex(xeno-complex)was significantly inhibited by M2γmacrophage in vitro.PPARγactivation also timely recruited CD68^(+)CD206^(+)tissue macrophage polarization to xeno-complex in vivo.These subsets alleviated proinflammatory cytokines(TNF-α,IFN-γ)at the inflammation site and decreased CD3^(+)CD8^(+)T lymphocytes in the periphery system.When translated to an orthotopic nonhuman primate model,PPARγ-primed M2 macrophages immunosuppressed IL-1β,IL-6,TNF-α,MMPs to enable xeno-complex to effectively escape immune-mediated rejection and initiate graft-host synergistic integrity.These collective activities promoted the differentiation of odontoblast-like and periodontal-like cells to guide pulp-dentin and cementum-PDLs-bone regeneration and rescued partially injured odontogenesis such as DSPP and periostin expression.Finally,the regenerated root showed structure-biomechanical and functional equivalency to the native tooth.The timely conversion of M1-to-M2 macrophage mainly orchestrated odontogenesis,fibrogenesis,and osteogenesis,which represents a potential modulator for intact parenchymal-stromal tissue regeneration of targeted organs. | Hui Li Jingjing Sun Hefeng Yang Xue Han Xiangyou Luo LiJun Liao Bo Yang Tian Zhu Fangjun Huo Weihua Guo Weidong Tian | 2021 | Bioactive Materials2021，6，4： | 2 |
| 3 | Research on polyfluorene derivatives end-capped by N-hexyl-carbazole and benzene显示文摘Copolymers of 9,9-dioctylfluorene (DOF) and 2-thienyl-benzothiadiazole (DBT) were synthesized by Suzuki reaction and end-capped by N-hexyl-carbazole and benzene, which were abbreviated as PDOF-DBT-Cz and PDOF-DBT-B, respectively. The photophysical, electrochemical and thermal properties of the copolymers were studied. The results indicated that replacement of N-hexyl-carbazole as end-capping group of PDOF-DBT can vary light color and improve luminescence efficiency. | Yang Xu Hua Wang FangFang Wei JianXin Hou HeFeng Zhou BingShe Xu | 2009 | Science China(Technological Sciences)2009，52，8： | 1 |
| 4 | An amorphous FeMoO_(4) nanorod array enabled high-efficiency oxygen evolution electrocatalysis in alkaline seawater显示文摘The development of highly efficient and durable oxygen evolution reaction(OER)catalysts for seawater electrolysis is of great importance for applications.Here,an amorphous FeMoO_(4) nanorod array on Ni foam is reported as a highly active OER electrocatalyst in alkaline seawater,requiring only overpotentials of 303 and 332 mV to achieve 100 and 300 mA·cm^(-2),respectively.Moreover,it shows strong long-term electrochemical durability for at least 50 h. | Jie Tang Shengjun Sun Xun He Hui Zhang Chaoxin Yang Min Zhang Meng Yue Hefeng Wang Yuntong Sun Yonglan Luo Sulaiman Alfaifi Asmaa Farouk Mohamed S.Hamdy Xuping Sun Huiqing Wang Binwu Ying | 2024 | Nano Research2024，17，4： | 0 |
| 5 | Comprehensive analysis of long noncoding RNAs and mRNAs expression profiles and functional networks during chondrogenic differentiation of murine ATDC5 cells显示文摘Chondrogenic differentiation is a coordinated biological process orchestrated by various cell signaling pathways,involving complex pathways regulated at both transcriptional and post-transcriptional levels.Long noncoding RNAs(lncRNAs)are emerging as important regulators in the modulation of multiple cell processes.However,the potential roles of lncRNAs and their regulatory mechanisms in chondrogenic differentiation remain largely unclear.In this study,microarray was performed to detect the expression profiles of lncRNAs and messenger RNAs(mRNAs)during chondrogenic differentiation of murine chondrogenic cell line ATDC5.Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis were performed to explore their functions.Coding-noncoding co-expression(CNC)and competing endogenous RNA(ceRNA)networks were also constructed with bioinformatics methods.The results revealed that 1009 lncRNAs and 1206 mRNAs were differentially regulated during chondrogenic differentiation.GO and KEGG pathway analysis indicated that the principal functions of the transcripts were associated with system development and extracellular matrix-receptor interaction,TGF-βsignaling,and PI3K-Akt signaling pathways.The CNC network showed that lncRNA AK136902 was positively correlated with prostaglandin F receptor(FP).The ceRNA network covered 3 lncRNAs,121 miRNAs and 241 edges.The upregulated lncRNA AK136902,AK016344,and ENSMUST00000180767 might promote chondrogenic differentiation by acting as ceRNAs.Knockdown of lncRNA AK136902 could inhibit the mRNA expression of FP and other chondrogenic related genes,including Aggrecan and Col2a1 during chondrogenic differentiation.Our results provide a new perspective on the modulation of lncRNAs during chondrogenic differentiation. | Wei Wang Yu Ding Yanhua Xu Hefeng Yang Wenjing Liu Haixia Wang Ceshi Chen Rong Liu Song Li | 2019 | Acta Biochimica et Biophysica Sinica2019，51，8： | 0 |
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