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您的检索式：作者名="Hehan Tang"
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| 1 | White matter connectivity damage secondary to hippocampal and amygdala target injuries in acute limbic encephalitis Diffusion tensor image and voxel-based morphometry paired study显示文摘BACKGROUND:Limbic encephalitis is a rare syndrome that specifically affects the limbic system. Magnetic resonance imaging(MRI) has been typically used to detect brain changes in this disease. However,the mechanisms of limbic encephalitis-related white matter damage remain poorly understood. OBJECTIVE:To characterize white matter connectivity changes secondary to injuries of the limbic system in limbic encephalitis through combined application of diffusion tensor imaging(DTI) and voxel-based morphometry. DESIGN,TIME AND SETTING:A non-randomized,controlled,clinical,neuroimaging,DTI study was performed at the Department of Radiology,West China Hospital in December 2008. PARTICIPANTS:A male,46-year-old,limbic encephalitis patient,as well as 11 age- and gender-matched healthy volunteers,were enrolled in the present study. METHODS:MRI was performed on the limbic encephalitis patient using a 3.0T MR scanner. Three-dimensional SPGR T1-weighted images and DTI were acquired in the patient and controls. Data were analyzed using Matlab 7.0 and SPM2 software. MAIN OUTCOME MEASURES:Results from routine MRI scan with contrast enhancement of patient,as well as fractional anisotropy and mean diffusivity value map differences between patient and controls. RESULTS:Significant symmetric MRI signal intensity abnormalities were observed with routine MRI. Affected bilateral hippocampi and amygdala exhibited hypointense signals in T1WI and hyperintense signals in T2 images.The DTI study revealed decreased fractional anisotropy values in the bilateral alveus and fimbria of the hippocampus,bilateral internal and external capsules,white matter of the right prefrontal area,and left corona radiate in the patient compared with normal controls(P<0.001). Significantly increased fractional anisotropy,mean diffusivity,or decreased mean diffusivity were not observed in the patient,compared with controls. CONCLUSION:Secondary white matter damage to the hippocampal alveus and fimbria was apparent in the limbic encephalitis patient.In addition,other white matter fiber injuries surrounded the limbic structures,which were not attributed to secondary limbic system injuries. | Ling Zou Wei Deng Hehan Tang Yi Wei Xiaoling Wen Zhengyan Li Weiwei Zhang QiangYuan Qiyong Gong | 2009 | Neural Regeneration Research2009，4，11： | 0 |
| 2 | Diffusion tensor imaging reveals brain abnormality patterns in a patient with semantic dementia显示文摘BACKGROUND: Previous studies regarding primary progressive aphasia (PPA) have focused on progressive,non-fluent aphasia.Little information is available with regard to the use of diffusion tensor imaging compared with conventional magnetic resonance imaging for the detection of subtle structural abnormalities.OBJECTIVE: To investigate and localize brain abnormalities in a Chinese patient with semantic dementia.DESIGN,TIME AND SETTING: A concurrent,non-randomized,case-controlled,neuroimaging,clinical trial was performed at the Department of Radiology,West China Hospital of Sichuan University in March 2009.PARTICIPANTS: One 75-year-old male patient,who was diagnosed with semantic dementia,and 21 age-and gender-matched healthy volunteers were recruited for the study.METHODS: Diffusion tensor imaging was used to determine mean diffusion (MD) and fractional anisotropy (FA) in the brains of the patient and the 21 healthy subjects.Voxel-based analysis of MD and FA values was performed using statistical parametric mapping.MAIN OUTCOME MEASURES: MD and FA value maps differences between patient and controls.RESULTS: MD was significantly increased in both cerebra,but was predominant on the left side and expanded to outside of the language-related region.Reduced MD was not detected in any of the brains.FA was shown to be decreased in the corpus callosum,but was increased in the basal ganglia.CONCLUSION: The present study provided clear in vivo magnetic imaging evidence of diffuse brain involvement in semantic dementia.Increases in MD were greater than in FA when brain diffusion alterations were detected,which suggested that MD could be a better marker of disease progression. | Qiang Yuan Qin Chen Hehan Tang Xintong Wu Qiyong Gong Dong Zhou Ling Zou | 2010 | Neural Regeneration Research2010，5，2： | 0 |
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