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您的检索式：作者名="Helder A.Santos"
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| 1 | Neonatal Fc receptor-targeted lignin-encapsulated porous silicon nanoparticles for enhanced cellular interactions and insulin permeation across the intestinal epithelium显示文摘Oral insulin delivery could change the life of millions of diabetic patients as an effective,safe,easy-to-use,and affordable alternative to insulin injections,known by an inherently thwarted patient compliance.Here,we designed a multistage nanoparticle(NP)system capable of circumventing the biological barriers that lead to poor drug absorption and bioavailability after oral administration.The nanosystem consists of an insulin-loaded porous silicon NP encapsulated into a pH-responsive lignin matrix,and surface-functionalized with the Fc fragment of immunoglobulin G,which acts as a targeting ligand for the neonatal Fc receptor(FcRn).The developed NPs presented small size(211±1 nm)and narrow size distribution.The NPs remained intact in stomach and intestinal pH conditions,releasing the drug exclusively at pH 7.4,which mimics blood circulation.This formulation showed to be highly cytocompatible,and surface plasmon resonance studies demonstrated that FcRn-targeted NPs present higher capacity to interact and being internalized by the Caco-2 cells,which express FcRn,as demonstrated by Western blot.Ultimately,in vitro permeability studies showed that Fc-functionalized NPs induced an increase in the amount of insulin that permeated across a Caco-2/HT29-MTX co-culture model,showing apparent permeability coefficients(Papp)of 2.37×106 cm/s,over the 1.66×106 cm/s observed for their non-functionalized counterparts.Overall,these results demonstrate the potential of these NPs for oral delivery of anti-diabetic drugs. | Joao P.Martins Patrícia Figueiredo Shiqi Wang Erika Espo Elena Celi Beatriz Martins Marianna Kemell Karina Moslova Ermei Makil Jarno Salonen Mauri A.Kostiainen Christian Celia Vincenzo Cerullo Tapani Viitala Bruno Sarmento Jouni Hirvonen Helder A.Santos | 2022 | Bioactive Materials2022，7，3： | 0 |
| 2 | Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential显示文摘Remarkable progress in phototherapy has been made in recent decades,due to its non-invasiveness and instant therapeutic efficacy.In addition,with the rapid development of nanoscience and nanotechnology,phototherapy systems based on nanoparticles or nanocomposites also evolved as an emerging hotspot in nanomedicine research,especially in cancer.In this review,first we briefly introduce the history of phototherapy,and the mechanisms of phototherapy in cancer treatment.Then,we summarize the representative development over the past three to five years in nanoparticle-based phototherapy and highlight the design of the innovative nanoparticles thereof.Finally,we discuss the feasibility and the potential of the nanoparticle-based phototherapy systems in clinical anticancer therapeutic applications,aiming to predict future research directions in this field.Our review is a tutorial work,aiming at providing useful insights to researchers in the field of nanotechnology,nanoscience and cancer. | Jiachen Li Shiqi Wang Flavia Fontana Christos Tapeinos Mohammad-Ali Shahbazi Huijie Han Helder A.Santos | 2023 | Bioactive Materials2023，，5： | 0 |
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