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| 1 | Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells显示文摘 | Arnold Isabelle C Dehzad Nina Reuter Sebastian Martin Helen Becher Burkhard Taube Christian Müller Anne | 2011 | Journal of Clinical Investigation2011，，8： | 4 |
| 2 | Investigation of hydration and pozzolanic reaction in reactive powder concrete (RPC) using 29Si NMR显示文摘 | Helene Z Marcel C Vincent M | 1996 | Cement and Concrete Research1996，26，1： | 1 |
| 3 | Analysis of nitrosamines in cosmetics显示文摘 | KANE I K-ETH G M HELENE C | 1990 | J Soc Cosmet Chem1990，41，： | 1 |
| 4 | Codon usage and gene function are related in sequences of Arabidopsis thaliana 显示文摘 | Helene C Fr6d6rique L M ichel C Alain H | 1998 | Gene1998，209，12： | 1 |
| 5 | Functional coupling of 3-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes显示文摘 | Helen C Doheny Caoimhe M | 2005 | J Clin Endocrinol Metab2005，90，10： | 1 |
| 6 | Flaw tolerance and crack resistance properties of alumina-aluminium titanate composites with tailored microstructure显示文摘 | Nitin P P Stephen J B Helen M C | 1993 | Journal of the American Ceramic Society1993，76，9： | 1 |
| 7 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 8 | The prevalence and management of asthma in primary-aged schoolchildren in the south of England显示文摘 | DONNA M C JENNY M W HELEN C | 2002 | Health Educ Res2002，97，2： | 1 |
| 9 | Breast feeding and mental and motor development at 12 months in a low-income population in northeast Brazil显示文摘 | Helenal E S De Carvalhol L M Becharal C S | 2007 | Paediatric & Perinatal Epidemiology2007，21，2： | 1 |
| 10 | Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth显示文摘 | Jean M Mary Z | 2001 | The Journal of Clinical Endocrinology & Metabolism2001，86，： | 1 |
| 11 | A formal model for consensus and negotiation in environmental management显示文摘 | HELEN M R MAR K C LISA M N | 2006 | Journal of Environmental Management2006，80，2： | 1 |
| 12 | The Ability of Dissolved Organic Matter (DOM) to Influence Benzopyrene Bioavailability Increases with DOM Biodegradation显示文摘 | GOURLAY C HELENE M VUILLEMIN T | 2005 | Ecotoxicology and Environmental Safety2005，61，： | 1 |
| 13 | Double-blind randomized controlled study of the efficacy, safety and tolerability of eszopiclone vs placebo for the treatment of patients with post-traumatic stress disorder and insomnia显示文摘BACKGROUND Sleep disturbance is a core feature of post-traumatic stress disorder(PTSD).Given the relationship between sleep disturbance and PTSD,there has been a relative paucity of studies examining the potential therapeutic impact of using pharmacotherapy to target sleep disturbance in patients with PTSD.Eszopiclone(ESZ)is a non-benzodiazepine y-aminobutyric acid-A receptor agonist indicated for the treatment of sleep and may affect sleep in patients with PTSD.AIM To evaluate the efficacy of ESZ vs placebo(PBO)for patients with PTSD and insomnia.METHODS The study was a 12-wk,double blind,randomized controlled trial with 3 mg of ESZ(n=13)or PBO(n=12).RESULTS Patients in both arms experienced significant improvement in PTSD symptoms as assessed by the Clinician-Administered PTSD Scale for DSM-IV(CAPS):ESZ(t11=-3.12,P=0.005)and PBO(t11=-3.5,P=0.002)and by self-report with the Short PTSD Rating Interview(ESZ t11=-3.38,P=0.003 and PBO t11=-4.48,P=0.0005).There were no significant differences between treatments on the CAPS(t22=-0.13,P=0.70)or the Short PTSD Rating Interview(t22=-0.58,P=0.56).Similarly,both treated groups improved on sleep measures as assessed by the Pittsburgh Sleep Quality Index with PTSD Addendum(PSQI)and on total sleep time(TST)and sleep latency assessed by actigraphy with no significant differences between groups(PSQI t22=-0.24,P=0.81;total sleep time t10=0.13,P=0.90 and sleep latency t10=0.68,P=0.50).There was a significant correlation between improvement in sleep and overall improvement in PTSD as measured by change scores on the PSQI and CAPS,r(8)=0.79,P=0.01 for ESZ treated subjects,but not for those treated with PBO r(9)=0.16,P=0.69.Adverse events of ESZ were consistent with the known profile of the medication including dysgeusia(30%,mild),sedation(20%,mild)and headache(20%,moderate to severe).CONCLUSION Results do not support the hypothesis of a specific positive effect of ESZ compared to PBO for measures of PTSD and associated sleep disturbance. | Sheila M Dowd Alyson K Zalta Helen J Burgess Elizabeth C Adkins Zerbrina Valdespino-Hayden Mark H Pollack | 2020 | World Journal of Psychiatry2020，10，3： | 1 |
| 14 | Change in maternal concerns during the six weeks postpartum period: a study of primiparous mothers in Dar Es Salaam, Tanzania 显示文摘 | Helen I L Kyllike C Siriel M | 2001 | J Midwifery & Women''s Health2001，46，4： | 1 |
| 15 | Personal authentication using hand images 显示文摘 | A JAY K DAVID C M W HELEN C SH | 2006 | Pattern Recognition Letter2006，，27： | 1 |
| 16 | Sodium-Glucose Cotransporter 2 Inhibition and Glycemic Control in Type 1 Diabetes: Results of an 8-Week Open-Label Proof-of-Concept Trial显示文摘 | Perkins Bruce A Cherney David ZI Partridge Helen Soleymanlou Nima Tschirhart Holly Zinman Bernard Fagan Nora M Kaspers Stefan Woerle Hans-Juergen Broedl Uli C Johansen Odd-Erik | 2014 | Diabetes Care2014，，5： | 1 |
| 17 | Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth显示文摘 | Helen C Jean M Mary Z | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 18 | Biopotential mouse embryonic liver stem cell lines contribute to liver regeneration and differentiation as bile ducts and hepatocyte显示文摘 | Helene Strick-Marchand Serban M Pieere C | 2004 | The National Academy of Sciences of the USA2004，10，22： | 1 |
| 19 | Functional coupling of β3-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes显示文摘 | Helen C Doheny Caoimhe M | 2005 | The Journal of Clinical Endocrinology & Metabolism2005，90，10： | 1 |
| 20 | Cerebrovascular Disease and Late-Life Depression显示文摘 | Helen C Daniel F Alan M | 2005 | Am J Geriatr Psychiatry2005，13，2： | 1 |
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