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| 1 | Lactobacilli,bifi dobacteria and E.coli nissle induce pro-and anti-inflammatory cytokines in peripheral blood mononuclear cells显示文摘AIM: To investigate whether the stimulation of peripher- al blood mononuclear cells (PBMNC) with the cell debris and cell extraction of different probiotic strains is similar or species specifi c. METHODS: Three strains of bifi dobacteria, 4 strains of lactobacilli, and E. coli nissle were sonicated and centri- fuged in order to divide them into cell extract and cell debris. PBMNC were separated by density gradient and incubated for 36 h with either the cell debris or the cell extract of single strains of probiotic bacteria in doses from 102 to 108 CFU/mL. Cell supernatants were taken and interleukin (IL)-10, IL-1β, and tumor necosis factor (TNF)-α were determined by ELISA. RESULTS: Depending on the species super-family, the strains had different stimulation patterns. Except for both L. casei strains, the cell extract of bifidobacteriaand lactobacilli had less stimulating capacity than cell debris, whereas the cell extract of E. coli nissle had simi- lar stimulating properties to that of the cell debris of the strain and significantly more stimulating capacity than that of bifi dobacteria and lactobacilli. The cell debris of bifi dobacteria stimulated more cytokine release than the cell debris of lactobacilli. The cell debris of lactobacilli did not have a stimulating capacity when lower concentra- tions were used. Neither cell extraction nor cell debris had an inhibitory effect on the production of the tested cytokines by stimulated PBMNC. CONCLUSION: The incubation of probiotic strains, which have been used in clinical trials for inflammatory diseases, with immunocompetent cells leads to different species specifi c reactions. High IL-10 response to cell de- bris of bifi dobacteria and E. coli nissle can be found. This corresponds to positive effects of bifi dobacteria and E. coli nissle in clinical trials for inflammatory bowel disease compared to negative outcomes obtained with lactoba- cilli. | Ulf Helwig Karen M Lammers Fernando Rizzello Patricia Brigidi Verena Rohleder Elisabetta Caramelli Paolo Giochetti Juergen Schrezenmeir Ulrich R Foelsch Stefan Schreiber Massimo Campieri | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 2 | Matrix cells from Wharton's jelly form neu- rons and glia显示文摘 | Mitchell KE ML Weiss BM Mitchell P Martin D Davis L Mo- rales B Helwig M Beerenstrauch K Abou - Easa T Hildreth D rroyer and S Medicetty | 2003 | Stem Cells2003，21，： | 1 |
| 3 | Corticosteroids and immunosuppressive therapy influence the result of QuantiFERON TB Gold testing in inflammatory bowel disease patients显示文摘 | Ulf Helwig Michael Müller Jürgen Hedderich Stefan Schreiber | 2011 | Journal of Crohn’s and Colitis2011，，4： | 1 |
| 4 | Advanced materials forultra-lightmass stable structures 显示文摘 | WAGNER R DEYERLER M HELWIG G | 1999 | SPIE1999，3737，： | 1 |
| 5 | Halo nevi 显示文摘 | WAYTE D M HELWIG E B | 1968 | Cancer1968，22，1： | 1 |
| 6 | Functional characterisation of UCP1 in the common carp: uncoupling activity in liver mitochondria and cold-induced expression in the brain 显示文摘 | Jastroch M Buckingham J A Helwig M | 2007 | J Comp Physiol B2007，177，： | 1 |
| 7 | Chinese-Adolescents' Reasoning about Democratic and Authority-Based Decision Making in Peer, Family, and School Contexts显示文摘 | Helwig C C Arnold M L Tan D L | 2003 | Child Development2003，74，3： | 1 |
| 8 | Flammability of wood-polypropylene composites显示文摘 | Borysiak S Paukszta D Helwig M | 2006 | Polymer Degradation and Stability2006，91，： | 1 |
| 9 | Arsenic-induced APL differentiation in cerebrospinal fluid 显示文摘 | Helwig A Klemm M Schttttig R | 2007 | Leuk Res2007，31，5： | 1 |
| 10 | Photoperiod- dependent regulation of carboxypeptidase E affects selective processing of neuropeptides in the seasonal Siberian hamster ( Phodopus sungorus ) 显示文摘 | Helwig M Herwig A Heldmaier G | 2013 | J Neuroendocrino12013，25，2： | 1 |
| 11 | Flammability of composites based on polypropylene and flax fibers显示文摘 | Helwig M Paukszta D | 2000 | Molecular Crystals and Liquid Crystals2000，，： | 1 |
| 12 | Flammability of wood-polypropylene composites显示文摘 | Borysiak S Paukszta D Helwig M | 2006 | Polymer degradation and stability2006，91，12： | 1 |
| 13 | Arsenic-induced APL differentiation in cerebrospinal fluid 显示文摘 | Helwig A Klemm M Schtittig R | 2007 | Leuk Res2007，31，5： | 1 |
| 14 | Plasmodium chabaudi malaria:protective immunization with surface membranes of infected erythrocytes显示文摘 | Wunderlich F Brenner HH Helwig M | 1988 | Infect Immun1988，56，12： | 1 |
| 15 | The intraosseous ganglia:a clinical-pathological report on 42 cases显示文摘 | Helwig U Lang S Baczynski M | 1994 | Arch Orthop Trauma Surg1994，114，： | 1 |
| 16 | Parathyroid hormone and calcium : interactions in the control of renin secretion in the isolated, nonfiltering rat kidney 显示文摘 | Helwig JJ Musso M J Judes C | 1991 | Endocrinology1991，129，3： | 1 |
| 17 | Squamous cel| carcinoma and adenoaeanthoma of the stomach显示文摘 | Boswell JT Cmdr M Helwig EB | 1965 | Cancer1965，18，： | 1 |
| 18 | Parathyroid hor- mone and calcium: interactions in the control of renin se- cretion in the isolated, nonfihering rat kidney 显示文摘 | Helwig JJ Musso M J Judes C | 1991 | Endo- crinology1991，129，： | 1 |
| 19 | The association of fatty acid-binding protein 2 A54 T polymorphism with postprandial lipemia depends on promoter variability显示文摘 | HELWIG U RUBIN D KLAPPER M | 2007 | Metabolism2007，56，6： | 1 |
| 20 | Matrix cells from Wharton's jelly form neurons and gila显示文摘 | Mitchell KE Weiss ML Mitchell BM Martin P Davis D Morales L Helwig B Beerenstrauch M Abou-Easa K Hildreth T Troyer D Medicetty S | | 0，，01： | 1 |
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