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| 1 | Medium-intensity acute exhaustive exercise induces neural cell apoptosis in the rat hippocampus显示文摘The present study assessed the influence of medium-intensity (treadmill at a speed of 19.3 m/min until exhaustion) and high-intensity (treadmill at a speed of 26.8 m/min until exhaustion) acute exhaustive exercise on rat hippocampal neural cell apoptosis. TUNEL staining showed significantly increased neural cell apoptosis in the hippocampal CA1 region of rats after medium- and high-intensity acute exhaustive exercise, particularly the medium-intensity acute exhaustive exercise, when compared with the control. Immunohistochemistry showed significantly increased expression of the antiapoptotic protein Bcl-2 and the proapoptotic protein Bax in the hippocampal CA1 region of rats after medium- and high-intensity acute exhaustive exercise. Additionally, the ratio of Bax to Bcl-2 increased in both exercise groups. In particular, the medium-intensity acute exhaustive exercise group had significantly higher Bax and Bcl-2 protein expression and a higher Bax/Bcl-2 ratio. These findings indicate that acute exhaustive exercise of different intensities can induce neural cell apoptosis in the hippocampus, and that medium-intensity acute exhaustive exercise results in greater damage when compared with high-intensity exercise. | Shanni Li Jin Liu Hengmei Yan | 2013 | Neural Regeneration Research2013，8，2： | 3 |
| 2 | Effect of Sr on microstructure and aging behavior of Mg-14Li alloys | Bin Jiang a,b,c,Ying Zeng b,Hengmei Yin a,b,Ruihong Li a,b,Fusheng Pan a,b a National Engineering Research Center for Magnesium Alloys,Chongqing University,Chongqing 400030,China b College of Materials Science and Engineering,Chongqing University,Chongqing 400030,China c New Materials Center,Chongqing Academy of Science and Technology,Chongqing 401123,China | 2012 | Progress in Natural Science:Materials International2012，22，2： | 3 |
| 3 | Effect of Mg 24 Y 5 intermetallic particles on grain refinement of Mg-9Li alloy显示文摘 | Ying Zeng Bin Jiang Mingxing Zhang Hengmei Yin Ruihong Li Fusheng Pan | 2014 | Intermetallics2014，，： | 1 |
| 4 | Psuedo-invariant eigenoperator method for some generalized Jaynes-Cummings mode显示文摘 | LI Hengmei FAN Hongyi | 2009 | Int J Theor Phys2009，48，： | 1 |
| 5 | Influence of long-period pesticide force on genetic polymorphism of wolf spider Pardosa pseudoannulata (Lycosidae: Araneae)显示文摘Wolf spiders are predators in large quantities in the fields. How wolf spiders keep their dominant species status under long-period pesticide force? To answer this question, eight geographical populations of Pardosa pseudoannulata were used as materials to test the influence of geographical habitats on their genomic DNA polymorphism. The RAPD pattern showed polymorphic variations among and within different populations. Total 84 bands amplified by 10 random primers, of which 62 (73.81%) are polymorphic, were generated from 55 individuals of eight geographical populations. Meanwhile, Shannon’s index (Ho= 0.5177) showed a rich genetic diversity of P. pseudoannulata, and most of the genetic variation (64.24%) was found within populations. Multiple regression analysis suggested that it is the climatic variation (such as annual average temperature etc.) that results in adaptive eco-geographic differentiation, and it is the long-period pesticide force that speeds up the genetic differentiation of P. pseudoannulata which changed the genetic diversity of the population. | Sun Jiying Fu Xiuqin Peng Guangxu Zhang Zhigang Yan Hengmei | 2007 | Progress in Natural Science:Materials International2007，17，10： | 1 |
| 6 | In vivo and in vitro antiproliferative and antimetastatic effects of hemolymph of Aspongopus chinensis Dallas on breast cancer cells显示文摘OBJECTIVE:To investigate the effects of Aspongopus(A.)chinensis hemolymph on the proliferation and metastasis of breast cancer cells.METHODS:The in vitro effects of A.chinensis hemolymph were investigated in murine(4T1)and human(HCC1937)breast cancer cell lines.Cytotoxicity,cell apoptosis,and cell migration were evaluated by using the cell counting kit-8 assay,Hoechst staining,and wound healing experiments,respectively.A syngeneic mouse model was established to evaluate the in vivo effects of the hemolymph extract on tumor growth and metastasis.Mouse body weight,tumor size,blood levels of function-related enzymes,and pathological features of the liver and kidney tissues were evaluated.RESULTS:The hemolymph of A.chinensis significantly inhibited in vitro tumor cell migration and viability while inducing apoptosis.Furthermore,it inhibited in vivo tumor growth and metastasis with a minimal effect on mouse body weight,and did not induce liver or kidney damage.CONCLUSION:Our results suggested that the A.chinensis hemolymph has antitumorigenic properties,suggesting it has potential as a novel therapeutic option for the treatment of metastatic breast cancer. | ZHAO Shuai TAN Jun YU Hengmei TIAN Ying WU Youfang LUO Rui GUO Jianjun | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 1 |
| 7 | CVaR measurement and operational risk management in commercial banks according to the peak value method of extreme value theory 显示文摘 | Y Fengge W Hengmei and L Jiaqi | 2013 | Mathematical and Computer Modelling2013，58，12： | 1 |
| 8 | Isolation and cultivation of murine hematopoietic stem cells and expression of hFIX mediated by recombinant lentiviral vectors in vitro显示文摘Hematopoietic stem cells(HSCs)are an attractive target for gene therapy,especially for inherited blood diseases.Moreover,recombinant lentiviral vectors are considered to be prospective in HSCs gene therapy for the high efficiency of infection.In this study,murine mononuclear cells(MNCs)were isolated from bone marrow and cultured in suspension,and then Lin−CD117+HSCs were isolated by immunomagnetic beads.During culturing,cells and colonies increased in HSCs supplied with cytokines while no change was observed in the control group without cytokines.FUXW recombinant lentiviral vectors were produced by calcium phosphate-mediated transient cotransfection infected MNCs from ICR and C57 mice.The hFIX expressions were 41.7±4.2 ng/mL and 34.5±6.6 ng/mL in supernatant on 7d.The hFIX expressions of HSCs infected by FUXW recombinant lentiviral vectors were 46.6±5.7 ng/mL(with cytokines)and 33.3±4.8 ng/mL(without cytokines)in supernatant on 7d.Results indicate that recombinant lentiviral vectors can infect murine MNCs and Lin−CD117+HSCs efficiently,and expression of the transgene can be improved when supplied with cytokines. | YAO Hengmei CHEN Haoming HUANG Lu SHEN Qi JIA Weiguo XUE Jinglun | 2006 | Frontiers in Biology2006，1，3： | 0 |
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