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| 1 | NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly显示文摘The impairment of mitochondrial bioenergetics,often coupled with exaggerated reactive oxygen species (ROS) production, is a fundamental disease mechanism in organs with a high demand for energy, including the heart. Building a more robust and safer cellular powerhouse holds the promise for protecting these organs in stressful conditions. Here, we demonstrate that NADH:ubiquinone oxidoreductase subunit AB1 (NDUFAB1), also known as mitochondrial acyl carrier protein, acts as a powerful cardio-protector by conferring greater capacity and efficiency of mitochondrial energy metabolism. In particular, NDUFAB1 not only serves as a complex I subunit, but also coordinates the assembly of respiratory complexes I, II, and III, and supercomplexes, through regulating iron-sulfur biosynthesis and complex I subunit stability. Cardiac-specific deletion of Ndufab1 in mice caused defective bioenergetics and elevated ROS levels, leading to progressive dilated cardiomyopathy and eventual heart failure and sudden death. Overexpression of Ndufab1 effectively enhanced mitochondrial bioenergetics while limiting ROS production and protected the heart against ischemia-reperfusion injury. Together, our findings identify that NDUFAB1 is a crucial regulator of mitochondrial energy and ROS metabolism through coordinating the assembly of respiratory complexes and supercomplexes, and thus provide a potential therapeutic target for the prevention and treatment of heart failure. | Tingting Hou Rufeng Zhang Chongshu Jian Wanqiu Ding Yanru Wang Shukuan Ling Qi Ma Xinli Hu Heping Cheng Xianhua Wang | 2019 | Cell Research2019，29，9： | 4 |
| 2 | Effects of feeding frequency and sugar concentrations on lifetime reproductive success of Meteorus pulchricornis (Hymenoptera: Braconidae)显示文摘 | Wu Heping Meng Ling Li Baoping | 2008 | Biological Control2008，，3： | 1 |
| 3 | Multiphysics Field Co-simulation Research Based on Electric Drive System for a Specific Type of Car显示文摘Electric drive systems for new energy cars are complex systems that should have multivariate,strong coupling,and non-linear characteristics and should also involve the multiphysics field.The singular simulation software used at present in the modeling of electric drive systems cannot simulate the influences of all the physics fields on the operating system.The co-simulation model used in this paper was based on a specific type of car.The motor control algorithm model was built in MATLAB/Simulink,the electromagnetic finite element model of the motor was built in ANSYS EM-Maxwell,and the motor controller hardware circuit was built in ANSYS EM-Simplorer.To make real-time connections among these software platforms,a multi-software co-simulation platform was built,and the co-simulation platform’s simulation results were input into STAR CCM+software to enable finite element modeling of the motor and running of thermal analysis.When compared with the electric drive system model built using single Simulink software,the simulation results from this co-simulation platform were more realistic and were shown to be closer to reality when the dynamic characteristics of the electric drive system’s power semiconductor switching devices and the motor’s electromagnetic characteristics were considered.Finally,by benchmarking the multiphysics field co-simulation platform simulation results using dyno bench test results,the validity of the co-simulation platform was verified and the development of the multiphysics field co-simulation of the basic electric drive system was complete. | Chuanfu Wang Yubo Lian Heping Ling Hua Pan Yuxin Zhang | 2019 | Automotive Innovation2019，2，3： | 1 |
| 4 | Implementation for a cloud battery management system based on the CHAIN framework显示文摘An intelligent battery management system is a crucial enabler for energy storage systems with high power output,increased safety and long lifetimes.With recent developments in cloud computing and the proliferation of big data,machine learning approaches have begun to deliver invaluable insights,which drives adaptive control of battery management systems(BMS)with improved performance.In this paper,a general framework utilizing an end-edge-cloud architecture for a cloud-based BMS is proposed,with the composition and function of each link described.Cloud-based BMS leverages from the Cyber Hierarchy and Interactional Network(CHAIN)framework to provide multi-scale insights,more advanced and efficient algorithms can be used to realize the state-of-X es-timation,thermal management,cell balancing,fault diagnosis and other functions of traditional BMS system.The battery intelligent monitoring and management platform can visually present battery performance,store working-data to help in-depth understanding of the microscopic evolutionary law,and provide support for the development of control strategies.Currently,the cloud-based BMS requires more effects on the multi-scale inte-grated modeling methods and remote upgrading capability of the controller,these two aspects are very important for the precise management and online upgrade of the system.The utility of this approach is highlighted not only for automotive applications,but for any battery energy storage system,providing a holistic framework for future intelligent and connected battery management. | Shichun Yang Zhengjie Zhang Rui Cao Mingyue Wang Hanchao Cheng Lisheng Zhang Yinan Jiang Yonglin Li Binbin Chen Heping Ling Yubo Lian Billy Wu Xinhua Liu | 2021 | Energy and AI2021，5，3： | 0 |
| 5 | Research progress and application of deep in-situ condition preserved coring and testing显示文摘With the depletion of shallow resources,the exploration of deep earth resources has become a global strategy.The study of the different patterns in the physical mechanical properties of rocks at different occurrence depths is the basis for exploring deep into the earth,with the core and premise being the acquisition and testing of deep in-situ core specimens.Based on the original idea of deep in-situ condition preserved coring(ICP-Coring)and testing,combined with theoretical modeling,numerical analysis,test platform development,indoor testing and engineering application,the principles and technologies of deep ICP-Coring are developed.This principle and technology consists of five parts:in-situ pressurepreserved coring(IPP-Coring),in-situ substance-preserved coring(ISP-Coring),in-situ temperaturepreserved coring(ITP-Coring),in-situ light-preserved coring(ILP-Coring),and in-situ moisturepreserved coring(IMP-Coring).The theory and technology of temperature and pressure reconstruction at different occurrence depths and in different environments are proposed,and prototype trial production was completed by following the principle of displacement and tests based on the in-situ reconstructed environment.The notable advances are as follows:(1)Deep in-situ coring system:A pressure-preserved controller with an ultimate bearing capacity greater than 140 MPa,highperformance(temperature-resistant,pressure-resistant,and low thermally conductive)temperaturepreserved materials,an active temperature control system,and high-barrier quality-preserved membrane materials were developed;a deep ICP-Coring capacity calibration platform was independently developed,a deep in-situ coring technology system was developed,and the acquisition of deep in-situ cores was realized.(2)In-situ storage displacement system:Following the dual-circuit hydraulic design idea,a single-drive source push-pull composite grabbing mechanism was designed;the design of the overall structure for the deep in-situ displacement storage system and ultrahigh pressure cabin structure was completed,which could realize docking the coring device and core displacement in the in-situ reconstructed environment.(3)Test analysis system:A noncontact acoustic-electric-magnetic test system was developed under the in-situ reconstructed environment,and the errors between the test results and traditional contact test results were mostly less than 10%;a detachable deep in-situ core true triaxial test system was developed,which could perform loading tests for deep in-situ cores.The relevant technological achievements were successfully applied to the exploration and development of deep resources,such as deep mines,deep-sea natural gas hydrates,and deep oil and gas.The research results provide technical and equipment support for the construction of a theoretical system for deep in-situ rock mechanics,the development of deep earth resources and energy,and the scientific exploration of different layers and occurrence depths(deep and ultradeep)of the Earth. | Heping Xie Yunqi Hu Mingzhong Gao Ling Chen Ru Zhang Tao Liu Feng Gao Hongwei Zhou Xiaobo Peng Xiongjun Li Jianbo Zhu Cunbao Li Ruidong Peng Yanan Gao Cong Li Jianan Li Zhiqiang He | 2023 | International Journal of Mining Science and Technology2023，33，11： | 0 |
| 6 | Development of a pressure coring system for the investigation of deep underground exploration显示文摘To provide a more accurate evaluation of the scale of deep underground resources,a new pressure coring system was carefully developed and its strength and safety of the engineering were verified by theoretical analyses and numerical simulation.The designed pressure coring system can obtain cores with length of 3 m and diameter of 50 mm at 70 MPa.The results of the ball-drop operation experiment demonstrate that differential motion assembly can effectively cut a safety pin by applying a tensile force of 4852 N,and it can lift the core tube through the center pole to complete a series of mechanical actions to seal the pressure.Additionally,by maintaining pressures at 70 MPa for 30 min,the pressure sealing capacity of the system was proven.Furthermore,a core sample with a diameter of 50 mm was obtained through a core drilling experiment and the coring performance of the pressure coring system was verified.This study can not only enrich the existing onshore coring technology but also provide a theoretical guide and design criteria for the development of similar pressure coring systems to meet the demand for deeper underground exploration. | Da Guo Ling Chen Zhongya Zhou Dingming Wang Yiwei Zhang Xun Yang Xin Fang Xiaojun Wang Heping Lu Lin Dai Heping Xie | 2023 | International Journal of Mining Science and Technology2023，33，11： | 0 |
| 7 | Preliminary research and scheme design of deep underground in situ geo-information detection experiment for Geology in Time显示文摘The deep earth,deep sea,and deep space are the main parts of the national“three deep”strategy,which is in the forefront of the strategic deployment clearly defined in China’s 14th Five-Year Plan(2021-2025)and the Long-Range Objectives Through the Year 2035.It is important to reveal the evolutionary process and mechanism of deep tectonics to understand the earth’s past,present and future.The academic con-notation of Geology in Time has been given for the first time,which refers to the multi-field evolution response process of geological bodies at different time and spatial scales caused by geological processes inside and outside the Earth.Based on the deep in situ detection space and the unique geological envi-ronment of China Jinping Underground Laboratory,the scientific issue of the correlation mechanism and law between deep internal time-varying and shallow geological response is given attention.Innovative research and frontier exploration on deep underground in situ geo-information detection experiments for Geology in Time are designed to be carried out,which will have the potential to explore the driving force of Geology in Time,reveal essential laws of deep earth science,and explore innovative technologies in deep underground engineering. | Heping Xie Ru Zhang Zetian Zhang Yinshuang Ai Jianhui Deng Yun Chen Yong Zhou Mingchuan Li Liqiang Liu Mingzhong Gao Zeqian Yang Weiqiang Ling Heng Gao Qijun Hao Kun Xiao Chendi Lou | 2024 | International Journal of Mining Science and Technology2024，34，1： | 0 |
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