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| 1 | The structural and accessory proteins M,ORF 4a,ORF 4b,and ORF 5 of Middle East respiratory syndrome coronavirus(MERS-CoV)are potent interferon antagonists显示文摘The newly emerged Middle East respiratory syndrome coronavirus(MERS-CoV)is a highly pathogenic respira-tory virus with pathogenic mechanisms that may be driven by innate immune pathways.The goal of this study is to characterize the expression of the structural(S,E,M,N)and accessory(ORF 3,ORF 4a,ORF 4b,ORF 5)proteins of MERS-CoV and to determine whether any of these pro-teins acts as an interferon antagonist.Individual structural and accessory protein-coding plasmids with an N-terminal HA tag were constructed and transiently transfected into cells,and their native expression and subcellular localiza-tion were assessed using Wes tern blotting and indirect immunofl uorescence.While ORF 4b demonstrated majorly nuclear localization,all of the other proteins demonstrated cytoplasmic localization.In addition,for the fi rst time,our experiments revealed that the M,ORF 4a,ORF 4b,and ORF 5 proteins are potent interferon antagonists.Further exami-nation revealed that the ORF 4a protein of MERS-CoV has the most potential to counteract the antiviral effects of IFN via the inhibition of both the interferon production(IFN-βpromoter activity,IRF-3/7 and NF-κB activation)and ISRE promoter element signaling pathways.Together,our re-sults provide new insights into the function and pathogenic role of the structural and accessory proteins of MERS-CoV. | Yang Yang Ling Zhang Heyuan Geng Yao Deng Baoying Huang Yin Guo Zhengdong Zhao Wenjie Tan | 2013 | Protein & Cell2013，4，12： | 25 |
| 2 | A Practical Pattern Recovery Approach Based on Both Structural and Behavioral Analysis显示文摘 | Huang Heyuan Zhang Shensheng Cao Jian | 2005 | The Journal of Systems and Software2005，75，12： | 1 |
| 3 | High-strength hydrogels:Fabrication,reinforcement mechanisms,and applications显示文摘With the continuous appearance and expansion of high-strength hydrogels in emerging fields such as industry,medicine,and green development,the synthesis and application of high-strength hydrogels have developed dramatically and achieved remarkable results from the aspects of raw materials,preparation methods,and reinforcement mechanisms.However,there is still a lack of systematic reviews on high-strength hydrogels.Herein,we first discuss the advantages of natural and synthetic materials,and the characteristics of high-strength hydrogels prepared from different raw materials;we then expound on the influence mechanism of physical interactions or chemical bonds on the strength of the hydrogel from three aspects:physical cross-linking,chemical cross-linking,and dynamic chemical cross-linking;at last,we systematically expound the strengthening strategies,including double network/multi-network,nanocomposite,topology,supramolecular polymerization,and characteristics and strengthening mechanisms of such high-strength hydrogels.In addition,based on the development status of high-strength hydrogels,we combined the application requirements and the existing drawbacks of high-strength hydrogels to propose their possible development directions in the future. | Heyuan Huang Zhicheng Dong Xiaoyang Ren Ben Jia Guowei Li Shaowen Zhou Xin Zhao Wenzhi Wang | 2023 | Nano Research2023，16，2： | 1 |
| 4 | Resonance-assisted light–control–light characteristics of SnS_2 on a microfiber knot resonator with fast response显示文摘An all-optical light–control–light functionality with the structure of a microfiber knot resonator (MKR) coated with tin disulfide (SnS_2) nanosheets is experimentally demonstrated. The evanescent light in the MKR [with a resonance Q of ~59,000 and an extinction ratio (ER) of ~26 dB] is exploited to enhance light–matter interaction by coating a two-dimensional material SnS_2 nanosheet onto it. Thanks to the enhanced light–matter interaction and the strong absorption property of SnS_2, the transmitted optical power can be tuned quasi-linearly with an external violet pump light power, where a transmitted optical power variation rate ΔT with respect to the violet light power of ~0.22 dB∕mW is obtained. In addition, the MKR structure possessing multiple resonances enables a direct experimental demonstration of the relationship between resonance properties (such as Q and ER), and the obtained ΔT variation rate with respect to the violet light power. It verifies experimentally that a higher resonance Q and a larger ER can lead to a higher ΔT variation rate. In terms of the operating speed, this device runs as fast as ~3.2 ms. This kind of all-optical light–control–light functional structure may find applications in future all-optical circuitry, handheld fiber sensors, etc. | HUIHUI LU ZHONGMIN WANG ZHIJIN HUANG JUN TAO HANQING XIONG WENTAO QIU HEYUAN GUAN HUAZHUO DONG JIANGLI DONG WENGUO ZHU JIANHUI YU YONGCHUN ZHONG YUNHAN LUO JUN ZHANG ZHE CHEN | 2018 | Photonics Research2018，6，12： | 0 |
| 5 | Atomic Ni directional-substitution on ZnIn_(2)S_(4) nanosheet to achieve the equilibrium of elevated redox capacity and efficient carrier-kinetics performance in photocatalysis显示文摘It is a challenge to coordinate carrier-kinetics performance and the redox capacity of photogenerated charges synchronously at the atomic level for boosting photocatalytic activity.Herein,the atomic Ni was introduced into the lattice of hexagonal ZnIn_(2)S_(4) nanosheets(Ni/ZnIn_(2)S_(4))via directionalsubstituting Zn atom with the facile hydrothermal method.The electronic structure calculations indicate that the introduction of Ni atom effectively extracts more electrons and acts as active site for subsequent reduction reaction.Besides the optimized light absorption range,the elevation of Efand ECBendows Ni/ZnIn_(2)S_(4) photocatalyst with the increased electron concentration and the enhanced reduction ability for surface reaction.Moreover,ultrafast transient absorption spectroscopy,as well as a series of electrochemical tests,demonstrates that Ni/ZnIn_(2)S_(4) possesses 2.15 times longer lifetime of the excited charge carriers and an order of magnitude increase for carrier mobility and separation efficiency compared with pristine ZnIn_(2)S_(4).These efficient kinetics performances of charge carriers and enhanced redox capacity synergistically boost photocatalytic activity,in which a 3-times higher conversion efficiency of nitrobenzene reduction was achieved upon Ni/ZnIn_(2)S_(4).Our study not only provides in-depth insights into the effect of atomic directional-substitution on the kinetic behavior of photogenerated charges,but also opens an avenue to the synchronous optimization of redox capacity and carrier-kinetics performance for efficient solar energy conversion. | Haibin Huang Guiyang Yu Xingze Zhao Boce Cui Jinshi Yu Chenyang Zhao Heyuan Liu Xiyou Li | 2024 | Journal of Energy Chemistry2024，88，1： | 0 |
| 6 | Resonant enhancement of second harmonic generation in etchless thin film lithium niobate heteronanostructure显示文摘Lithium niobate has received interest in nonlinear frequency conversion due to its wide transparency window,from ultraviolet to mid-infrared spectral regions,and large second-order nonlinear susceptibility.However,its nanostructure is generally difficult to etch,resulting in low-Q resonance and lossy nanostructures for second harmonic generation.By applying the concept of bound states in the continuum,we performed theoretical and experimental investigations on high-Q resonant etchless thin-film lithium niobate with Si O_(2) nanostructures on top for highly efficient second harmonic generation.In the fabricated nanostructured devices,a resonance with a Q factor of 980 leads to the strong enhancement of second harmonic generation by over 1500 times compared with that in unpatterned lithium niobate thin film.Although the pump slightly deviates from central resonance,an absolute conversion efficiency of 6.87×10^(-7) can be achieved with the fundamental pump peak intensity of 44.65 MW/cm^(2),thus contributing to the normalized conversion efficiency of 1.54×10^(-5)cm^(2)/GW.Our work establishes an etchless lithium niobate device for various applications,such as integrated nonlinear nanophotonics,terahertz frequency generation,and quantum information processing. | Zhijin Huang Kaiwen Luo Ziwei Feng Zhanyuan Zhang Yang Li Wentao Qiu Heyuan Guan Yi Xu Xiangping Li Huihui Lu | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，10： | 0 |
| 7 | Photoexcitation dynamics and energy engineering in supramolecular doping of organic conjugated molecules显示文摘Doping and blending strategies are crucial means to precisely control the excited states and energy level in conjugated molecular systems.However,effective models and platforms are rarely proposed to systematically explore the effects of the formation of trapped doped centers on heterogeneous structures,energy level and ultrafast photophysical process.Herein,for deeply understanding the impact of molecular doping in film energy levels and photoexcitation dynamics,we set a supramolecular N-B coordination composed by the conjugated molecules of pyridine functionalized diarylfluorene(host material),named as ODPF-Phpy and ODPF-(Phpy)2,and the molecule of tris(perfluorophenyl)borane(BCF)(guest material).The generation of the molecular-level coordination bond increased the binding energy of N atoms and tuned the band-gap,leading to a new fluorescent emission center with longer excitation wavelength and emission wavelength.The intermolecular Forster resonance energy transfer(FRET)in blending flms make it present inconsistent fluorescent behaviors compared to that in solution.The charge transfer(CT)state of N-B coordinated compounds and the changed dielectric constant of blending films resulted in a large PL spectra red-shift with the increased dopant ratio,causing a wide-tunable fluorescent color.The excited state behaviors of two compounds in blending system was further investigated by the transient absorption(TA)spectroscopy.Finally,we found supramolecular coordination blending can effectively improve the films'photoluminescence quantum yield(PLQY)and conductivity.We believe this exploration in the internal coordination mechanisms would deepen the insights about doped semiconductors and is helpful in developing novel high-efficient fluorescent systems. | Xiang An Chuanxin Wei Lubing Bai Jun Zhou Le Wang Yamin Han Lili Sun Jinyi Lin Heyuan Liu Jiewei Lil Man Xu Haifeng Ling Linghai Xie Wei Huang | 2023 | Light(Science & Applications)2023，12，2： | 0 |
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