|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | FAM19A4 is a novel cytokine ligand of formyl peptide receptor I (FPR 1) and is able to promote the migration and phagocytosis of macrophages显示文摘FAM19A4 是为有顺序类似 19 的家庭的缩写(chemokine (C-C 主题)-like) 成员 A4,它能分泌的蛋白质在正常纸巾在底层被表示。坚定的 FAM19A4 遗体的生物功能,和它的潜在的受体是 unclarified。在这研究,我们证明 FAM19A4 是古典能分泌的蛋白质,我们第一次证实它的成熟蛋白质由 95 氨基酸组成。我们发现这新奇 cytokine 的表示是 upregulated 在里面 lipopolysaccharide (LPS ) 刺激了单核白血球和巨噬细胞并且典型地在极化的 M1。FAM19A4 在巨噬细胞上显示出趋化性的活动并且随蛋白质 kinase B (Akt ) 的 phosphorylation 的显著增加在 vitro 并且在 vivo 提高 zymosan 的巨噬细胞吞噬作用。FAM19A4 能也在 zymosan 刺激之上增加反应的氧种类(ROS ) 的版本。基于受体成为主观,收音机 ligand 绑定试金和受体阻塞,而且,我们第一次证明 FAM19A4 是甲酰肽受体 1 的新奇 ligand (FPR1 ) 。上述数据显示在煽动性的刺激之上, monocyte/macrophage-derived FAM19A4 可以在病原的感染期间在巨噬细胞的移植和激活起一个关键作用。 | Wenyan Wang Ting Li Xiaolin Wang Wanxiong Yuan Yingying Cheng Heyu Zhang Enquan Xu Yingmei Zhang Shuang Shi Dalong Ma Wenling Han | 2015 | Cellular & Molecular Immunology2015，12，5： | 8 |
| 2 | Fish forewarning of comprehensive toxicity in water environment based on Bayesian sequential method显示文摘Environmental impact of pollutants can be analyzed effectively by acquiring fish behavioral signals in water with biological behavior sensors. However, a variety of factors, such as the complexity of biological organisms themselves, the device error and the environmental noise, may compromise the accuracy and timeliness of model predictions. The current methods lack prior knowledge about the fish behavioral signals corresponding to characteristic pollutants, and in the event of a pollutant invasion, the fish behavioral signals are poorly discriminated. Therefore, we propose a novel method based on Bayesian sequential,which utilizes multi-channel prior knowledge to calculate the outlier sequence based on wavelet feature followed by calculating the anomaly probability of observed values. Furthermore, the relationship between the anomaly probability and toxicity is analyzed in order to achieve forewarning effectively. At last, our algorithm for fish toxicity detection is verified by integrating the data on laboratory acceptance of characteristic pollutants. The results show that only one false positive occurred in the six experiments, the present algorithm is effective in suppressing false positives and negatives, which increases the reliability of toxicity detections, and thereby has certain applicability and universality in engineering applications. | Kaifeng Rao Li Tang Xin Zhang Heyu Xiang Liang Tang Yong Liu Wei Wang Jie Jiang Mei Ma Yiping Xu Zijian Wang | 2021 | Journal of Environmental Sciences2021，33，12： | 2 |
| 3 | Improvement in the risk assessment of oral leukoplakia through morphology-related copy number analysis显示文摘Oral leukoplakia is the most common type of oral potentially malignant disorders and considered a precursor lesion to oral squamous cell carcinoma.However,a predictor of oral leukoplakia prognosis has not yet been identified.We investigated whether copy number alteration patterns may effectively predict the prognostic outcomes of oral leukoplakia using routinely processed paraffin sections.Comparison of copy number alteration patterns between oral leukoplakia with hyperplasia(HOL,n=22)and dysplasia(DOL,n=21)showed that oral leukoplakia with dysplasia had a higher copy number alteration rate(86%)than oral leukoplakia with hyperplasia(46%).Oral leukoplakia with dysplasia exhibited a wider range of genomic variations across all chromosomes compared with oral leukoplakia with hyperplasia.We also examined a retrospective cohort of 477 patients with oral leukoplakia with hyperplasia with detailed follow-up information.The malignant transformation(MT,n=19)and leukoplakia recurrence(LR,n=253)groups had higher frequencies of aneuploidy events and copy number loss rate than the free of disease(FD,n=205)group.Together,our results revealed the association between the degree of copy number alterations and the histological grade of oral leukoplakia and demonstrated that copy number alteration may be effective for prognosis prediction in oral leukoplakia patients with hyperplasia. | Xiaotian Li Lu Liu Jianyun Zhang Ming Ma Lisha Sun Xuefen Li Heyu Zhang Jianbin Wang Yanyi Huang Tiejun Li | 2021 | Science China(Life Sciences)2021，64，9： | 2 |
| 4 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hkknxbwubkov96pwx.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 5 | A Symmetric Key Exchange Protocol Bsaed on Virtual S-Box显示文摘 | YIN Yifeng GAN Yong WEN Heyu LI Tianbao | 2014 | China Communications2014，11，A02： | 2 |
| 6 | LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells显示文摘We recently demonstrated that leukocyte Ig-like receptor 4(LILRB4)expressed by monocytic acute myeloid leukemia(AML)cells mediates T-cell inhibition and leukemia cell infiltration via its intracellular domain.The cytoplasmic domain of LILRB4 contains three immunoreceptor tyrosine-based inhibitory motifs(ITIMs);the tyrosines at positions 360,412,and 442 are phosphorylation sites.Here,we analyzed how the ITIMs of LILRB4 in AML cells mediate its function.Our in vitro and in vivo data show that Y412 and Y442,but not Y360,of LILRB4 are required for T-cell inhibition,and all three ITIMs are needed for leukemia cell infiltration.We constructed chimeric proteins containing the extracellular domain of LILRB4 and the intracellular domain of LILRB1 and vice versa.The intracellular domain of LILRB4,but not that of LILRB1,mediates T-cell suppression and AML cell migration.Our studies thus defined the unique signaling roles of LILRB4 ITIMs in AML cells. | Zunling Li Mi Deng Fangfang Huang Changzhu Jin Shuang Sun Heyu Chen Xiaoye Liu Licai He Ali HSadek Cheng Cheng Zhang | 2020 | Cellular & Molecular Immunology2020，17，3： | 1 |
| 7 | Mg-xonotlite and Its Coexisting Phases显示文摘 | Qian Guangren Xu Guangliang Li Heyu | 1997 | Cement and Concrete Research1997，27，3： | 1 |
| 8 | Emission Probabilities and Energy Spectra of Hydrogen Isotopes in Reactions ^(40)Ar+^(112,124)Sn at 30 MeV/u显示文摘Hot nuclei with differentN/Z ratio were produced by using^(40)Ar beam on^(112)Sn and^(124)Sn target,respectively.The energy spectra and the emission probabilities of hydrogen isotopes are analyzed in the 30 MeV/u^940)Ar+^(112,124)Sn reactions.Partial emission probability P_i of a certain species i is defined here | Xiao Zhigang, Jin Genming, Wu Heyu, Wei Zhiyong, Wang Hongwei, Duan Limin Hu Rongjiang, Li Zuyu, Zhang Baoguo, Zhu Yongtai and Wang Sufang | 2001 | IMP & HIRFL Annual Report2001，，1： | 1 |
| 9 | Efficient computation of dendritic growth with r-adaptive finite element methods显示文摘 | Wang Heyu Li Ruo Tang Tao | 2008 | J Comput Phys2008，227，： | 1 |
| 10 | Effect of the sonic hedgehog inhibitor GDC-0449 on an in vitro isogenic cellular model simulating odontogenic keratocysts显示文摘Odontogenic keratocysts(OKCs) are common cystic lesions of odontogenic epithelial origin that can occur sporadically or in association with naevoid basal cell carcinoma syndrome(NBCCS). OKCs are locally aggressive, cause marked destruction of the jaw bones and have a propensity to recur. PTCH1 mutations(at ~80%) are frequently detected in the epithelia of both NBCCS-related and sporadic OKCs, suggesting that PTCH1 inactivation might constitutively activate sonic hedgehog(SHH) signalling and play a major role in disease pathogenesis. Thus, small molecule inhibitors of SHH signalling might represent a new treatment strategy for OKCs. However, studies on the molecular mechanisms associated with OKCs have been hampered by limited epithelial cell yields during OKC explant culture. Here, we constructed an isogenic PTCH1^(R135 X/+) cellular model of PTCH1 inactivation by introducing a heterozygous mutation, namely, c.403 C>T(p.R135 X), which has been identified in OKC patients, into a human embryonic stem cell line using the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated 9(Cas9) system. This was followed by the induction of epithelial differentiation. Using this in vitro isogenic cellular model, we verified that the PTCH1 R135 X/+heterozygous mutation causes ligand-independent activation of SHH signalling due to PTCH1 haploinsufficiency. This activation was found to be downregulated in a dose-dependent manner by the SHH pathway inhibitor GDC-0449. In addition, through inhibition of activated SHH signalling, the enhanced proliferation observed in these induced cells was suppressed, suggesting that GDC-0449 might represent an effective inhibitor of the SHH pathway for use during OKC treatment. | Jiemei Zhai Heyu Zhang Jianyun Zhang Ran Zhang Yingying Hong Jiafei Qu Feng Chen Tiejun Li | 2019 | International Journal of Oral Science2019，11，1： | 1 |
| 11 | Visible light assisted enzyme-photocatalytic cascade degradation of organophosphorus pesticides显示文摘The worldwide application of organophosphorus pesticides(OPs)has promoted agricultural development,but their gradual accumulation in soil and water can seriously affect the central nervous system of humans and other mammals.Organophosphorus hydrolase(OPH)is an effective enzyme that can catalyze the degradation of the residual OPs.However,the degradation products such as p-nitrophenol(p-NP)is still toxic.Thus,it is of great significance to develop a multi-functional support that can be simultaneously used for the immobilization of OPH and the further degradation of p-NP.Herein,a visible light assisted enzyme-photocatalytic integrated catalyst was constructed by immobilizing OPH on hollow structured Au-TiO_(2)(named OPH@H-Au-TiO_(2))for the degradation of OPs.The obtained OPH@H-Au-TiO_(2)can degrade methyl parathion to p-NP by OPH and then degrade p-NP to hydroquinone with low toxicity by using H-Au-TiO_(2)under visible light.OPH molecules were immobilized on HAu-TiO_(2)through adsorption method to prepare OPH@H-Au-TiO_(2).After 2.5 h of reaction,methyl parathion is completely degraded,and about 82.64%of the generated p-NP is further degraded into hydroquinone.After reused for 4 times,the OPH@H-Au-TiO_(2)retains more than 80%of the initial degradation activity.This research presents a new insight in designing and constructing multi-functional biocatalyst,which greatly expands the application scenarios and industrial value of enzyme catalysis. | Ying Zhang Xue Cao Yufeng Yang Sumin Guan Xiaotian Wang Heyu Li Xiaobing Zheng Liya Zhou Yanjun Jiang Jing Gao | 2023 | Green Chemical Engineering2023，4，1： | 1 |
| 12 | Reaction characteristics investigation of CeO_(2)-enhanced CaSO_(4) oxygen carrier with lignite显示文摘Calcium sulfate(CaSO_(4))has been verified as a promising oxygen carrier(OC)in the chemical looping combustion(CLC)for its high oxygen capacity,abundant reserve and low cost,but its low reactivity and deleterious sulfur species emission from the side reactions of CaSO_(4) should be well considered for its wide application in CLC.In order to promote the reactivity of CaSO_(4) and increase its potential to inhibit the gaseous sulfur emission,a CeO_(2)-enhanced CaSO_(4) OC mixed OC of core–shell structure was prepared using the combined template synthesis method.Reaction characteristics of the prepared CaSO_(4)-CeO_(2) mixed OC with a typical lignite was first conducted and systematically investigated,and an improved reactivity of the prepared CaSO_(4)-CeO_(2) mixed OC was demonstrated than its single component CaSO_(4) or CeO_(2) due to the fast transfer and exchange of oxygen from the CaSO_(4) substrate to coal via the doped CeO_(2).Furthermore,the solid products formed from the mixed CaSO_(4)-CeO_(2) OC with the selected coal were collected and analyzed.Especially,evolution and redistribution of the sulfur species of different forms were focused.At the latter reaction stage of YN reaction with the CaSO_(4)-CeO_(2) mixed OC,the SO_(2) emitted from the side reactions of CaSO_(4) was greatly diminished and the doped CeO_(2) was proven effective to directionally fix the SO_(2) released to turn into different solid sulfur compounds,which were determined as Ce_(2)O_(2)S,Ce_(2)S_(3) and Ce_(2)(SO_(4))_(3)·5H_(2)O and formed through the different pathways.In addition,good regeneration of the reduced CaSO_(4)-CeO_(2) mixed OC could be reached in spite of the unavoidable interaction between the included minerals in coal and the reduced mixed OC.Overall,the combined template method-made CaSO_(4)-CeO_(2) mixed OC reported herein was not only endowed with enhanced reactivity for coal conversion,but also owned the potential to directionally fix the gaseous sulfur emission,which is quite applicable as OC for simultaneous decarbonatization and desulfurization in the real CLC process. | Baowen Wang Zhongyuan Cai Heyu Li Yanchen Liang Tao Jiang Ning Ding Haibo Zhao | 2022 | Chinese Journal of Chemical Engineering2022，35，2： | 1 |
| 13 | Molecule diffusion behaviours of waterproof sealants into silicone rubber insulation for submarine cable joint based on molecular dynamics simulations显示文摘The repair joints of high-voltage cables play a significant role in the urgent cable main-tenance,by recovering cable conductor,insulation,shielding layer and waterproof layer especially for submarine cables.However,the molecule diffusion and permeation pro-cesses from waterproof sealant into the cable joint insulation occur,leading to the insulation ageing and deterioration.In this article,the molecule diffusion behaviours of six typical molecules from the asphalt-based and polyurethane-based waterproof sealants into silicone rubber insulation are investigated.The results show that the order of diffusion coefficients is as follows,phenanthrene>fluoranthene>pyrene>benzo[k]fluoranthene>indeno[1,2,3-cd]pyrene>polyurethane(PU).The relative molecular mass and binding energy are pivotal factors affecting the diffusion behaviour,while there is a linear relationship between the logarithm of the diffusion coefficient and the ratio of binding energy to relative molecular mass.Besides,the rising ambient temperature in-creases the fraction of free volume of silicone rubber and decreases the binding energy,thus resulting in a higher diffusion coefficient and an enhanced permeation process of the asphalt-based sealant.In summary,the PU-based waterproof sealant,with a much lower permeability than the asphalt-based material,has a potential application in the waterproof layer for high-voltage submarine cable repair joints. | Zhenpeng Zhang Heyu Wang Zhonglei Li Jiankang Zhao Shaohua Wang Wenlin Pan Wenjie Li Te Li Boxue Du | 2021 | High Voltage2021，6，2： | 1 |
| 14 | Platelets and platelet alloantigens:Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia显示文摘Platelets play critical roles in hemostasis and thrombosis.Emerging evidence indicates that they are versatile cells and also involved in many other physiological processes and disease states.Fetal and neonatal alloimmune thrombocytopenia(FNAIT)is a life threatening bleeding disorder caused by fetal platelet destruction by maternal alloantibodies developed during pregnancy.Gene polymorphisms cause platelet surface protein incompatibilities between mother and fetus,and ultimately lead to maternal alloimmunization.FNAIT is the most common cause of intracranial hemorrhage in full-term infants and can also lead to intrauterine growth retardation and miscarriage.Proper diagnosis,prevention and treatment of FNAIT is challenging due to insufficient knowledge of the disease and a lack of routine screening as well as its frequent occurrence in first pregnancies.Given the ethical difficulties in performing basic research on human fetuses and neonates,animal models are essential to improve our understanding of the pathogenesis and treatment of FNAIT.The aim of this review is to provide an overview on platelets,hemostasis and thrombocytopenia with a focus on the advancements made in FNAIT by utilizing animal models. | Brian Vadasz Pingguo Chen Issaka Yougbare Darko Zdravic June Li Conglei Li Naadiya Carrim Heyu Ni | 2015 | Genes & Diseases2015，2，2： | 1 |
| 15 | Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCII^(hi) neutrophils显示文摘Breast cancer can metastasize to various organs,including the lungs.The immune microenvironment of the organs to be metastasized plays a crucial role in the metastasis of breast cancer.Infection with pathogens such as viruses and bacteria can alter the immune status of the lung.However,the effect of chronic inflammation caused by bacteria on the formation of a premetastatic niche within the lung is unclear,and the contribution of specific immune mediators to tumor metastasis also remains largely undetermined.Here,we used a mouse model revealing that chronic pulmonary bacterial infection augmented breast cancer lung metastasis by recruiting a distinct subtype of tumor-infiltrating MHCII^(hi) neutrophils into the lung,which exhibit cancer-promoting properties.Functionally,MHCII^(hi) neutrophils enhanced the lung metastasis of breast cancer in a cell-intrinsic manner.Furthermore,we identified CCL2 from lung tissues as an important environmental signal to recruit and maintain MHCII^(hi) neutrophils.Our findings clearly link bacterial-immune crosstalk to breast cancer lung metastasis and define MHCII^(hi) neutrophils as the principal mediator between chronic infection and tumor metastasis. | Teng Ma Yu Tang Taolin Wang Yang Yang Yige Zhang Ruihuan Wang Yongxin Zhang Yi Li Mingbo Wu Miao Tang Xueli Hu Chaoyu Zou Yuan Ren Huan Liu Qianhua Zhang Heyue Li Min Wu Jing Li Xikun Zhou | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 16 | Segregation of Re at theγ/γ'boundary of Ni-based single crystal superalloys revealed by first-principles calculations based Monte-Carlo simulations显示文摘Nickel-based single crystal superalloys have been widely used in aero-engines and gas turbine engines.To improve the creep resistance,rhenium is often added to the alloys.However,it is not yet fully under-stood how the added Re elements distribute in the alloys and how the microstructure evolves with the addition of Re.Here,we performed extensive first-principles calculations based Monte-Carlo simulated annealing of Ni-Al-Re ternary alloys with different Re concentrations ranging from 0.5 at.%to 6.0 at.%.The results demonstrate that with the decreasing temperature,most of Re atoms stay in theγphase,while a few of Re atoms stay in theγ'phase and tend to occupy the Al positions.At low temperatures,the Re atoms segregate at theγ/γ'boundary,in good agreement with experiment.We find that the disorder-order transition temperature of the Ni-Al-Re ternary alloys increases with the Re concentration due to the Re-enhanced Al-Al ordering tendency.In addition,we observe that at low temperatures the Re segregation at theγ/γ'boundary promotes the formation of Ni 4 Re-or Ni 8 Re-like local structures as the Re concentration is over 2 at.%.The formation of a large amount of these local structures consumes the Re atoms in solid solutions,and thus from the solid-solution strengthening point of view,this would have a negative influence on the creep resistance of the superalloys.This work provides important atomistic insights on the Re distribution and its effects on the stability of superalloys. | Heyu Zhu Jiantao Wang Lei Wang Yongpeng Shi Mingfeng Liu Jiangxu Li Yun Chen Yingche Ma Peitao Liu Xing-Qiu Chen | 2023 | Journal of Materials Science & Technology2023，，12： | 0 |
| 17 | Particles attrition of binary mixtures in the coal-fueled chemical looping system based on fluidized bed显示文摘In this work,a reactive air jet attrition device with auto-recording and collection of elutriated fines was developed.Results established insights into the physiochemical interaction and further correlated attrition behaviors between char and oxygen carriers under various operation modes.The attrition rate increased by over 110% upon the introduced CO_(2),which brought in the significant effect of thermo-chemical stress,similarly in effects of the increased char addition ratio and the decreased sizes of char or hematite in different extents.For the char-hematite co-attrition process,the elutriated carbon loss of char with poor mechanical strength was found to be over 10%,while the reactive iron loss of hematite was found to be 6.3%,and was enriched in elutriated fines.The reaction-derived thermochemical stress and the collision-derived mechanical stress jointly controls the particle attrition during the cyclic transformation of oxygen carrier particles in coal-fueled chemical looping fluidization,especially sig-nificant in its reduction stage. | Heyu Li Zhe Sun Yan Cao | 2024 | Particuology2024，86，3： | 0 |
| 18 | Non-reproducibility of Cross Sections Measured in Dissipative Reaction of ^(19)F+^(27)Al显示文摘The measurement of cross sections of dissipative collision for the reaction system of 119F+27Al has been carried out at China Institute of Atomic Energy, Beijing. In this measurement, the 19F8+ beam was provided by the HI-13 tandem accelerator at incident energy of 114 MeV. Three sets of △E-E telescope were employed to identify the charge number Z of the fragments emitted at +57°, +31°and -29°in laboratory system. | Dong Yuchuan, Wang Qi, Li Songlin, Duan Limin, Xu Hushan, Xu Huagen Chen Ruofu, Wu Heyu and Han Jianlong | 2004 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2004，，1： | 0 |
| 19 | Correction to: LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells显示文摘In this article,published online on 7 November 2019,there was an unintended error during image processing of Fig.1a and Fig.6c leading to wrong pictures to appear.These pictures have now been replaced with the appropriate pictures that were generated for this experiment.The corrected Fig.1 and Fig.6 are shown here.The conclusion made from the experiments remains unaltered.The inconvenience caused by this error is deeply regretted. | Zunling Li Mi Deng Fangfang Huang Changzhu Jin Shuang Sun Heyu Chen Xiaoye Liu Licai He Ali H.Sadek Cheng Cheng Zhang | 2020 | Cellular & Molecular Immunology2020，17，3： | 0 |
| 20 | STING,a critical contributor to SARS-CoV-2 immunopathology显示文摘Recently,a study published in Nature by Domizio et al.1 revealed the underlying mechanism of aberrant immunopathology during the late phase of infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The authors provided evidence demonstrating that stimulator of interferon genes(STING)plays a unique role in the alveolus-capillary cytokine storm induced by mitochondrial DNA(mtDNA)during coronavirus disease 2019(COVID-19)(Fig.1).Some studies stressed that the STING agonists block the SARS-CoV-2 infection via triggering the type I interferons(IFNs)response,2,3 while others revealed that SARS-CoV-2 induces the chromatin DNA traveling to cytosol by promoting the cell-tocell fusion,resulting in the activation of cGAS-STING signaling. | Heyu Li Fangfang Zhou Long Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员