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您的检索式：作者名="Hideki IGISU"
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| 1 | Crylamide Eneephalopathy显示文摘 | Hideki IGISU Masato MATSUOKA | 2002 | Journal of Occupational Health2002，44，： | 1 |
| 2 | 辐射诱导IEC-6细胞MAPK信号转导途径的激活(英文)显示文摘研究检测了γ辐射对IEC 6肠上皮细胞丝裂原激活的蛋白激酶 (MAPKS)的激活效应。 6Gyγ辐射未引起ERK蛋白磷酸化的显著改变 ,而辐照射后 30minJNK与 p38MAPK蛋白磷酸化显著增强 ,ERK、JNK和p38MAPK的总蛋白表达水平未见明显的变化。受照后 12h细胞存活率显著降低。螯合细胞内Ca2 +可几乎完全抑制γ辐照引起的JNK与 p38MAPK的蛋白磷酸化 ,而清除细胞外Ca2 +却无此作用。p38MAPK的激活与γ辐射诱导的细胞凋亡显著相关 ,而ERK则无明显的关联。实验结果表明 ,γ辐射是一种强的JNK与 p38MAPK激活因素 ,并且细胞内储存Ca2 +的释放在γ辐射诱导的IEC | 周舟 王小华 Igisu Hideki 林远 楼淑芬 Matsuoka Masato 程天民 余争平 | 2002 | 辐射研究与辐射工艺学报2002，20，2： | 1 |
| 3 | Magnetic resonance for evaluation of toxic encephalopathies: Implications from animal experiments显示文摘 | Hideki Igisu Yoshimasa Kinoshita | 2006 | Neurotoxicology2006，，2： | 1 |
| 4 | Differential activation of mitogen-activated protein kinases by γ-irradi-ation in IEC-6 cells: Role of intracellular Ca^(2+)显示文摘Abstract Objective:To explore the effects of γ-irradiation on mitogen-activatedprotein kinases(MAPKs) and role intracellular calcium in this event in intestinal epithelial cell line 6(IEC-6 cells).Methods:After cultured rat IIEC-6 cells with or without the pretreatment of intracellular Ca^2+ chelator were exposed to γ-ir-radiation of 6 Gy, the total and phosphorylated MAPKs in the cells were determined with Western blotting and apoptosis was examined with flow cytometry.Activities of Extracellular signal-regulated protein kinase (ERK) and p38 MAPK were determined by using immuoprecipitation followed by Western blotting.Results:In response to γ-irradiation,phosphorylation of ERK was not significantly observed ,while the levels of phos-phorylated c-Jun NH2-terminal kinase(JNK) and p38 MAPK were increased in 30 min and reached the peak 2h after exposure to 6Gy γ-irradiation,though the cell viability was significantly lowered 12h.On the other hand, no obvious changes were seen in the total protein levels of ERK, JNK and p38 MAPK.Chelation of in-tracellular Ca^2+ almost completely suppressed the JNK and p38 MAPK phosphorylation induced by γ-irradiation is a potent activator for JNK and p38 MAPK, and Ca^2+ mobilized from intracellular stores plays an important role in the activation of MAPKs and the induction of apoptosis in IEC-6 cells. | 周舟 王小华 Igisu Hideki 林远 楼淑芬 Matsuoka Masato 程天民 余争平 | 2002 | Journal of Medical Colleges of PLA(China)2002，17，3： | 0 |
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