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| 1 | Modified docetaxel, cisplatin and capecitabine for stage Ⅳ gastric cancer in Japanese patients: A feasibility study显示文摘AIM To evaluate the feasibility of chemotherapy including fluoropyrimidine, platinum and taxane with modified dosages for unresectable gastric cancer in Japanese patients.METHODS We performed a feasibility study of a modified docetaxel, cisplatin and capecitabine (DCX) regimen for stage Ⅳ gastric cancer. In particular, 30 or 40 mg/m^2 of docetaxel on day 1, 60 mg/m^2 of cisplatin on day 1, and 2000 mg/m^2 of capecitabine for 2 wk were administered every three weeks.RESULTS Three patients were treated with modified DCX(m DCX) with 30 mg/m^2 docetaxel, and five patients were treated with this regimen with 40 mg/m^2 docetaxel. Grade 3 or 4 neutropenia was observed in six of the eight patients; no patients exhibited febrile neutropenia. Partial response was achieved in four of the eight patients. Three patients underwent gastrectomy, which achieved R0 resection without residual tumors in dissected lymph nodes. In one of these three patients, resected specimens revealed pathological complete response in the primary lesion and in lymph nodes.CONCLUSION m DCX was well tolerated by Japanese patients with stage Ⅳ gastric cancer. This regimen might be useful for allowing gastric cancer patients with distant lymph node metastasis to undergo conversion surgery. | Osamu Maeda Ayumu Matsuoka Ryoji Miyahara Kohei Funasaka Yoshiki Hirooka Masahide Fukaya Masato Nagino Yasuhiro Kodera Hidemi Goto Yuichi Ando | 2017 | World Journal of Gastroenterology2017，23，6： | 4 |
| 2 | Fluoride-induced cyclooxygenase-2 expression and prostaglandin E 2 production in A549 human pulmonary epithelial cells显示文摘 | Wakako Ridley Masato Matsuoka | 2009 | Toxicology Letters2009，，3： | 1 |
| 3 | Activation of c-Jun NH2-Terminal Kinase(JNK/SAPK) in LLC-PKa Cells by Cadmlum显示文摘 | Matsuoka Masato Iglsu Hideki | 1998 | Biochemical and Biophysical Research Communications1998，251，2： | 1 |
| 4 | Increased levels of platelet-derived microparticles in patients with diabetic retinopathy显示文摘 | Nahoko Ogata Masahito Imaizumi Shosaku Nomura Akira Shozu Miwa Arichi Masato Matsuoka Miyo Matsumura | 2004 | Diabetes Research and Clinical Practice2004，，3： | 1 |
| 5 | Crylamide Eneephalopathy显示文摘 | Hideki IGISU Masato MATSUOKA | 2002 | Journal of Occupational Health2002，44，： | 1 |
| 6 | Photocatalytic decomposition of NO under visible light irradiation on the Cr‐ion‐implanted TiO 2 thin film photocatalyst显示文摘 | Masato Takeuchi Hiromi Yamashita Masaya Matsuoka Masakazu Anpo Takashi Hirao Nobuhisa Itoh Nobuya Iwamoto | 2000 | Catalysis Letters2000，，2： | 1 |
| 7 | 辐射诱导IEC-6细胞MAPK信号转导途径的激活(英文)显示文摘研究检测了γ辐射对IEC 6肠上皮细胞丝裂原激活的蛋白激酶 (MAPKS)的激活效应。 6Gyγ辐射未引起ERK蛋白磷酸化的显著改变 ,而辐照射后 30minJNK与 p38MAPK蛋白磷酸化显著增强 ,ERK、JNK和p38MAPK的总蛋白表达水平未见明显的变化。受照后 12h细胞存活率显著降低。螯合细胞内Ca2 +可几乎完全抑制γ辐照引起的JNK与 p38MAPK的蛋白磷酸化 ,而清除细胞外Ca2 +却无此作用。p38MAPK的激活与γ辐射诱导的细胞凋亡显著相关 ,而ERK则无明显的关联。实验结果表明 ,γ辐射是一种强的JNK与 p38MAPK激活因素 ,并且细胞内储存Ca2 +的释放在γ辐射诱导的IEC | 周舟 王小华 Igisu Hideki 林远 楼淑芬 Matsuoka Masato 程天民 余争平 | 2002 | 辐射研究与辐射工艺学报2002，20，2： | 1 |
| 8 | Photocatalytic decomposition of NO under visible light irradiation on the Cr‐ion‐implanted TiO2 thin film photocatalyst显示文摘 | Masato Takeuchi Hiromi Yamashita Masaya Matsuoka Masakazu Anpo Takashi Hirao Nobuhisa Itoh Nobuya Iwamoto | 2000 | Catalysis Letters (-)2000，，2： | 1 |
| 9 | Surgery for ulcerative colitis in 1,000 patients显示文摘 | Hiroki Ikeuchi Motoi Uchino Hiroki Matsuoka Toshihiro Bando Takayuki Matsumoto Naohiro Tomita Yasutugu Syoji Masato Kusunoki Takehira Yamamura Joji Utsunomiya | 2010 | International Journal of Colorectal Disease2010，，8： | 1 |
| 10 | Effects of Intraocular Ranibizumab and Bevacizumab in Transgenic Mice Expressing Human Vascular Endothelial Growth Factor显示文摘 | Katsuaki Miki Akiko Miki Masato Matsuoka Daisuke Muramatsu Sean F. Hackett Peter A. Campochiaro | 2009 | Ophthalmology2009，，9： | 1 |
| 11 | Photocatalytic decomposition of NO under visible light irradiation on the Cr‐ion‐implanted TiO2 thin film photocatalyst显示文摘 | Masato Takeuchi Hiromi Yamashita Masaya Matsuoka Masakazu Anpo Takashi Hirao Nobuhisa Itoh Nobuya Iwamoto | 2000 | Catalysis Letters (-)2000，，2： | 1 |
| 12 | Activation of c-Jun NH2-terminal kinase (JNK/SAPK) in LLC-PK1 cells by cadmium 显示文摘 | lgisu Hideki | 1998 | Biochemical and Biophysical Research Communications1998，251，2： | 1 |
| 13 | Photocatalytic decomposition of NO under visible light irradiation on the Cr‐ion‐implanted TiO2 thin film photocatalyst显示文摘 | Masato Takeuchi Hiromi Yamashita Masaya Matsuoka Masakazu Anpo Takashi Hirao Nobuhisa Itoh Nobuya Iwamoto | 2000 | Catalysis Letters (-)2000，，2： | 1 |
| 14 | Age is an independent adverse prognostic factor for overall survival in acute myeloid leukemia in Japan显示文摘AIM: To elucidate risk factors for survival of elderly acute myeloid leukemia(AML) patients in a real-world practice by observational study. METHODS: We conducted a population-based study in 213 adult and elderly AML patients(127 males and 86 females) in Kagawa Prefecture, Japan. To construct this cohort, we gathered all data for patients diagnosed with AML at 7 hospitals in Kagawa between 2006 and 2010. The primary end point was overall survival(OS) after AML diagnosis. Unadjusted Kaplan-Meier survival plots were used to determine OS in the overall cohort. Multivariate analysis was used to determine the independent adverse prognostic factors for OS, with the covariates of interest including age, gender, race/ethnicity, CCI, education, median income, metropolitan statistical area size and history of myelodysplastic syndrome.RESULTS: The average population of Kagawa during the study period was 992489, and the incidence of AML was 4.26 per 100000 person-years. A total of 197 patients with non-acute promyelocytic leukemia(non-APL)(119 males and 78 females) were also included. The median age of non-APL patients was 70 years(average 67, range 24-95). The 5-year OS rate was 21.1%. Subsequent analysis by age group showed that the survival rate declined with age; the 5-year OS rates of non-APL patients younger than 64 years, 65-74 years, and older than 75 years were 41.5%, 14.1%, and 8.9%, respectively. Multivariate analysis revealed that unfavorable risk karyotype, older age, poor performance status(PS)(3-4), lack of induction chemotherapy, and antecedent haematological disease were independent prognostic predictors. In the subgroup analysis, we also found that older patients with non-APL had lower complete remission rates and higher early death rates than younger patients, irrespective of PS. However, intensive chemotherapy was a significant predictor for longer survival not only in the patients < 75 years of age, but also in those over 75 with PS 0-2. CONCLUSION: Age would contribute considerable life expectancy to indicate induction chemotherapy with eligible dose of cytotoxic drugs for a favorable case even in advanced elderly. | Hiroaki Ohnishi Osamu Imataki Yasunori Kawachi Makoto Ide Kimihiro Kawakami Masato Waki Hidetaka Takimoto Yasuo Hoshijima Tetsuya Fukumoto Kensuke Matsumoto Fusako Waki Akihito Matsuoka Takamichi Shintani Makiko Uemura Shigeyuki Yokokura Teruhisa Taoka Takuya Matsunaga | 2014 | World Journal of Hematology2014，3，3： | 0 |
| 15 | Differential activation of mitogen-activated protein kinases by γ-irradi-ation in IEC-6 cells: Role of intracellular Ca^(2+)显示文摘Abstract Objective:To explore the effects of γ-irradiation on mitogen-activatedprotein kinases(MAPKs) and role intracellular calcium in this event in intestinal epithelial cell line 6(IEC-6 cells).Methods:After cultured rat IIEC-6 cells with or without the pretreatment of intracellular Ca^2+ chelator were exposed to γ-ir-radiation of 6 Gy, the total and phosphorylated MAPKs in the cells were determined with Western blotting and apoptosis was examined with flow cytometry.Activities of Extracellular signal-regulated protein kinase (ERK) and p38 MAPK were determined by using immuoprecipitation followed by Western blotting.Results:In response to γ-irradiation,phosphorylation of ERK was not significantly observed ,while the levels of phos-phorylated c-Jun NH2-terminal kinase(JNK) and p38 MAPK were increased in 30 min and reached the peak 2h after exposure to 6Gy γ-irradiation,though the cell viability was significantly lowered 12h.On the other hand, no obvious changes were seen in the total protein levels of ERK, JNK and p38 MAPK.Chelation of in-tracellular Ca^2+ almost completely suppressed the JNK and p38 MAPK phosphorylation induced by γ-irradiation is a potent activator for JNK and p38 MAPK, and Ca^2+ mobilized from intracellular stores plays an important role in the activation of MAPKs and the induction of apoptosis in IEC-6 cells. | 周舟 王小华 Igisu Hideki 林远 楼淑芬 Matsuoka Masato 程天民 余争平 | 2002 | Journal of Medical Colleges of PLA(China)2002，17，3： | 0 |
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