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| 1 | Molecular pathogenesis of sporadiccolorectal cancers显示文摘Colorectal cancer(CRC)results from the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic mucosa to adenocarcinoma.Approximately 75%of CRCs are sporadic and occur in people without genetic predisposition or family history of CRC.During the past two decades,sporadic CRCs were classified into three major groups according to frequently altered/mutated genes.These genes have been identified by linkage analyses of cancer-prone families and by individual mutation analyses of candidate genes selected on the basis of functional data.In the first half of this review,we describe the genetic pathways of sporadic CRCs and their clinicopathologic features.Recently,large-scale genome analyses have detected many infrequently mutated genes as well as a small number of frequently mutated genes.These infrequently mutated genes are likely described in a limited number of pathways.Gene-oriented models of CRC progression are being replaced by pathway-oriented models.In the second half of this review,we summarize the present knowledge of this research field and discuss its prospects. | Hidetsugu Yamagishi Hajime Kuroda Yasuo Imai Hideyuki Hiraishi | 2016 | Chinese Journal of Cancer2016，35，1： | 7 |
| 2 | Endoscopic and biopsy diagnoses of superficial, nonampullary, duodenal adenocarcinomas显示文摘AIM: To investigate the accuracy of endoscopic or biopsy diagnoses of superficial nonampullary duodenal epithelial tumors(NADETs).METHODS:Clinicopathological data were reviewed for84 superficial NADETs from 74 patients who underwent surgery or endoscopic resection between September2002 and August 2014 at a single prefectural cancer center.Superficial NADETs were defined as lesions confined to the mucosa or submucosa.Demographic and clinicopathological data were retrieved from charts,endoscopic and pathologic reports.Endoscopic reports included endoscopic diagnosis,location,gross type,diameter,color,and presence or absence of biopsy.Endoscopic diagnoses were made by an endoscopist in charge of the examination before biopsy specimens were obtained.Endoscopic images were obtained using routine,front-view,high-resolution video endoscopy,and chromoendoscopy with indigocarmine was performed for all lesions.Endoscopic images were reviewed by at least two endoscopists to assess endoscopic findings indicative of carcinoma.Preoperative diagnoses based on endoscopy and biopsy findings were compared with histological diagnoses of resected specimens.Sensitivity,specificity,and accuracy were assessed for endoscopic diagnosis and biopsy diagnosis.RESULTS:The majority(81%)of the lesions were located in the second portion of the duodenum.The median lesion diameter was 14.5 mm according to final histology.Surgery was performed for 49 lesions from 39 patients,and 35 lesions from 35 patients were endoscopically resected.Final histology confirmed 65carcinomas,15 adenomas,and 3 hyperplasias.A finaldiagnosis of duodenal carcinoma was made for 91%(52/57)of the lesions diagnosed as carcinoma by endoscopy and 93%(42/45)of the lesions diagnosed as carcinoma by biopsy.The sensitivity,specificity,and accuracy of endoscopic diagnoses were 80%,72%,and 78%,respectively,whereas those of biopsy diagnoses were 72%,80%,and 74%,respectively.Preoperative diagnoses of carcinomas were made in88%(57/65)of the carcinoma lesions via endoscopy or biopsy.Endoscopic findings associated with carcinoma were red color,depression,and mixed-type morphology.CONCLUSION:Preoperative endoscopy and biopsy showed similar accuracies in the diagnosis of carcinoma in patients with superficial NADETs. | Naomi Kakushima Hideyuki Kanemoto Keiko Sasaki Noboru Kawata Masaki Tanaka Kohei Takizawa Kenichiro Imai Kinichi Hotta Hiroyuki Matsubayashi Hiroyuki Ono | 2015 | World Journal of Gastroenterology2015，21，18： | 3 |
| 3 | Clinical importance of colonoscopy in patients with gastric neoplasm undergoing endoscopic submucosal dissection显示文摘AIM To evaluate the usefulness of total colonoscopy(TCS) for patients undergoing gastric endoscopic submucosal dissection(ESD) and to assess risk factors for colorectal neoplasms.METHODS Of the 263 patients who underwent ESD at our department between May 2010 and December 2013, 172 patients undergoing TCS during a one-year period before and after ESD were targeted. After excluding patients with a history of surgery or endoscopic therapy for colorectal neoplasms, 158 patients were analyzed. Of the 868 asymptomatic patients who underwent TCS during the same period because of positive fecal immunochemical test(FIT) results, 158 patients with no history of either surgery or endoscopic therapy for colorectal neoplasms who were matched for age and sex served as the control group for comparison.RESULTS TCS revealed adenoma less than 10 mm in 53 patients(33.6%), advanced adenoma in 17(10.8%), early colorectal cancer in 5(3.2%), and advanced colorectalcancer in 4(2.5%). When the presence or absence of adenoma less than 10 mm, advanced adenoma, and colorectal cancer and the number of adenomas were compared between patients undergoing ESD and FITpositive patients, there were no statistically significant differences in any of the parameters assessed. The patients undergoing ESD appeared to have the same risk of colorectal neoplasms as the FIT-positive patients. Colorectal neoplasms were clearly more common in men than in women(P = 0.031). Advanced adenoma and cancer were significantly more frequent in patients with at least two of the following conditions: hypertension, dyslipidemia, and diabetes mellitus(P = 0.019).CONCLUSION In patients undergoing gastric ESD, TCS appears to be important for detecting synchronous double neoplasms. Advanced adenoma and cancer were more common in patients with at least two of the following conditions: hypertension, dyslipidemia, and diabetes mellitus. Caution is therefore especially warranted in patients with these risk factors. | Chieko Tsuchida Naoto Yoshitake Hitoshi Kino Yoshihito Kaneko Masakazu Nakano Kohei Tsuchida Keiichi Tominaga Takako Sasai Hironori Masuyama Hidetsugu Yamagishi Yasuo Imai Hideyuki Hiraishi | 2017 | World Journal of Gastroenterology2017，23，23： | 3 |
| 4 | Function of RNA-binding protein Musashi-1 in stem cells显示文摘 | Hideyuki Okano Hironori Kawahara Masako Toriya Keio Nakao Shinsuke Shibata Takao Imai | 2005 | Experimental Cell Research2005，，2： | 2 |
| 5 | Water purification with sintered porous materials fabricated at 400℃ from sea bottom sediments显示文摘A sintering technology for preparing porous materials from sea bottom sediments was developed for use in water purification.The purpose of the present study was to develop methods for converting the sea bottom sediments dredged from Ago Bay into value-added recycled products.The sintered products fabricated at 400℃were found to be very effective adsorbents for the removal of heavy metals. | DABWAN Ahmed H A IMAI Daizo KANECO Satoshi SENMATSU Isamu NAKAHAMA Katsuyuki KATSUMATA Hideyuki SUZUKI Tohru OHTA Kiyohisa | 2008 | Journal of Environmental Sciences2008，20，2： | 2 |
| 6 | Functional assessment versus conventional volumetric assessment in the prediction of operative outcomes after major hepatectomy显示文摘 | Hiromitsu Hayashi Toru Beppu Hirohisa Okabe Hideyuki Kuroki Shigeki Nakagawa Katsunori Imai Hidetoshi Nitta Akira Chikamoto Takatoshi Ishiko Hideo Baba | 2014 | Surgery2014，，： | 2 |
| 7 | Va-gally mediated heart rate recovery after exercise is ac-celerated in athletes but blunted in patients with chronicheart failure 显示文摘 | Katsuji Imai Hideyuki Sato Masatsugu Hori | 1994 | Journal of the American College ofCardiology1994，24，6： | 1 |
| 8 | Clinical evaluation of plasma des-γ-carboxy prothrombin as a marker protein of hepatocellular carcinoma in patients with tumors of various sizes显示文摘 | Dr. Akinori Kasahara MD Norio Hayashi MD Hideyuki Fusamoto MD Yoshio Kawada MD Yasukiyo Imai MD Hideo Yamamoto MD Eijiro Hayashi MD Toshio Ogihara MD Takenobu Kamada MD | 1993 | Digestive Diseases and Sciences1993，，12： | 1 |
| 9 | Ovarian development and induced oviposition of the overwintering swimming crab Portunus trituberculatus (Brachyura:Portunidae) reared in the laboratory显示文摘 | Katsuyuki HAMASAKI Hideyuki IMAI Nobuhiko AKIYAMA | 2004 | FISHERIES SCIENCE2004，，70： | 1 |
| 10 | Some properties of minimal solutions for a fuzzy relation equation显示文摘 | Hideyuki Imai Masaaki Miyakoshi Tsutomu D | 1997 | Fuzzy Sets and Systems1997，90，： | 1 |
| 11 | About Influence formation processi Vavistor of SiO2 and Cr2O3显示文摘 | HIDEYUKI KANAI MOTOMASA IMAI | 1988 | Journal of Materials Science1988，23，： | 1 |
| 12 | XPS analysis of p-type Cu-doped CdS thin films显示文摘 | Takashi Abe Yasube Kashiwaba Mamoru Baba Jun Imai Hideyuki Sasaki | 2001 | Applied Surface Science2001，，： | 1 |
| 13 | Probably cor- rect k - nearest neighbor search in high dimensions 显示文摘 | Jun Toyama Mineichi Kudo Hideyuki Imai | 2010 | PatternRecognition2010，43，： | 1 |
| 14 | Ready chemical conversion of acid hydrolysis lignin into water-soluble lignosulfonate II: Hydroxymethylation and subsequent sulfonation of phenolized lignin model compounds显示文摘 | Seiichi Yasuda Eri Hamaguchi Yasuyuki Matsushita Hideyuki Goto Takanori Imai | 1998 | Journal of Wood Science1998，，2： | 1 |
| 15 | High CD44s expression is associated with the EMT expression profile and intrahepatic dissemination of hepatocellular carcinoma after local ablation therapy显示文摘 | Kosuke Mima Hiromitsu Hayashi Katsunori Imai Hideyuki Kuroki Shigeki Nakagawa Hirohisa Okabe Akira Chikamoto Masayuki Watanabe Toru Beppu Hideo Baba | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，4： | 1 |
| 16 | The Glu298Asp polymorphism in endothelial nitric oxide synthase gene is associated with coronary in-stent restenosis显示文摘 | Tomomichi Suzuki Kenji Okumura Takahito Sone Tai Kosokabe Hideyuki Tsuboi Junichiro Kondo Hiroaki Mukawa Hiroki Kamiya Takahito Tomida Hajime Imai Hideo Matsui Tetsuo Hayakawa | 2002 | International Journal of Cardiology2002，，： | 1 |
| 17 | The period of powers of a fuzzy matrix显示文摘 | Hideyuki Imai Yuichiro Okahara MasaakiMiyakoshi | 2000 | Fuzzy Sets and Systems2000，，109： | 1 |
| 18 | Mouse-Musashi-1, a Neural RNA-Binding Protein Highly Enriched in the Mammalian CNS Stem Cell显示文摘 | Shin-ichi Sakakibara Takao Imai Kayoko Hamaguchi Masataka Okabe Jun Aruga Kazunori Nakajima Daisuke Yasutomi Takashi Nagata Yasuyuki Kurihara Seiichi Uesugi Takaki Miyata Masaharu Ogawa Katsuhiko Mikoshiba Hideyuki Okano | 1996 | Developmental Biology1996，，2： | 1 |
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