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| 1 | Impact of postoperative intravenous fluid administration on complications following elective hepato-pancreato-biliary surgery显示文摘Background: The impact of perioperative intravenous fluid administration on surgical outcomes has been documented in literature, but not specifically studied in the context of hepato-pancreato-biliary(HPB) surgery. This study aimed to investigate the impact of postoperative intravenous fluid administration on intensive care unit(ICU), in this subgroup of patients. Methods: A single-center retrospective cohort of 241 HPB patients was assessed, focusing on intravenous fluid administration in ICU, during the first 24 h. Intravenous fluid variables were compared to hospital stay and postoperative complications. Data were assessed using Spearman's correlation test for bivariate correlations and logistic regression for multivariate analysis. Results: The median volume of intravenous fluid administered in the first 24 h postoperatively was 4380 mL, of which 2200 mL was crystalloid, 1500 mL colloid and 680 mL 'other' fluid. Patients with one or more complications had a higher median total intravenous fluid input(4790 vs. 4300 mL), higher colloid volume(20 0 0 vs. 150 0 mL), lower urine output(1595 vs. 1900 mL) and greater overall fluid balance( + 3040 vs. + 2553 mL) than those without complications. There were correlations between total intravenous fluid volume administered( r = 0.278, P < 0.001), intravenous colloid input( r = 0.278, P < 0.001), urine output( r =-0.295, P < 0.001), positive fluid balance( r = 0.344, P < 0.001) and length of hospital stay. Logistic regression model was constructed to predict the occurrence of one or more complications; total intravenous fluid volume and overall fluid balance were both independent significant predictors(OR = 2.463, P = 0.007; OR = 1.001, P = 0.011; respectively). Conclusions: Administration of high volumes of intravenous fluids in the first 24 hours post-HPB surgery, along with higher positive fluid balance is associated with a higher rate of complications and longer hospital stay. Moreover, lower urine output is associated with longer hospital stay. Whether these are the cause of complications or the result of them remains unclear. | Daniel Martin Panagis M.Lykoudis Gabriel Jones David Highton Alan Shaw Sarah James Qiang Wei Giuseppe Fusai | 2018 | Hepatobiliary & Pancreatic Diseases International2018,17,5: | 2 |
| 2 | Rationale for a trial of immunosuppressive therapy in acute schizophrenia 显示文摘 | KNIGHT JG MENKES DB HIGHTON J | 2007 | Molecular Psychiatry2007,34,12: | 1 |
| 3 | Neuromuscular, biochemical and perceptual post - match fatigue in professional rugby league forwards and backs 显示文摘 | Twist C Waldron M Highton J Burt D and Daniels M | 2012 | J Sports Sci2012,30,: | 1 |
| 4 | Retentive and stress characteristics for a magnetically-retained partial overdenture 显示文摘 | Highton R Caputo AA Matyas J | 1986 | J Oral Rehabil1986,13,5: | 1 |
| 5 | A photoelastic study 6 of stresses ton porcelain laminate preparations显示文摘 | Highton R Caputo AA Mitys J | 1987 | J Pros- thet Dent1987,58,2: | 1 |
| 6 | Rationale for a trial of immunosu -ppressive therapy in acute schizophrenia显示文摘 | KNIGHT J G MENKES D B HIGHTON J | 2007 | Molecular Psychiatry2007,34,12: | 1 |
| 7 | Mathematical modelling of near-infrared spectroscopy signals and intracranial pressure in brain-injured pa- tients显示文摘 | Highton D Panovska-Griffiths J Smith M Elwell C E | 2013 | Adv Exp Med Biol2013,789,: | 1 |
| 8 | A photoelastic study of stresses on porcelain laminate preparations显示文摘 | Highton R Caputo AA Matyas J | 1987 | Prosther Dent1987,58,: | 1 |
| 9 | cytokine profile of the rheumatoid nodule suggests that id a Th1 granuloma显示文摘 | Hessian PA Highton J Kean A | 2003 | Arthritis Rheum2003,48,2: | 1 |
| 10 | Mathematical modelling of near-infrared spectroscopy signals and intracranial pressure in brain-injured patients 显示文摘 | Highton D Panovska-Griffiths J Smith M | 2013 | Adv Exp Med Biol2013,789,: | 1 |
| 11 | Cytokine profile of the rheumatoid nodule suggests that it is a Th1 granuloma显示文摘 | Hessian P A Highton J Kean A | 2003 | Arthritis Rheum2003,48,2: | 1 |
| 12 | Cytokine profile of the rheumatoid nodule suggests that is a Th1 granuloma显示文摘 | HESSIAN PA HIGHTON J KEAN A | 2003 | Arthritis Rheum2003,48,2: | 1 |
| 13 | Retentive and siress characteristics for a magnetically retained partialoverdenture显示文摘 | Highton R Caputo A A Matyas J | 1986 | J Oral Rehabil1986,13,5: | 1 |
| 14 | Rationale for a trial of immunosuppressive therapy in acute schizophrenia显示文摘 | Knight JG Menkes DB Highton J | 2007 | Molecular Psychiatry2007,12,5: | 1 |
| 15 | Rationale for a trial of immunosuppressive therapy in acute schizophrenia显示文摘 | Knight JG Menkes DB Highton J | 2007 | Molecular Paychiatry2007,12,5: | 1 |
| 16 | Cell death by apoptosisis a feature of the rheumatoid nodule显示文摘 | Highton J Hessian PA Kean A | 2003 | Ann Rheum Dis2003,62,1: | 1 |
| 17 | Retentive characteristics of different magnetic systems for dental applications显示文摘 | Highton R Caputo AA Pezzoli M | 1986 | J Prosthet Dent1986,6,1: | 1 |
| 18 | Renal impairment and gout显示文摘 | Gibson T Highton J Potter C | 1980 | Ann Rheum Dis1980,39,5: | 1 |
| 19 | Pneumonitis associated with leflunomide : A profile of New Zealand and Australian reports 显示文摘 | Savage RL Highton J Boyd IW | 2006 | In- tern Med J2006,36,: | 1 |
| 20 | cytokine profile of the rheumatoid nodule suggests that id a Thl 显示文摘 | Hessian PA Highton J Kean A | 2003 | granuloma Arthritis Rheum2003,48,2: | 1 |