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| 1 | Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells显示文摘Enzymes 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 and-4(PFKFB-3 and PFKFB-4)play a significant role in the regulation of glycolysis in cancer cells as well as its proliferation and survival.The expression of these mRNAs is increased in malignant tumors and strongly induced in different cancer cell lines by hypoxia inducible factor(HIF)through active HIF binding sites in promoter region of PFKFB-4 and PFKFB-3 genes.Moreover,the expression and hypoxia responsibility of PFKFB-4 and PFKFB-3 was also shown for pancreatic(Panc1,PSN-1,and MIA PaCa-2)as well as gastric(MKN45 and NUGC3)cancer cells.At the same time,their basal expression level and hypoxia responsiveness vary in the different cells studied:the highest level of PFKFB-4 protein expression was found in NUGC3 gastric cancer cell line and lowest in Panc1 cells,with a stronger response to hypoxia in the pancreatic cancer cell line.Overexpression of different PFKFB in pancreatic and gastric cancer cells under hypoxic condition is correlated with enhanced expression of vascular endothelial growth factor(VEGF)and Glut1 mRNA as well as with increased level of HIF-1αprotein.Increased expression of different PFKFB genes was also demonstrated in gastric,lung,breast,and colon cancers as compared to corresponding nonmalignant tissue counterparts from the same patients,being more robust in the breast and lung tumors.Moreover,induction of PFKFB-4 mRNA expression in the breast and lung cancers is stronger than PFKFB-3mRNA.The levels of both PFKFB-4 and PFKFB-3 proteins in non-malignant gastric and colon tissues were more pronounced than in the non-malignant breast and lung tissues.It is interesting to note that Panc1and PSN-1 cells transfected with dominant/negative PFKFB-3(dnPFKFB-3)showed a lower level of endogenous PFKFB-3,PFKFB-4,and VEGF mRNA expressions as well as a decreased proliferation rate of these cells.Moreover,a similar effect had dnPFKFB-4.In conclusion,there is strong evidence that PFKFB-4 and PFKFB-3 isoenzymes are induced under hypoxia in pancreatic and other cancer cell lines,are overexpressed in gastric,colon,lung,and breast malignant tumors and undergo changes in their metabolism that contribute to the proliferation and survival of cancer cells.Thus,targeting these PFKFB may therefore present new therapeutic opportunities. | Oleksandr H Minchenko Katsuya Tsuchihara Dmytro O Minchenko Andreas Bikfalvi Hiroyasu Esumi | 2014 | World Journal of Gastroenterology2014，20，38： | 17 |
| 2 | Isoreticular expansion of metal-organic frameworks with triangular and square building units and the lowest calculated density for porous crystals显示文摘 | Furukawa Hiroyasu Bok Go Yong Ko Nakeun Park Young Kwan Uribe-Romo Femando J Kim Jahenn O'Keeffe Michael Yaghi Omar M | 2011 | Inorganic Chemistry2011，50，： | 1 |
| 3 | Ultrahigh porosity in metal-organic frameworks 显示文摘 | Furukawa Hiroyasu Ko Nakeun Go Yong Bok Aratani Naoki Choi Sang Beom Choi Eunwoo Ozgtir Yazaydin A Snurr Randall Q O'Keeffe Michael Kim Jaheon Yaghi Omar M | 2010 | Science2010，329，： | 1 |
| 4 | New cucurbitae triterpenoids from Momordica charantia L显示文摘 | Majekodunmi O F Yoshio T Hiroyasu Y | 1990 | Journal of Natural Products1990，53，6： | 1 |
| 5 | Adaptive inhibitors of HIV-1 protease显示文摘 | Emesto F | 2005 | Prog Biophys Mol Biol2005，88，2： | 1 |
| 6 | Adaptive inhibitors of HIV-1 protease显示文摘 | HIROYASU O ERNESTO F | 2005 | Prog Biophys Mol Biol2005，88，2： | 1 |
| 7 | Colossal cages in zeolitic imidazolate frameworks as selective carbon dioxide reservoirs显示文摘 | Wang Bo Fumkawa Hiroyasu Yaghi O M | 2008 | Nature2008，453，： | 1 |
| 8 | Overcoming drug resistance in HIV-1 chemotherapy: The binding thermo- dynamics of amprenavir and TMC-126 to wild-type and drug-resistant mutants of the HIV-1 protease 显示文摘 | Hiroyasu O Adrian V C Dong X | 2002 | Protein Sci2002，11，8： | 1 |
| 9 | Localization and pharmacological characterization of H perospirone - binding sites in rat brain 显示文摘 | Hiroyasu T Yukihiro O Mitsutaka N | 1998 | Gen Pharmacol1998，31，： | 1 |
| 10 | Prospective study of depressive symptoms and risk of stroke among Japanese显示文摘 | Tetsuga O Hiroyasu I Shiji S | 2001 | Stroke2001，32，4： | 1 |
| 11 | Prospective study of depressive symptoms and risk of stroke among Japanese显示文摘 | Tetsuga O Hiroyasu I Shiji S | 2001 | Stroke2001，32，4： | 1 |
| 12 | Long - term outcome of autoimmune pancreatitis after oral prednisolone therapy 显示文摘 | Takayoshi N Fummitake T Hiroyasu O | 2006 | Internal Medicine2006，45，8： | 1 |
| 13 | The chemistry and applications of metal-organic frameworks 显示文摘 | Hiroyasu F Kyle E C Michael O K Omar M Yaghi O M | 2013 | Science2013，34，12： | 1 |
| 14 | Noise suppression effect of soft magnetic Co-Pd-B-O films with large and Bs显示文摘 | Shigehiro O Tadayoshi I Hiroyasu F | 2006 | IEEE Trans Magn2006，42，10： | 1 |
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