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| 1 | Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction显示文摘AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary obstruction.METHODS: Multicenter retrospective study was conducted in patients who underwent plastic stent(PS) or nasobiliary catheter(NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedurerelated adverse events, stent/catheter dysfunction(occlusion or migration of PS/NBC, developmentof cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution(bilirubin level < 3.0 mg/d L) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression analysis.RESULTS: In total, 419 patients were included in the study(PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients(46%), bile duct cancer in 172(41%), gallbladder cancer in three(1%), and ampullary cancer in 50(12%). The median serum total bilirubin was 7.8 mg/d L and 324 patients(77%) had ≥ 3.0 mg/d L. During the median time to surgery of 29 d [interquartile range(IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio(SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method(PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored. | Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike Yu Yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide Nobuo Toda Iruru Maetani Yuji Sakai Takao Itoi Masatsugu Nagahama Yousuke Nakai Hiroyuki Isayama | 2016 | World Journal of Gastroenterology2016，22，14： | 18 |
| 2 | Improvement of prognosis for unresectable biliary tract cancer显示文摘AIM:To evaluate the chemotherapeutic outcomes and confirm the recent improvement of prognosis for unresectable biliary tract cancer.METHODS:A total of 186 consecutive patients with unresectable biliary tract cancer,who had been treated with chemotherapy between 2000 and 2009 at five institutions in Japan,were retrospectively analyzed.These patients were divided into three groups based on the year beginning chemotherapy:Group A(2000-2003),Group B(2004-2006),and Group C(2007-2009).The data were fixed at the end of December 2011.Overall survival and time-to-progression were analyzed and compared chronologically.RESULTS:No patient characteristics were significantly different among the three groups.The gallbladder was involved in about half of the patients in each group,and metastatic biliary tract cancer was present in three quarters of the enrollees.In Group A,5-fluorouracilbased chemotherapies were primarily selected as firstline chemotherapy,and only 24% were treated with second-line chemotherapy.In Group B,gemcitabine or S-1 monotherapy was mainly introduced as firstline chemotherapy,and 51% of the patients who were refractory to first-line chemotherapy were treated with second-line chemotherapy mainly with monotherapy.In Group C,the combination therapy with gemcitabine and S-1 was mainly chosen as first-line chemotherapy,and 53% of the patients refractory to first-line chemotherapy were treated with second-line chemotherapy mainly with combination therapy.The median timeto-progressions were 4.4 mo,3.5 mo and 5.9 mo in Groups A,B and C,respectively(4.4 mo vs 3.5 mo vs 5.9 mo,P < 0.01).The median overall survivals were 7.1,7.3,and 11.7 mo in Groups A,B and C(7.1 mo vs 7.3 mo vs 11.7 mo,P = 0.03).Induction rates of all three drugs(gemcitabine,platinum analogs,and fluoropyrimidine) in Groups A,B and C were 4%,2% and 27%(4% vs 2% vs 27%,P < 0.01).CONCLUSION:The prognosis of unresectable biliary tract cancer has improved recently.Using three effective drugs(gemcitabine,platinum analogs,and fluoropyrimidine) may improve the prognosis of this cancer. | Takashi Sasaki Hiroyuki Isayama Yousuke Nakai Naminatsu Takahara Naoki Sasahira Hirofumi Kogure Suguru Mizuno Hiroshi Yagioka Yukiko Ito Natsuyo Yamamoto Kenji Hirano Nobuo Toda Minoru Tada Masao Omata Kazuhiko Koike | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 3 | Clinical analysis of high serum IgE in autoimmune pancreatitis显示文摘AIM: To clarify the clinical significance of high serum IgE in autoimmune pancreatitis (AIP). METHODS: Forty-two AIP patients, whose IgE was measured before steroid treatment, were analyzed. To evaluate the relationship between IgE levels and the disease activity of AIP, we examined (1) Frequency of high IgE (> 170 IU/mL) and concomitant allergic dis-eases requiring treatment; (2) Correlations between IgG, IgG4, and IgE; (3) Relationship between the presence of extrapancreatic lesions and IgE; (4) Re-lationship between clinical relapse and IgE in patients treated with steroids, and (5) Transition of IgE before and after steroid treatment. RESULTS: IgE was elevated in 36/42 (86%) patients.Concomitant allergic disease was observed in seven patients (allergic rhinitis in three, bronchial asthma in three, and urticaria in one). There were no signifi-cant correlations between IgG, IgG4, and IgE (r = -0.168 for IgG, and r = -0.188 for IgG4). There was no significant difference in IgE in the patients with and without extrapancreatic lesions (526 ± 531 IU/mL vs 819 ± 768 IU/mL, P = 0.163), with and without clini-cal relapse (457 ± 346 IU/mL vs 784 ± 786 IU/mL, P = 0.374). There was no significant difference in IgE between before and after steroid treatment (723 ± 744 IU/mL vs 673 ± 660 IU/mL, P = 0.633). CONCLUSION: Although IgE does not necessarily reflect the disease activity, IgE might be useful for the diagnosis of AIP in an inactive stage. | Kenji Hirano Minoru Tada Hiroyuki Isayama Kazumichi Kawakubo Hiroshi Yagioka Takashi Sasaki Hirofumi Kogure Yousuke Nakai Naoki Sasahira Takeshi Tsujino Nobuo Toda Kazuhiko Koike | 2010 | World Journal of Gastroenterology2010，16，41： | 4 |
| 4 | FEM Modeling of Crack Propagation in a Model Multiphase Alloy显示文摘在这篇论文,几个广泛地应用的破裂标准数字地首先被检验, crack-tip-region J 积分标准被证实更适用在有弹性塑料的多相的材料预言破裂角度。然后,在理想化的树枝状的二阶段的 Al-7 百分比 Si 合金的裂缝繁殖用 anelastic 塑料的有限元素方法被建模。有裂缝扩展的裂缝生长驱动力的变化也被表明。裂缝路径被 alpha 阶段的存在显著地在裂缝尖端附近影响,这被发现,并且裂缝生长驱动力到处急速地变化。最后,在二阶段的模型合金的模仿的破裂路径与试验性地观察的破裂路径相比。 | Lihe QIAN Seishi NISHIDO Hiroyuki TODA Toshiro KOBA YASHI | 2006 | Journal of Materials Science & Technology2006，22，1： | 2 |
| 5 | Risk factors for pancreatitis following transpapillary self-expandable metal stent placement显示文摘 | Kazumichi Kawakubo Hiroyuki Isayama Yousuke Nakai Osamu Togawa Naoki Sasahira Hirofumi Kogure Takashi Sasaki Saburo Matsubara Natsuyo Yamamoto Kenji Hirano Takeshi Tsujino Nobuo Toda Minoru Tada Masao Omata Kazuhiko Koike | 2012 | Surgical Endoscopy2012，，3： | 2 |
| 6 | Outcomes after clearance of pancreatic stones with or without pancreatic stenting显示文摘 | Naoki Sasahira Minoru Tada Hiroyuki Isayama Kenji Hirano Yousuke Nakai Natsuyo Yamamoto Takeshi Tsujino Nobuo Toda Yutaka Komatsu Haruhiko Yoshida Takao Kawabe Masao Omata | 2007 | Journal of Gastroenterology2007，，1： | 2 |
| 7 | Measurement of radial and axial forces of biliary self-expandable metallic stents显示文摘 | Hiroyuki Isayama Yousuke Nakai Yoshihide Toyokawa Osamu Togawa Chimyon Gon Yukiko Ito Yoko Yashima Hiroshi Yagioka Hirofumi Kogure Takashi Sasaki Toshihiko Arizumi Saburo Matsubara Natsuyo Yamamoto Naoki Sasahira Kenji Hirano Takeshi Tsujino Nobuo Toda Mi | 2009 | Gastrointestinal Endoscopy2009，，1： | 2 |
| 8 | Cholecystitis After Metallic Stent Placement in Patients With Malignant Distal Biliary Obstruction显示文摘 | Hiroyuki Isayama Takao Kawabe Yousuke Nakai Takeshi Tsujino Naoki Sasahira Natsuyo Yamamoto Toshihiko Arizumi Osamu Togawa Saburou Matsubara Yukiko Ito Takashi Sasaki Kenji Hirano Nobuo Toda Yutaka Komatsu Minoru Tada Haruhiko Yoshida Masao Omata | 2006 | Clinical Gastroenterology and Hepatology2006，，9： | 1 |
| 9 | Predictors of Left Main or Three-Vessel Disease in Patients Who Have Acute Coronary Syndromes With Non–ST-Segment Elevation显示文摘 | Masami Kosuge Kazuo Kimura Toshiyuki Ishikawa Toshiaki Ebina Tomoaki Shimizu Kiyoshi Hibi Noritaka Toda Yoshio Tahara Kengo Tsukahara Masahiko Kanna Jyunn Okuda Naoki Nozawa Hiroyuki Ozaki Hideto Yano Satoshi Umemura | 2005 | The American Journal of Cardiology2005，，11： | 1 |
| 10 | Enhancement of the Electroreduction of Oxygen on Pt Alloys with Fe, Ni, and Co显示文摘 | Takako Toda Hiroshi Igarashi Hiroyuki Uchida | 1999 | Journal of The Electrochemical Society1999，146，10： | 1 |
| 11 | Detection of common bile duct stones: comparison between endoscopic ultrasonography, magnetic resonance cholangiography, and helical-computed-tomographic cholangiography显示文摘 | Shintaro Kondo Hiroyuki Isayama Masaaki Akahane Nobuo Toda Naoki Sasahira Yosuke Nakai Natsuyo Yamamoto Kenji Hirano Yutaka Komatsu Minoru Tada Haruhiko Yoshida Takao Kawabe Kuni Ohtomo Masao Omata | 2004 | European Journal of Radiology2004，，2： | 1 |
| 12 | In-situ high resolution X-ray tomography of fracture micromechanisms in aluminiurn foam 显示文摘 | Hiroyuki Toda Tomomi Ohgaki Kentaro Uesugi | 2004 | The Spring-8 Research Forntiers2004，，： | 1 |
| 13 | Factors Associated with the Development of Reflux Esophagitis After Helicobacter pylori Eradication显示文摘 | Katsuhiko Tsukada MD Hiroyuki Katoh MD Tatsuya Miyazaki MD Minoru Fukuchi MD Hiroyuki Kuwano MD Hitoshi Kimura MD Yasuyuki Fukai MD Takanori Inose MD Teiji Motojima MD Naotaka Toda MD Shuji Yamada MD | 2006 | Digestive Diseases and Sciences2006，，3： | 1 |
| 14 | Relationships between tensile deformation behavior and microstructure in Ti–Nb–Ta–Zr system alloys显示文摘 | Nobuhito Sakaguchi Mitsuo Niinomi Toshikazu Akahori Junji Takeda Hiroyuki Toda | 2005 | Materials Science & Engineering C2005，，3： | 1 |
| 15 | Usefulness of Transient Elastography for Noninvasive and Reliable Estimation of Right-Sided Filling Pressure in Heart Failure显示文摘 | Tatsunori Taniguchi Yasushi Sakata Tomohito Ohtani Isamu Mizote Yasuharu Takeda Yoshihiro Asano Masaharu Masuda Hitoshi Minamiguchi Machiko Kanzaki Yasuhiro Ichibori Hiroyuki Nishi Koichi Toda Yoshiki Sawa Issei Komuro | 2013 | The American Journal of Cardiology2013，，： | 1 |
| 16 | Multicenter phase II study of S-1 monotherapy as second-line chemotherapy for advanced biliary tract cancer refractory to gemcitabine显示文摘 | Takashi Sasaki Hiroyuki Isayama Yousuke Nakai Suguru Mizuno Keisuke Yamamoto Hiroshi Yagioka Yoko Yashima Kazumichi Kawakubo Hirofumi Kogure Osamu Togawa Saburo Matsubara Yukiko Ito Naoki Sasahira Kenji Hirano Takeshi Tsujino Nobuo Toda Minoru Tada Masao | 2012 | Investigational New Drugs2012，，2： | 1 |
| 17 | Enhancement of the electro-reduction of oxygen on Pt alloys with Fe, Ni, and Co显示文摘 | Takako Toda Hiroshi Igarashi Hiroyuki Uchida | 1999 | J Electrochem Soc1999，146，10： | 1 |
| 18 | Multicenter phase II study of S-1 monotherapy as second-line chemotherapy for advanced biliary tract cancer refractory to gemcitabine显示文摘 | Takashi Sasaki Hiroyuki Isayama Yousuke Nakai Suguru Mizuno Keisuke Yamamoto Hiroshi Yagioka Yoko Yashima Kazumichi Kawakubo Hirofumi Kogure Osamu Togawa Saburo Matsubara Yukiko Ito Naoki Sasahira Kenji Hirano Takeshi Tsujino Nobuo Toda Minoru Tada Masao | 2012 | Investigational New Drugs2012，，2： | 1 |
| 19 | Plants and the Environment. Brief exposure to low‐pH stress causes irreversible damage to the growing root in Arabidopsis thaliana : pectin–Ca interaction may play an important role in proton rhizotoxicity显示文摘 | Hiroyuki Koyama Tomomi Toda | 2001 | Journal of Experimental Botany2001，，： | 1 |
| 20 | Mechanical analysis of toughness degradation due to premature fracture of course inclusions in wrought aluminium alloys显示文摘 | Hiroyuki Toda Toshiro Kobayashi Akihiro Takahashi | 2000 | Materials Science & Engineering A2000，，1： | 1 |
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