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| 1 | Basic and Therapeutic Aspects of Angiogenesis显示文摘 | Michael Potente Holger Gerhardt Peter Carmeliet | 2011 | Cell2011，，6： | 1 |
| 2 | A new meth- od for large scale isolation of kidney glomeruli from mice 显示文摘 | Minoru Takemoto NA Holger Gerhardt AL | 2002 | Am J Pathol2002，161，3： | 1 |
| 3 | Basic and Therapeutic Aspects of Angiogenesis显示文摘 | Michael Potente Holger Gerhardt Peter Carmeliet | 2011 | Cell2011，，6： | 1 |
| 4 | Preparing for CARTRONIC-Interface and New Strategies for Torque Coordination andConversion in a Spark Ignition Engine-Management System显示文摘 | Bernhard Mencher Holger Jessen Lilian Kaiser and Jurgen Gerhardt | 2001 | SAE2001，，： | 1 |
| 5 | Creatinine-based glomerular filtration rate estimation in patients with liver disease: the new Chronic Kidney Disease Epidemiology Collaboration equation is not better显示文摘 | Thomas Gerhardt Uwe P?ge Birgit Stoffel-Wagner Holger Palmedo Tilman Sauerbruch Rainer Peter Woitas | 2011 | European Journal of Gastroenterology & Hepatology2011，，11： | 1 |
| 6 | Angiogenesis: A Team Effort Coordinated by Notch显示文摘 | L.-K. Phng Holger Gerhardt | 2009 | Developmental Cell2009，，2： | 1 |
| 7 | Endothelial-pericyte interactions in angiogenesis显示文摘 | Holger Gerhardt Christer Betsholtz | 2003 | Cell and Tissue Research2003，，1： | 1 |
| 8 | Basic and Therapeutic Aspects of Angiogenesis显示文摘 | Michael Potente Holger Gerhardt Peter Carmeliet | 2011 | Cell2011，，6： | 1 |
| 9 | Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice显示文摘 | Fu Jianxin Gerhardt Holger McDaniel J Michael Xia Baoyun Liu Xiaowei Ivanciu Lacramioara Ny Annelii Hermans Karlien Silasi-Mansat Robert McGee Samuel Nye Emma Ju Tongzhong Ramirez Maria I Carmeliet Peter Cummings Richard D Lupu Florea Xia | 2008 | Journal of Clinical Investigation2008，，11： | 1 |
| 10 | Creatinine-based glomerular filtration rate estimation in patients with liver disease: the new Chronic Kidney Disease Epidemiology Collaboration equation is not better显示文摘 | Thomas Gerhardt Uwe P?ge Birgit Stoffel-Wagner Holger Palmedo Tilman Sauerbruch Rainer Peter Woitas | 2011 | European Journal of Gastroenterology & Hepatology2011，，11： | 1 |
| 11 | A 96-wells fluidic system for high-throughput screenings under laminar high wall shear stress conditions显示文摘The ability of endothelial cells to respond to blood flow is fundamental for the correct formation and maintenance of a functional and hierarchically organized vascular network.Defective flow responses,in particular related to high flow conditions,have been associated with atherosclerosis,stroke,arteriovenous malformations,and neurodegenerative diseases.Yet,the molecular mechanisms involved in high flow response are still poorly understood.Here,we described the development and validation of a 96-wells fluidic system,with interchangeable cell culture and fluidics,to perform high-throughput screenings under laminar high-flow conditions.We demonstrated that endothelial cells in our newly developed 96-wells fluidic system respond to fluid flow-induced shear stress by aligning along the flow direction and increasing the levels of KLF2 and KLF4.We further demonstrate that our 96-wells fluidic system allows for efficient gene knock-down compatible with automated liquid handling for high-throughput screening platforms.Overall,we propose that this modular 96-well fluidic system is an excellent platform to perform genome-wide and/or drug screenings to identify the molecular mechanisms involved in the responses of endothelial cells to high wall shear stress. | Catarina Gonçalves Fonseca Vânia Silvério David Barata Wolfgang Giese Holger Gerhardt Susana Cardoso Claudio Areias Franco | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
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