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| 1 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 2 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 3 | Veno-occlusive disease(VOD) in Crohn's disease(CD) treated with azathioprine显示文摘 | HOLTMANN M SCHREINER O KOHLER H | 2003 | Dig Dis Sci2003，48，8： | 1 |
| 4 | Methanol to pro-pylene MTP-Lurgis way显示文摘 | ROTHAEME M HOLTMANN H D | 2002 | Erdol Erdgas Kohle2002，，5： | 1 |
| 5 | Methanol to Propylene MTP:Lurgi’s Way显示文摘 | Rothaemel M Holtmann H D | 2002 | Erdol Erdgas Kohle2002，，5： | 1 |
| 6 | Hamburg: MTP, methanol to propylene, lurgi's way, creating value from light olefins production and conver- sion显示文摘 | Rothaemel M Holtmann H D | 2001 | 2001，，： | 1 |
| 7 | Prokinetics in patients with gastroparesis:a systematic analysis显示文摘 | Sturm A Holtmann G Goebell H | | 0，，05： | 1 |
| 8 | Multiple control of interleukin-8 gene expression显示文摘 | Hoffmann E Dittrich Breiholz O Holtmann H | 2002 | J Leukoe Biol2002，72，5： | 1 |
| 9 | Split-radix FFT algorithm显示文摘 | Holtmann H | 1984 | Electronic Letters1984，20，1： | 1 |
| 10 | The MAPK kinase kinase TAK1 plays a central role in coupling the interleukin-1 receptor to both transcriptional and RNA-targeted mechanisms of gene regulation显示文摘 | Holtmann H Enninga J Kalble S | | 0，，： | 1 |
| 11 | Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine-or stress-activated signal transduction pathways显示文摘 | Holtmann H Winzen R Holland P | | 0，，： | 1 |
| 12 | CASE REPORT: Veno-Occlusive Disease (VOD) in Crohn’s Disease (CD) Treated with Azathioprine显示文摘 | M. Holtmann O. Schreiner H. K?hler U. Denzer M. Neurath P.R. Galle T. H?hler | 2003 | Digestive Diseases and Sciences2003，，8： | 1 |
| 13 | Methanol to propylene MTP - Lurgi's way: Erdal und Kohle - Erdgas- Petrochemie 显示文摘 | ROTHAEMEL M HOLTMANN H D | 2002 | Erdol Erdgas Kohle2002，118，5： | 1 |
| 14 | Split-radix FFT Algorithm显示文摘 | DUHAMEL P HOLTMANN H | 1984 | Electronics Letters1984，20，1： | 1 |
| 15 | Advances in propylene production routes显示文摘 | Rothaemel M Holtmann H D | 2002 | J Erdol Erdgas Kohle2002，118，5： | 1 |
| 16 | Induction of interlukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine or stress activated signal transduction pathways显示文摘 | Holtmann H Winzen R Holland P | 1999 | Mol Cell Biol1999，19，： | 1 |
| 17 | Stress-activated protein kinase/Jun N-terminal kinase is required for interleukin(IL)-1-induced IL-6 and IL-8 gene expression in the human epidermal carcinoma cell line KB显示文摘 | Krause A Holtmann H Eickemeier S | | 0，，： | 1 |
| 18 | Prokinetics in patients with gastroparesis:A systematic analysis显示文摘 | STURN A HOLTMANN G GOEBELL H | 1999 | Digestion1999，60，： | 1 |
| 19 | Methanol to Propylene MTP-Lurgi's Way显示文摘 | Pothaemel M Holtmann H D | 2002 | Petrochemie2002，，118： | 1 |
| 20 | The anti - motionsickness mechanism of ginger:a comparative study with placebo and dimen - hydrinate 显示文摘 | Holtmann S Clarke AN H SchererH | 1989 | Acta Otolaryngol ( stockh )1989，108，34： | 1 |
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