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| 1 | Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease显示文摘Netrin-1,an axon guidance factor,and its receptor UNC5B play important roles in axonal development and angiogenesis.This study examined netrin-1 and UNC5B expression in kidneys with diabetic kidney disease (DKD) and investigated their roles in angiogenesis.Netrin-1 and UNC5B were upregulated in streptozotocininduced DKD Wistar rats,and their expression was compared with that in healthy controls.However,exogenous netrin-1 in UNC5B-depleted human renal glomerular endothelial cells (HRGECs) inhibited cell migration and tubulogenesis.This effect was likely associated with SRC pathway deactivation.Netrin-1 treatment also eliminated the pro-angiogenic effects of exogenous VEGF-165 on UNC5B-silenced HRGECs.These results indicate that UNC5B antagonizes netrin-1 and that UNC5B upregulation contributes partly to enhancing angiogenesis in DKD.Therefore,introducing exogenous netrin-1 and depleting endogenous UNC5B are potential strategies for reducing the incidence of early angiogenesis and mitigating kidney injury in DKD. | Xiaojing Jiao Dong Zhang Quan Hong Lei Yan Qiuxia Han Fengmin Shao Guangyan Cai Xiangmei Chen Hanyu Zhu | 2020 | Frontiers of Medicine2020，14，3： | 7 |
| 2 | Functional assembly of root-associated microbial consortia improves nutrient efficiency and yield in soybean显示文摘Root-associated microbes are critical for plant growth and nutrient acquisition. However, scant information exists on optimizing communities of beneficial root-associated microbes or the mechanisms underlying their interactions with host plants. In this report, we demonstrate that rootassociated microbes are critical influencers of host plant growth and nutrient acquisition. Three synthetic communities(SynComs) were constructed based on functional screening of 1,893 microbial strains isolated from root-associated compartments of soybean plants. Functional assemblage of SynComs promoted significant plant growth and nutrient acquisition under both N/P nutrient deficiency and sufficiency conditions.Field trials further revealed that application of SynComs stably and significantly promoted plant growth, facilitated N and P acquisition, and subsequently increased soybean yield. Among the tested communities, SynCom1 exhibited the greatest promotion effect, with yield increases of up to 36.1% observed in two field sites. Further RNA-seq implied that SynCom application systemically regulates N and P signaling networks at the transcriptional level, which leads to increased representation of important growth pathways, especially those related to auxin responses. Overall,this study details a promising strategy for constructing SynComs based on functional screening,which are capable of enhancing nutrient acquisition and crop yield through the activities of beneficial root-associated microbes. | Cunhu Wang Yanjun Li Mingjia Li Kefei Zhang Wenjing Ma Lei Zheng Hanyu Xu Baofeng Cui Ran Liu Yongqing Yang Yongjia Zhong Hong Liao | 2021 | Journal of Integrative Plant Biology2021，63，6： | 5 |
| 3 | In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures显示文摘 | Chao Ni Yuhui Chen Musheng Zeng Rongjuan Pei Yong Du Linquan Tang Mengyi Wang Yazhuo Hu Hanyu Zhu Meifang He Xiawei Wei Shan Wang Xiangkai Ning Manna Wang Jufang Wang Li Ma Xinwen Chen Qiang Sun Hong Tang Ying Wang Xiaoning Wang | 2015 | Cell Research2015，25，7： | 3 |
| 4 | Restoration algorithms for turbulence-degraded images based on optimized estimation of discrete values of overall point spread functions显示文摘 | Zhang Tianxu Hong Hanyu Shen Jun | 2005 | Optical Engineering2005，44，1： | 1 |
| 5 | Fast restoration approach for rota- tional motion blurred image based on deconvolution along the blurring paths 显示文摘 | Hong Hanyu Zhang Tianxu | 2003 | Optical Engineering2003，42，12： | 1 |
| 6 | Optimization design containing dimension and buffer parameters of landing legs for reusable landing vehicle显示文摘For the landing legs with single air chamber in the buffer structure of the reusable landing vehicle,the geometric topological models and the dynamic model associated with the hard points of the landing legs are established.The geometric constraint relationship in the design of the landing legs is also obtained.The whole vehicle dropping test is conducted,and the test results agree well with that of the simulation model,which validates the dynamic model.Based on the verified model,the effect of hard point positions on the performance of the landing system is analyzed.The multidisciplinary collaborative optimization algorithm and archive-based micro genetic algorithm(CO-AMGA)are used to optimize the design parameters that contain the hard points and the damper.Compared with artificial iteration,the maximum landing impact acceleration response of the vehicle and the buffer struct maximum force are reduced by 30.70%and 14.51%respectively,and the maximum length of retractable pillar decreases by 8.54%while the design margin increases by 69.11%.The proposed optimization method is efficient and can greatly facilitate the design of landing legs. | Bo LEI Ming ZHANG Hanyu LIN Hong NIE | 2022 | Chinese Journal of Aeronautics2022，35，3： | 1 |
| 7 | Fast restoration ap- proach for rotational motion blurred image based on deconvolution along the blurring paths 显示文摘 | HONG Hanyu ZHANG Tianxu | 2003 | Optical Engineering2003，42，12： | 1 |
| 8 | Universal deblurring method for real images using transition region显示文摘 | HONG Hanyu LI Liangcheng PARK In Kyu | 2012 | Optical Engineering2012，51，4： | 1 |
| 9 | Fast Restoration Approach for Rota- tional Motion Blurred Image Based on Deconvolution Along the Blurring Paths显示文摘 | Hong Hanyu Zhang Tianxu | 2003 | Optical Engineering2003，42，12： | 1 |
| 10 | THE CADD AND SIMULATION SYSTEM OFTHE NEW-TYPE GEAR显示文摘THECADDANDSIMULATIONSYSTEMOFTHENEW-TYPEGEARHongHanyu;GuanRongchangTHECADDANDSIMULATIONSYSTEMOFTHENEW-TYPEGEAR￥HongHanyu;GuanR... | Hong Hanyu Guan Rongchang | 1994 | Computer Aided Drafting,Design and Manufacturing1994，4，2： | 1 |
| 11 | Blind restorationof real turbulence - degraded image with complicatedbackgrounds using anisotropic regularization 显示文摘 | Hong Hanyu Li Liangcheng Zhang Tianxu | 2012 | OpticsCommunications2012，285，24： | 1 |
| 12 | Single-image Motion Deblurring Using Adaptive Anisotropic Regularization显示文摘 | Hong Hanyu Park I K | 2010 | Optical Engineering2010，49，9： | 1 |
| 13 | Pharmacodynamic advantages and characteristics of traditional Chinese medicine in prevention and treatment of ischemic stroke显示文摘Ischemic stroke(IS) is a severe cerebrovascular disease with a high incidence, mortality, and disability rate. The first-line treatment for IS is the use of recombinant tissue plasminogen activator(r-t PA).Regrettably, numerous patients encounter delays in treatment due to the narrow therapeutic window and the associated risk of hemorrhage. Traditional Chinese medicine(TCM) has exhibited distinct advantages in preventing and treating IS. TCM enhances cerebral microcirculation, alleviates neurological disorders, regulates energy metabolism, mitigates infammation, reduces oxidative stress injuries, and inhibits apoptosis, thereby mitigating brain damage and preventing IS recurrence. This article summarizes the etiology, pathogenesis, therapeutic strategies, and relationship with modern biology of IS from the perspective of TCM, describes the advantages of TCM in the treatment of IS, and further reviews the pharmacodynamic characteristics and advantages of TCM in the acute and recovery phases of IS as well as in post-stroke complications. Additionally, it offers valuable insights and references for the clinical application of TCM in IS prevention and treatment, as well as for the development of novel drugs. | Hanyu Zhang Bowen Jin Xinyu You Pengrong Yi Hong Guo Lin Niu Qingsheng Yin Jiangwei Shi Yanjun Zhang Pengwei Zhuang | 2023 | Chinese Herbal Medicines2023，15，4： | 0 |
| 14 | Unveiling non-radiative center control in CsPbBr_(3) nanocrystals:A comprehensive comparative analysis of hot injection and ligandassisted reprecipitation approaches显示文摘Metal-halide perovskite nanocrystals(NCs)have gained significant attention in the field of optoelectronic and photonic devices due to their promising applications.Despite their exceptional optical properties,the impact of different synthetic strategies on the fundamental nature of NCs,such as nonradiative recombination centers,remains poorly understood.In this study,we investigated the photophysical properties of CsPbBr_(3) NCs synthesized using two distinct methods,hot injection and ligand-assisted reprecipitation,at the individual particle level.We observed different blinking behaviors under specific photoexcitation power densities and proposed,through intensity-lifetime analysis and Monte-Carlo simulations,that these different synthetic strategies can fabricate NCs with similar crystal structures but distinct surface quenchers with varying energy levels,which significantly affected the photo-induced blinking-down and blinking-up behaviors in individual NCs.Our findings indicate a practical and feasible approach for controlling defect engineering in perovskite NCs,with significant implications for their use in optoelectronic and other technological applications. | Daocheng Hong Yuchen Zhang Shuhan Pan Hanyu Liu Wei Mao Wanli Zhang Yuhui Ye Zhihong Wei Xuxing Lu Xiaoyong Wang Zhenda Lu Yuxi Tian | 2024 | Nano Research2024，17，5： | 0 |
| 15 | Research on a novel restoration algorithm of turbulence-degraded images with alternant iterations显示文摘A new restoration algorithm based on double loops and alternant iterations is proposed to restore the object image effectively from a few frames of turbulence-degraded images. Based on the double loops, the iterative relations for estimating the turbulent point spread function PSF and object image alternately are derived. The restoration experiments have been made on computers, showing that the proposed algorithm can obtain the optimal estimations of the object and the point spread function, with the feasibility and practicality of the proposed algorithm being convincing. | Liu Chunsheng Hong Hanyu Zhang Tianxu | 2006 | Journal of Systems Engineering and Electronics2006，17，3： | 0 |
| 16 | INTERCROPPING TEA PLANTATIONS WITH SOYBEAN AND RAPESEED ENHANCES NITROGEN FIXATION THROUGH SHIFTS IN SOIL MICROBIAL COMMUNITIES显示文摘Intercropping with eco-friendly crops is a well-known strategy for improving agriculture sustainability with benefits throughout the soil community,though the range of crop impacts on soil microbiota and extent of feedbacks to crops remain largely unclear.This study evaluated the impacts of different intercropping systems on soil bacterial community composition,diversity,and potential functions in tea gardens.Intercropping systems were found to be significantly influenced soil microbiota.Within the three tested intercropping systems(tea-soybean,tea-rapeseed and tea-soybean-rapeseed),the teasoybean-rapeseed intercropping system had the most dramatic influence on soil microbiota,with increases in richness accompanied by shifts in the structure of tea garden soil bacterial networks.Specifically,relative abundance of potentially beneficial bacteria associated with essential mineral nutrient cycling increased significantly in the tea-soybean-rapeseed intercropping system.In addition,soil microbial functions related to nutrient cycling functions were significantly enhanced.This was in accordance with increasing relative abundance of nitrogen cycling bacteria,including Burkholderia spp.and Rhodanobacter spp.Based on these results,it is proposed that intercropping tea plantation with soybean and rapeseed may benefit soil microbiota,and thereby promises to be an important strategy for improving soil health in ecologically sound tea production systems. | Yongjia ZHONG Lini LIANG Ruineng XU Hanyu XU Lili SUN Hong LIAO | 2022 | Frontiers of Agricultural Science and Engineering2022，9，3： | 0 |
| 17 | Dihydroartemisinin attenuates ischemia/reperfusion-induced renal tubular senescence by activating autophagy显示文摘Acute kidney injury(AKI)is an important factor for the occurrence and development of CKD.The protective effect of dihydroartemisinin on AKI and and reported mechanism have not been reported.In this study,we used two animal models including ischemia-reperfusion and UUO,as well as a high-glucose-stimulated HK-2 cell model,to evaluate the protective effect of dihydroartemisinin on premature senescence of renal tubular epithelial cells in vitro and in vivo.We demonstrated that dihydroartemisinin improved renal aging and renal injury by activating autophagy.In addition,we found that co-treatment with chloroquine,an autophagy inhibitor,abolished the anti-renal aging effect of dihydroartemisinin in vitro.These findings suggested that activation of autophagy/elimination of senescent cell might be a useful strategy to prevent AKI/UUO induced renal tubular senescence and fibrosis. | LIU Huiling HUANG Zhou JIANG Hong SU Ke SI Zilin WU Wenhui WANG Hanyu LI Dongxue TAN Ninghua ZHANG Zhihao | 2023 | Chinese Journal of Natural Medicines2023，21，9： | 0 |
| 18 | Adsorption behavior of CO_(2) in magnesite micro-pores at high temperature and pressure显示文摘The fluid inclusions in mantle rocks and melt indicated that a large amount of CO_(2)fluid exists in the deep earth,which is of great significance for understanding the deep carbon cycle and the composition of mantle.However,it was also suggested that carbonate minerals were likely to be the main host of mantle carbon.At the same time,the distribution and behavior of carbon in the mantle still remain a puzzle.In this paper,the adsorption behavior and occurrence characteristics of supercritical CO_(2)in magnesite(MgCO3)pores were studied by the Grand Canonical Monte Carlo method(GCMC)under the different conditions of CO_(2)pressures(0–100 MPa),temperatures(350–1500 K)and the pore sizes(7.5–30Å).The simulated results showed that the adsorption of CO_(2)in magnesite was a physical adsorption,which was mainly controlled by the intermolecular force.The gas adsorption became more stable when the adsorption site shifted from the high energy site to the low energy site with increasing pressure(P)and decreasing temperature(T)and pore size.At the same time,the variations of excess adsorption amounts of CO_(2)in the pores of magnesite(Nexcess)under the different conditions were quantitatively calculated.It was found that the Nexcess decreased with increasing T,but increased with increasing P and pore size.The results favor understanding the CO_(2)migration,seismic precursor observations,and heat transfer process in the deep earth. | Longxing Yang Lei Liu Hong Liu Li Yi Xiaoyu Gu Haibo Liu Hanyu Wang | 2021 | Geoscience Frontiers2021，12，2： | 0 |
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