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| 1 | Endoscopic papillary large balloon dilation for the removal of bile duct stones显示文摘Endoscopic papillary large balloon dilation(EPLBD)with endoscopic sphincterotomy(EST)has been widely used as the alternative to EST along with endoscopic mechanical lithotripsy(EML)for the removal of large or difficult bile duct stones.Furthermore,EPLBD without EST was recently introduced as its simplified alternative technique.Thus,we systematically searched PubMed,Medline,the Cochrane Library and EMBASE,and analyzed all gathered data of EPLBD with and without EST,respectively,by using a single standardized definition,reviewing relevant literatures,published between 2003and June 2013,where it was performed with largediameter balloons(12-20 mm).The outcomes,including the initial success rate,the rate of needs for EML,and the overall success rate,and adverse events were assessed in each and compared between both of two procedures:'EPLBD with EST'and'EPLBD without EST'.A total of 2511 procedures from 30 published articles were included in EPLBD with EST,while a total of413 procedures from 3 published articles were included in EPLBD without EST.In the results of outcomes,the overall success rate was 96.5%in EPLBD with EST and97.2%in EPLBD without EST,showing no significant difference between both of them.The initial success rate(84.0%vs 76.2%,P<0.001)and the success rate of EPLBD without EML(83.2%vs 76.7%,P=0.001)was significantly higher,while the rate of use of EML was significantly lower(14.1%vs 21.6%,P<0.001),in EPLBD with EST.The rate of overall adverse events,pancreatitis,bleeding,perforation,other adverse events,surgery for adverse events,and fatal adverse events were 8.3%,2.4%,3.6%,0.6%,1.7%,0.2%and 0.2%in EPLBD with EST and 7.0%,3.9%,1.9%,0.5%,0.7%,0%and 0%in EPLBD without EST,respectively,showing no significant difference between both of them.In conclusion,recent accumulated results of EPLBD with or even without EST suggest that it is a safe and effective procedure for the removal of large or difficult bile duct stones without any additional risk of severe adverse events,when performed under appropriate guidelines. | Jin Hong Kim Min Jae Yang Jae Chul Hwang Byung Moo Yoo | 2013 | World Journal of Gastroenterology2013，19，46： | 12 |
| 2 | Thioredoxin and thioredoxin-interacting protein as prognostic markers for gastric cancer recurrence显示文摘AIM:To evaluate the potential of thioredoxin (TXN) and thioredoxin-interacting protein (TXNIP) expression as biomarkers for predicting gastric cancer recurrence. METHODS:TXN and TXNIP expression levels were acquired from gene expression microarray data for 65 human gastric cancer tissues. We determined whether each gene expression level was associated with cancer recurrence and investigated the relationship between the two genes. For validation, the expression levels of TXN and TXNIP were measured by quantitative real- time reverse transcription polymerase chain reaction in 68 independent stage Ⅲ gastric cancer patients. The correlation between gene expression and cancer prognosis was evaluated. Immunohistochemical staining was performed to investigate the protein expression levels of TXN and TXNIP and to characterize the expression patterns of each protein. RESULTS:TXN was a prognosis-related gene (P = 0.009), whereas TXNIP, a TXN inhibitor, demonstrated a negative correlation with TXN in the gene expression microarray data. In the 68 stage Ⅲ patients, the expression levels of both TXN and TXNIP had a statistically significant effect on recurrence-free survival (RFS, P = 0.008 and P = 0.036, respectively). The low TXN and high TXNIP expression group exhibited a better prognosis than the other groups, and the high TXN and low TXNIP expression group exhibited a poorer prognosis (P < 0.001 for RFS and P = 0.001 for overall survival). More than half of the patients in the simulta-neously high TXN and low TXNIP expression group ex- perienced a recurrence within 1 year after curative surgery, and the 5-year survival rate of the patients in this group was 29%, compared with 89% in the low TXN and high TXNIP expression group. The TXN protein was overexpressed in 65% of the gastric cancer tissues, whereas the TXNIP protein was underexpressed in 85% of the cancer cells. In a correlation analysis, TXN and TXNIP were highly correlated with many oncogenes and tumor suppressors as well as with genes related to energy, protein synthesis and autophagy. CONCLUSION:TXN and TXNIP are promising prognostic markers for gastric cancer, and performing personalized adjuvant treatment based on TXN and TXNIP expression levels would be an effective practice in the treatment of gastric cancer. | Jae Yun Lim Sun Och Yoo Soon Won Hong Jong Won Kim Seung Ho Choi Jae Yong Cho | 2012 | World Journal of Gastroenterology2012，18，39： | 4 |
| 3 | Analysis on sports and recreation activity-related eye injuries presenting to the Emergency Department显示文摘AIM:To investigate the incidence and general characteristics of sports-related eye injuries in patients visiting the Emergency Department. METHODS: A cross-sectional,multi-center,observational study.Patients with an injured eye who visited the Emergency Department at one of nine hospitals in Korea were enrolled.All data were prospectively collected between March and September 2010 using a questionnaire.Eye injuries that occurred during risky sports were examined by gender and age.Additionally,the rate of open globe injuries that occurred with and without protective eyewear was examined for each activity.Continuous variables were compared using Student's t-test and categorical variables were compared using Chi-square test.RESULTS: A total of 446 patients had sports-related eye injuries.Teenagers(10-19 years old) and young adults(20-29 years old) had the most eye injuries.Eye injuries accounted for 0.2% of Emergency Department patients.Baseball was the most common cause of sports-related eye injuries,followed by soccer and hiking.Protective gear was worn by 9.4% of all patients.Patients that were 30-39 years of age had the highest rate of protective gear use,followed by patients that were 40-49 years of age.The proportion of sports-related eye injuries that were open-globe injuries was highest for soccer and hiking.CONCLUSION: Although injuries were most common in patients below the age of 10 years,these patients had the lowest rate of protective eyewear use.Injuries in adults over 40 years of age most commonly occurred during hiking,but the rate of protective eyewear use was low.Young athletes should be educated on and provided with protective eyewear and policies protective gear use should be established.For older adults,eye protection should be encouraged,especially during hiking. | Sungbae Moon Hyun Wook Ryoo Jae Yun Ahn Jung Bae Park Kang Suk Seo Sang Do Shin Kyoung Jun Song Kang Hyun Lee In Sool Yoo Jin Seong Cho Hyun Ho Ryu Tae Oh Jeong Seok Ran Yeom Young Taek Kim Sung Ok Hong | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 3 |
| 4 | Clinicopathologic features and prognosis of combined hepatocellular cholangiocarcinoma显示文摘 | Kwang Cheol Koh Hyuk Lee Moon Seok Choi Joon Hyoek Lee Seung Woon Paik Byung Chul Yoo Jong Chul Rhee Jae Won Cho Cheol Keun Park Hong Joo Kim | 2005 | The American Journal of Surgery2005，，1： | 2 |
| 5 | uPAR expression under hypoxic conditions depends on iNOS modulated ERK phosphorylation in the MDA-MB-231 breast carcinoma cell line显示文摘尿激 plasminogen 使活跃之物受体(uPAR ) 戏在癌症侵略和转移和 uPAR 表示的一个主要角色在各种各样的癌症类型与差的预后被相关。而且, uPAR 的表示在 hypoxic 条件下面被增加。氮的氧化物(没有) 并且它可诱导的氮的氧化物 synthase (i NOS ) 生产的代谢物是 hypoxic 应力的重要产品,并且可以不激活或调制细胞外的信号调整 kinase (英皇家空军之阶级最低之兵) 。这里,我们在 MDA-MB-231 人的乳癌房间线在 hypoxic 条件,和 i NOS 并且不的调节效果下面在 A, uPAR,和激活的英皇家空军之阶级最低之兵层次上面评估了。房间在 hypoxic 或 normoxic 孵卵器被孵化并且与 PD98059 对待(一个 MEK 1/2 禁止者,它废除英皇家空军之阶级最低之兵 phosphorylation ) 并且 aminoguanidine (选择 i NOS 禁止者) 。uPAR 表示,英皇家空军之阶级最低之兵 phosphorylation,并且在 A 上面,活动被发现在 hypoxic 条件下面被增加。而且当房间在 hypoxic 条件下面与 PD98059 被对待时, uPAR 低调整,而 aminoguanidine 显著地以一种剂量依赖者方式增加了英皇家空军之阶级最低之兵 phosphorylation。而且, aminoguanidine 增加了 uPAR 表示并且由 PD98059 阻止了 uPAR 表示的抑制。这些结果证明 uPAR 被组织缺氧导致,那增加的 uPAR 表情被英皇家空军之阶级最低之兵 phosphorylation 调停,它被 iNOS/NO 接着在 MDA-MB-231 房间调制。我们结束那 iNOS/NO 在下面经由英皇家空军之阶级最低之兵小径调整在 hypoxic 条件下面调整 uPAR 的表示。 | So Young Yoon Yoo Jung Lee Jae Hong Seo Hwa Jung Sung Kyong Hwa Park In Keun Choi Seok Jin Kim Sang Cheul Oh Chul Won Choi Byung Soo Kim Sang Won Shin Yeul Hong Kim Jun Suk Kim | 2006 | Cell Research2006，16，1： | 2 |
| 6 | How Can We Predict the Presence of Missed Synchronous Lesions After Endoscopic Submucosal Dissection for Early Gastric Cancers or Gastric Adenomas?显示文摘 | Jun Hwan Yoo Sung Jae Shin Kee Myung Lee Jae Myoung Choi Jeong Ook Wi Dong Hoon Kim Sun Gyo Lim Jae Chul Hwang Jae Youn Cheong Byung Moo Yoo Kwang Jae Lee Jin Hong Kim Sung Won Cho | 2013 | Journal of Clinical Gastroenterology2013，，2： | 2 |
| 7 | Human hepatocellular carcinomas with “Stemness”‐related marker expression: keratin 19 expression and a poor prognosis显示文摘 | Haeryoung Kim Gi Hong Choi Deuk Chae Na Ei Young Ahn Gwang Il Kim Jae Eun Lee Jai Young Cho Jeong Eun Yoo Jin Sub Choi Young Nyun Park | 2011 | Hepatology2011，，5： | 2 |
| 8 | Risk factors for perforations associated with endoscopic submucosal dissection in gastric lesions: emphasis on perforation type显示文摘 | Jun Hwan Yoo Sung Jae Shin Kee Myung Lee Jae Myoung Choi Jeong Ook Wi Dong Hoon Kim Sun Gyo Lim Jae Chul Hwang Jae Youn Cheong Byung Moo Yoo Kwang Jae Lee Jin Hong Kim Sung Won Cho | 2012 | Surgical Endoscopy2012，，9： | 1 |
| 9 | Formation of bilayer Ni-SiC composite coatings by electrodeposition 显示文摘 | Sun Kyu Kim Hong Jae Yoo | 1998 | Surface and Coating Technology1998，，： | 1 |
| 10 | Formation of bilayer Ni-SiC composite coatings by electrodeposition显示文摘 | Sun Kyu Kim Hong Jae Yoo | 1998 | Surface and Coatings Technology1998，，： | 1 |
| 11 | Inactivating mutations of caspase-8 gene in colorectal carcinomas显示文摘 | Hong Sug Kim Jong Woo Lee Young Hwa Soung Won Sang Park Su Young Kim Jong Heun Lee Jik Young Park Youg Gu Cho Chang Jae Kim Seong Whan Jeong Suk Woo Nam Sang Ho Kim Jung Young Lee Nam Jin Yoo Sug Hyung Lee | 2003 | Gastroenterology2003，，3： | 1 |
| 12 | A randomized, prospective trial on efficacy and tolerability of low-volume bowel preparation methods for colonoscopy显示文摘 | In Kyung Yoo Jong Soo Lee Hoon Jai Chun Yoon Tae Jeen Bora Keum Eun Sun Kim Hyuk Soon Choi Jae Min Lee Seung Han Kim Seung Joo Nam Hyo Sung Kang Hong Sik Lee Chang Duck Kim Soon Ho Um Yeon Seok Seo Ho Sang Ryu | 2014 | Digestive and Liver Disease2014，，： | 1 |
| 13 | Invasion and EMT-associated genes are up-regulated in B viral hepatocellular carcinoma with high expression of CD133-human and cell culture study显示文摘 | Deuk Chae Na Jae Eun Lee Jeong Eun Yoo Bong-Kyeong Oh Gi Hong Choi Young Nyun Park | 2010 | Experimental and Molecular Pathology2010，，1： | 1 |
| 14 | Formation of bilayer Ni-SiC composite coatings by electordeposition显示文摘 | Sun Kyu Kim Hong Jae Yoo | 1998 | Surface and coatings Technology1998，，： | 1 |
| 15 | Palliative treatment of malignant gastroduodenal obstruction with metallic stent: prospective comparison of covered and uncovered stents显示文摘 | Kee Myung Lee Sang Jo Choi Sung Jae Shin Jae Chul Hwang Sun Gyo Lim Jae Yeon Jung Byung Moo Yoo Sung Won Cho Jin Hong Kim | 2009 | Scandinavian Journal of Gastroenterology2009，，7： | 1 |
| 16 | Comparison of uncovered stent with covered stent for treatment of malignant colorectal obstruction <ce:link locator='fx1'/>显示文摘 | Kee Myung Lee Sung Jae Shin Jae Chul Hwang Jae Youn Cheong Byung Moo Yoo Kwang Jae Lee Ki Baik Hahm Jin Hong Kim Sung Won Cho | 2007 | Gastrointestinal Endoscopy2007，，5： | 1 |
| 17 | Formation of bilayer Ni-SiC composite coatings by electrodeposition显示文摘 | Sun Kyu Kim Hong Jae Yoo | 1998 | Surface Coatings Technology1998，，108109： | 1 |
| 18 | Formation of bilayer NiSiC composite coatings by electrodeposition显示文摘 | Sun Kyu Kim Hong Jae Yoo | 1998 | Surface and Coatings Technology1998，，： | 1 |
| 19 | Formation of bilayer Ni–SiC composite coatings by electrodeposition显示文摘 | Sun Kyu Kim Hong Jae Yoo | 1998 | Surface & Coatings Technology1998，，： | 1 |
| 20 | Formation of bilayer Ni - SiC composite coatings by electordeposition 显示文摘 | Sun Kyu Kim Hong Jae Yoo | 1998 | Surface and coatings Technology1998，108，109： | 1 |
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