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| 1 | 阿德福韦双酯治疗拉米夫定耐药的慢性乙肝患者时出现的耐药问题显示文摘背景:阿德福韦双酯(ADV)是一种有效治疗野生型和耐拉米夫定乙肝病毒(HBV)的核苷酸类药物。在使用核苷酸类药物治疗慢性乙肝时,当治疗时间为48、96、144周时,耐ADV变异体出现的累积发生率分别为0、0.8-3%和0-5.9%。 | Yeon JE Yoo W Hong SP | 2006 | 中国处方药2006，，3： | 80 |
| 2 | Proteome analysis of hepatocellular carcinoma by laser capture microdissection显示文摘 | Ai J Tan Y Ying W Hong Y Liu S Wu M Qian X Wang H | 2006 | 第二军医大学学报2006，27，5： | 14 |
| 3 | 用防老剂及并用防老剂提高轮胎胶料的耐屈挠疲劳和动态臭氧龟裂性能显示文摘为了延长轮胎使用寿命 ,轮胎公司一直在试图研究改进轮胎各部件的屈挠疲劳性能和轮胎外部件如胎侧、胎面及三角胶在动态臭氧条件下的耐龟裂性能。本文研究了用各种防老剂及其并用来改进轮胎内部件的屈挠疲劳性能 ,还评价了通过防老剂并用来改进外部件的动态臭氧龟裂性能 ,并进而推荐了适宜的防老剂及防老剂并用。此外 ,本文还根据实验室的试验结果 ,讨论了防老剂如何防止氧化破坏及臭氧如何与防老剂发生反应的假设机理。 | Hong S W Lin C Y | 2002 | 轮胎工业2002，22，3： | 7 |
| 4 | High-dose methylprednisolone can induce remissions in patients with fludarabine- refractory chronic lymphocytic leukaemia显示文摘 | Xu, W Miao, KR Hong, M Zhu, DX Fang, C Dong, HJ Wang, DM Cao, X Li, JY | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 5 |
| 5 | The New Synthesis of Azo Urea from Substituted Semicarbazide显示文摘Using N-bromosuccinimide and pridine as the 0xidation s}-stem to dehydrogenale anly substituted semicarbazide to form azo compounds is described for the firs1 time in this paper Nine azo conlpounds have been prepared in excellent lield under mild condition This method onle needs simple instrument and short reaction | Xiao Yang WANG Yu Lu WANG Jian Ping LI Cai ’Lan W’ANG Hong WANG (Department of Chemistry ,Henan Normal University Xinxiang 453002 ) | 1997 | Chinese Chemical Letters1997，8，6： | 5 |
| 6 | 多肽和蛋白质的反相高效液相色谱研究——色谱行为的多样性显示文摘以C8 柱为固定相 ,研究了微管结合蛋白2中两段重要肽段(肽1 ,肽2)和猪胰岛素在反相色谱上的保留行为。当以甲醇溶液为流动相时 ,猪胰岛素保留因子的对数值(lnK′)随流动相有机溶剂体积分数(φ)的变化呈现很好的线性关系。当以乙腈为流动相测定肽1的lnK′随 φ变化关系时 ,所得结果显示lnK′与 φ呈现良好的二次曲线关系。以乙腈为流动相测定肽1和肽2的Van'tHoff曲线(lnK′与1/T的关系图)时 ,发现两种多肽的Van'tHoff曲线分别呈二次和三次方曲线。所有这些结果说明多肽和蛋白质在反相色谱中保留行为的复杂性。 | 郭敏亮 Milton T W HEARN Hooi Hong KEAH | 2000 | 分析测试学报2000，19，4： | 4 |
| 7 | Simultaneous measurement of strain and temperature: graphical representation显示文摘Simultaneousmeasurementofstrainandtemperature:graphicalrepresentation⒇WJin(Dept.Electr.Eng.,HongKongPolytechnicUniv.)WCMichie... | W Jin (Dept. Electr. Eng., Hong Kong Polytechnic Univ. ) W C Michie, G Thursby, M Konstantaki, B Culshaw (Optoelectron. Div., Univ. of Strathclyde, Glasgow, UK) | 1997 | 大连理工大学学报1997，37，S2： | 3 |
| 8 | Distribution and fate of organochlorine pollutants in the Pearl River Estuary 显示文摘 | Hong H Chen W Xu L | 1999 | Marine Pollution Bulletin1999，29，： | 2 |
| 9 | Characterization of inhibitor and corrosion product film using electrochemical impedance spectroscopy(EIS) 显示文摘 | Wang H B Hong T Jepson W P | 2001 | Corrosion2001，，： | 2 |
| 10 | Roles of Ba/Ti ratios in the dielectric properties of BaTiO3 ceramics显示文摘 | LEE J K HONG K S JANG J W | 2001 | J Am Ceram Soc2001，84，9： | 2 |
| 11 | Clinical predictors of thiopurine-related adverse events in Crohn's disease显示文摘AIM: To determine the incidence and predictors of thiopurine-related adverse events. METHODS: Subjects with Crohn's disease who were followed in the Alberta Inflammatory Bowel Disease Consortium patient database registry were identified. Retrospective chart review was conducted between August 5th, 2010 and June 1st, 2012. We collected data on: age at diagnosis; sex; disease location and behaviour at time of prescribing thiopurine; perianal fistulising disease at or prior to thiopurine prescription; smoking status at time of thiopurine prescription, use of corticosteroid within 6 mo of diagnosis; dosage, age at onset, and cessation of 5-aminosalicyclic acid(5-ASA); anti-tumour necrosis factor medication exposure and intestinal resection before thiopurine prescription. The primary outcome of interest was the first adverse event that led to discontinuation of the first thiopurine medication used. Logistic regression models were used to associate clinical characteristics with outcomes after adjusting for potential confounders. Risk estimates were presented as odds ratios(OR) with 95% CI. Effect modification by age and sex were explored.RESULTS: Our cohort had a median follow-up duration of 5.8 years [interquartile range(IQR 25th-75th) 2.7-9.1]. Thiopurine therapy was discontinued in 31.3% of patients because of: hypersensitivity reactions(7.1%), acute pancreatitis(6.2%), gastrointestinal intolerance(5.4%), leucopenia(3.7%), hepatotoxicity(3.4%), infection(1.1%) and other reasons(4.3%). A higher incidence of thiopurine withdrawal was observed in patients over the age of 40(39.4%, P = 0.007). A sexby-age interaction(P = 0.04) was observed. Females older than 40 years of age had an increased risk of thiopurine discontinuation due to an adverse event(age above 40 vs age below 40, adjusted OR = 2.8; 95%CI: 1.4-5.6). In contrast, age did not influence thiopurine withdrawal in males(age above 40 vs below 40, adjusted OR = 0.9; 95%CI: 0.4-2.1). Other clinical variables(disease location and phenotype, perianal disease, smoking history, history of intestinal resection and prior 5-ASA or corticosteroid use) were not associated with an increased risk an adverse event leading to therapy cessation. CONCLUSION: Thiopurine withdrawal due to adverse events is commoner in women over the age of 40 at prescription. These findings need to be replicated in other cohorts. | Gordon W Moran Marie-France Dubeau Gilaad G Kaplan Hong Yang Bertus Eksteen Subrata Ghosh Remo Panaccione | 2015 | World Journal of Gastroenterology2015，21，25： | 2 |
| 12 | Characterization of UV-cured polyester acrylate films containing acrylate functional polydimethylsiloxane显示文摘 | Kim H K Ju H T Hong J W | 2003 | European Polymer Journal2003，39，11： | 1 |
| 13 | A fast procedure for computing incremental growth distances显示文摘 | Hong S M Yeo J H Park H W | 2000 | Robotics2000，18，4： | 1 |
| 14 | Load Factor Calibration for the Proposed 2005 Edition of the National Building Code for Canada: Companion-action Load Combinations 显示文摘 | Bartlett F M Hong H P Zhou W | 2003 | Canadian Journal of Civil Engineering2003，，30： | 1 |
| 15 | Effect of steam treatment on soluble phenolic content and antioxidant activity of the Chaga mushroom (Inonotus obliquus)显示文摘 | JU H K CHUNG H W HONG S S | 2010 | Food Chemistry2010，119，： | 1 |
| 16 | Diamond Formation from a System of SiC and a Metal显示文摘 | Hong S M Li W Jia X P | 1993 | Diamond Related Mater1993，2，： | 1 |
| 17 | Photocatalytic degradation of phenol in aqueous nitrogen-doped TiO2 suspensions with various light sources 显示文摘 | Wang Z P Cai W M Hong X T | 2005 | Appl Catal B Environ2005，57，： | 1 |
| 18 | Structure-activity relationships of quercetin in antagonizing hydrogen peroxide-induced calcium dysregulation in PC12 cells 显示文摘 | Hong W James AJ | 1999 | Free Radical Biology & Medicine1999，27，56： | 1 |
| 19 | Study on corrosion inhibitor in large pipelines under multiphase flow using EIS显示文摘 | Hong T Sun Y H Jepson W P | 2002 | Corrosion Science2002，44，： | 1 |
| 20 | Texture development and its effect on mechanical properties of an AZ61 Mg alloy fabricated by equal channel angular pressing显示文摘 | Kim W J Hong S I Kim Y S | 2003 | Acta Mater2003，51，11： | 1 |
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