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| 1 | Effect of hepatocyte apoptosis induced by TNF-α on acute severe hepatitis in mouse models显示文摘AIM To study the effect of hepatocyteapoptosis and necrosis induced by TNF-α on thepathogenesis of acute severe hepatitis(ASH).METHODS The model of ASH was prepared inD-galactosamine(GAIN)sensitized BALB/c miceby injection of either endotoxin(ET)or tumornecrosis factor-α(TNF-α).Morphologicalchanges of apoptotic hepatocytes were studiedby both light and electron microscope and in siteend labeling method(ISEL).Molecular biologicalchanges of DNA ladder were observed byelectrophoresis of extract from liver tissues.Biochemical changes were measured by alanineaminotransferase(ALT),asparticaminotransferase(AST)and TNF-α.The relationbetween apoptosis and necrosis was evaluatedsimultaneously.RESULTS The sequence of hepatocyteapoptosis,necrosis,and final death from ASHwas observed both in GAIN/ET and GAIN/TNF-agroup.Apoptosis was prominent at 3.5 h and 5 hafter injection of inducer,while necrosis becamedominant at 9 h after challenge.The appearanceof apoptosis was earlier in GAIN/TNF-α groupthan that in GAIN/ ET group.Pretreatment ofmice with antiTNF IgG1 may completely preventthe liver injury induced by GalN/ET.CONCLUSION TNF-α can cause liver damageby inducing hepatic apoptosis and necrosis inmice with endotoxemia. | Guo Qing Zang Xia Qiu Zhou Hong Yu Qing Xie Guo Ming Zhao Bin Wang Qing Guo Yue Qin Xiang Dan Liao Department of Infectious Diseases,Rujin Hospital,Shanghai Second Medical University,Shanghai 200025,China | 2000 | World Journal of Gastroenterology2000，6，5： | 30 |
| 2 | Cystatin C is a biomarker for predicting acute kidney injury in patients with acute-on-chronic liver failure显示文摘AIM:To investigate serum cystatin C level as an early biomarker for predicting acute kidney injury(AKI)in patients with acute-on-chronic liver failure(ACLF).METHODS:Fifty-six consecutive patients with hepatitis B virus-related ACLF who had normal serum creatinine(Cr)level(<1.2 mg/dL in men,or<1.1 mg/dL in women)were enrolled in the Liver Failure Treatment and Research Center of Beijing 302 Hospital between August 2011 and October 2012.Thirty patients with chronic hepatitis B(CHB)and 30 healthy controls in the same study period were also included.Measurement of serum cystatin C(CysC)was performed by a particle-enhanced immunonephelometry assay using the BN Prospec nephelometer system.The ACLF patients were followed during their hospitalization period.RESULTS:In the ACLF group,serum level of CysC was 1.1±0.4 mg/L,which was significantly higher(P<0.01)than those in the healthy controls(0.6±0.3mg/L)and CHB patients(0.7±0.2 mg/L).During the hospitalization period,eight ACLF patients developed AKI.Logistic regression analysis indicated that CysC level was an independent risk factor for AKI development(odds ratio=1.8;95%CI:1.4-2.3,P=0.021).The cutoff value of serum CysC for prediction of AKI in ACLF patients was 1.21 mg/L.The baseline CysC-based estimated glomerular filtration rate(eGFR CysC)was significantly lower than the creatinine-based eGFR(eGFR CG and eGFR MDRD)in ACLF patients with AKI,suggesting that baseline eGFR CysC represented early renal function in ACLF patients while the Cr levels were still within the normal ranges.CONCLUSION:Serum CysC provides early prediction of renal dysfunction in ACLF patients with a normal serum Cr level. | Zhi-Hong Wan Jian-Jun Wang Shao-Li You Hong-Ling Liu Bing Zhu Hong Zang Chen Li Jing Chen Shao-Jie Xin | 2013 | World Journal of Gastroenterology2013，19，48： | 20 |
| 3 | Clinical characteristics and corticosteroid therapy in patients with autoimmune-hepatitis-induced liver failure显示文摘AIM:To investigate the clinical features,response to corticosteroids,and prognosis of autoimmune hepatitis(AIH)-induced liver failure in China.METHODS:A total of 22 patients(19 female and 3male;average age 51±15 years)with AIH-induced liver failure treated in our hospital from 2004 to 2012were retrospectively analyzed.Clinical,biochemical and pathological characteristics of the 22 patients and responses to corticosteroid treatment in seven patients were examined retrospectively.The patients were divided into survivor and non-survivor groups,and the clinical characteristics and prognosis were compared between the two groups.The t test was used for data analysis of all categorical variables,and overall survival was calculated by the Kaplan-Meier method.RESULTS:At the time of diagnosis,mean IgG was2473±983 mg/dL,with three(18.8%)patients showing normal levels.All of the patients had elevated serum levels of antinuclear antibody(≥1:640).Liver histology from one patient showed diagnostic pathological changes,including massive necrosis and plasma cell infiltration.Four patients survived(18.2%)and 18died(81.8%)without liver transplantation.The results showed that patients with low admission Model for End-Stage Liver Disease(MELD)scores(21.50±2.08vs 30.61±6.70,P<0.05)and corticosteroid therapy(100%vs 16.7%,P<0.05)had better prognosis.A total of seven patients received corticosteroid therapy,of whom,four responded and survived,and the other three died.Survivors showed young age,shorter duration from diagnosis to corticosteroid therapy,low MELD score,and absence of hepatic encephalopathy at the time of corticosteroid administration.Six patients who were administered corticosteroids acquired fungal infections but recovered after antifungal therapy.CONCLUSION:Early diagnosis and corticosteroid therapy are essential for improving the prognosis of patients with AIH-induced liver failure without liver transplantation. | Bing Zhu Shao-Li You Zhi-Hong Wan Hong-Ling Liu Yi-Hui Rong Hong Zang Shao-Jie Xin | 2014 | World Journal of Gastroenterology2014，20，23： | 10 |
| 4 | Microstructure and wear-resistant properties of NiCr–Cr_3C_2 coating with Ni45 transition layer produced by laser cladding显示文摘NiCr–Cr3C2 metal–ceramic composite coating is commonly produced on metal substrate by laser cladding to be used as wear-resistant coating under medium- or high-temperature working conditions.The coating has high hardness, generally over three times that of the substrate.In order to make the hardness increase gradually from substrate to coating surface, the nickel-based alloy Ni45 was chosen as the transition layer and Ni Cr–Cr3C2 coating was indirectly cladded on 20Cr2Ni4 A substrate.Microstructure and composition of the coating were characterized by scanning electron microscope(SEM), energy-dispersive spectroscopy(EDS) and X-ray diffraction(XRD).Microhardness of the cross section of the coating was measured.Friction and wear behavior of Ni Cr–Cr3C2coating and substrate were investigated through sliding against the Si C ball at 20, 100 and 300 °C.The morphologies of worn surfaces were analyzed by SEM and EDS.The results show that the hardness of Ni45 transition layer is between that of the substrate and Ni Cr–Cr3C2coating, which avoids hardness jump and stress concentration of the coating.Ni Cr–Cr3C2coating contains hard phases of Cr3C2 and Cr7C3which enhance the wear resistance.With thetemperature increasing, friction coefficient and wear rate of the substrate increase significantly.Compared with the substrate, Ni Cr–Cr3C2coating has lower friction coefficient and wear rate at 100 and 300 °C, which verifies the good wear resistance of NiCr–Cr3C2 coating. | Chun-Cheng Zang Yan-Zhong Wang Yi-Du Zhang Jin-Hua Li Hong Zeng De-Qiang Zhang | 2015 | Rare Metals2015，34，7： | 9 |
| 5 | Pediatric liver transplantation in 31 consecutive children显示文摘背景尽管肝移植为结束阶段肝疾病成为了标准治疗,小儿科的肝移植的经验在中国被限制。在这篇文章,我们在小儿科的肝移植报导我们的经验,并且在他们的指示,外科的技术,和手术后的管理总结它的人物。31 个孩子(18 岁) 在我们的中心经历了肝移植的方法。在移植的吝啬的年龄是 12.4 岁(从 5 个月到 18 年) 与是的 7 个孩子一起在移植的不到 4 岁。经历了肝移植的病人的最普通的诊断是胆汁的闭锁,威尔森的疾病,主要胆汁的肝硬化,肝糖存储疾病, hepatoblastoma,脲周期缺点,暴发性的肝的失败,等等。外科的过程包括了 12 标准(没有 venovenous,绕过) , 6 pigyback, 6 还原剂尺寸, 3 裂口, 3 生活施主肝移植,和 1 个牙齿肝移植。三倍药(FK506,类固醇,和 mycophenolate mofetil ) 抑制免疫力的政体在大多数病人被使用。病人们被跟随在上面为 21.8 个月的一个平均数。结果 31 个病人中的五个在 perioperative 时间期间死了;死亡率是 16.1% 。死亡的原因是感染,主要非功能,心失败,和 hypovolemic 吃惊。在 10 个病人的手术后的复杂并发症包括了胆汁的漏,尖锐拒绝,腹的感染,肝炎 B 病毒(HBV ) 或丙肝病毒(HCV ) 感染,和肺的感染。在 1- 的全面耐心的累积幸存率, 3- ,并且 5 年是 78.1% , 62.6% , 62.6% ,小儿科的肝移植的最普通的指示是的 respectively.Conclusions 先天的结束阶段肝疾病。根据病人的年龄和身体重量,标准,骑在背肩上,还原剂尺寸,裂口,或生活施主肝移植应该被执行。小儿科的肝移植特别要求更高外科的技巧。早手术后的管理是成功的关键。手术后的胆汁漏缝是普通的,但是大多数病人经历了有的肝移植更好的预后。 | SHEN Zhong-yang WANG Zi-fa ZHU Zhi-jun ZANG Yun-jin ZHENG Hong DENG Yong-lin PAN Cheng CHEN Xin-guo | 2008 | Chinese Medical Journal2008，，20： | 8 |
| 6 | Variability in the composition and export of silica in the Huanghe River Basin显示文摘Concentrations of suspended particle material(SPM), dissolved silicate(DSi), biogenic silica(BSi), phytoliths(plant produced siliceous microscopic structures), and other parameters were analyzed to examine the influence of both natural processes and human activities on silica delivery to the estuary of the Huanghe River(Yellow River). Our results indicate that the concentrations of DSi in the river decreased significantly since 1986. Approximately 34% of dissolved silica was trapped in the basin between 1986 and 2010 due to a reduction of soil erosion. Phytoliths comprised 67.2%–96.3% of BSi, with the smoothing bar type being the dominant form. Concentrations of BSi are significantly higher in the Huanghe River compared to other major rivers throughout the world due to its high sediment yield. We also found that the ratios of BSi/(BSi+DSi) and BSi/SPM were approximately 0.5 and 0.003 at Lijin near the river mouth, indicating that BSi carried in suspension by the Huanghe River was an important component of the rivers silica load. Significant amounts of BSi were also composed of phytoliths in Bohai Sea sediments near the Huanghe River estuary with the smoothing bar form again being the most abundant. The relatively high specific fluxes of BSi in the Huanghe River reflect its high turbidity and high erosion rates in the basin. The high sediment load originating on the Loess Plateau is likely responsible for the higher BSi flux, in agreement with a general trend of increasing BSi flux with increasing sediment flux in global river systems. This study demonstrates that BSi transported by rivers can be composed largely of phytoliths originating from the erosion of topsoils. The flux of phytoliths in river's suspended sediment load may therefore represent a significant contribution to the biogeochemical cycle of silica in coastal waters. | RAN XiangBin CHE Hong ZANG JiaYe YU YongGui LIU Sen ZHENG LiLi | 2015 | Science China Earth Sciences2015，58，11： | 7 |
| 7 | Robust superhydrophobic polyurethane sponge functionalized with perfluorinated graphene oxide for efficient immiscible oil/water mixture, stable emulsion separation and crude oil dehydration显示文摘In recent years, graphene oxide(GO), prepared by the modified Hummers’ method, and its derivatives have become a focus of research owing to their outstanding physical and chemical properties and low cost. Drawing inspiration from the mussel protein,a facile and environmentally-friendly method was employed to fabricate superhydrophobic/superoleophilic reduced graphene oxide(rGO) derivative. The preparation comprises two steps: coating GO nanosheets with polydopamine(PDA) and subsequent reaction with 1H,1H,2H,2H-perfluorodecanethiol. Due to the excellent adhesive ability of PDA, the resulting f PDA modified rGO nanosheets(rGO-f PDA) were firmly immobilized onto polyurethane(PU) sponge skeleton by a simple drop-coating method. The as-prepared rGO-f PDA functionalized sponge exhibited superhydrophobic behavior with a water contact angle of 162°±2°, high organic adsorption capacity, recyclability and stable oil/water separation behavior under different acidic/alkaline conditions. Due to its facile fabrication technique and outstanding properties, the superhydrophobic-superoleophilic PU-rGOf PDA sponge holds great promise as an oil adsorbent for cleaning up large-scale pollution of oil and organic solvents, and dehydrating crude oil. | CAO Ning GUO JingYu BOUKHERROUB Rabah SHAO QingGuo ZANG XiaoBei LI Jin LIN XueQiang JU Hong LIU EnYang ZHOU ChaoFan LI HuiPing | 2019 | Science China(Technological Sciences)2019，62，9： | 6 |
| 8 | Effects of magnesium on the performance of sows and their piglets显示文摘The objective of this study was to evaluate the effects of supplemental magnesium(Mg) on the performance of gilts and parity 3 sows and their piglets.Fifty-six gilts(Trial 1) and 56 sows(Trial 2) were assigned to one of 4treatments according to their mating weight,respectively.The treatments comprised corn-soybean meal based gestation and lactation diets(0.21%magnesium) supplemented with 0,0.015,0.03,or 0.045%Mg from mating until weaning.The results showed that magnesium supplementation significantly(P < 0.05) reduced the weaning to estrus interval in both gilts and sows.There were significant effects(P < 0.05) of supplemental magnesium on the total number of piglets born,born alive and weaned in sows.In late gestation and lactation,the digestibility of crude fiber(quadratic effects,P< 0.05),and crude protein(P< 0.05),were significantly influenced by magnesium in gilts and sows,respectively.There were differences among the 4 groups in terms of the apparent digestibility of dry matter and crude fiber in sows(P< 0.05) during both early and late gestation.The apparent digestibility of gross energy was increased for sows in late gestation(P< 0.05),and lactation(quadratic effects,P< 0.05).At farrowing and weaning,serum prolactin levels and alkaline phosphate activities linearly increased in sows as the Mg supplementation increased(P < 0.05).Serum Mg of sows at farrowing and serum urea nitrogen of sows at weaning was significantly influenced by Mg supplementation(P< 0.05).The Mg concentration in sow colostrum and the serum of their piglets were increased by supplemental magnesium(P < 0.05).In addition,growth hormone levels were linearly elevated(P< 0.05) in the serum of piglets suckling sows.Our data demonstrated that supplemental magnesium has the potential to improve the reproduction performance of sows,and the suitable supplemental dose ranged from 0.015%to 0.03%. | Jianjun Zang Jingshu Chen Ji Tian Aina Wang Hong Liu Shengdi Hu Xiangrong Che Yongxi Ma Junjun Wang Chunlin Wang Guanghua Du Xi Ma | 2015 | Journal of Animal Science and Biotechnology2015，6，1： | 3 |
| 9 | INFLUENCE OF THE SCORER PARAMETER PROFILE ON THE WAVELENGTH OF TRAPPED LEE WAVES显示文摘A three-layer theoretical model was established,in which the atmosphere is divided into three layers based on the Scorer parameter l2 ,which is large in the middle layer and small in the other two layers. The wave number formula of lee waves was deduced with this theoretical model,and a typical example for the lee wave was calculated. Thus,the influence of changes in the thickness of every layer and values of the Scorer parameter in every layer was examined. The results show that the wavelength decreases with an increase in the thickness of the lower and the middle layers and is more sensitive to the changes in the middle layer. Therefore,if the changes in these two layers are different,the changes in the middle layer will dominate the changes in the wavelength. The results also show that the wavelength decreases with the increase in the value of l2 in every layer,among which the sensitivity to the l2 in the upper layer is the most striking. The calculation results reasonably can explain the influence of diurnal changes on the wavelength. The example was simulated using Advanced Regional Prediction System model,and the sensitivity experiments were performed to confirm the effects of the Scorer parameter profiles on the wavelengths. The simulated results are consistent with the calculated results. | ZANG Zeng-liang ZHANG Ming HUANG Hong | 2007 | Journal of Hydrodynamics2007，19，2： | 3 |
| 10 | Applications of nanogenerators for biomedical engineering and healthcare systems显示文摘The dream of human beings for long living has stimulated the rapid development of biomedical and healthcare equipment.However,conventional biomedical and healthcare devices have shortcomings such as short service life,large equipment size,and high potential safety hazards.Indeed,the power supply for conventional implantable device remains predominantly batteries.The emerging nanogenerators,which harvest micro/nanomechanical energy and thermal energy from human beings and convert into electrical energy,provide an ideal solution for self-powering of biomedical devices.The combination of nanogenerators and biomedicine has been accelerating the development of self-powered biomedical equipment.This article first introduces the operating principle of nanogenerators and then reviews the progress of nanogenerators in biomedical applications,including power supply,smart sensing,and effective treatment.Besides,the microbial disinfection and biodegradation performances of nanogenerators have been updated.Next,the protection devices have been discussed such as face mask with air filtering function together with real-time monitoring of human health from the respiration and heat emission.Besides,the nanogenerator devices have been categorized by the types of mechanical energy from human beings,such as the body movement,tissue and organ activities,energy from chemical reactions,and gravitational potential energy.Eventually,the challenges and future opportunities in the applications of nanogenerators are delivered in the conclusive remarks. | Wanli Wang Jinbo Pang Jie Su Fujiang Li Qiang Li Xiaoxiong Wang Jingang Wang Bergoi Ibarlucea Xiaoyan Liu Yufen Li Weijia Zhou Kai Wang Qingfang Han Lei Liu Ruohan Zang Mark HRümmeli Yang Li Hong Liu Han Hu Gianaurelio Cuniberti | 2022 | InfoMat2022，4，2： | 2 |
| 11 | 茉莉酸甲酯与水杨酸诱导的大白菜叶片与根系硫苷含量系统性变化研究(英文)显示文摘目的:通过单独或混合施用茉莉酸甲酯与水杨酸,研究两者在诱导大白菜硫苷合成方面的差异及其相互作用。创新点:试验中,首次通过混合喷施或灌施茉莉酸甲酯与水杨酸,研究两者在诱导大白菜硫苷合成过程中的相互作用。方法:试验过程中采用高效液相色谱法分析各硫苷组分的具体含量,为分析茉莉酸甲酯与水杨酸单独或混合施用在诱导大白菜硫苷合成过程中的作用奠定了基础。结论:茉莉酸甲酯与水杨酸处理后,大白菜根系比叶片积累更多的硫苷,吲哚族硫苷比其他种类的硫苷积累更快;茉莉酸甲酯诱导硫苷合成的效果好于水杨酸,而且诱导时间更长;茉莉酸甲酯与水杨酸在诱导大白菜根系硫苷合成过程中具有反协同效应。 | Yun-xiang ZANG Jia-li GE Ling-hui HUANG Fei GAO Xi-shan LV Wei-wei ZHENG Seung-beom HONG Zhu-jun ZHU | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，8： | 2 |
| 12 | Current and Passive Smokers Have Poorer Quantity and Quality of Diet in Shanghai, China: A Crosssectional Survey显示文摘Smoking is a major risk factor for chronic diseases,it has been estimated that 300 million adults currently smoke in China,and the smoking prevalence in males is as high as 52.9%,with 1million smoking-related deaths yearly.Therefore,smoking is also a huge health burden in China[1].Researchers have suggested an association between diet and smoking status with respect to both food and nutrient intakes.According to such studies,smokers tended to have a poor diet. | WANG Zheng Yuan LI Li ZANG Jia Jie SHI Ze Huan JIN Wei QI De Yun TANG Chuan Xi GAO Hong Mei WANG Jin Xiang ZHU Zhen Ni JIA Xiao Dong GUO Chang Yi | 2019 | Biomedical and Environmental Sciences2019，32，10： | 2 |
| 13 | Assessment of trace metal contamination in groundwater in a highly urbanizing area of Shenfu New District, Northeast China显示文摘 | Yintao LU Xinghua ZANG Hong YAO Shichao ZHANG Shaobin SUN Fang LIU | 2018 | Frontiers of Earth Science2018，12，3： | 2 |
| 14 | Recipient dendritic cells modified by RNA interference targeting CD80 and CD86 elicit T cell hyporesponsiveness via enhanced T cell apoptosis显示文摘 | HONG Jun GU Xiao-dong XIANG Jian-bin ZHANG Zhe ZANG Yi-wen ZHANG Qun-hua QIAN Shi-guang CHEN Zong-you | 2013 | Chinese Medical Journal2013，，11： | 2 |
| 15 | Molecular basis for CENP-N recognition of CENP-A nucleosome on the human kinetochore显示文摘 | Tian Tian Xiaorun Li Yingying Liu Chengliang Wang Xing Liu Guoqiang Bi Xuan Zhang Xuebiao Yao Z Hong Zhou Jianye Zang | 2018 | Cell Research2018，28，3： | 2 |
| 16 | Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients显示文摘 | Dekai Qiu Qixia Wang Hui Wang Qing Xie Guoqing Zang Hong Jiang Chuantao Tu Jinsheng Guo Shuncai Zhang Jianshe Wang Yi Lu Ying Han Lei Shen Xiaoyu Chen Xiqi Hu Xiaojin Wang Chengwei Chen Qingchun Fu Xiong Ma | 2010 | Journal of Hepatology2010，，： | 2 |
| 17 | Plant regeneration of turf -type common bermudagrass (Cynoclon dactylon )via somatic em- bryogenesis from seed -derived callus显示文摘 | Zang Y X Hong S B Murugesan D J | 2006 | Hortic Environ Biotech2006，47，： | 1 |
| 18 | Bifurcation of limit cycles near equivariant compound cycles显示文摘In this paper we study some equivariant systems on the plane. We first give some criteria for the outer or inner stability of compound cycles of these systems. Then we investigate the number of limit cycles which appear near a compound cycle of a Hamiltonian equivariant system under equivariant perturbations. In the last part of the paper we present an application of our general theory to show that a Z3 equivariant system can have 13 limit cycles. | Mao-an HAN Tong-hua ZHANG Hong ZANG | 2007 | Science China Mathematics2007，50，4： | 1 |
| 19 | Neutrophil gelatinase- associated lipocalin protects renal tubular epithelial cells in hypoxia-reperfusion by reducing apoptosis 显示文摘 | Zang X Zheng F Hong H J | 2014 | Int Urol Nephrol2014，46，8： | 1 |
| 20 | Blocking effects of serum reactive antibodies induced by glatiramer acetate treatment in multiple sclerosis显示文摘 | SALAMA HH HONG J ZANG YC | 2003 | Brain2003，126，12： | 1 |
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