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| 1 | Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways显示文摘Herein,we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy(DCM)by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model.Advanced glycation end-products(AGEs),an important pathogenic factor of DCM,were found to induce ferroptosis in engineered cardiac tissues(ECTs),as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7 A11 levels.Typical morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron microscopy.Inhibition of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and dysfunction.Ferroptosis was also evidenced in the heart of type 2 diabetic mice with DCM.Inhibition of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of diabetes.Nuclear factor erythroid 2-related factor 2(NRF2)activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7 A11 levels.The protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase(AMPK)-dependent.These findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM;sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 activation.This suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM. | Xiang Wang Xinxin Chen Wenqian Zhou Hongbo Men Terigen Bao Yike Sun Quanwei Wang Yi Tan Bradley B.Keller Qian Tong Yang Zheng Lu Cai | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 20 |
| 2 | KIF2C:a novel link between Wnt/β-catenin and mTORCI signaling in the pathogenesis of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and is the fourth-leading cause of cancer-related deaths worldwide.HCC is refractory to many standard cancer treatments and the prognosis is often poor,highlighting a pressing need to identify biomarkers of aggressiveness and potential targets for future treatments.Kinesin family member 2C(KIF2C)is reported to be highly expressed in several human tumors.Nevertheless,the molecular mechanisms underlying the role of KIF2C in tumor development and progression have not been investigated.In this study,we found that KIF2C expression was significantly upregulated in HCC,and that KIF2C up-regulation was associated with a poor prognosis.Utilizing both gain and loss of function assays,we showed that KIF2C promoted HCC cell proliferation,migration,invasion,and metastasis both in vitro and in vivo.Mechanistically,we identified TBC1D7 as a binding partner of KIF2C,and this interaction disrupts the formation of the TSC complex,resulting in the enhancement of mammalian target of rapamycin complexl(mTORCI)signal transduction.Additionally,we found that KIF2C is a direct target of the Wnt/β-catenin pathway,and acts as a key factor in mediating the crosstalk between Wnt/β-catenin and mTORCI signaling.Thus,the results of our study establish a link between Wnt/β-catenin and mTORCI signaling,which highlights the potential of KIF2C as a therapeutic target for the treatment of HCC. | Shi Wei Miaomiao Dai Chi Zhang Kai Teng Fengwei Wang Hongbo Li Weipeng Sun Zihao Feng Tiebang Kang Xinyuan Guan Ruihua Xu Muyan Cai Dan Xie | 2021 | Protein & Cell2021，12，10： | 8 |
| 3 | FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis显示文摘Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis(RA).Fatty acid-binding protein 4(FABP4),a novel adipokine that regulates inflammation and angiogenesis,has been extensively studied in a variety of organs and diseases.However,the effect of FABP4 on RA remains unclear.Here,we found that FABP4 expression was upregulated in synovial M1-polarized macrophages in RA.The increase in FABP4 promoted synovitis,angiogenesis,and cartilage degradation to exacerbate RA progression in vivo and in vitro,whereas BMS309403(a FABP4 inhibitor)and anagliptin(dipeptidyl peptidase 4 inhibitor)inhibited FABP4 expression in serum and synovial M1-polarized macrophages in mice to alleviate RA progression.Further studies showed that constitutive activation of mammalian target of rapamycin complex 1(mTORC1)by TSC1 deletion specifically in the myeloid lineage regulated FABP4 expression in macrophages to exacerbate RA progression in mice.In contrast,inhibition of mTORC1 by ras homolog enriched in brain(Rheb1)disruption specifically in the myeloid lineage reduced FABP4 expression in macrophages to attenuate RA development in mice.Our findings established an essential role of FABP4 that is secreted by M1-polarized macrophages in synovitis,angiogenesis,and cartilage degradation in RA.BMS309403 and anagliptin inhibited FABP4 expression in synovial M1-polarized macrophages to alleviate RA development.Hence,FABP4 may represent a potential target for RA therapy. | Dong Guo Chuangxin Lin Yuheng Lu Hong Guan Weizhong Qi Hongbo Zhang Yan Shao Chun Zeng Rongkai Zhang Haiyan Zhang Xiaochun Bai Daozhang Cai | 2022 | Bone Research2022，10，4： | 5 |
| 4 | Energy Efficiency and Spectrum Efficiency in Underlay Device-to-Device Communications Enabled Cellular Networks显示文摘In this paper, we investigate the energy efficiency and spectrum efficiency, including one-hop device-to-device(D2D) communications mode and two-way amplify-and-forward(AF) relaying D2D communications mode in underlay D2D communications enabled cellular networks. An analysis of average energy efficiency and spectrum efficiency are developed and closed-form expressions are obtained for two types of D2D communications modes under the effect of Rayleigh fading channel, path loss, and co-channel interference. Analytical results are validated through numerical simulations. Based on the simulation, the effects of the interference, the distance between D2D pair and the position of relay node on the energy efficiency and spectrum efficiency of D2D communications are investigated. The optimal D2D transmission powers of these two modes to maximize the energy efficiency are also investigated. | Yan Cai Yiyang Ni Jun Zhang Su Zhao Hongbo Zhu | 2019 | China Communications2019，16，4： | 5 |
| 5 | Trajectory prediction of cyclist based on dynamic Bayesian network and long short-term memory model at unsignalized intersections显示文摘Cyclist trajectory prediction is of great significance for both active collision avoidance and path planning of intelligent vehicles.This paper presents a trajectory prediction method for the motion intention of cyclists in real traffic scenarios.This method is based on dynamic Bayesian network(DBN)and long short-term memory(LSTM).The motion intention of cyclists is hard to predict owing to potential large uncertainties.The DBN is used to infer the distribution of cyclists’intentions at intersections to improve the prediction time.The LSTM with encoder-decoder is used to predict the cyclists’trajectories to improve the accuracy of prediction.Therefore,the DBN and LSTM are adopted to guarantee prediction accuracy and improve the prediction time.The experiment results are presented to show the effectiveness of the predict strategies. | Hongbo GAO Hang SU Yingfeng CAI Renfei WU Zhengyuan HAO Yongneng XU Wei WU Jianqing WANG Zhijun LI Zhen KAN | 2021 | Science China(Information Sciences)2021，64，7： | 4 |
| 6 | Power Allocation for NOMA in D2D Relay Communications显示文摘Non-orthogonal multiple access(NOMA)is considered as one of the key technologies for the fifth generation(5G)wireless communications.The integration of NOMA and device-to-device(D2D)communications has recently attracted wide attention.In this paper,a relaying D2D communications assisted with cooperative relaying systems using NOMA(DRC-NOMA)is considered.We analyze the ergodic sum-rate for the proposed system and then derive the closed-form expressions.In addition,an optimal power allocation strategy maximizing the ergodic sum-rate is proposed based on these analysis results.Numerical results show the good agreement between the results of analysis and Monte Carlo method.The proposed DRC-NOMA has a great improvement of the ergodic sum-rate in the small regime of average channel gain of D2D pair. | Yan Cai Chunhua Ke Yiyang Ni Jun Zhang Hongbo Zhu | 2021 | China Communications2021，18，1： | 4 |
| 7 | Solid rocket motor propellant grain burnback simulation based on fast minimum distance function calculation and improved marching tetrahedron method显示文摘To efficiently compute arbitrary propellant grain evolution of the burning surface with uniform and non-uniform burning rate for solid rocket motor,a unified framework of burning surface regression simulation has been developed based on minimum distance function.In order to speed up the computation of the mini-mum distance between grid nodes of grain and the triangular mesh of burning surface,a fast distance querying method based on the equal size cube voxel structure was employed.An improved marching tetrahedron method based on piecewise linear approximation was carried out on second-order tetrahedral elements,achieved high-efficiency and adequate accuracy of burning surface extraction simultaneously.The cases of star grain,finocyl grain,and non-uniform tube grain were studied to verify the proposed method.The observed result indicates that the grain burnback computation method could realize the accurate simulation on unstructured tetrahedral mesh with a desirable performance on computational time. | Pengfei REN Hongbo WANG Guofeng ZHOU Jiani LI Qiang CAI Jiaquan YU Ya YUAN | 2021 | Chinese Journal of Aeronautics2021，34，4： | 2 |
| 8 | Performance for Device-to-Device Communication with Three-Time-Slot Two-Way Amplify-and-Forward Relay Protocol显示文摘Multi-hop device-to-device(D2D) communication can significantly improve the system performance. This paper studied the outage performance of D2 D communication assisted by another D2 D user using three-timeslot two-way amplify-and-forward relaying protocol over Rayleigh fading channels. Considering the co-channel interference from cellular user at the D2 D node,the approximate expression for the overall outage probability was derived. Furthermore,a power allocation optimum method to minimize the outage probability was developed,and the closed form expression for the optimal power allocation coefficient at the relay was derived. Simulation results demonstrate accuracy of the derived outage probability expressions. Simulation results also demonstrate that the outage performance can be improved using the proposed optimal power allocation method. | CAI Yan NI Yiyang ZHU Hongbo | 2015 | China Communications2015，12，11： | 2 |
| 9 | Scaling effects on combustion modes in a single-side expansion kerosene-fueled scramjet combustor显示文摘The combustion modes in two different scramjet combustors with the mass flow rates of 1.8 kg/s and 3.6 kg/s are experimentally investigated to explore the scaling effects on supersonic combustion with a Mach number 2.0 inflow.It is found that the scramjet combustor with a larger scale can broaden the flame rich blowout limit.As the Equivalence Ratio(ER)increases,the combustion in the small-scale combustor maintains in the cavity-stabilized mode,and the flamebase moves downstream along the cavity shear layer;however,the combustion in the large-scale combustor gradually transfers from the cavity-stabilized mode to the jet-wake-stabilized mode.The differences in the cavity residence time,the ignition delay time and the Damkohler number caused by different scales of the scramjet combustor are likely to account for the scaling effects on the combustion modes. | Fan LI Mingbo SUN Jiajian ZHU Zun CAI Hongbo WANG Yanxiang ZHANG Yongchao SUN | 2021 | Chinese Journal of Aeronautics2021，34，5： | 2 |
| 10 | An nhibitory effect of AAAD1 on bladder tumor cellular proliferation in vivo显示文摘 | Hongbo Hu Chunli Luo Xiaozhong Cai | 2006 | Chinese Journal of Clinical Oneology2006，3，： | 1 |
| 11 | A new coordinated control strategy for boiler-turbine system of coal-fired power plant显示文摘 | Li Shaoyuan Liu Hongbo Cai Wenjian | 1996 | IEEE Transactions on Control Systems Technology1996，4，1： | 1 |
| 12 | Enhancing the number of high-energy electrons deposited to a compressed pellet via double cones in fast ignition显示文摘 | Cai Hongbo Mima K Zhou Wemin | 2009 | Physical Review Letters2009，102，24： | 1 |
| 13 | Novel multi-walled nanotubes-supported and alkali-promoted Ru catalysts for ammonia synthesis under atmosphenic pressure显示文摘 | Chen Hongbo Lin Jingdong Cai Yun | 2001 | Applied Surface Science2001，180，1： | 1 |
| 14 | Transient Perform- ances Analysis and Experiment for Optical Current Transformer 显示文摘 | LI Hongbo CAI Xingguo ZHANG Guoqing | 2014 | Lecture Notes in Electrical Engineering2014，258，： | 1 |
| 15 | How large are the impacts of carbon-motivated border tax adjustments on China and how to mitigate them显示文摘 | LI Aijun ZHANG Aizhen CAI Hongbo | 2013 | Energy Policy2013，63，： | 1 |
| 16 | Analysis of electromagnetic pulses generation from laser coupling with polymer targets: Effect of metal content in target显示文摘Powerful lasers interacting with solid targets can generate intense electromagnetic pulses(EMPs).In this study,EMPs produced by a pulsed laser(1 ps,100 J)shooting at CH targets doped with different titanium(Ti)contents at the XG-III laser facility are measured and analyzed.The results demonstrate that the intensity of EMPs first increases with Ti doping content from 1%to 7%and then decreases.The electron spectra show that EMP emission is closely related to the hot electrons ejected from the target surface,which is confirmed by an analysis based on the target–holder–ground equivalent antenna model.The conclusions of this study provide a new approach to achieve tunable EMP radiation by adjusting the metal content of solid targets,and will also help in understanding the mechanism ofEMPgeneration and ejection of hot electrons during laser coupling with targets. | Yadong Xia Feng Zhang Hongbo Cai Weimin Zhou Chao Tian Bo Zhang Dongxiao Liu Tao Yi Yilin Xu Feng Wang Tingshuai Li Shaoping Zhu | 2020 | Matter and Radiation at Extremes2020，5，1： | 1 |
| 17 | Fine mapping of quantitative trait loci for acid phosphatase activity in maize leaf under low phosphorus stress显示文摘 | Hongbo Qiu Xiupeng Mei Chaoxian Liu Jiuguang Wang Guoqiang Wang Xu Wang Zheng Liu Yilin Cai | 2013 | Molecular Breeding2013，，3： | 1 |
| 18 | Review on formation mechanism analysis method and control strategy of urban haze in China显示文摘Due to the rapid urbanization and industrialization,and excessive consumption of fossil fuel,haze weather characterized by PM2.5 has become a severe pollution problem in major Chinese cities recently,which has harmful effect on the air quality,visibility,clime system and human health.To indicate suitable directions for the prevention and control of haze pollution,the pollutant source apportionment and formation mechanism of urban haze should be figured out firstly.In this work,we briefly review the frequently-used methods for PM2.5 source apportionment and formation mechanism analysis of urban haze based on normal perspective in recent years.Furthermore,based on the new perspective of systematic methodology,the utilization of fault tree approach for the causation mechanism analysis of urban haze is significantly introduced and discussed.Finally,the recent progress on controlling strategies of urban haze in China is also synoptically introduced and discussed.It is expected that more effective tool/method can be found,developed and employed for the causation mechanism analysis and risk management of urban haze in China. | Weiqing Huang Lirong Cai Haifeng Dang Zhe Jiao Hongbo Fan Faliang Cheng | 2019 | Chinese Journal of Chemical Engineering2019，27，7： | 1 |
| 19 | Isolation of fetal hepatocytes for clinical transplantation显示文摘 | Cai Hongbo Nakazawa F Ramaehandran V | 2001 | Cell transplantation2001，10，6： | 1 |
| 20 | Novel multi- walled nanotubes-supported and alkali-promoted Ru catalysts for ammonia synthesis under atmosphenic pressure 显示文摘 | Chen Hongbo Lin Jingdong Cai Yun | 2001 | Applied Surface Science2001，180，： | 1 |
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